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11. 发明授权

US5049359A Apparatus for biochemical analysis 失效
标题翻译：生化分析装置
公开(公告)号：US5049359A
公开(公告)日：1991-09-17
申请号：US489870
申请日：1990-03-06
申请人： Masahi Azuma , Yasuhiro Satoh , Takashi Ishihara
发明人： Masahi Azuma , Yasuhiro Satoh , Takashi Ishihara
IPC分类号： G01N33/48 , G01N21/25 , G01N21/75 , G01N21/78 , G01N33/52 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/00712 , G01N21/253 , G01N21/8483 , G01N35/00029 , G01N35/0092 , G01N2035/00049 , G01N2035/00138 , G01N2035/0097 , G01N35/00732 , G01N35/025 , G01N35/10 , Y10T436/112499
摘要： An apparatus for biochemical analysis wherein a measuring element is conveyed by a conveying device to a dispensing unit for dispensing a substance to be measured into the measuring elements. On the conveyed device a photometric device for subjecting the measuring elements to photometry, and a discharging device for discharging the measuring elements from the conveying device are mounted. The measurement of the elements can be conducted by two or more measuring methods.
摘要翻译：一种用于生化分析的装置，其中测量元件由输送装置输送到用于将待测量物质分配到测量元件中的分配单元。在被输送的装置上安装有测量元件进行测光的测光装置，以及用于将测量元件从输送装置排出的放电装置。元件的测量可以通过两种或多种测量方法进行。

12. 发明授权

US4795613A Biochemical analyzer 失效
标题翻译：生化分析仪
公开(公告)号：US4795613A
公开(公告)日：1989-01-03
申请号：US53548
申请日：1987-05-26
申请人： Masashi Azuma , Tuneo Narushima , Takashi Ishihara
发明人： Masashi Azuma , Tuneo Narushima , Takashi Ishihara
IPC分类号： G01N33/48 , G01N21/75 , G01N21/78 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/00029 , G01N35/00732 , G01N2035/00049 , G01N2035/00376 , G01N2035/00396 , G01N2035/00762 , G01N2035/00772 , G01N35/025 , Y10T436/112499
摘要： A biochemical analyzer provided with a disk for engaging and conveying measuring elements and an analyzing method wherein information held by the measuring elements is detected and the engagement and conveyance of these elements can be controlled on the basis of the detected information. The biochemical analyzer is provided with engagement slots for the measuring elements.
摘要翻译：一种生物化学分析装置，其具有用于接合和传送测量元件的盘，以及分析方法，其中检测由测量元件保存的信息，并且可以基于检测到的信息来控制这些元件的接合和传送。生化分析仪设有用于测量元件的接合槽。

13. 发明申请

US20130096284A1 METHOD FOR PURIFYING PROTEIN USING AMINO ACID 审中-公开
标题翻译：使用氨基酸净化蛋白质的方法
公开(公告)号：US20130096284A1
公开(公告)日：2013-04-18
申请号：US13806582
申请日：2011-06-20
申请人： Takashi Ishihara
发明人： Takashi Ishihara
IPC分类号： C07K1/18 , C07K1/36 , C07K1/16
CPC分类号： C07K1/18 , C07K1/16 , C07K1/165 , C07K1/20 , C07K1/22 , C07K1/36 , C07K16/065
摘要： In large-scale purification of proteins such as antibodies, an economic high-purity purification method is required. The present invention relates to a method for purifying a protein, including one or more chromatographic processes, in which an amino acid; or a dipeptide, an oligopeptide, or a polyamino acid thereof is included in a buffer solution used in at least one chromatographic processes (equilibration buffer, wash buffer, and elution buffer), thereby purifying a high-purity protein with a very small quantity of the impurity (e.g., polymers or host cell proteins).
摘要翻译：在蛋白质如抗体的大规模纯化中，需要经济的高纯度纯化方法。本发明涉及一种纯化蛋白质的方法，包括一个或多个色谱方法，其中氨基酸; 或二肽，寡肽或其聚氨基酸包含在至少一个色谱法（平衡缓冲液，洗涤缓冲液和洗脱缓冲液）中使用的缓冲溶液中，由此纯化具有非常少量杂质（如聚合物或宿主细胞蛋白）。

