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11. 发明授权

US07139607B1 Arrhythmia discrimination 有权
标题翻译：心律失常辨别
公开(公告)号：US07139607B1
公开(公告)日：2006-11-21
申请号：US10460597
申请日：2003-06-11
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/36114 , A61N1/3622 , A61N1/3684 , A61N1/3962
摘要： Various exemplary methods include altering conduction and/or operation of the AV node and/or AV bundle to help classify arrhythmias.
摘要翻译：各种示例性方法包括改变AV节点和/或AV束的传导和/或操作以帮助分类心律失常。

12. 发明授权

US06970744B1 Bioenergy generator 失效
标题翻译：生物能源发电机
公开(公告)号：US06970744B1
公开(公告)日：2005-11-29
申请号：US10640832
申请日：2003-08-13
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61N1/18 , A61N1/378
CPC分类号： A61N1/3785
摘要： A biogenerator, having a biomotor portion and a generator portion, suitable for use with, in and/or as an implantable device. A method of inducing an electromagnetic force in a coil using a biomotor.
摘要翻译：具有生物电动机部分和发电机部分的生物发生器，适用于和/或作为可植入装置使用。使用生物电动机在线圈中诱发电磁力的方法。

13. 发明授权

US08016764B1 Systems and methods for evaluating ventricular dyssynchrony using atrial and ventricular pressure measurements obtained by an implantable medical device 有权
标题翻译：使用由可植入医疗装置获得的心房和心室压力测量值来评估心室不同步的系统和方法
公开(公告)号：US08016764B1
公开(公告)日：2011-09-13
申请号：US11557887
申请日：2006-11-08
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/02158 , A61B5/0452 , A61M2230/04
摘要： Techniques are provided for exploiting left atrial pressure (LAP) measurements to determine various ventricular mechanical and electromechanical contraction intervals and for evaluating ventricular dyssynchrony based on those intervals. In one example, LAP measurements are combined with right ventricular pressure (RVP) measurements to determine the interventricular mechanical delay, which is the primary parameter representative of ventricular dyssynchrony. Other intervals determined based, in part, on LAP measurements include the electromechanical delay for the left ventricle (LV), as well as the LV systolic and diastolic intervals. Techniques are also described herein for detecting various RV intervals including the electromechanical delay for the RV, as well as the RV systolic and diastolic intervals.
摘要翻译：提供了用于开发左心房压力（LAP）测量以确定各种心室机械和机电收缩间隔以及基于那些间隔来评估心室不同步的技术。在一个示例中，将LAP测量与右心室压力（RVP）测量结合以确定室间机械延迟，其是代表心室不同步的主要参数。部分基于LAP测量确定的其他间隔包括左心室（LV）的机电延迟以及LV收缩期和舒张期。本文还描述了用于检测包括RV的机电延迟以及RV收缩期和舒张期间的各种RV间期的技术。

14. 发明申请

US20080287818A1 PRESSURE MEASUREMENT-BASED ISCHEMIA DETECTION 审中-公开
标题翻译：基于压力测量的ISCHEMIA检测
公开(公告)号：US20080287818A1
公开(公告)日：2008-11-20
申请号：US11737650
申请日：2007-04-19
申请人： Anne M. Shelchuk , Dan E. Gutfinger
发明人： Anne M. Shelchuk , Dan E. Gutfinger
IPC分类号： A61B5/02
CPC分类号： A61B5/0456 , A61B5/0215 , A61N1/365 , A61N1/36564 , A61N1/36585 , A61N1/3684
摘要： In some aspects ischemia is indicated based on cardiac pressure measurements. For example, ischemia may be indicated based on an increase in an intraventricular electromechanical delay where mechanical contractions are detected by measuring pressure in a cardiac chamber. Ischemia detection also may involve obtaining timing information relating to a mechanical contraction of at least one ventricle to identify an intraventricular dyssynchrony. In this case, pressure measurements may be used to identify the timing of the mechanical contraction. Ischemia may be indicated based on a change in a time interval associated with a systolic interval of a ventricle. Ischemia also may be indicated based on an intracardiac electrogram-based indication of ischemia in conjunction with an increase in mean left atrial pressure and/or an increase in the size of a v-wave.
摘要翻译：在一些方面，基于心脏压力测量指示缺血。例如，可以基于通过测量心室中的压力来检测机械收缩的心室内机电延迟的增加来指示缺血。缺血检测还可能涉及获得与至少一个心室的机械收缩相关的定时信息，以识别心室内不同步。在这种情况下，可以使用压力测量来识别机械收缩的时间。可以基于与心室的收缩期间隔相关联的时间间隔的变化来指示缺血。还可以基于基于心内电描记图的缺血指示以及平均左心房压力的增加和/或v波的大小的增加来指示缺血。

