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11. 发明授权

US08005539B2 Implantable medical device crosstalk evaluation and mitigation 有权
标题翻译：植入式医疗器械串扰评估和缓解
公开(公告)号：US08005539B2
公开(公告)日：2011-08-23
申请号：US12362773
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/00
CPC分类号： A61N1/3605 , A61N1/36114 , A61N1/36521 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

12. 发明申请

US20110105929A1 MEASURING T-WAVE ALTERNANS 有权
标题翻译：测量T波形ALTERNANS
公开(公告)号：US20110105929A1
公开(公告)日：2011-05-05
申请号：US12610062
申请日：2009-10-30
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61B5/0432 , A61B5/0452 , A61N1/39 , A61N1/362
CPC分类号： A61B5/0452
摘要： Techniques for monitoring T-wave alternans (TWAs) in a patient are described. An implantable medical device (IMD), such as an implantable pacemaker, cardioverter, or diagnostic device, generates an EGM signal, e.g., a far field EGM signal, samples the EGM signal to obtain a single T-wave amplitude value for each T-wave over a plurality of beats, and stores the T-wave amplitude values in memory. The IMD creates a time series of the T-wave amplitude values stored in memory, calculates the power spectral density for the times series, and selects a power spectral density of a particular frequency, e.g., 0.5 cycles per beat, as the TWA value. The IMD may periodically determine TWA values for the patient and store the values in memory. The TWA values may be presented to medical personnel, e.g., as a trend. The IMD may deliver or modify therapy, or provide an alert, based on the TWA values.
摘要翻译：描述了用于监测患者中的T波交替（TWAs）的技术。诸如可植入心脏起搏器，心律转复器或诊断装置的可植入医疗装置（IMD）生成例如远场EGM信号的EGM信号，对EGM信号进行采样，以获得每个T- 在多个节拍中波动，并将T波幅度值存储在存储器中。 IMD产生存储在存储器中的T波幅度值的时间序列，计算时间序列的功率谱密度，并选择特定频率的功率谱密度，例如每个节拍0.5个周期作为TWA值。 IMD可以周期性地确定患者的TWA值并将值存储在存储器中。 TWA值可以呈现给医务人员，例如作为趋势。 IMD可以根据TWA值提供或修改治疗或提供警报。

13. 发明申请

US20100114211A1 SHUNT-CURRENT REDUCTION TECHNIQUES FOR AN IMPLANTABLE THERAPY SYSTEM 有权
标题翻译：用于可植入治疗系统的分流电流减少技术
公开(公告)号：US20100114211A1
公开(公告)日：2010-05-06
申请号：US12551331
申请日：2009-08-31
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
IPC分类号： A61N1/08 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3718 , A61N1/08 , A61N1/086 , A61N1/36114 , A61N1/37288
摘要： Techniques for minimizing interference between the first and second medical devices or between the different therapy modules of a common medical device are described herein. In some examples, a medical device may include shunt-current mitigation circuitry and/or at least one clamping structure that helps minimize or even eliminate shunt-current that feeds into a first therapy module of the medical device via one or more electrodes electrically connected to the first therapy module. The shunt-current may be generated by the delivery of electrical stimulation by a second therapy module. The second therapy module may be enclosed in a common housing with the first therapy module or may be separate, e.g., a part of a separate medical device.
摘要翻译：本文描述了用于最小化第一和第二医疗装置之间或在普通医疗装置的不同治疗模块之间的干扰的技术。在一些示例中，医疗装置可以包括分流电流缓解电路和/或至少一个夹持结构，其有助于最小化或甚至消除通过电连接到医疗装置的一个或多个电极馈入医疗装置的第一治疗模块的分流电流第一疗法模块。分流电流可以通过第二治疗模块的电刺激递送来产生。第二治疗模块可以用第一治疗模块封闭在共同的壳体中，或者可以是分离的，例如单独的医疗装置的一部分。

14. 发明申请

US20100114201A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
标题翻译：可伸缩医疗器械CROSSTALK评估和缓解
公开(公告)号：US20100114201A1
公开(公告)日：2010-05-06
申请号：US12362838
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/37 , A61B5/0205
CPC分类号： A61N1/3621 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3706 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

15. 发明申请

US20080228133A1 DELIVERY OF A SYMPATHOLYTIC CARDIOVASCULAR AGENT TO THE CENTRAL NERVOUS SYSTEM 有权
标题翻译：向中央神经系统递送病理性心脏血管代谢
公开(公告)号：US20080228133A1
公开(公告)日：2008-09-18
申请号：US12128046
申请日：2008-05-28
申请人： KEITH R. HILDEBRAND , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
发明人： KEITH R. HILDEBRAND , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
IPC分类号： A61M31/00
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和右美托咪定）。

16. 发明申请

US20070276453A1 METHOD AND APPARATUS TO MINIMIZE THE EFFECTS OF A CARDIAC INSULT 审中-公开
标题翻译：减轻心脏病的效果的方法和装置
公开(公告)号：US20070276453A1
公开(公告)日：2007-11-29
申请号：US11837811
申请日：2007-08-13
申请人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou , Rahul Mehra
发明人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou , Rahul Mehra
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided to peripheral nerves, intrinsic cardiac nerves, sympathetic ganglia, cranial nerves, and may generally be directed to the vertebral column, or within the chest wall of the patient.
摘要翻译：提供了一种用于保护心脏组织免受侮辱的方法和装置。所述方法包括识别呃等的发生，例如心脏病发作，并且响应于识别侮辱的发生而向患者身体中的一个或多个预定神经传递电刺激。刺激可以提供给外周神经，内在的心脏神经，交感神经节，颅神经，并且通常可以被引导到脊柱或患者的胸壁内。

