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11. 发明授权

US07674256B2 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US07674256B2
公开(公告)日：2010-03-09
申请号：US11082677
申请日：2005-03-17
申请人： Nassir Marrouche , Daniel M. Lafontaine
发明人： Nassir Marrouche , Daniel M. Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

12. 发明授权

US07566343B2 Cardiac valve, system, and method 有权
标题翻译：心脏瓣膜，系统和方法
公开(公告)号：US07566343B2
公开(公告)日：2009-07-28
申请号：US10933088
申请日：2004-09-02
申请人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
发明人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.
摘要翻译：具有支撑框架的心脏瓣膜具有第一端构件和与所述第一端构件基本上固定的距离关系相对的第二端构件，以及在所述支撑框架上延伸以允许液体通过所述瓣膜的单向流动的盖。

13. 发明授权

US07022120B2 Cryoplasty device and method 失效
公开(公告)号：US07022120B2
公开(公告)日：2006-04-04
申请号：US10659116
申请日：2003-09-10
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104 , C21B13/0033 , C22B5/14 , C22B23/021
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

14. 发明授权

US06656199B1 Magnetic clamp assembly for an elongated flexible medical device 失效
标题翻译：用于细长柔性医疗设备的磁性夹具组件
公开(公告)号：US06656199B1
公开(公告)日：2003-12-02
申请号：US09645222
申请日：2000-08-24
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B500
CPC分类号： A61M25/0127
摘要： A magnetic clamp assembly for an elongated flexible medical device. The clamp assembly includes magnetic clamp members operably coupled to clamp a portion of the flexible medical device to secure the medical device during treatment.
摘要翻译：一种用于细长柔性医疗装置的磁夹组件。夹具组件包括可操作地联接以夹紧柔性医疗装置的一部分以在治疗期间固定医疗装置的磁性夹具构件。

15. 发明授权

US06648878B2 Cryoplasty device and method 有权
公开(公告)号：US06648878B2
公开(公告)日：2003-11-18
申请号：US09916147
申请日：2001-07-25
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104 , C21B13/0033 , C22B5/14 , C22B23/021
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

16. 发明授权

US06497711B1 Therectomy device having a light weight drive shaft and an imaging device 失效
标题翻译：动脉粥样硬化切除装置具有重量轻的驱动轴和成像装置
公开(公告)号：US06497711B1
公开(公告)日：2002-12-24
申请号：US09639873
申请日：2000-08-16
申请人： Mark Plaia , Robert L. Barry , Daniel M. Lafontaine
发明人： Mark Plaia , Robert L. Barry , Daniel M. Lafontaine
IPC分类号： A61B1722
CPC分类号： A61B17/320758 , A61B17/221 , A61B17/320725 , A61B90/37 , A61B2017/320004 , A61B2017/320733 , A61B2090/378
摘要： An atherectomy device having the ability to create variably sized lumens in a vessel. An ablation burr rotated by a drive shaft is routed through a control shaft having a bend in its distal end. The control shaft is in turn routed through a surrounding guide catheter. By extending or retracting the bend of the control shaft into the distal end of the guide catheter, the lateral displacement of the ablation burr is varied. A lumen in a vessel is created by rotating the control shaft within the surrounding guide catheter. In addition, the atherectomy device may include an integrated imaging sensor contained within a separate lumen of the catheter surrounding the drive shaft. The imaging sensor provides images of the interior of the vessel wall to determine if an occlusion has been removed by operation of the ablation burr. The catheter may include a self-expanding stent at its distal end to force the ablation burr against a vessel wall in order to create various sized lumens in a patient's vasculature. Finally, the drive shaft that rotates the ablation burr is made of a lightweight polymeric material such as a liquid crystal polymer having fibers that are braided to provide desired torque and flexibility characteristics of the drive shaft.
摘要翻译：具有在血管中产生可变大小的腔的能力的粥样斑块切除装置。由驱动轴旋转的消融毛刺通过其远端具有弯曲部的控制轴布置。控制轴又穿过周围的引导导管。通过将控制轴的弯曲部延伸或缩回到导向导管的远端，消融毛刺的横向位移变化。通过在周围的引导导管内旋转控制轴来产生容器中的内腔。另外，粥样斑块切除装置可以包括集成的成像传感器，其包含在围绕驱动轴的导管的分开的内腔内。成像传感器提供血管壁内部的图像，以确定是否通过消融毛刺的操作去除了闭塞。导管可以在其远端包括自扩张支架，以迫使消融毛刺抵靠血管壁，以在患者的脉管系统中产生各种尺寸的腔。最后，旋转消融毛刺的驱动轴由轻质的聚合物材料制成，例如具有编织纤维的液晶聚合物，以提供驱动轴的期望的扭矩和柔性特性。

