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11. 发明授权

US07635452B2 System, kit, and method for measuring membrane diffusion 失效
标题翻译：用于测量膜扩散的系统，试剂盒和方法
公开(公告)号：US07635452B2
公开(公告)日：2009-12-22
申请号：US10669276
申请日：2003-09-24
申请人： Stephen B. Roscoe , Neal A. Rakow , Michael L. Husberg , Lester H. McIntosh, III
发明人： Stephen B. Roscoe , Neal A. Rakow , Michael L. Husberg , Lester H. McIntosh, III
IPC分类号： G01N33/00
CPC分类号： B01L3/5025 , G01N13/00 , G01N33/15 , G01N2013/003 , G01N2015/086
摘要： A system for measuring diffusion of a compound across a membrane generally comprises a membrane held between a first base having a plurality of outwardly extending hollow projections and a second base fastened to the first base and having a plurality of recessed tapered openings therein adapted to engage the plurality of hollow projections. Methods for measuring membrane diffusion using such systems are included. The system components are also provided in kit form.
摘要翻译：用于测量化合物穿过膜的扩散的系统通常包括保持在具有多个向外延伸的中空突出部的第一基座和固定到第一基座的第二基座之间并具有多个凹入的锥形开口的膜，其中适于接合多个中空突起。包括使用这种系统测量膜扩散的方法。系统组件也以套件形式提供。

12. 发明授权

US6100214A Polymeric supported catalysts for olefin polymerization 失效
标题翻译：用于烯烃聚合的聚合载体催化剂
公开(公告)号：US6100214A
公开(公告)日：2000-08-08
申请号：US092752
申请日：1998-06-05
申请人： John F. Walzer, Jr. , Anthony J. Dias , Jean M J Frechet , Stephen B. Roscoe
发明人： John F. Walzer, Jr. , Anthony J. Dias , Jean M J Frechet , Stephen B. Roscoe
IPC分类号： C08F4/02 , C08F4/619 , C08F4/6192 , C08F4/64 , C08F4/642 , C08F4/643 , C08F4/659 , C08F4/6592 , C08F10/00 , C08F210/16 , B01J31/00 , B01J37/00 , C08F4/44 , C08F4/60
CPC分类号： C08F10/00 , C08F210/16 , C08F4/61908 , C08F4/6192 , C08F4/65908 , C08F4/65922 , Y10S526/943
摘要： The described invention provides a low fouling, high particle density polymerization process and an olefin polymerization catalyst composition comprising the reaction product of a) an organic polymeric support i) having a surface area of from about 1 to 10 m.sup.2 /g and ii) functionalized with an acidic proton-containing ammonium salt of a non-coordinating anion, and b) an organometallic transition metal compound having ancillary ligands, at least one labile ligand capable of abstraction by protonation by said ammonium salt and at least one labile ligand into which an olefinic monomer can insert for polymerization. In a preferred embodiment, the polymeric support has a surface area of .ltoreq.10 m.sup.2 /g and is particularly suitable for use with high activity organometallic, transition metal catalyst compounds.
摘要翻译：所述发明提供低结垢，高颗粒密度聚合方法和烯烃聚合催化剂组合物，其包含a）有机聚合物载体i）的反应产物，其表面积为约1-10m 2 / g，和ii）用非配位阴离子的含酸性质子的铵盐，以及b）具有辅助配体的有机金属过渡金属化合物，至少一个能够被所述铵盐质子化而被抽出的不稳定配体和至少一个不稳定的配体，烯属单体可插入聚合。在优选的实施方案中，聚合物载体的表面积为= 10m 2 / g，特别适用于高活性有机金属过渡金属催化剂化合物。

13. 发明申请

US20120301911A1 Rapid Detection of Molds that Produce Glucose Oxidase 有权
标题翻译：快速检测产生葡萄糖氧化酶的模具
公开(公告)号：US20120301911A1
公开(公告)日：2012-11-29
申请号：US13515856
申请日：2010-12-21
申请人： Stephen B. Roscoe , Michael J. Svarovsky , Stephanie J. Moeller
发明人： Stephen B. Roscoe , Michael J. Svarovsky , Stephanie J. Moeller
IPC分类号： G01N21/78
CPC分类号： C12Q1/04 , C12Q1/045 , C12Q1/26 , C12Q1/54
摘要： Methods and kits are disclosed for detecting microorganisms that produce glucose oxidase. The method includes providing a culture medium and a hydrogen peroxide indicating reagent comprising a chromogenic substrate that can provide a detectable chromogenic reaction indicating the presence of a microorganism that produces glucose oxidase, and additional methods are disclosed for differentiating microorganisms by the detection of an additional chromogenic reaction.
摘要翻译：公开了用于检测产生葡萄糖氧化酶的微生物的方法和试剂盒。该方法包括提供培养基和过氧化氢指示试剂，其包含可产生可产生葡萄糖氧化酶的微生物存在的可检测的生色反应的显色底物，并且公开了用于通过检测另外的显色性来分化微生物的另外的方法反应。