17. 发明授权

US07177680B2 Field stimulation about a discontinuity of the myocardium to capture the heart at reduced pacing thresholds 失效
标题翻译：关于心肌不连续的场刺激，以降低的起搏阈值捕获心脏
公开(公告)号：US07177680B2
公开(公告)日：2007-02-13
申请号：US10403636
申请日：2003-03-31
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0573 , A61N1/0587
摘要： Improved pacing thresholds for capturing the heart are achieved by forming a discontinuity in the cardiac tissue of the heart chamber, disposing a pacing electrode at a distance less than a space constant of the cardiac tissue from the discontinuity in the cardiac tissue, and applying a stimulus of a first polarity at an energy insufficient to cause the directly stimulated tissue adjacent to the pacing electrode to propagate a depolarization wave through the cardiac tissue mass of the heart chamber but sufficient to induce a transmembrane potential change at the tissue adjacent to the discontinuity that results in a propagated wave front. Thus, pacing energy is advantageously reduced.
摘要翻译：通过在心脏室的心脏组织中形成不连续性来实现用于捕获心脏的改善的起搏阈值，将起搏电极设置在心脏组织的距离小于心脏组织的间隔常数的距离处，并施加刺激第一极性的能量不足以引起与起搏电极相邻的直接受刺激的组织通过心室的心脏组织块传播去极化波，但是足以在与不连续性相邻的组织处诱导跨膜电位变化，在传播的波前。因此，起搏能量有利地降低。

18. 发明申请

US20060116596A1 Method and apparatus for detection and monitoring of T-wave alternans 审中-公开
标题翻译：用于检测和监测T波交替的方法和装置
公开(公告)号：US20060116596A1
公开(公告)日：2006-06-01
申请号：US11000541
申请日：2004-12-01
申请人： Xiaohong Zhou , Thomas Mullen , Jeffrey Gillberg , Robert Stadler
发明人： Xiaohong Zhou , Thomas Mullen , Jeffrey Gillberg , Robert Stadler
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0422 , A61B5/0452
摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.
摘要翻译：提供了一种使用从植入电极接收的心脏EGM信号评估T波交替（TWA）的系统和方法。从由自动增益控制读出放大器接收的信号测量T波信号参数。通过T波参数测量或使用频谱技术的逐拍比较来计算TWA测量。 TWA测量值和测量条件用于检测临床重要的TWA。 TWA评估还包括在多向量TWA评估中区分一致和不一致的TWA，并确定TWA测量与QRS交替，机械交替和其他生理事件的关联。病理性心脏事件的预测是针对TWA评估做出的。提供对心脏事件预测的响应。

19. 发明申请

US20060095081A1 Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead 有权
标题翻译：通过神经系统刺激治疗系统或医用电导体感测心脏活动的方法和装置
公开(公告)号：US20060095081A1
公开(公告)日：2006-05-04
申请号：US11116970
申请日：2005-04-28
申请人： Xiaohong Zhou , Thomas Mullen , Michael Hill , Steve Laporte , Gary King
发明人： Xiaohong Zhou , Thomas Mullen , Michael Hill , Steve Laporte , Gary King
IPC分类号： A61N1/18
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36135
摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.
摘要翻译：根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。

20. 发明授权

US06528998B1 Method and apparatus to reduce the effects of maxwell terms and other perturbation magnetic fields in MR images 失效
标题翻译：减少麦克斯韦术语和其他扰动磁场对MR图像影响的方法和装置
公开(公告)号：US06528998B1
公开(公告)日：2003-03-04
申请号：US09540768
申请日：2000-03-31
申请人： Xiaohong Zhou , Joseph K. Maier , Steven J. Huff
发明人： Xiaohong Zhou , Joseph K. Maier , Steven J. Huff
IPC分类号： G01V300
CPC分类号： G01R33/56581
摘要： A method and apparatus for correcting ghosting artifacts that are related to Maxwell fields and/or other perturbation magnetic fields is disclosed. The method and apparatus includes acquiring MR image n-space data and an MR reference scan, each having perturbation field effects therein. After determining phase correction values from the MR reference scan and reconstructing an MR image using the phase correction values, a projection phase error is calculated from the reconstructed MR image and then subtracted from the reference scan, the result of which is used to determine a new set of phase correction values. The new set of phase correction values is applied to the acquired MR image data to reconstruct a new image. The reconstructed new image can then be reused to calculate a new projection phase error, which again is subtracted from the reference scan data and the process is repeated until an image of desired ghost artifact reduction is achieved.
摘要翻译：公开了一种用于校正与麦克斯韦尔场和/或其他扰动磁场相关的重影伪像的方法和装置。该方法和装置包括获取每个在其中具有扰动场效应的MR图像n空间数据和MR参考扫描。在从MR参考扫描确定相位校正值并使用相位校正值重建MR图像之后，从重建的MR图像计算投影相位误差，然后从参考扫描中减去其结果，其结果用于确定新的一组相位校正值。将新的相位校正值集合应用于所获取的MR图像数据以重构新图像。然后可以重新构建重建的新图像以计算新的投影相位误差，其再次从参考扫描数据中减去，并且重复该过程，直到实现期望的鬼影伪像减少的图像。

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