14. 发明授权

US08419113B2 Structural member for vehicle 失效
标题翻译：车辆结构件
公开(公告)号：US08419113B2
公开(公告)日：2013-04-16
申请号：US13124714
申请日：2008-11-17
申请人： Daichi Kunishi , Takashi Ishihara
发明人： Daichi Kunishi , Takashi Ishihara
IPC分类号： B60N99/00
CPC分类号： B62D25/04 , B62D21/157 , B62D25/025
摘要： Through holes 14, which passes through a side wall portion 12b of an outer reinforcement 12, is formed at a lower portion of a center pillar 1. The through hole 14 is formed substantially in a D shape, and includes a linear portion 14a and a circular are portion 14b that is connected to both ends of the linear portion 14a. The length of the circular arc portion 14b is longer than that of the linear portion 14a. The linear portion 14a is disposed close to the inside of a vehicle, and the circular arc portion 14b is disposed close to the outside of a vehicle. If the circular arc portion 14b allows for deformation in length as described above, tensile stress is not easily applied to the circular arc portion when a load F is applied to the center pillar by a side collision. Accordingly, the fracturing of a center pillar 1 does not easily occur.
摘要翻译：穿过外部加强件12的侧壁部分12b的通孔14形成在中心柱1的下部。通孔14形成为大致D形，并且包括直线部分14a和圆形部分14b连接到直线部分14a的两端。圆弧部分14b的长度比直线部分14a的长度长。直线部14a靠近车辆内侧配置，圆弧部14b配置在车辆外侧。如果圆弧部分14b如上所述地允许长度变形，则当通过侧面碰撞将负载F施加到中心支柱时，拉伸应力不容易施加到圆弧部分。因此，中柱1的压裂不容易发生。

15. 发明授权

US08298387B2 Reactive oxygen species measuring device 有权
标题翻译：活性氧物质测量装置
公开(公告)号：US08298387B2
公开(公告)日：2012-10-30
申请号：US10547142
申请日：2004-02-24
申请人： Makoto Yuasa , Fumio Mizoguchi , Hitoshi Takebayashi , Masahiko Abe , Masumi Koishi , Shigeru Kido , Masamitsu Nagahama , Masayuki Kawasaki , Masahiko Yokosuka , Takashi Ishihara , Rizwangul Ibrahim
发明人： Makoto Yuasa , Fumio Mizoguchi , Hitoshi Takebayashi , Masahiko Abe , Masumi Koishi , Shigeru Kido , Masamitsu Nagahama , Masayuki Kawasaki , Masahiko Yokosuka , Takashi Ishihara , Rizwangul Ibrahim
IPC分类号： C12Q1/32
CPC分类号： G01N27/404 , A61B5/14542 , A61B5/14865 , G01N27/3271
摘要： A reactive oxygen species measuring device according to the present invention comprises a reactive oxygen species sensor provided with an electrode assembly capable of detecting the presence of reactive oxygen species or the like in terms of an electric current, a power source means for applying a measuring voltage to the reactive oxygen species sensor, and a reactive oxygen species concentration measuring means for measuring a concentration of the reactive oxygen species or the like from the current detected by the reactive oxygen species sensor. According to the present invention, a concentration of reactive oxygen species or the like such as in vivo or in vitro superoxide anion radical (O2−.) can be measured reliably, and the entire device can be formed in a smaller size and always mounted to a living body.
摘要翻译：根据本发明的活性氧物质测量装置包括具有电极组件的活性氧物质传感器，该电极组件能够根据电流检测活性氧等的存在，用于施加测量电压的电源装置和活性氧物质浓度测定单元，用于从活性氧物质传感器检测出的电流测定活性氧等的浓度。根据本发明，可以可靠地测量体内或体外超氧化物阴离子自由基（O2-）等活性氧等的浓度，整个装置可以形成为更小的尺寸并且始终安装到一个活体。