15. 发明授权

US07403819B1 Parasympathetic nerve stimulation for control of AV conduction 有权
标题翻译：副交感神经刺激用于控制AV传导
公开(公告)号：US07403819B1
公开(公告)日：2008-07-22
申请号：US10460145
申请日：2003-06-11
申请人： Anne M. Shelchuk , Gene A. Bornzin , Eric Falkenberg
发明人： Anne M. Shelchuk , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/34 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/36114
摘要： Exemplary methods for affecting conduction and/or operation of the AV node and/or AV bundle. Various exemplary methods include delivery of one or more stimulation pulses to affect conduction and/or operation of an AV node and/or AV bundle. Such delivery optionally stimulates nerves and/or tissue. Nerve stimulation optionally includes parasympathetic nerve stimulation to decrease conduction of the AV node and/or AV bundle. Tissue stimulation optionally causes tissue to enter a refractory period. Various exemplary methods include delivering one or more stimulation pulses during postinspiration. Other exemplary methods and/or devices are also disclosed.
摘要翻译：用于影响AV节点和/或AV束的传导和/或操作的示例性方法。各种示例性方法包括递送一个或多个刺激脉冲以影响AV节点和/或AV束的传导和/或操作。这种递送可选地刺激神经和/或组织。神经刺激任选地包括副交感神经刺激以减少AV结和/或AV束的传导。组织刺激任选地使组织进入不应期。各种示例性方法包括在后吸烟期间递送一个或多个刺激脉冲。还公开了其它示例性方法和/或设备。

16. 发明授权

US09414754B1 Systems and methods for evaluating ventricular dyssynchrony using atrial and ventricular pressure measurements obtained by an implantable medical device 有权
标题翻译：使用由可植入医疗装置获得的心房和心室压力测量值来评估心室不同步的系统和方法
公开(公告)号：US09414754B1
公开(公告)日：2016-08-16
申请号：US13207302
申请日：2011-08-10
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61B5/02 , A61B5/021 , A61B5/0452
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/02158 , A61B5/0452 , A61M2230/04
摘要： Techniques are provided for exploiting left atrial pressure (LAP) measurements to determine various ventricular mechanical and electromechanical contraction intervals and for evaluating ventricular dyssynchrony based on those intervals. In one example, LAP measurements are combined with right ventricular pressure (RVP) measurements to determine the interventricular mechanical delay, which is the primary parameter representative of ventricular dyssynchrony. Other intervals determined based, in part, on LAP measurements include the electromechanical delay for the left ventricle (LV), as well as the LV systolic and diastolic intervals. Techniques are also described herein for detecting various RV intervals including the electromechanical delay for the RV, as well as the RV systolic and diastolic intervals.
摘要翻译：提供了用于开发左心房压力（LAP）测量以确定各种心室机械和机电收缩间隔以及基于那些间隔来评估心室不同步的技术。在一个示例中，将LAP测量与右心室压力（RVP）测量结合以确定室间机械延迟，其是代表心室不同步的主要参数。部分基于LAP测量确定的其他间隔包括左心室（LV）的机电延迟以及LV收缩期和舒张期。本文还描述了用于检测包括RV的机电延迟以及RV收缩期和舒张期间的各种RV间期的技术。

