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11. 发明申请

US20050288297A1 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US20050288297A1
公开(公告)日：2005-12-29
申请号：US11210028
申请日：2005-08-22
申请人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/12 , C07D403/12
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

12. 发明申请

US20050101609A1 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US20050101609A1
公开(公告)日：2005-05-12
申请号：US10344736
申请日：2001-08-17
申请人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D43/04 , C07D43/14
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method ol inhibiling kinascs and tre ating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention prtvides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及一种通过抑制激酶的磷酸化来抑制哺乳动物抑制哺乳动物的疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法，血管重构，癌症和肾小球硬化症。

13. 发明授权

US08324205B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US08324205B2
公开(公告)日：2012-12-04
申请号：US12471280
申请日：2009-05-22
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/535 , A61K31/497
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

14. 发明授权

US06982266B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US06982266B2
公开(公告)日：2006-01-03
申请号：US10344736
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A01K31/675 , A01K31/517 , C07D43/02 , C07D239/72
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法，血管重构，癌症和肾小球硬化症。

15. 发明授权

US06956039B2 Nitrogenous heterocylic compounds 失效
标题翻译：含氮杂环化合物
公开(公告)号：US06956039B2
公开(公告)日：2005-10-18
申请号：US10344737
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D487/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

16. 发明授权

US06423716B1 Nitrogenous heterocyclic compounds 有权
标题翻译：含氮杂环化合物
公开(公告)号：US06423716B1
公开(公告)日：2002-07-23
申请号：US09647490
申请日：2000-09-29
申请人： Kenji Matsuno , Yuji Nomoto , Michio Ichimura , Shin-ichi Ide , Shoji Oda
发明人： Kenji Matsuno , Yuji Nomoto , Michio Ichimura , Shin-ichi Ide , Shoji Oda
IPC分类号： A61K3150
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR1R2 (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and R2 represents a hydrogen atom, etc. ), OR4, or SR5; V represents an oxygen atom, a sulfur atom, N—R6, or CR7R8, at least one of X, Y and Z represents a nitrogen atom, and the others are the same or different, and each represents a nitrogen atom or C—RA; and D1, D2, D3 and D4 each independently represent C—RB, a nitrogen atom, an oxygen atom, a sulfur atom, etc., optional adjoining two among D1 to D4 are combined to represent a nitrogen atom, N—R2A, an oxygen atom, a sulfur atom, etc., or optional adjoining two selected from D1 to D4 represent C—RB″ (wherein two RB″s are combined to represent substituted or unsubstituted alicyclic alkene, substituted or unsubstituted pyrrole, substituted or unsubstituted pyrazole, etc.; or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由式（I）表示的含氮杂环化合物：其中W表示1,4-哌嗪二基等; U表示NR1R2（其中R1表示氢原子，取代或未取代的烷基等; R2表示氢原子等），OR4或SR5; V表示氧原子，硫原子，N-R6或CR7R8，X，Y和Z中的至少一个表示氮原子，其它相同或不同，表示氮原子或C-RA ; D1，D2，D3和D4各自独立地表示C-RB，氮原子，氧原子，硫原子等，D1〜D4中任意相邻的2个相互组合，表示氮原子，N-R2A，氧原子，硫原子等，或选自D1〜D4中任意相邻的2个表示C-RB“（其中两个RB'组合以代表取代或未取代的脂环族烯烃，取代或未取代的吡咯，取代或未取代的吡唑等;或其药学上可接受的盐。

17. 发明授权

US5661147A Imidazoquinazoline derivatives 失效
标题翻译：咪唑喹唑啉衍生物
公开(公告)号：US5661147A
公开(公告)日：1997-08-26
申请号：US424274
申请日：1995-04-26
申请人： Daisuke Machii , Kenji Matsuno , Iwao Kinoshita , Yuji Nomoto , Haruki Takai , Tetsuji Ohno , Ken Nagashima , Tomoko Ishikawa , Koji Yamada , Michio Ichimura , Hiroshi Kase
发明人： Daisuke Machii , Kenji Matsuno , Iwao Kinoshita , Yuji Nomoto , Haruki Takai , Tetsuji Ohno , Ken Nagashima , Tomoko Ishikawa , Koji Yamada , Michio Ichimura , Hiroshi Kase
IPC分类号： C07D487/04 , C07D417/04 , A61K31/505 , C07D243/08 , C07D413/04
CPC分类号： C07D487/04
摘要： The present invention relates to imidazoquinazoline derivatives represented by the general formula (I): ##STR1## or pharmacologically acceptable salts thereof. The compounds of the present invention have strong and selective cGMP-specific PDE inhibitory activity and are useful for treating or ameliorating cardiovascular diseases such as thrombosis, angina pectoris, hypertension, arterial sclerosis and the like, as well as asthma and the like.
摘要翻译： PCT No.PCT / JP94 / 01456 Sec。 371日期1995年04月26日 102（e）日期1995年4月26日PCT 1994年9月2日PCT PCT。出版物WO95 / 06648 日期：1995年3月9日本发明涉及由通式（I）表示的咪唑并喹唑啉衍生物或其药理学上可接受的盐。本发明的化合物具有强的选择性cGMP特异性PDE抑制活性，可用于治疗或改善心血管疾病如血栓形成，心绞痛，高血压，动脉硬化等，以及哮喘等。

