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11. 发明申请

US20080119372A1 Microarray and Method of Fabricating the Same 审中-公开
标题翻译：微阵列及其制造方法
公开(公告)号：US20080119372A1
公开(公告)日：2008-05-22
申请号：US11748163
申请日：2007-05-14
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
IPC分类号： C40B40/14 , C40B50/00
CPC分类号： C40B40/06 , C40B50/18 , C40B60/14
摘要： A microarray includes a substrate, a siloxane resin layer represented by the following general formula 1 or 2 and includes a siloxane resin having a molecular weight of about 1,000 to about 10,000: where R1 and R2 are independently hydrocarbons having 1 to 30 carbon atoms and X1 and X2 are independently a hydroxyl, aldehyde, carboxyl amino, amide, thiol halo, or sulfonate group, and a plurality of oligomer probes coupled with the siloxane resin layer.
摘要翻译：微阵列包括基底，由以下通式1或2表示的硅氧烷树脂层，并且包括分子量为约1,000至约10,000的硅氧烷树脂：其中R 1和R 2， 2个独立地是具有1至30个碳原子的烃，X 1和X 2独立地是羟基，醛，羧基氨基，酰胺，硫醇卤素或磺酸酯基和与硅氧烷树脂层结合的多个低聚物探针。

12. 发明授权

US07935519B2 DNA chip, DNA chip kit, and method of manufacturing the DNA chip 有权
标题翻译： DNA芯片，DNA芯片套件和DNA芯片的制造方法
公开(公告)号：US07935519B2
公开(公告)日：2011-05-03
申请号：US11790351
申请日：2007-04-25
申请人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim
发明人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： G01N27/3278 , Y10S977/704 , Y10S977/792 , Y10S977/924
摘要： A DNA chip includes a substrate, at least one first electrode and at least one second electrode on the substrate, the first electrode and the second electrode being opposite to and separated from each other, multiple oligonucleotide probes, one end of the oligonucleotide probes being immobilized on the first electrode, and a charge-carrier transport layer on the second electrode, the charge-carrier layer contacting an other end of the oligonucleotide probes.
摘要翻译： DNA芯片包括：衬底，至少一个第一电极和至少一个第二电极，所述衬底上的所述第一电极和所述第二电极彼此相对并分离，多个寡核苷酸探针，所述寡核苷酸探针的一端被固定在第一电极上和第二电极上的电荷 - 载流子传输层，电荷载流子层与寡核苷酸探针的另一端接触。

13. 发明申请

US20070259365A1 Multifunctional Oligomer Probe Array and Method of Manufacturing the Same 审中-公开
标题翻译：多功能低聚物探针阵列及其制造方法
公开(公告)号：US20070259365A1
公开(公告)日：2007-11-08
申请号：US11743477
申请日：2007-05-02
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
IPC分类号： C12Q1/68 , C07H21/04 , C12M3/00
CPC分类号： C07H21/04 , B01J19/0046 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/14
摘要： A multifunctional oligomer probe array capable of simultaneously performing different analyses such as gene expression profiling and genotyping includes a substrate, a first array region, a second array region, and a column spacer. The first array region has a plurality of first probe cell active regions, one or more oligomer probes, and a first probe cell defining region, wherein the plurality of first probe cell active regions are disposed on or in the substrate. The second array region has a plurality of second probe cell active regions, one or more oligomer probes, and a second probe cell defining region, wherein the plurality of second probe cell active regions are disposed on or in the substrate. The column spacer prevents cross-talk between a target sample applied to the first array region and another target sample applied to the second array region.
摘要翻译：能够同时进行基因表达谱和基因分型等不同分析的多功能低聚物探针阵列包括基片，第一阵列区，第二阵列区和柱间隔物。第一阵列区域具有多个第一探针单元活性区域，一个或多个低聚物探针和第一探针单元限定区域，其中多个第一探针单元有源区域设置在基底上或基底中。第二阵列区域具有多个第二探针单元活性区域，一个或多个低聚物探针和第二探针单元限定区域，其中多个第二探针单元有源区域设置在基底上或基底中。列间隔物防止施加到第一阵列区域的目标样本与施加到第二阵列区域的另一目标样本之间的串扰。

