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11. 发明授权

US08603023B2 Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods 有权
标题翻译：肠内制动诱导管腔内治疗物质洗脱装置及方法
公开(公告)号：US08603023B2
公开(公告)日：2013-12-10
申请号：US13105029
申请日：2011-05-11
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M5/00 , A61M29/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F5/0079 , A61F2002/045
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

12. 发明申请

US20110295178A1 Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 审中-公开
标题翻译：肠制动诱导腔内治疗物质洗脱装置及方法
公开(公告)号：US20110295178A1
公开(公告)日：2011-12-01
申请号：US13104321
申请日：2011-05-10
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M5/00
CPC分类号： A61F5/0079 , A61K9/0065 , A61M5/14276 , A61M31/002 , A61M39/0208 , A61M2210/106 , A61M2210/1064
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices may be accomplished via stabilized implantable systems and ingestible pills. In one aspect, a method of inducing satiety includes implanting an implant within a lumen of a gastrointestinal tract and retaining a portion of chyme that flows by the implant within a body of the implant. The method further involves re-releasing the retained chyme from the implant into the gastrointestinal tract at a predetermined rate slower than a rate caused by natural peristalsis.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置可以通过稳定的可植入系统和可摄取的药丸来实现。一方面，一种诱导饱腹感的方法包括将植入物植入胃肠道的内腔中，并且将植入物流动的部分保持在植入物的体内。该方法还包括以比由天然蠕动引起的速率慢的预定速率将留置的食糜从植入物再释放到胃肠道中。

13. 发明申请

US20110295185A1 Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 有权
标题翻译：肠制动诱导腔内治疗物质洗脱装置及方法
公开(公告)号：US20110295185A1
公开(公告)日：2011-12-01
申请号：US13104313
申请日：2011-05-10
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M37/00 , A61K31/20 , A61M5/00 , A61F2/00 , A61M5/168 , A61N1/36
CPC分类号： A61M31/002 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F2002/045 , A61K9/0065 , A61M5/14276 , A61M39/0208 , A61M2210/106 , A61M2210/1064 , A61N1/0509 , A61N1/36007 , A61N1/37205
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质从植入物到胃肠道。

14. 发明申请

US20110295180A1 INTESTINAL BRAKE INDUCING INTRALUMINAL THERAPEUTIC SUBSTANCE ELUTING DEVICES AND METHODS 有权
标题翻译： INTESTINAL BRAKE INDING IN INTRALUMINAL THERAPEUTIC THEAPEUTIC TYSTURE ELDTING ELTERTING DEVICES AND METHODS
公开(公告)号：US20110295180A1
公开(公告)日：2011-12-01
申请号：US13105029
申请日：2011-05-11
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F5/0079 , A61F2002/045
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

15. 发明授权

US09545191B2 Method for suture lacing 有权
标题翻译：缝线法的方法
公开(公告)号：US09545191B2
公开(公告)日：2017-01-17
申请号：US11394126
申请日：2006-03-31
申请人： Michael J. Stokes , Andrew M. Zwolinski , Mark S. Ortiz , Frederick E. Shelton, IV
发明人： Michael J. Stokes , Andrew M. Zwolinski , Mark S. Ortiz , Frederick E. Shelton, IV
IPC分类号： A61B17/04 , A61B17/12 , A61B1/005 , A61B1/00 , A61B1/273 , A61B17/06 , A61B17/062 , A61B1/313 , A61B5/026 , A61B17/00 , A61B17/30
CPC分类号： A61B1/005 , A61B1/00087 , A61B1/00094 , A61B1/00133 , A61B1/0014 , A61B1/2736 , A61B1/313 , A61B5/026 , A61B5/0261 , A61B17/00491 , A61B17/0466 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/0493 , A61B17/06066 , A61B17/062 , A61B34/20 , A61B90/36 , A61B2017/00022 , A61B2017/00292 , A61B2017/00296 , A61B2017/00407 , A61B2017/00469 , A61B2017/00477 , A61B2017/00561 , A61B2017/0479 , A61B2017/0496 , A61B2017/06076 , A61B2017/0608 , A61B2017/06185 , A61B2017/306 , A61B2090/037 , A61B2090/0811 , A61B2090/374 , A61B2090/378
摘要： A method for suture lacing includes providing a suture with a needle attached thereto, inserting the needle and suture into an organ through a passageway, throwing a single stitch through a first tissue member, throwing a single stitch through an opposed and spaced apart second tissue member, repeating the preceding step at least once, bringing the first and second tissue members in contact by tensioning the suture, whereby suture drag is minimized during the tensioning and even tissue compression substantially achieved, and securing the suture.
摘要翻译：用于缝合线的方法包括：提供缝合线，其上附着有针，将针和缝合线插入器官通过通道，将单个针迹投掷穿过第一组织构件，将单个针迹穿过相对且间隔开的第二组织构件，重复前述步骤至少一次，通过张紧缝合线使第一和第二组织构件接触，由此缝合线阻力在张紧期间被最小化，甚至基本上实现组织压缩，并且固定缝合线。

