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11. 发明授权

US5504215A Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation 失效
公开(公告)号：US5504215A
公开(公告)日：1996-04-02
申请号：US458079
申请日：1995-06-01
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.

12. 发明授权

US5565482A Heteroarylpyranopyrazolyl derivatives for the treatment of inflammation 失效
标题翻译：异芳基吡喃并吡唑衍生物用于治疗炎症
公开(公告)号：US5565482A
公开(公告)日：1996-10-15
申请号：US536925
申请日：1995-09-29
申请人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
发明人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
IPC分类号： C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D495/04 , A61K31/415 , C07D491/14
CPC分类号： C07D491/04 , C07D495/04
摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

13. 发明授权

US5547975A Benzopyranopyrazolyl derivatives for the treatment of inflammation 失效
标题翻译：苯并吡喃并吡唑衍生物用于治疗炎症
公开(公告)号：US5547975A
公开(公告)日：1996-08-20
申请号：US309291
申请日：1994-09-20
申请人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
发明人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
IPC分类号： C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D495/04 , A61K31/415 , A61K31/63
CPC分类号： C07D491/04 , C07D495/04
摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

14. 发明授权

US5670532A Pyrazolyl derivatives for the treatment of inflammation 失效
标题翻译：吡唑基衍生物用于治疗炎症
公开(公告)号：US5670532A
公开(公告)日：1997-09-23
申请号：US719501
申请日：1996-09-25
申请人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
发明人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
IPC分类号： C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D495/04 , A61K31/415 , A61K31/435 , C07D487/04
CPC分类号： C07D491/04 , C07D495/04
摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

15. 发明授权

US5510496A Substituted pyrazolyl benzenesulfonamides 失效
标题翻译：取代的吡唑基苯磺酰胺
公开(公告)号：US5510496A
公开(公告)日：1996-04-23
申请号：US456441
申请日：1995-06-01
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , James W. Malecha , Stephen R. Bertenshaw , Matthew J. Graneto
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , James W. Malecha , Stephen R. Bertenshaw , Matthew J. Graneto
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R.sup.1 is selected from sulfamyl, fluoro, chloro, methyl, hydroxyl, methoxy and trifluoromethyl: wherein R.sup.2 is selected from hydrido, difiuoromethyl, trifluoromethyl, amido, dichloromethyl, trichloromethyl, pentafluoroethyl, cyano, heptatluoropropyl, difluorochloromethyl, methoxycarbonyl, dichlorofluoromethyl, N-phenylamido, N-3-fluorophenyl) amido, 2-pyridylamido, N-(4-methylphenyl)amido, hydroxypropyl, N-(3-chlorophenyl)amido, N-(4-methoxyphenyl)amido, hydroxymethyl, hydroxyethyl, carboxylpropyl, carboxymethyl and carboxyethyl; wherein R.sup.3 is selected from hydrido, methyl, triflouromethyl, fluoro, chloro and bromo; wherein R.sup.4 is selected from phenyl, biphenyl, pyrazinyl, cyclohexyl, cyclohexenyl and thienyl; and wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from chloro, bromo, fluoro, methylthio, methylsulfonyl, morpholinyl, amino, methyl, ethyl, propyl, isopropyl, butyl, ethoxy, nitro, chloromethyl, trifluoromethoxy, trifluoroenhoxy, fluoromethyl, methoxy, difluoromethyl, trifluoromethyl, dichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, and difluoropropyl; or wherein R.sup.3 and R.sup.4 together form ##STR2## provided R.sup.2 and R.sup.3 are not both hydrido; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I定义：其中R 1选自氨磺酰基，氟，氯，甲基，羟基，甲氧基和三氟甲基：其中R 2选自氢，二氟甲基，三氟甲基，酰氨基，二氯甲基，三氯甲基，五氟乙基，氰基，七氟丙基，二氟氯甲基，甲氧基羰基，二氯氟甲基，N-苯基酰氨基，N-3-氟苯基）酰氨基，2-吡啶基酰氨基，N-（4-甲基苯基）酰氨基，羟丙基，N-（3-氯苯基） N-（4-甲氧基苯基）酰氨基，羟甲基，羟乙基，羧基丙基，羧甲基和羧乙基; 其中R 3选自氢，甲基，三氟甲基，氟，氯和溴; 其中R 4选自苯基，联苯基，吡嗪基，环己基，环己烯基和噻吩基; 并且其中R 4在可取代位置任选被一个或多个选自氯，溴，氟，甲硫基，甲基磺酰基，吗啉基，氨基，甲基，乙基，丙基，异丙基，丁基，乙氧基，硝基，氯甲基，三氟甲氧基，三氟甲氧基氟甲基，甲氧基，二氟甲基，三氟甲基，二氯甲基，五氟乙基，七氟丙基，二氟氯甲基，二氯氟甲基，二氟乙基和二氟丙基; 或者其中R3和R4一起形成“IMAGE”，其中R2和R3不都是氢的; 或其药学上可接受的盐。