14. 发明授权

US08034747B2 Photolabile compound, oligomer probe array and substrate for oligomer probe array containing the same, and manufacturing method of the same 失效
标题翻译：不稳定化合物，低聚物探针阵列和含有相同的低聚物探针阵列的底物及其制备方法相同
公开(公告)号：US08034747B2
公开(公告)日：2011-10-11
申请号：US12019843
申请日：2008-01-25
申请人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Man-hyoung Ryoo
发明人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Man-hyoung Ryoo
IPC分类号： C40B50/14
CPC分类号： C07H19/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07D215/14 , C07F9/2408 , C07F9/60 , C07F9/65515 , C07H21/00 , C40B50/14 , Y02P20/55 , Y10T436/143333
摘要： A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.
摘要翻译：公开了一种光不稳定化合物，低聚物探针阵列和包含其的低聚物探针阵列用基板及其制造方法。

15. 发明申请

US20080188380A1 PHOTOLABILE COMPOUND, OLIGOMER PROBE ARRAY AND SUBSTRATE FOR OLIGOMER PROBE ARRAY CONTAINING THE SAME, AND MANUFACTURING METHOD OF THE SAME 失效
标题翻译：低分子化合物，低聚物探针阵列和含有其的低聚物探针阵列的底物及其制造方法
公开(公告)号：US20080188380A1
公开(公告)日：2008-08-07
申请号：US12019843
申请日：2008-01-25
申请人： SUNG-MIN CHI , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Man-hyoung Ryoo
发明人： SUNG-MIN CHI , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Man-hyoung Ryoo
IPC分类号： C40B40/04 , C07H15/18 , C07H15/26 , C40B50/18 , C40B60/14
CPC分类号： C07H19/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07D215/14 , C07F9/2408 , C07F9/60 , C07F9/65515 , C07H21/00 , C40B50/14 , Y02P20/55 , Y10T436/143333
摘要： A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.
摘要翻译：公开了一种光不稳定化合物，低聚物探针阵列和包含其的低聚物探针阵列用基板及其制造方法。

16. 发明申请

US20080176764A1 Oligomer probe array chips, masks used to produce the same, and hybridization analysis methods using the same 审中-公开
标题翻译：寡聚体探针阵列芯片，用于制备相同的掩模，以及使用其的杂交分析方法
公开(公告)号：US20080176764A1
公开(公告)日：2008-07-24
申请号：US12003131
申请日：2007-12-20
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim , Han-ku Cho
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim , Han-ku Cho
IPC分类号： C40B40/06 , B32B3/00 , G06K9/34
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , Y10T428/24612 , C12Q2565/513
摘要： Example embodiments may include an oligomer probe array chip based on an analysis-friendly layout. Example oligomer probe array chips may include a substrate, a main array on the substrate having a plurality of sub-arrays in rows or panels, and/or a plurality of alignment spot arrays outside of each of the sub-arrays. The sub-arrays may include a plurality of spots arranged in a matrix to which oligomer probes having different sequences may be attached. Example embodiments may further provide masks for fabricating oligomer probe array chips and hybridization analysis methods of oligomer probe array chips.
摘要翻译：示例性实施例可以包括基于分析友好布局的低聚物探针阵列芯片。示例性低聚物探针阵列芯片可以包括衬底，衬底上的主阵列具有排或面板中的多个子阵列，和/或每个子阵列外部的多个对准点阵列。子阵列可以包括布置在矩阵中的多个点，可以连接具有不同序列的低聚物探针。示例性实施例还可以提供用于制造低聚物探针阵列芯片的掩模和低聚物探针阵列芯片的杂交分析方法。

17. 发明申请

US20070259418A1 DNA chip, DNA chip kit, and method of manufacturing the DNA chip 有权
标题翻译： DNA芯片，DNA芯片套件和DNA芯片的制造方法
公开(公告)号：US20070259418A1
公开(公告)日：2007-11-08
申请号：US11790351
申请日：2007-04-25
申请人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim
发明人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim
IPC分类号： C12M1/34
CPC分类号： G01N27/3278 , Y10S977/704 , Y10S977/792 , Y10S977/924
摘要： A DNA chip includes a substrate, at least one first electrode and at least one second electrode on the substrate, the first electrode and the second electrode being opposite to and separated from each other, multiple oligonucleotide probes, one end of the oligonucleotide probes being immobilized on the first electrode, and a charge-carrier transport layer on the second electrode, the charge-carrier layer contacting an other end of the oligonucleotide probes.
摘要翻译： DNA芯片包括：衬底，至少一个第一电极和至少一个第二电极，所述衬底上的所述第一电极和所述第二电极彼此相对并分离，多个寡核苷酸探针，所述寡核苷酸探针的一端被固定在第一电极上和第二电极上的电荷 - 载流子传输层，电荷载流子层与寡核苷酸探针的另一端接触。