14. 发明授权

US06245700B1 Transparent microspheres 有权
标题翻译：透明微球
公开(公告)号：US06245700B1
公开(公告)日：2001-06-12
申请号：US09362323
申请日：1999-07-27
申请人： Kenton D. Budd , Toshihiro Kasai , Stephen B. Roscoe , Chikafumi Yokoyama , John E. Bailey
发明人： Kenton D. Budd , Toshihiro Kasai , Stephen B. Roscoe , Chikafumi Yokoyama , John E. Bailey
IPC分类号： C03C1202
CPC分类号： C03C12/02 , C03C1/00 , C03C3/062 , Y10S977/775 , Y10S977/776 , Y10T428/2982
摘要： Transparent solid microspheres that contain titania plus alumina, zirconia, and/or silica in a total content of at least about 75% by weight, based on the total weight of the solid microspheres, wherein the total content of alumina, zirconia, and titania is greater than the content of silica.
摘要翻译：基于固体微球的总重量，含有总重量至少约75重量％的二氧化钛加氧化铝，氧化锆和/或二氧化硅的透明固体微球，其中氧化铝，氧化锆和二氧化钛的总含量为大于二氧化硅的含量。

15. 发明授权

US09434975B2 Fluorogenic or fluorophoric compounds and uses thereof 有权
标题翻译：荧光或荧光化合物及其用途
公开(公告)号：US09434975B2
公开(公告)日：2016-09-06
申请号：US14008905
申请日：2012-03-05
申请人： Stephen B. Roscoe , Shih-Hung Chou , Stephanie J. Moeller , Jesse D. Miller , Kurt J. Halverson , Jason W. Bjork
发明人： Stephen B. Roscoe , Shih-Hung Chou , Stephanie J. Moeller , Jesse D. Miller , Kurt J. Halverson , Jason W. Bjork
IPC分类号： C12Q1/04 , C07D311/16 , C07D405/04 , C07D409/04 , C07H17/075 , G01N33/52 , G01N33/58
CPC分类号： C12Q1/04 , C07D311/16 , C07D405/04 , C07D409/04 , C07H17/075 , C09B57/02 , C12Q1/045 , G01N33/525 , G01N33/582
摘要： Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.
摘要翻译：提供了荧光或荧光的化合物。还提供了包含化合物的组合物和制品。另外，提供使用该化合物检测微生物的方法。化合物是氟化的，并且可以在酸性条件下有利地使用。

16. 发明授权

US08951748B2 Rapid detection of molds that produce glucose oxidase 有权
标题翻译：快速检测产生葡萄糖氧化酶的霉菌
公开(公告)号：US08951748B2
公开(公告)日：2015-02-10
申请号：US13515856
申请日：2010-12-21
申请人： Stephen B. Roscoe , Michael J. Svarovsky , Stephanie J. Moeller
发明人： Stephen B. Roscoe , Michael J. Svarovsky , Stephanie J. Moeller
IPC分类号： G01N33/573 , C12Q1/04 , C12Q1/26 , C12Q1/54
CPC分类号： C12Q1/04 , C12Q1/045 , C12Q1/26 , C12Q1/54
摘要： Methods and kits are disclosed for detecting microorganisms that produce glucose oxidase. The method includes providing a culture medium and a hydrogen peroxide indicating reagent comprising a chromogenic substrate that can provide a detectable chromogenic reaction indicating the presence of a microorganism that produces glucose oxidase, and additional methods are disclosed for differentiating microorganisms by the detection of an additional chromogenic reaction.
摘要翻译：公开了用于检测产生葡萄糖氧化酶的微生物的方法和试剂盒。该方法包括提供培养基和过氧化氢指示试剂，其包含可产生可产生葡萄糖氧化酶的微生物存在的可检测的生色反应的显色底物，并且公开了用于通过检测另外的显色性来分化微生物的另外的方法反应。

17. 发明申请

US20110143334A1 MICROBIOLOGICAL SYSTEMS AND METHODS OF FLUID SAMPLE ANALYSIS 有权
标题翻译：微生物系统和流体样品分析方法
公开(公告)号：US20110143334A1
公开(公告)日：2011-06-16
申请号：US12808317
申请日：2008-12-18
申请人： Stephen B. Roscoe , Manjiri T. Kshirsagar , Cynthia D. Zook
发明人： Stephen B. Roscoe , Manjiri T. Kshirsagar , Cynthia D. Zook
IPC分类号： C12Q1/04 , C12Q1/06 , C12Q1/70 , C12Q1/10 , C12Q1/14 , C12M1/12 , C12M1/34
CPC分类号： C12Q1/10 , C12M25/06 , C12M41/36 , C12Q1/04 , C12Q1/06 , C12Q1/24 , G01N2333/245 , Y02A50/54
摘要： Methods and systems for detecting the presence of a target microorganism in a liquid sample are provided. Methods comprise the steps of passing the liquid sample through a surface filter, placing the surface filter into contact with a culture device, incubating the culture device for a period of time and detecting the presence of a target microorganism. Methods may be used with an automated detection system.
摘要翻译：提供了用于检测液体样品中目标微生物的存在的方法和系统。方法包括使液体样品通过表面过滤器，使表面过滤器与培养装置接触，培养培养装置一段时间并检测目标微生物的存在的步骤。方法可以与自动检测系统一起使用。