16. 发明授权

US08118820B2 Method for instrument insertion through a body orifice 有权
标题翻译：仪器通过体孔插入的方法
公开(公告)号：US08118820B2
公开(公告)日：2012-02-21
申请号：US11394174
申请日：2006-03-31
申请人： Michael J. Stokes , Thomas E. Albrecht , Mark S. Ortiz , Mark S. Zeiner , Andrew M. Zwolinski , Frederick E. Shelton, IV
发明人： Michael J. Stokes , Thomas E. Albrecht , Mark S. Ortiz , Mark S. Zeiner , Andrew M. Zwolinski , Frederick E. Shelton, IV
IPC分类号： A61B17/04
CPC分类号： A61B17/0469
摘要： A method for inserting an instrument through a natural orifice. The instrument has a low profile orientation and a deployed orientation which is larger than the size of the natural orifice through which it is to be inserted. The method is achieved by coupling the instrument to an endoscope and placing the instrument in its low profile orientation, inserting the endoscope and the instrument through a natural orifice to a target position within a body while the instrument is in its low profile orientation, actuating the instrument to it is deployed orientation, and returning the instrument to its low profile orientation and withdrawing the instrument from the body through the natural orifice.
摘要翻译：一种通过天然孔口插入仪器的方法。仪器具有低轮廓取向和展开方向，其大于被插入的自然孔的尺寸。该方法通过将仪器连接到内窥镜并将仪器置于其低轮廓取向来实现，其中，当仪器处于其低剖面取向时，将内窥镜和仪器通过自然孔口插入到身体内的目标位置，致动仪器部署方向，并将仪器返回到其低调方向，并将仪器从身体通过自然孔抽出。

17. 发明申请

US20110040309A1 IMPLANTABLE RESTRICTION DEVICE WITH SPACER 审中-公开
标题翻译：带间隔的可植入限制装置
公开(公告)号：US20110040309A1
公开(公告)日：2011-02-17
申请号：US12541579
申请日：2009-08-14
申请人： Daniel F. Dlugos, JR. , Chad P. Boudreaux , Robert P. Gill , Steven G. Hall , Christopher J. Hess , Jerome R. Morgan , Frederick E. Shelton, IV , Jeffrey S. Swayze , Omar J. Vakharia , Lauren S. Weaner , William Bruce Weisenburgh, II , Andrew M. Zwolinski
发明人： Daniel F. Dlugos, JR. , Chad P. Boudreaux , Robert P. Gill , Steven G. Hall , Christopher J. Hess , Jerome R. Morgan , Frederick E. Shelton, IV , Jeffrey S. Swayze , Omar J. Vakharia , Lauren S. Weaner , William Bruce Weisenburgh, II , Andrew M. Zwolinski
IPC分类号： A61B17/00
CPC分类号： A61F5/005 , A61F5/0086
摘要： An implantable restriction device includes a belt and a balloon secured to the belt for engagement with tissue when the implantable restriction device is positioned about the stomach. A spacer is associated with the belt for maintaining the restriction device in a spaced relation with a staple line employed during gastric reduction surgery.
摘要翻译：植入式限制装置包括带和固定到带上的球囊，当可植入的限制装置围绕胃定位时，与球体接合。间隔件与带相关联，用于将限制装置与胃减压手术期间使用的缝合线保持间隔开。