16. 发明授权

US07258041B2 Bicycle crank assembly 有权
标题翻译：自行车曲柄组合
公开(公告)号：US07258041B2
公开(公告)日：2007-08-21
申请号：US10773243
申请日：2004-02-09
申请人： Masahiro Yamanaka , Yoko Terasawa , Sota Hamada , Takahiro Nakano , Yoshiyuki Yoshida , Takashi Ishihara , Toshiaki Tatsumi
发明人： Masahiro Yamanaka , Yoko Terasawa , Sota Hamada , Takahiro Nakano , Yoshiyuki Yoshida , Takashi Ishihara , Toshiaki Tatsumi
IPC分类号： G05G1/14
CPC分类号： B62M3/003 , Y10T74/2165
摘要： A bicycle crank assembly has a right crank crimp-fastened to a crank shaft in such a manner that the external appearance is attractive. The crank shaft has a first and second portions with the second portion being positioned on the right side of the first portion and having a larger diameter than the first portion. The right crank has a sprocket mounting part, a right crank arm part, and an engagement bore formed in the center of the sprocket mounting part. The right crank is crimp-fastened to the crank shaft by installing the second portion of the crank shaft into the engagement bore and pressing the periphery of the engagement bore toward the outside in the axial direction of the crank shaft such that the pressed portion bulges radially inward and an annular space is formed between the crank shaft and the engagement bore.
摘要翻译：自行车曲柄组件具有以外观吸引人的方式卷曲地紧固到曲轴上的右曲柄。曲柄轴具有第一和第二部分，第二部分位于第一部分的右侧并具有比第一部分更大的直径。右曲柄具有链轮安装部，右曲柄臂部和形成在链轮安装部的中心的接合孔。通过将曲轴的第二部分安装到接合孔中并将曲柄的周边沿着曲柄轴的轴线方向向外侧按压，使得压紧部分径向地凸出，将右曲柄卷曲紧固到曲轴上向内，并且在曲轴和接合孔之间形成环形空间。

17. 发明申请

US20060257972A1 Purification of human monoclonal antibody and human polyclonal antibody 审中-公开
标题翻译：纯化人单克隆抗体和人多克隆抗体
公开(公告)号：US20060257972A1
公开(公告)日：2006-11-16
申请号：US10551182
申请日：2004-03-15
申请人： Takashi Ishihara
发明人： Takashi Ishihara
IPC分类号： C07K16/18 , C12P21/06
CPC分类号： C07K16/065 , C07K1/18 , C07K1/20 , C07K1/22 , C07K1/36 , C07K2317/21
摘要： This invention provides a method for separating and purifying human monoclonal antibodies and human polyclonal antibodies from an antibody-containing mixture where such antibodies are primarily used for therapeutic applications and are occasionally used for diagnostic and reagent applications. This method comprises at least the following steps of: (1) purification via anion exchange chromatography; (2) purification via cation exchange chromatography following step (1); and separation of human antibodies from artiodactyl antibodies from a mixture that contains human antibodies and artiodactyl antibodies via protein A affinity chromatography that employs pH gradient elution.
摘要翻译：本发明提供从含抗体的混合物中分离和纯化人单克隆抗体和人多克隆抗体的方法，其中这些抗体主要用于治疗应用，并偶尔用于诊断和试剂应用。该方法至少包括以下步骤：（1）通过阴离子交换色谱法纯化; （2）通过步骤（1）之后的阳离子交换层析纯化; 以及通过使用pH梯度洗脱的蛋白A亲和色谱法从含有人抗体和偶氮二酰基抗体的混合物中分离人抗体与偶氮二酰基抗体。