16. 再颁专利

USRE44048E1 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder 失效
标题翻译： 4- [5-（4-甲基苯基）-3-（三氟甲基）-1H-吡唑-1-基]苯磺酰胺，用于治疗炎症或炎症相关疾病
公开(公告)号：USRE44048E1
公开(公告)日：2013-03-05
申请号：US12205319
申请日：1994-11-14
申请人： John J. Talley , Stephen R. Bertenshaw , Julie M. Miyashiro
发明人： John J. Talley , Stephen R. Bertenshaw , Julie M. Miyashiro
IPC分类号： A61K31/415
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: or a pharmaceutically-acceptable salt thereof. A method of treating inflammation or an inflammation-associated disorder in a subject by administering a therapeutically-effective dose of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, or a pharmaceutically-acceptable salt thereof, to the subject.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：或其药学上可接受的盐。一种通过施用治疗有效剂量的4- [5-（4-甲基苯基）-3-（三氟甲基）-1H-吡唑-1-基]苯磺酰胺或治疗有效剂量的治疗受试者的炎症或炎症相关疾病的方法，或其药学上可接受的盐。

17. 发明授权

US07012094B1 Substituted furans and furanones for the treatment of inflammation 失效
标题翻译：取代呋喃和呋喃酮用于治疗炎症
公开(公告)号：US07012094B1
公开(公告)日：2006-03-14
申请号：US08425022
申请日：1995-04-19
申请人： Stephen R. Bertenshaw , John J. Talley
发明人： Stephen R. Bertenshaw , John J. Talley
IPC分类号： A61K31/341 , C07D307/52 , C07D307/46
CPC分类号： C07D409/04 , A61K31/341 , A61K31/365 , C07D307/38 , C07D307/58 , C07D333/16 , C07D333/18 , C07D333/28 , C07D333/38
摘要： A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类3,4-二芳基取代的噻吩，呋喃和吡咯衍生物及其类似物，含有它们的药物组合物和使用它们治疗炎症和炎症相关疾病的方法。特别感兴趣的化合物由式I定义：其中Y选自O，S和NR 1; 其中R 1选自氢和低级烷基; 其中X是一个或两个选自氢，卤素，低级烷氧基羰基和羧基的取代基; 其中R 2和R 3独立地是芳基或杂芳基; 并且其中R 2和R 3在任选被一个或多个选自亚磺酰基，烷基磺酰基，卤素，低级烷氧基和低级烷基基团的基团任选取代; 或其药学上可接受的盐。

18. 发明授权

US5643933A Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US5643933A
公开(公告)日：1997-07-01
申请号：US460324
申请日：1995-06-02
申请人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
发明人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
IPC分类号： A61P29/00 , C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12 , A61K31/44 , A61K31/42 , A61K31/425 , C07D413/06 , C07D417/02 , C09D263/32
CPC分类号： C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

19. 发明授权

US5633272A Substituted isoxazoles for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的异恶唑
公开(公告)号：US5633272A
公开(公告)日：1997-05-27
申请号：US473884
申请日：1995-06-07
申请人： John J. Talley , David L. Brown , Srinivasan Nagarajan , Jeffery S. Carter , Richard M. Weier , Michael A. Stealey , Paul W. Collins , Roland S. Rogers, deceased , Karen Seibert
发明人： John J. Talley , David L. Brown , Srinivasan Nagarajan , Jeffery S. Carter , Richard M. Weier , Michael A. Stealey , Paul W. Collins , Roland S. Rogers, deceased , Karen Seibert
IPC分类号： A61P29/00 , C07D261/08 , C07D261/10 , C07D261/12 , C07D261/18 , C07D413/04 , C07D261/06 , A61K31/42 , C07D261/14
CPC分类号： C07D261/10 , C07D261/08 , C07D261/12 , C07D261/18 , C07D413/04
摘要： A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.1 is selected from hydroxyl, lower alkyl, carboxyl, lower carboxyalkyl, lower aminocarbonylalkyl, lower alkoxycarbonylalkyl, lower aralkyl, lower alkoxyalkyl, lower aralkoxyalkyl, lower alkylthioalkyl, lower aralkylthioalkyl, lower alkylaminoalkyl, lower aryloxyalkyl, lower arylthioalkyl, lower haloalkyl, lower hydroxylalkyl, cycloalkyl, cycloalkylalkyl, and aralkyl; wherein R.sup.3 is selected from cycloalkyl, cycloalkenyl, aryl, and heteroaryl; wherein R.sup.3 is optionally substituted at a substitutable position with one or more radicals independently selected from lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; and wherein R.sup.4 is selected from lower alkyl, hydroxyl and amino; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类用于治疗炎症和炎症相关疾病的取代的异恶唑基化合物。特别感兴趣的化合物由式II其中R1选自羟基，低级烷基，羧基，低级羧基烷基，低级氨基羰基烷基，低级烷氧基羰基烷基，低级芳烷基，低级烷氧基烷基，低级芳烷氧基烷基，低级烷硫基烷基，低级芳烷硫基烷基，低级低级芳氧基烷基，低级芳基硫代烷基，低级卤代烷基，低级羟基烷基，环烷基，环烷基烷基和芳烷基; 其中R 3选自环烷基，环烯基，芳基和杂芳基; 其中R 3在可取代的位置任选被一个或多个独立地选自低级烷基亚磺酰基，低级烷基，氰基，羧基，低级烷氧基羰基，低级卤代烷基，羟基，低级羟烷基，低级卤代烷氧基，氨基，低级烷基氨基，低级芳基氨基，低级氨基烷基，硝基，卤素，低级烷氧基，氨基磺酰基和低级烷硫基; 并且其中R 4选自低级烷基，羟基和氨基; 或其药学上可接受的盐。

20. 发明授权

US06677364B2 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06677364B2
公开(公告)日：2004-01-13
申请号：US10004960
申请日：2001-12-04
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
发明人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K314178
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

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