18. 发明授权

US6127541A Imidazoquinazoline derivatives 失效
标题翻译：咪唑喹唑啉衍生物
公开(公告)号：US6127541A
公开(公告)日：2000-10-03
申请号：US65061
申请日：1998-04-27
申请人： Yasuo Onoda , Yuji Nomoto , Tetsuji Ohno , Koji Yamada , Michio Ichimura
发明人： Yasuo Onoda , Yuji Nomoto , Tetsuji Ohno , Koji Yamada , Michio Ichimura
IPC分类号： C07D487/04 , C07D487/02
CPC分类号： C07D487/04
摘要： Imidazoquinoline derivatives of the formula ##STR1## (wherein X may be O or S) provide selective cyclic guanosine 3',5' monophosphate (cGMP)--specific phosphodiesterase (PDE) inhibitory activity. The compounds are useful for treating or ameliorating cardiovascular disease such as thrombosis, angina pectoris, hypertension, heart failure and arterial sclerosis, as well as asthma, impotence and the like.
摘要翻译： PCT No.PCT / JP97 / 03023 Sec。 371日期：1998年4月27日 102（e）日期1998年4月27日PCT 1997年8月29日PCT公布。出版物WO98 / 08848 日期：1998年3月5日式（其中X可以是O或S）的咪唑并喹啉衍生物提供选择性环状鸟苷3'，5'单磷酸（cGMP）特异性磷酸二酯酶（PDE）抑制活性。该化合物可用于治疗或改善心血管疾病如血栓形成，心绞痛，高血压，心力衰竭和动脉硬化，以及哮喘，阳ence等。

19. 发明申请

US20100226803A1 Electric Pump 有权
公开(公告)号：US20100226803A1
公开(公告)日：2010-09-09
申请号：US12784529
申请日：2010-05-21
申请人： Fumio TAJIMA , Masashi Kitamura , Yuji Enomoto , Yuji Nomoto , Kenya Takarai
发明人： Fumio TAJIMA , Masashi Kitamura , Yuji Enomoto , Yuji Nomoto , Kenya Takarai
IPC分类号： F04D13/06 , H02K1/12 , H02K1/02 , H02K1/04
CPC分类号： F04D13/064 , B60L1/003 , B60L1/02 , B60L3/0061 , B60L11/14 , B60L2210/40 , B60L2240/34 , B60L2240/36 , B60L2240/425 , B60L2270/142 , B60L2270/145 , F04D13/0633 , H02K1/02 , H02K1/145 , H02K5/12 , H02K7/14 , H02K21/145 , Y02T10/641 , Y02T10/642 , Y02T10/70 , Y02T10/7077 , Y02T10/7241
摘要： A pump is driven by a compact electric motor in which a coil is disposed in a ring form around and along a stator core which has a plurality of claw magnetic poles that extend alternately from both ends of one member of the stator core toward the end of the other member thereof. A stator core can be made from a compressed powder core by molding with resin, with the molded portion able to serve as a partition separating pump and motor units.

20. 发明授权

US06270314B1 Water pump for an internal combustion engine 有权
标题翻译：内燃机用水泵
公开(公告)号：US06270314B1
公开(公告)日：2001-08-07
申请号：US09397149
申请日：1999-09-16
申请人： Yuji Nomoto
发明人： Yuji Nomoto
IPC分类号： F04D2916
CPC分类号： F04D29/426 , F04D29/086 , F04D29/167
摘要： A water pump for an internal combustion engine having a pump casing and a pump cover that forms a circulation cavity. A plate is positioned interface of the pump casing and the pump cover and divides the circulation cavity into an inlet passage and an outlet passage and has a seal portion that seals against the leakage between the inlet passage and the outlet passage of a gap of the interface of the pump casing and the pump cover.
摘要翻译：一种用于内燃机的水泵，其具有形成循环腔的泵壳体和泵盖。板被定位在泵壳体和泵盖的界面上，并将循环腔分成入口通道和出口通道，并且具有密封部分，该密封部分密封入口通道和出口通道之间的界面间隙的泄漏的泵壳和泵盖。

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