18. 发明授权

US06784843B2 Multi-resonance antenna 有权
标题翻译：多谐振天线
公开(公告)号：US06784843B2
公开(公告)日：2004-08-31
申请号：US10257878
申请日：2002-10-17
申请人： Kengo Onaka , Shoji Nagumo , Takashi Ishihara , Jin Sato , Akira Miyata , Kazunari Kawahata
发明人： Kengo Onaka , Shoji Nagumo , Takashi Ishihara , Jin Sato , Akira Miyata , Kazunari Kawahata
IPC分类号： H01Q138
CPC分类号： H01Q19/005 , H01Q1/243 , H01Q1/38 , H01Q5/378 , H01Q9/0421 , H01Q9/0442 , H01Q9/045
摘要： In a multi-resonance antenna, at an open end of a radiation electrode of a feeding element and an open end of a radiation electrode of a parasitic element capacitance loading electrodes and ground electrodes are arranged opposite to each other. In the opposing portions, electric-field deflectors are provided, thus reducing the electric-field coupling between the feeding element and the parasitic element.
摘要翻译：在多共振天线中，在馈电元件的放射电极的开口端和寄生元件电容负载电极和接地电极的放射电极的开口端彼此相对布置。在相对部分中，提供电场偏转器，从而减小馈电元件和寄生元件之间的电场耦合。

19. 发明授权

US06657593B2 Surface mount type antenna and radio transmitter and receiver using the same 失效
公开(公告)号：US06657593B2
公开(公告)日：2003-12-02
申请号：US10155118
申请日：2002-05-28
申请人： Shoji Nagumo , Kengo Onaka , Takashi Ishihara , Jin Sato
发明人： Shoji Nagumo , Kengo Onaka , Takashi Ishihara , Jin Sato
IPC分类号： H01Q138
CPC分类号： H01Q9/0421 , H01Q1/38 , H01Q5/357 , H01Q5/378 , H01Q5/385 , H01Q5/392
摘要： A surface mount type antenna includes a loop-shaped fed radiation electrode provided on a substrate, and a non-fed radiation electrode is arranged close to the fed radiation electrode with a gap provided therebetween. One end side of the non-fed radiation electrode is grounded, and the other end side is an open end. A signal is sent to the non-fed radiation electrode from the fed radiation electrode by electromagnetic coupling to perform a resonant operation. The fed radiation electrode and the non-fed radiation electrode generate a double-resonant state. The double resonance extends the frequency band. When the fed radiation electrode and the non-fed radiation electrode are provided on the substrate to define an antenna, the size of the antenna is greatly reduced.

20. 发明授权

US06614401B2 Antenna-electrode structure and communication apparatus having the same 有权
公开(公告)号：US06614401B2
公开(公告)日：2003-09-02
申请号：US10096587
申请日：2002-03-14
申请人： Kengo Onaka , Shoji Nagumo , Takashi Ishihara , Jin Sato , Akira Miyata , Kazunari Kawahata
发明人： Kengo Onaka , Shoji Nagumo , Takashi Ishihara , Jin Sato , Akira Miyata , Kazunari Kawahata
IPC分类号： H01Q138
CPC分类号： H01Q9/0442 , H01Q1/243 , H01Q1/38 , H01Q5/378
摘要： An antenna-electrode structure includes a feeding radiant-electrode and a grounded portion arranged such that an open-end of the feeding radiant-electrode defines a capacitance to the grounded portion therebetween, and a non-feeding radiant-electrode arranged to electromagnetically couple the feeding radiant-electrode. The non-feeding radiant electrode is arranged such that an open-end thereof defines a capacitance to the grounded portion therebetween to produce a dual-frequency resonance state together with the feeding radiant-electrode. In response to a signal supplied from a signal-supply source, the feeding radiant-electrode performs an antenna action and the non-feeding radiant-electrode in turn performs an antenna action by signal transmission from the feeding radiant-electrode, such that by being excited from these actions, the grounded portion also performs an antenna action. Because of the antenna action of the grounded portion, the sizes of the feeding radiant-electrode and the non-feeding radiant electrode are reduced.

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