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11. 发明申请

US20110038941A1 Lipid Nanoparticle Compositions and Methods of Making and Using the Same 审中-公开
标题翻译：脂质纳米颗粒组合物及其制备和使用方法
公开(公告)号：US20110038941A1
公开(公告)日：2011-02-17
申请号：US12810900
申请日：2008-12-23
申请人： Robert J. Lee , Bo Yu , L. James Lee
发明人： Robert J. Lee , Bo Yu , L. James Lee
IPC分类号： A61K9/00 , A61K31/7088 , B01J19/00 , A61K39/395 , A61P35/00 , B32B37/16
CPC分类号： C12N15/88 , A61K48/00
摘要： Oligonucleotide-lipid nanoparticles made of at least one oligonucleotide, at least one lipid and at least one complexation agent for the oligonucleotide, methods of making and using, and devices for making the same are disclosed.
摘要翻译：公开了由至少一种寡核苷酸，寡核苷酸，至少一种脂质和至少一种寡核苷酸络合剂制备的寡核苷酸 - 脂质纳米颗粒，其制备和使用方法及其制备方法。

12. 发明授权

US06909715B1 Method and apparatus for the reduction of upstream request processing latency in a cable modem termination system 有权
标题翻译：用于减少有线调制解调器终端系统中的上游请求处理延迟的方法和装置
公开(公告)号：US06909715B1
公开(公告)日：2005-06-21
申请号：US09652718
申请日：2000-08-31
申请人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
发明人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
IPC分类号： H04L12/28 , H04L12/56
CPC分类号： H04L47/2441 , H04L12/2801 , H04L12/66 , H04L47/15 , H04L47/35 , H04L47/70 , H04L47/788 , H04L47/821
摘要： Upstream requests such a bandwidth requests, are processed by CMTS out of order on a priority basis to reduce latency in responding to the request. Specifically, a cable modem termination system (CMTS) is connected to a plurality of cable modems by a cable plant. The CMTS has a burst receiver adapted to be connected to the cable plant to process upstream data packet units and bandwidth requests transmitted by the cable modems. Each packet includes a header that uniquely distinguishes the bandwidth requests from other data types. Packet data units are arranged in a first memory queue. Bandwidth requests are arranged in a second memory queue. The headers of the packets processed by the burst receiver are inspected as they arrive at the CMTS to determine if the packets are packet data units or bandwidth requests. Packet data units are routed to the first memory queue. Bandwidth requests are routed to the second memory queue. Bandwidth allocation MAP messages are generated from the bandwidth requests stored in the second queue and transmitted downstream to the cable modems. The packet data units stored in the first queue are coupled to a data output for further distribution.
摘要翻译：上行请求这样的带宽请求由CMTS按优先级顺序处理，以减少响应请求的延迟。具体来说，电缆调制解调器终端系统（CMTS）由电缆设备连接到多个电缆调制解调器。 CMTS具有适于连接到电缆设备的突发接收器，以处理由电缆调制解调器发送的上行数据分组单元和带宽请求。每个数据包包括一个能够唯一区分带宽请求与其他数据类型的头。分组数据单元被布置在第一存储器队列中。带宽请求被排列在第二个存储器队列中。由突发接收器处理的分组的报头在到达CMTS时进行检查，以确定分组是分组数据单元还是带宽请求。分组数据单元被路由到第一个存储器队列。带宽请求被路由到第二个内存队列。带宽分配MAP消息是从存储在第二个队列中的带宽请求产生的，并向下游发送到电缆调制解调器。存储在第一队列中的分组数据单元被耦合到数据输出用于进一步分配。