18. 发明授权

US07667032B2 Method of manufacturing a microarray 失效
标题翻译：微阵列的制造方法
公开(公告)号：US07667032B2
公开(公告)日：2010-02-23
申请号：US11748175
申请日：2007-05-14
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00382 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/18
摘要： A method of manufacturing a microarray includes providing a substrate having a surface that is immobilized with a functional group protected with an acid-labile protecting group and capable of coupling with an oligomer probe, providing a photoacid generator onto the substrate, disposing on the substrate an imprint template comprising a convex region and a plurality of concave regions surrounding the convex region so that the convex region contacts with or is adjacent to an upper surface of the substrate to define a plurality of reaction zones by the upper surface of the substrate and the convex region and the concave regions of the imprint template, exposing one or more of the reaction zones to light so that an acid is generated by the photoacid generator in the one or more exposed reaction zones and a functional group in the one or more exposed reaction zones is deprotected by the acid, and providing an oligomer probe onto the substrate so that the oligomer probe couples with the deprotected functional group.
摘要翻译：一种制造微阵列的方法包括提供具有固定有被酸不稳定保护基团保护的官能团并且能够与低聚物探针耦合的表面的基底，在基底上提供光致酸产生剂，在基底上设置压印模板，其包括凸区域和围绕所述凸区域的多个凹区域，使得所述凸区域与所述衬底的上表面接触或邻近所述衬底的上表面，以通过所述衬底的上表面和所述凸起部分限定多个反应区域区域和压印模板的凹区域，使一个或多个反应区域曝光，使得在一个或多个暴露的反应区域中的光酸产生剂产生酸，并且在一个或多个暴露的反应区域中的官能团通过酸脱保护，并在基底上提供低聚物探针，使得寡聚物探针与沉淀物结合无效的功能组。

19. 发明申请

US20080214409A1 Substrate structure, oligomer probe array and methods for producing the same 审中-公开
标题翻译：底物结构，低聚物探针阵列及其制备方法
公开(公告)号：US20080214409A1
公开(公告)日：2008-09-04
申请号：US12068715
申请日：2008-02-11
申请人： Kyoung-seon Kim , Sung-min Chi , Jung-hwan Hah , Won-sun Kim
发明人： Kyoung-seon Kim , Sung-min Chi , Jung-hwan Hah , Won-sun Kim
IPC分类号： C40B40/04 , C40B50/18 , B32B9/00 , B05D1/36
CPC分类号： B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B50/18 , C40B80/00 , Y10T428/31504
摘要： Disclosed are substrate structures, an oligomer probe array and methods of producing the same. The substrate structure may include a substrate, and an intermediate film including the chemical structure represented by the following Formula 1, on the substrate. (wherein R1 is alkyl, aryl, alkoxy, nitrile, ester, phenyl, hydroxyl, aliphatic lactone, cycloalkyl or cycloalkenyl, R2 is alkyl, aryl, alkoxy, nitrile, ester, phenyl, hydroxyl, aliphatic lactone, cycloalkyl or cycloalkenyl, and X is coupled with the substrate directly or via an immobilization layer).
摘要翻译：公开了底物结构，低聚物探针阵列及其制备方法。衬底结构可以包括衬底和在衬底上包含由下式1表示的化学结构的中间膜。（其中R 1是烷基，芳基，烷氧基，腈，酯，苯基，羟基，脂族内酯，环烷基或环烯基，R 2是烷基，芳基，烷氧基，腈，酯，苯基，羟基，脂族内酯，环烷基或环烯基，X直接或通过固定层与底物偶联）。

20. 发明申请

US20080194424A1 OLIGOMER PROBE ARRAY 审中-公开
标题翻译：低分辨率探头阵列
公开(公告)号：US20080194424A1
公开(公告)日：2008-08-14
申请号：US12029582
申请日：2008-02-12
申请人： Won-sun Kim , Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Man-Hyoung Ryoo
发明人： Won-sun Kim , Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Man-Hyoung Ryoo
IPC分类号： C40B40/06
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00432 , B01J2219/00434 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C12Q2563/155
摘要： An oligomer probe array includes a substrate, an immobilization layer on the substrate, nanoparticles coupled to the immobilization layer and forming a photonic crystal structure, and oligomer probes coupled to the nanoparticles. The immobilization layer includes probe cell regions coupled to nanoparticles. Adjacent probe cell regions are separated by a probe cell separation region.
摘要翻译：低聚物探针阵列包括基底，基底上的固定层，与固定层结合并形成光子晶体结构的纳米颗粒以及耦合到纳米颗粒的低聚物探针。固定层包括耦合到纳米颗粒的探针细胞区域。相邻的探针细胞区域被探针细胞分离区分离。

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