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11. 发明申请

US20170100520A1 PATTERNED SURFACE 审中-公开
公开(公告)号：US20170100520A1
公开(公告)日：2017-04-13
申请号：US15316976
申请日：2015-06-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Russell F. Ross
IPC分类号： A61L27/50 , A61L27/58 , A61L27/26
CPC分类号： A61L27/50 , A61L27/26 , A61L27/34 , A61L27/58 , A61L2400/18 , A61L2420/02 , C08L23/12
摘要： The present disclosure provides patterned materials that may be useful in reducing certain negative effects associated with damaged tissue in vivo. The patterned materials can modify the healing process, and may minimize the formation of scar tissue. Such effects can provide inhibition of adhesion between tissues and/or reduction of fibrotic encapsulation around implanted medical devices.

12. 发明申请

US20160106965A1 Microneedles With Improved Open Channel Cross-Sectional Geometries 有权
标题翻译：具有改进的开放通道横截面几何的微针
公开(公告)号：US20160106965A1
公开(公告)日：2016-04-21
申请号：US14787044
申请日：2014-05-20
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Andrew Baker , Russell F. Ross , Sridhar Ranganathan
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0038
摘要： In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid-to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.
摘要翻译：在一个方面，药物递送装置可以包括容纳液体药物制剂和与储存器流体连通的微针组件的储存器。微针组件可以包括多个微针，每个微针限定用于接收药物制剂的开放通道。开放通道可以具有约0.1至约0.8的归一化液压半径。当容纳固定体积的药物制剂时，开放通道也可具有液体 - 固体的界面能量和液体至蒸汽的界面能量。此外，可以选择和构造药物制剂和开放通道的横截面几何形状，使得当药物制剂的固定体积的长度增加时，液体 - 固体能量超过液体至蒸气能量在开放的渠道内。

13. 发明申请

US20150360018A1 Drug Delivery Device 有权
标题翻译：药物输送装置
公开(公告)号：US20150360018A1
公开(公告)日：2015-12-17
申请号：US14762534
申请日：2014-02-28
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Andrew Baker , Russell F. Ross , Luke Hagan
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0061 , A61M2210/04
摘要： A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.
摘要翻译：公开了一种药物递送装置，其可以包括具有限定上表面和下表面的支撑物的皮肤穿透组件。皮肤穿透组件还可以包括从下表面向外延伸的多个皮肤穿透构件。每个皮肤穿透构件可以限定用于接收药物制剂的通道。此外，装置可以包括邻近支撑件的上表面定位的储存器，用于初始保持药物制剂。储存器可以包括顶表面和底表面，并且可以限定在顶表面和底表面之间延伸的多个通道。通道可以被配置成使药物制剂保持在通道内以防止重力。

14. 发明申请

US20140287019A1 Implantable Devices for Delivery of Bioactive Agents 审中-公开
标题翻译：用于递送生物活性剂的植入式装置
公开(公告)号：US20140287019A1
公开(公告)日：2014-09-25
申请号：US14354223
申请日：2012-10-16
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Jeremy Ollerenshaw , Emily Reichart , Russell F. Ross
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61F2/82 , A61F2002/0081 , A61F2250/0067 , A61K9/0024 , A61K9/0097 , A61L27/50 , A61L27/54 , A61L31/14 , A61L31/16 , A61L2400/12 , A61L2400/18 , A61M37/0015 , A61M2037/0053
摘要： An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described. The device includes a pattern of structures fabricated on a surface of the device to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The device may be located adjacent tissue such as an endovascular implant or a perivascular implant, and may deliver the bioactive agent without triggering an immune or foreign body response to the bioactive agent.
摘要翻译：描述了一种用于利用该装置将生物活性剂递送至有需要的受试者的可植入递送装置和方法。该装置包括在该装置的表面上制造以形成纳米形貌的结构图案。可以制造随机或非随机的结构图案，例如包括不同尺寸和/或形状的结构的复杂图案。该装置可以位于相邻组织例如血管外植入物或血管周围植入物处，并且可以递送生物活性剂而不引发对生物活性剂的免疫或异物反应。

15. 发明申请

US20170036005A1 DRAPED MICRONEEDLE ARRAY 有权
标题翻译：卷曲麦克风阵列
公开(公告)号：US20170036005A1
公开(公告)日：2017-02-09
申请号：US14914302
申请日：2015-04-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Andrew T. Baker , Elizabeth Deibler Gadsby , Russell F. Ross
IPC分类号： A61M37/00 , B29C35/08
CPC分类号： A61M37/0015 , A61B5/150022 , A61B5/150435 , A61B5/150984 , A61M2037/0038 , A61M2037/0053 , B29C35/0805 , B29L2031/753
摘要： The configuration of an elongate aperture in a membrane draped over a microneedle assembly may be controlled by controlling the manner in which the aperture is formed and/or by controlling the manner in which the membrane is draped. At least a portion of the membrane may be spaced apart from a microneedle so that a gap is defined between the membrane and the microneedle. The gap may be configured for at least partially controlling the formation of the elongate aperture. The shape of the gap may optionally be at least partially defined by a pleat in the membrane. Any pleats may be aligned in a predetermined manner. The elongate aperture may be formed by a piercing member that is passed through a hole in the microneedle assembly prior to piercing the membrane. The piercing member may be a laser beam.
摘要翻译：可以通过控制形成孔的方式和/或通过控制膜被覆盖的方式来控制在微针组件上覆盖的膜中的细长孔的构造。膜的至少一部分可以与微针间隔开，使得在膜和微针之间限定间隙。间隙可以被配置为至少部分地控制细长孔的形成。间隙的形状可以任选地至少部分地由膜中的褶皱限定。任何褶可以以预定的方式对齐。细长孔可以由刺穿构件形成，该穿孔构件在穿透膜之前通过微针组件中的孔。刺穿构件可以是激光束。