13. 发明申请

US20110280913A1 Methods and Compositions for Delivering Therapeutic Agents in the Treatment of B-Cell Related Disorders 审中-公开
标题翻译：在治疗B细胞相关疾病中提供治疗药物的方法和组合物
公开(公告)号：US20110280913A1
公开(公告)日：2011-11-17
申请号：US13056009
申请日：2009-07-28
申请人： John C. Byrd , Natarajan Muthusamy , Robert J. Lee , James L. Lee , Rosa Lapalombella , Bo Yu
发明人： John C. Byrd , Natarajan Muthusamy , Robert J. Lee , James L. Lee , Rosa Lapalombella , Bo Yu
IPC分类号： A61K9/00 , C12N5/0781 , A61P37/04 , G01N33/566 , A61K35/02 , A61K39/395 , C12Q1/02
CPC分类号： A61K9/0019 , A61K31/454 , A61K39/39558 , A61K2300/00
摘要： Methods and compositions for treating and/or diagnosing a B-cell malignancy are described.
摘要翻译：描述了用于治疗和/或诊断B细胞恶性肿瘤的方法和组合物。

14. 发明授权

US4597149A Mandrel for forming an internal enlargement for a gasket or sealing ring in a pipe or tube 失效
标题翻译：用于在管道或管道中形成垫圈或密封环的内部扩大部件的心轴
公开(公告)号：US4597149A
公开(公告)日：1986-07-01
申请号：US782108
申请日：1985-09-30
申请人： Robert J. Lee
发明人： Robert J. Lee
IPC分类号： B29C57/02 , B29C17/00
CPC分类号： B29C57/025 , Y10T29/53657
摘要： A mandrel device which guides the end of a pipe or tube to a position outwardly of the path of an expander body, with a camming mechanism to force the expander body from an inward position to an outward position, and holding that outward position so as to achieve the desired gasket-receiving enlargement of the tubular work object. In a subsequent stage, another camming feature forces the expander body radially inwardly, to permit the tubular work object, now carrying the sealing ring in a position which would mean interference by the expander body, to be released over the end of the mandrel. The two camming components are carried by sub-assemblies axially movable with respect to stationary parts of the mandrel; and they are interrelated to have both movement together and movement with respect to one another, achieving the outward and inward camming effects in a plural-stage motion sequence and nature.
摘要翻译：一种心轴装置，其将管子的端部引导到膨胀机主体的路径外侧的位置，具有凸轮机构，用于迫使膨胀机主体从向内的位置向外的位置，并且保持向外的位置，以便实现了管状加工对象的期望的垫片接收放大。在随后的阶段中，另一个凸轮特征迫使膨胀机主体径向向内，以允许管状工作对象现在将密封环承载在一定位置上，该位置将意味着膨胀机主体的干扰将在心轴端部释放。两个凸轮部件由相对于心轴的静止部件可轴向移动的子组件承载; 它们是相互关联的，它们相互运动在一起，相互移动，实现了多阶段运动顺序和性质的向外和向内的凸轮效应。

15. 发明授权

US08582577B2 Modem with voice processing capability 失效
标题翻译：具有语音处理能力的调制解调器
公开(公告)号：US08582577B2
公开(公告)日：2013-11-12
申请号：US13092255
申请日：2011-04-22
申请人： James C. Thi , Theodore F. Rabenko , David Hartman , Robert M. Lukas , Kenneth J. Unger , Ramin Borazjani , Shane P. Lansing , Robert J. Lee , Todd L. Brooks , Kevin L. Miller
发明人： James C. Thi , Theodore F. Rabenko , David Hartman , Robert M. Lukas , Kenneth J. Unger , Ramin Borazjani , Shane P. Lansing , Robert J. Lee , Todd L. Brooks , Kevin L. Miller
IPC分类号： H04L12/28 , H04M9/08
CPC分类号： H04M7/0087 , H04B3/23 , H04B3/234 , H04J3/0632 , H04J3/0638 , H04L12/2801 , H04L12/2834 , H04L12/5692 , H04L12/66 , H04L29/06027 , H04L65/1069 , H04M7/006 , H04M7/125 , H04N7/10 , H04N21/2383 , H04N21/4382
摘要： A system is configured to facilitate bidirectional voice communication between a number of data and/or telephony devices.
摘要翻译：系统被配置为促进多个数据和/或电话设备之间的双向语音通信。