17. 发明授权

US5873835A Intravascular pressure and flow sensor 失效
标题翻译：血管内压力和流量传感器
公开(公告)号：US5873835A
公开(公告)日：1999-02-23
申请号：US527815
申请日：1995-09-13
申请人： Roger N. Hastings , Paul T. Feld , Daniel M. Lafontaine , Kenneth R. Larson , Richard R. Prather
发明人： Roger N. Hastings , Paul T. Feld , Daniel M. Lafontaine , Kenneth R. Larson , Richard R. Prather
IPC分类号： A61B5/0215 , A61B5/028 , A61M25/00 , A61M29/02 , G01F1/68 , G01F1/69 , G01F1/698 , G01P5/12
CPC分类号： A61B5/6851 , A61B5/0215 , A61B5/028 , A61M25/104 , G01F1/68 , G01F1/69 , G01F1/698 , G01P5/12 , H01F1/447 , H01F21/06 , A61M2025/0002 , A61M2205/3331 , A61M2205/36
摘要： An intravascular device for measuring blood pressure and flow is disclosed, which includes an elongate shaft having a pressure transducer and a flow transducer connected to its distal end. The pressure transducer may be a ferrofluid-type pressure transducer and the flow transducer may be an anemometer-type flow transducer. Measurement circuitry is also disclosed which provides a means for simultaneous measurement of both blood pressure and blood flow parameters. A sensor shield may be employed to isolate radial blood flow which is indicative of turbulent blood flow. An alternative blood flow measurement device is also disclosed which utilizes a thin metal film anemometer to measure flow in a vascular lumen.
摘要翻译：公开了一种用于测量血压和血流的血管内装置，其包括具有压力换能器和连接到其远端的流量传感器的细长轴。压力传感器可以是铁磁流体型压力传感器，并且流量传感器可以是风速计型流量变换器。还公开了测量电路，其提供用于同时测量血压和血流参数的手段。可以使用传感器屏蔽来分离指示湍流血流的径向血流。还公开了一种替代的血流测量装置，其利用薄金属薄膜风速计来测量血管腔中的流动。

18. 发明授权

US5728064A Balloon catheter with improved pressure source 失效
标题翻译：球囊导管具有改善的压力源
公开(公告)号：US5728064A
公开(公告)日：1998-03-17
申请号：US619375
申请日：1996-05-21
申请人： Matthew M. Burns , Daniel M. Lafontaine
发明人： Matthew M. Burns , Daniel M. Lafontaine
IPC分类号： A61M25/00 , A61F2/958 , A61M29/00
CPC分类号： A61M25/10187 , A61M25/1018 , A61M2025/0063 , A61M2025/0098 , A61M2025/1077
摘要： A balloon catheter having a long shaft with an inflatable balloon connected to its distal end with a pressure source connected to the shaft at an invivo point which operates to inflate and deflate the balloon. The balloon catheter may be a fixed-wire type, an over-the-wire type, or an single-operator-exchange type catheter. The pressure source may include a piston and a chamber with an actuation member attached to the piston. The actuation member may be a solid rod or a hollow robe. In the case where the actuation member is a hollow tube, the tube may be used to introduce inflation fluid into the pressure source and the inflation lumen. A receptacle such as a reel or tubular hoop may be used to contain the actuation member when pulled proximally. A pressure sensor/gauge and a balloon sizing scale may be incorporated into the catheter assembly to assist the treating physician in monitoring the procedure. A longitudinally oscillating drive, such as a solenoid, may be operatively connected to the pressure source.
摘要翻译：具有长轴的球囊导管，其具有连接到其远端的可膨胀气囊，压力源在操作以使气囊膨胀和放气的invivo点处连接到轴。球囊导管可以是固定线型，线上型或单操作者交换型导管。压力源可以包括活塞和具有附接到活塞的致动构件的室。致动构件可以是实心杆或中空长袍。在致动构件是中空管的情况下，管可用于将充气流体引入压力源和膨胀腔。诸如卷轴或管状环的容器可以用于在向近侧拉动时容纳致动构件。可以将压力传感器/量规和气囊尺寸标尺结合到导管组件中，以帮助治疗医师监测该过程。诸如螺线管的纵向振荡驱动器可以可操作地连接到压力源。