17. 发明授权

US08321018B2 Systems and methods for reducing occurrences of atrial arrhythmias 有权
标题翻译：减少心房心律失常发生的系统和方法
公开(公告)号：US08321018B2
公开(公告)日：2012-11-27
申请号：US13027174
申请日：2011-02-14
申请人： Sergio Shkurovich , Anne M. Shelchuk
发明人： Sergio Shkurovich , Anne M. Shelchuk
IPC分类号： A61N1/00
CPC分类号： A61N1/3624 , A61B5/0031 , A61B5/0215 , A61B5/053 , A61B5/4836 , A61B5/6869 , A61B5/6876 , A61B5/7275 , A61B2562/0247 , A61N1/36564 , A61N1/3682 , A61N1/3684 , G06F19/00
摘要： A method for reducing occurrences of atrial arrhythmias includes obtaining measures indicative of atrial pressure of a patient, and monitoring for a change in the measures indicative of atrial pressure that is indicative of an increased vulnerability to an atrial arrhythmia. In response to detecting the change in the measures indicative of atrial pressure that is indicative of the increased vulnerability to an atrial arrhythmia, pacing therapy that is adapted to reduce atrial pressure and thereby reduce vulnerability to an atrial arrhythmia is selectively delivered. Additionally, or alternatively, pacing therapy is adjusted to reduce atrial pressure and thereby reduce vulnerability to an atrial arrhythmia.
摘要翻译：减少心房心律失常发生的方法包括获得指示患者心房压力的措施，以及监测指示心房压力改变的措施的变化，其指示心房心律失常易受伤害性增加。响应于检测指示心房压力的指标的变化，其指示心房心律失常增加的易感性，选择性地递送适于减少心房压力并因此降低心房心律失常的易失性的起搏治疗。此外，或者，调节起搏治疗以减少心房压力，从而降低心房心律失常的易感性。

18. 发明授权

US07245967B1 Parasympathetic nerve stimulation for termination of supraventricular arrhythmias 有权
标题翻译：副交感神经刺激终止室上性心律失常
公开(公告)号：US07245967B1
公开(公告)日：2007-07-17
申请号：US10460149
申请日：2003-06-11
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36114
摘要： Terminating supraventricular arrhythmias through parasympathetic nerve stimulation. The method comprises detecting a supraventricular arrhythmia, stimulating a parasympathetic nerve and determining whether the supraventricular arrhythmia terminated or worsened. Various exemplary methods include delivering one or more stimulation pulses during postinspiration and/or in response to one or more cardiac events.
摘要翻译：通过副交感神经刺激终止室上性心律失常。该方法包括检测室上性心律失常，刺激副交感神经并确定室上性心律失常是否终止或恶化。各种示例性方法包括在吸烟期间和/或响应于一个或多个心脏事件递送一个或多个刺激脉冲。

19. 发明授权

US07225017B1 Parasympathetic nerve stimulation for ICD and/or ATP patients 失效
标题翻译： ICD和/或ATP患者的副交感神经刺激
公开(公告)号：US07225017B1
公开(公告)日：2007-05-29
申请号：US10856107
申请日：2004-05-28
申请人： Anne M. Shelchuk
发明人： Anne M. Shelchuk
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3956 , A61N1/3962 , A61N2001/0585
摘要： Exemplary methods for increasing efficiency and/or increasing success of terminating ventricular tachyarrhythmia. An exemplary method includes stimulation of a parasympathetic nerve before, during and/or after delivery of antitachycardia pacing pulses, a cardioversion stimulus and/or a defibrillation stimulus. Various exemplary methods include delivering one or more stimulation pulses during postinspiration. Other methods and/or devices are also disclosed.
摘要翻译：用于提高终止室性快速性心律失常的效率和/或增加成功的示例性方法。示例性方法包括在递送抗心动过速起搏脉冲之前，期间和/或之后刺激副交感神经，复律刺激和/或除颤刺激。各种示例性方法包括在后吸烟期间递送一个或多个刺激脉冲。还公开了其它方法和/或装置。

20. 发明授权

US07181277B1 Methods and systems for reducing the likelihood of arrhythmia onset 有权
标题翻译：减少心律失常发作的可能性的方法和系统
公开(公告)号：US07181277B1
公开(公告)日：2007-02-20
申请号：US10386729
申请日：2003-03-11
申请人： Anne M. Shelchuk , Mark W. Kroll
发明人： Anne M. Shelchuk , Mark W. Kroll
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3627
摘要： Various embodiments are directed to providing systems and methods that can reduce the likelihood of arrhythmia onset by effecting a treatment, responsive to a detected premature event, that mimics or otherwise attempts to emulate a healthy heart's natural recovery process. In one particular embodiment, the premature event comprises a premature ventricular contraction or “PVC”, and the treatment comprises pacing the patient to mimic or otherwise emulate a turbulence pattern that is typically exhibited by a healthy heart when the heart attempts to recover from the PVC.
摘要翻译：各种实施方案涉及提供系统和方法，所述系统和方法可以通过对模拟或以其他方式尝试仿效健康心脏的自然恢复过程的检测到的早产事件进行治疗来减少心律不齐发作的可能性。在一个具体实施方案中，早发事件包括早产性心室收缩或“PVC”，并且治疗包括起搏患者以模仿或以其他方式模拟当心脏试图从PVC中恢复时通常由健康心脏展现的湍流模式。

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