16. 发明授权

US07822037B2 Apparatus for the reduction of uplink request processing latency in a wireless communication system 有权
标题翻译：用于在无线通信系统中减少上行链路请求处理等待时间的装置
公开(公告)号：US07822037B2
公开(公告)日：2010-10-26
申请号：US11835251
申请日：2007-08-07
申请人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
发明人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
IPC分类号： H04L12/28
CPC分类号： H04L47/2441 , H04L12/2801 , H04L12/66 , H04L47/15 , H04L47/35 , H04L47/70 , H04L47/788 , H04L47/821
摘要： Upstream requests such a bandwidth requests, are processed by CMTS out of order on a priority basis to reduce latency in responding to the request. Specifically, a cable modem termination system (CMTS) is connected to a plurality of cable modems by a cable plant. The CMTS has a burst receiver adapted to be connected to the cable plant to process upstream data packet units and bandwidth requests transmitted by the cable modems. Each packet includes a header that uniquely distinguishes the bandwidth requests from other data types. Packet data units are arranged in a first memory queue. Bandwidth requests are arranged in a second memory queue. The headers of the packets processed by the burst receiver are inspected as they arrive at the CMTS to determine if the packets are packet data units or bandwidth requests. Packet data units are routed to the first memory queue. Bandwidth requests are routed to the second memory queue. Bandwidth allocation MAP messages are generated from the bandwidth requests stored in the second queue and transmitted downstream to the cable modems. The packet data units stored in the first queue are coupled to a data output for further distribution.
摘要翻译：上行请求这样的带宽请求由CMTS按优先级顺序处理，以减少响应请求的延迟。具体来说，电缆调制解调器终端系统（CMTS）由电缆设备连接到多个电缆调制解调器。 CMTS具有适于连接到电缆设备的突发接收器，以处理由电缆调制解调器发送的上行数据分组单元和带宽请求。每个数据包包括一个能够唯一区分带宽请求与其他数据类型的头。分组数据单元被布置在第一存储器队列中。带宽请求被排列在第二个存储器队列中。由突发接收器处理的分组的报头在到达CMTS时进行检查，以确定分组是分组数据单元还是带宽请求。分组数据单元被路由到第一个存储器队列。带宽请求被路由到第二个内存队列。带宽分配MAP消息是从存储在第二个队列中的带宽请求产生的，并向下游发送到电缆调制解调器。存储在第一队列中的分组数据单元被耦合到数据输出用于进一步分配。

17. 发明授权

US5908777A Lipidic vector for nucleic acid delivery 失效
标题翻译：用于核酸递送的脂质载体
公开(公告)号：US5908777A
公开(公告)日：1999-06-01
申请号：US494296
申请日：1995-06-23
申请人： Robert J. Lee , Leaf Huang
发明人： Robert J. Lee , Leaf Huang
IPC分类号： C07K14/285 , C12N15/88 , C12N15/63
CPC分类号： C12N15/88 , C07K14/285
摘要： A simple, rapid method for creating a lipidic vector for delivery of a therapeutic molecule entails bringing the molecule into contact with a polycation, thereby forming a complex, and then mixing the complex with an anionic lipidic preparation. Tissue-specific targeting peptides, fusogenic peptides and nucleus-targeting peptides also can be added to the lipid preparation. The result is a stable lipidic vector of reduced immunogenicity and cytotoxicity. The vector also displays enhanced transfection activity.
摘要翻译：用于产生用于递送治疗性分子的脂质载体的简单且快速的方法需要使分子与聚阳离子接触，从而形成复合物，然后将该配合物与阴离子脂质制剂混合。组织特异性靶向肽，融合肽和核 - 靶向肽也可加入到脂质制剂中。结果是具有降低的免疫原性和细胞毒性的稳定的脂质载体。载体还显示增强的转染活性。