19. 发明授权

US5647847A Balloon catheter with improved pressure source 失效
标题翻译：球囊导管具有改善的压力源
公开(公告)号：US5647847A
公开(公告)日：1997-07-15
申请号：US334831
申请日：1994-11-04
申请人： Daniel M. Lafontaine , Daniel O. Adams , John W. Humphrey
发明人： Daniel M. Lafontaine , Daniel O. Adams , John W. Humphrey
IPC分类号： A61M25/00 , A61F2/958 , A61M29/00
CPC分类号： A61M25/10185 , A61M25/1018 , A61M25/10188 , A61M2025/0063 , A61M2025/0098 , A61M2025/1077
摘要： A balloon catheter which has an elongate shaft with an inflatable balloon connected to its distal end and a manifold connected to its proximal end. The manifold may be fixedly or removably attached to the shaft and includes a barrel with a plunger movably disposed inside it. The manifold may be held with one hand and the plunger may be actuated with one finger or thumb on the same hand. The barrel may have an internal volume of less than 5 cc and an internal diameter of less than 0.25 inches. The catheter also has a prep port which may be connected at or near the proximal end of the catheter. The prep port facilitates prepping of the catheter system. A seal (e.g. a releasable cap or a valve) may be connected to the prep port for sealing off the prep port during use. A pressure transducer may be mounted to the catheter (e.g. on the shaft, the manifold, the prep port, or the seal) to permit measurement of the pressure within the inflation lumen and the balloon. The pressure transducer may be operably connected to a pressure display and the display may be connected to the proximal end of the catheter or may be remotely located from the catheter. Data may be transmitted to the remote display by wire or wireless transmission (e.g. infrared, radio frequency, or magnetic transmission). Alternate embodiments and methods of use are also disclosed.
摘要翻译：一种气囊导管，其具有连接到其远端的可膨胀气囊的细长轴和连接到其近端的歧管。歧管可以固定地或可移除地附接到轴上并且包括具有可移动地设置在其内的柱塞的筒。歧管可以用一只手握住，并且柱塞可以用一只手指或拇指在同一只手上致动。枪管可具有小于5cc的内部容积和小于0.25英寸的内径。该导管还具有可在导管的近端处或其附近连接的制备端口。准备端口有利于导管系统的准备。可以将密封件（例如可释放盖或阀）连接到准备端口，以在使用期间密封准备端口。压力换能器可以安装到导管（例如在轴，歧管，制备端口或密封件上），以允许测量充气腔和气囊内的压力。压力传感器可以可操作地连接到压力显示器，并且显示器可以连接到导管的近端，或者可以远离导管定位。数据可以通过有线或无线传输（例如红外线，射频或磁性传输）发送到远程显示器。还公开了替代实施例和使用方法。

20. 发明授权

US08932349B2 Cardiac valve, system, and method 有权
公开(公告)号：US08932349B2
公开(公告)日：2015-01-13
申请号：US13214520
申请日：2011-08-22
申请人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
发明人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.

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