18. 发明申请

US20100280327A1 METHODS AND DEVICES FOR PROVIDING ACCESS THROUGH TISSUE TO A SURGICAL SITE 审中-公开
标题翻译：用于向外科手术组织提供通路的方法和装置
公开(公告)号：US20100280327A1
公开(公告)日：2010-11-04
申请号：US12435075
申请日：2009-05-04
申请人： Rudolph H. Nobis , Andrew M. Zwolinski
发明人： Rudolph H. Nobis , Andrew M. Zwolinski
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B1/32 , A61B17/0293 , A61B2017/3443 , A61B2017/3466
摘要： Methods and devices are provided for providing access through tissue to a surgical site. In one embodiment, a surgical access device can be configured to move between a first, expanded configuration, and a second, compressed configuration. As the device moves from the first configuration to the second configuration, a longitudinal length of the device can decrease, thereby allowing the device to be securely positioned in tissue and reducing a distance that the device extends into a body cavity.
摘要翻译：提供了用于提供通过组织进入外科手术部位的方法和装置。在一个实施例中，手术进入装置可被配置成在第一扩张配置和第二压缩配置之间移动。当设备从第一配置移动到第二配置时，设备的纵向长度可以减小，从而允许设备被牢固地定位在组织中并且减小设备延伸到体腔中的距离。

19. 发明申请

US20100191050A1 VARIABLE LENGTH ACCESSORY FOR GUIDING A FLEXIBLE ENDOSCOPIC TOOL 审中-公开
标题翻译：可变长度附件，用于指导柔性内窥镜工具
公开(公告)号：US20100191050A1
公开(公告)日：2010-07-29
申请号：US12359053
申请日：2009-01-23
申请人： Andrew M. Zwolinski
发明人： Andrew M. Zwolinski
IPC分类号： A61B1/018 , A61B1/01
CPC分类号： A61B1/018 , A61B1/00128 , A61B1/00133 , A61B17/3478 , A61B34/70 , A61B2017/00477 , A61B2017/00991 , A61B2017/3443 , A61B2017/347
摘要： The present invention includes, in various embodiments, a surgical accessory for guiding a flexible endoscopic tool into an endoscope. In at least one embodiment, the surgical accessory includes a variable length assembly having a first component and a second component, a first connector, and a second connector. In such embodiments, the first component can be telescopically engaged with the second component, wherein the first and second components are adapted to insertably receive a flexible portion of a flexible endoscopic tool. In such embodiments, the first connector is configured to releasably connect the first component to the flexible endoscopic tool and the second connector is configured to releasably connect the second component to an endoscope.
摘要翻译：在各种实施例中，本发明包括用于将柔性内窥镜工具引导到内窥镜中的外科附件。在至少一个实施例中，手术附件包括具有第一部件和第二部件，第一连接器和第二连接器的可变长度组件。在这样的实施例中，第一部件可以与第二部件可伸缩地接合，其中第一和第二部件适于可插入地容纳柔性内窥镜工具的柔性部分。在这样的实施例中，第一连接器构造成将第一部件可释放地连接到柔性内窥镜工具，并且第二连接器构造成将第二部件可释放地连接到内窥镜。

20. 发明申请

US20090299362A1 ELECTRICAL ABLATION DEVICE 有权
标题翻译：电气装置
公开(公告)号：US20090299362A1
公开(公告)日：2009-12-03
申请号：US12130010
申请日：2008-05-30
申请人： Gary L. Long , Andrew M. Zwolinski
发明人： Gary L. Long , Andrew M. Zwolinski
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2017/2215 , A61B2017/2945 , A61B2018/00601 , A61B2018/1213 , A61B2018/1422 , A61B2018/1432 , A61B2018/1475
摘要： An electrical ablation apparatus includes a housing extending along a longitudinal axis. A first electrode and a second electrode are disposed within the housing. The electrodes are configured to connect to electrically conductive wires. The first and second electrodes are separated by a gap. The second electrode includes first and second prongs defining an opening suitable to receive tissue to be ablated therebetween. When the first and second electrodes are energized at a predetermined energy level, an electric current suitable to ablate the tissue flows across the gap and forms an electric arc between the distal end of the first electrode and the tissue. A system includes an energy source to drive the electrical ablation apparatus. A method includes introducing the electrical ablation apparatus into a patient and ablating tissue with the electric arc.
摘要翻译：电切除装置包括沿着纵向轴线延伸的壳体。第一电极和第二电极设置在壳体内。电极被配置成连接到导电线。第一和第二电极被间隙隔开。第二电极包括限定适于接收要在其间被烧蚀的组织的开口的第一和第二插脚。当第一和第二电极以预定能量级供电时，适于消融组织的电流流过间隙，并在第一电极的远端和组织之间形成电弧。一种系统包括用于驱动电消融装置的能量源。一种方法包括将电消融装置引入患者并用电弧消融组织。

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