16. 发明授权

US09550053B2 Transdermal delivery of high viscosity bioactive agents 有权
标题翻译：透皮输送高粘度生物活性剂
公开(公告)号：US09550053B2
公开(公告)日：2017-01-24
申请号：US14354229
申请日：2012-10-16
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Russell F. Ross
IPC分类号： A61M5/32 , A61M37/00 , A61K9/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61K31/167 , A61K31/485 , A61K31/5575 , A61K31/70 , A61K38/1808 , A61K38/191 , A61K38/20 , A61K38/21 , A61K38/26 , A61K38/28 , A61M2037/0007 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061
摘要： A device and method for delivering a high viscosity composition is described. The composition includes a bioactive agent for delivery to a subject in need thereof. The method delivers the bioactive agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. The device includes one or more microneedles with structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes.
摘要翻译：描述了用于输送高粘度组合物的装置和方法。组合物包括用于递送至有需要的受试者的生物活性剂。该方法将生物活性剂以高生物利用度递送，并且对身体的自然防御机制几乎没有药剂损失。该装置包括一个或多个微针，其具有在微针的表面上制造的结构以形成纳米形貌。可以制造随机或非随机的结构图案，例如包括不同尺寸和/或形状的结构的复杂图案。

17. 发明申请

US20150367117A1 Transdermal Drug Delivery Device 审中-公开
标题翻译：透皮给药装置
公开(公告)号：US20150367117A1
公开(公告)日：2015-12-24
申请号：US14762844
申请日：2014-02-28
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Russell F. Ross , Luke Hagan , Alexander Malkin , Derek Hatchett , Jacob Marks , Thomas Lutzow
IPC分类号： A61M37/00 , A61M5/158
CPC分类号： A61M37/0015 , A61M5/158 , A61M5/42 , A61M5/425 , A61M2005/1587 , A61M2037/0023 , A61M2037/0061
摘要： A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releaseably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.
摘要翻译：公开了一种透皮药物输送装置，其可以包括包括上壳体部分和下壳体部分的壳体。下壳体部分可以限定底表面，其包括皮肤附接装置，用于将下壳体部分可释放地附接到使用者的皮肤上。上壳体部分可以至少部分地围绕该装置的中心区域。该装置还可以包括设置在中心区域内的微针组件和储存器。储存器可以与微针组件流体连通。此外，该装置可以包括设置在中心区域内的微针组件上方的推动元件。推动元件可以被配置为提供具有透射通过微针组件的向下部件的连续双边力，以及透过皮肤附接装置的向上部件。

18. 发明申请

US20140343532A1 Transdermal Delivery of High Viscosity Bioactive Agents 有权
标题翻译：透皮输送高粘度生物活性剂
公开(公告)号：US20140343532A1
公开(公告)日：2014-11-20
申请号：US14354229
申请日：2012-10-16
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Russell F. Ross
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61K31/167 , A61K31/485 , A61K31/5575 , A61K31/70 , A61K38/1808 , A61K38/191 , A61K38/20 , A61K38/21 , A61K38/26 , A61K38/28 , A61M2037/0007 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061
摘要： A device and method for delivering a high viscosity composition is described. The composition includes a bioactive agent for delivery to a subject in need thereof. The method delivers the bioactive agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. The device includes one or more microneedles with structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes.
摘要翻译：描述了用于输送高粘度组合物的装置和方法。组合物包括用于递送至有需要的受试者的生物活性剂。该方法将生物活性剂以高生物利用度递送，并且对身体的自然防御机制几乎没有药剂损失。该装置包括一个或多个微针，其具有在微针的表面上制造的结构以形成纳米形貌。可以制造随机或非随机的结构图案，例如包括不同大小和/或形状的结构的复杂图案。

19. 发明授权

US10183156B2 Transdermal drug delivery device 有权
公开(公告)号：US10183156B2
公开(公告)日：2019-01-22
申请号：US14762844
申请日：2014-02-28
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Russell F. Ross , Luke Hagan , Alexander Malkin , Derek Hatchett , Jacob Marks , Thomas Lutzow
IPC分类号： A61M37/00 , A61M5/42 , A61M5/158
摘要： A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.

20. 发明申请

US20180289853A1 ABSORBENT ARTICLES CONTAINING A MULTIFUNCTIONAL GEL 审中-公开
公开(公告)号：US20180289853A1
公开(公告)日：2018-10-11
申请号：US16007447
申请日：2018-06-13
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Ali Yahiaoui , Candace Dyan Krautkramer , Margaret G. Latimer , Jack Nelson Lindon , Russell F. Ross , Melissa Jean Jacobs , Garry Roland Woltman
IPC分类号： A61L15/58 , A61L15/60 , A61F13/82 , A61F13/53
摘要： Improved skin-adhesive compositions for bonding a substrate, such as an absorbent article, to skin are disclosed. More particularly, the skin-adhesive composition has an improved, yet gentle, adhesion to the skin of a user, while maintaining strong, effective bonding to various inanimate, non-skin substrates. In one embodiment, the skin-adhesive composition can provide one or more skin benefit agents to the user. The skin-adhesive composition may be applied to an absorbent article, such as a panty-liner, sanitary napkin, or an incontinence article, for directly adhering the article to the skin of a user.

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