18. 发明授权

US09435739B2 Methods and compositions to detect a biological activity 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US09435739B2
公开(公告)日：2016-09-06
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： C12Q1/44 , G01N21/64 , C12Q1/04
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包含具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再利用者，9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

19. 发明授权

US08518664B2 Methods of determining the amount of microorganisms present in a test sample 有权
标题翻译：确定测试样品中存在的微生物量的方法
公开(公告)号：US08518664B2
公开(公告)日：2013-08-27
申请号：US13513794
申请日：2010-12-17
申请人： Stephen B. Roscoe , Phillip A. Bolea , Stephanie J. Moeller
发明人： Stephen B. Roscoe , Phillip A. Bolea , Stephanie J. Moeller
IPC分类号： C12Q1/04
CPC分类号： G01N21/643 , C12Q1/04 , C12Q1/06
摘要： Methods of determining the amount of microorganisms present in a test sample. The methods include a) incubating the test sample with a growth media to form an incubated sample, wherein the growth media includes an enzyme substrate and the enzyme substrate includes an enzymatically hydrolyzable group and a fluorescent group, wherein microorganisms present in the test sample include an enzyme that hydrolyzes the hydrolyzable group from the fluorescent group to form a fluorescently detectable product, wherein the fluorescently detectable product has both an acidic and basic species; b) exciting the fluorescently detectable product with light having a wavelength of Exλiso for a time sufficient for the fluorescently detectable product to emit light, wherein Exλiso is the absorbance isosbestic point of the fluorescently detectable product; c) detecting light emitted at a wavelength of Emλ1; and d) quantifying the light emitted at the wavelength of Emλ1, wherein the quantity of the light emitted at the wavelength Emλ1 is indicative of the amount of microorganisms present in the test sample.
摘要翻译：确定测试样品中存在的微生物量的方法。所述方法包括：a）用生长培养基孵育所述测试样品以形成孵育的样品，其中所述生长培养基包括酶底物，并且所述酶底物包括酶促水解基团和荧光基团，其中存在于所述测试样品中的微生物包括从荧光基团水解可水解基团以形成荧光检测产物的酶，其中荧光检测产物具有酸性和碱性物质; b）用具有Exlambdaiso波长的光激发荧光检测产物足够的荧光检测产物发光的时间，其中Exlambdaiso是荧光检测产物的吸光度等值点; c）检测在波长λ1处发射的光; 以及d）量化在λ1波长处发射的光，其中在波长λ1处发射的光的量指示测试样品中存在的微生物的量。

20. 发明申请

US20120252049A1 METHODS OF DETECTING MICROORGANISMS AND KITS THEREFORE 有权
标题翻译：检测微生物和试剂盒的方法
公开(公告)号：US20120252049A1
公开(公告)日：2012-10-04
申请号：US13513794
申请日：2010-12-17
申请人： Stephen B. Roscoe , Phillip A. Bolea , Stephanie J. Moeller
发明人： Stephen B. Roscoe , Phillip A. Bolea , Stephanie J. Moeller
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N21/643 , C12Q1/04 , C12Q1/06
摘要： A method of detecting microorganisms in a test sample is provided. The method includes the steps of: a) incubating the test sample with a growth media to form an incubated sample, wherein the growth media includes an enzyme substrate and the enzyme substrate includes an enzymatically hydrolysable group and a fluorescent group, wherein microorganisms present in the test sample include an enzyme that hydrolyzes the hydrolysable group from the fluorescent group to form a fluorescently detectable product, wherein the fluorescently detectable product has both an acidic and basic species; b) exciting the fluorescently detectable product with light having a wavelength of Exλiso for a time sufficient for the fluorescently detectable product to emit light, wherein Exλiso is the absorbance isosbestic point of the fluorescently detectable product; and c) detecting light emitted at a wavelength of Emλ1.
摘要翻译：提供了一种检测试样中微生物的方法。该方法包括以下步骤：a）用生长培养基孵育测试样品以形成孵育的样品，其中生长培养基包括酶底物，酶底物包括酶促水解基团和荧光基团，其中存在于测试样品包括从荧光基团水解可水解基团以形成荧光可检测产物的酶，其中荧光检测产物具有酸性和碱性物质; b）用具有Exλiso波长的光激发荧光检测产物足够的荧光检测产物发光的时间，其中Exλiso是荧光检测产物的吸光度等值点; 以及c）检测在Emλ1的波长处发射的光。

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