18. 发明授权

US3998744A Oil fracturing spacing agents 失效
$Oil fracturing spacing agents$
标题翻译：油压间隔剂
公开(公告)号：US3998744A
公开(公告)日：1976-12-21
申请号：US568598
申请日：1975-04-16
申请人： Vernon W. Arnold , Robert J. Lee
发明人： Vernon W. Arnold , Robert J. Lee
IPC分类号： C09K8/62 , E21B43/267 , E21B43/26
CPC分类号： E21B43/267 , C09K8/62 , Y10S507/924
摘要： Oil-soluble spacing agents for use in fracturing underground oil or gas formations comprising polymerized dimethyl-alpha-methylstyrenes.
摘要翻译：用于压裂地下油或气体地层的油溶性间隔剂，包括聚合的二甲基-α-甲基苯乙烯。

19. 发明授权

US09634783B2 Systems and methods for serial packet synchronization in a voice processing system 有权
公开(公告)号：US09634783B2
公开(公告)日：2017-04-25
申请号：US12577526
申请日：2009-10-12
申请人： Robert J. Lee
发明人： Robert J. Lee
IPC分类号： H04J3/06 , H04L7/04
CPC分类号： H04J3/0685 , H04L7/041
摘要： A serial packet sync encoder is used to encode a serial packet sync datastream. In an embodiment, the serial packet sync datastream is made up of the packet sync vector and a unique preamble bit sequence that is preselected. In another embodiment, the serial packet sync datastream is made up of a non-unique bit sequence. A serial packet sync transmitter is used to transmit the serial packet sync datastream. A serial packet sync receiver is provided for receiving the serial packet sync datastream. In an embodiment, the serial packet sync transmitter and the serial packet sync receiver are shift registers. In this way, the serial packet sync datastream can be transmitted and received using only a single pin. The serial packet sync datastream is useful for providing an indication that an event, such as a grant arrival, has occurred. A preamble comparator is provided to compare the received serial packet sync datastream and the preselected preamble to determine if the two match. In cases where a match is made, the packet sync vector is written into a holding register for access from other applications and or system components such as a digital signal processor.

20. 发明授权

US07899034B2 Methods for the synchronization of multiple base stations in a wireless communication system 有权
标题翻译：无线通信系统中多个基站同步的方法
公开(公告)号：US07899034B2
公开(公告)日：2011-03-01
申请号：US11701509
申请日：2007-02-02
申请人： Anders Hebsgaard , David R. Dworkin , Lisa V. Denney , Robert J. Lee , Thomas J. Quigley
发明人： Anders Hebsgaard , David R. Dworkin , Lisa V. Denney , Robert J. Lee , Thomas J. Quigley
IPC分类号： H04L12/66
CPC分类号： H04L25/03343 , H04B1/1036 , H04J3/0664 , H04J3/067 , H04J3/0682 , H04L12/2801 , H04L2025/03808
摘要： A plurality of base station devices are linked together and synchronized to facilitate communication between the respective base station devices and respective downlink subscriber stations. According to one embodiment of the invention, one of the base station devices is designated as a master device, and the other base station devices are designated as slave devices. The respective base station devices are connected to each other by means of a synchronization bus. The master base station device then generates and broadcasts a future time stamp value, which is received by the respective slave base station devices. When the time stamp counter in the master base station device reaches the transmitted value, a control signal is broadcast over the synchronization bus. The slave base station devices then retrieve the time stamp value and reset their respective local time stamp counters to the received value. In this manner, the base station devices are synchronized.
摘要翻译：多个基站设备被链接在一起并被同步以便于各个基站设备和相应的下行链路用户站之间的通信。根据本发明的一个实施例，基站设备之一被指定为主设备，而其它基站设备被指定为从设备。各个基站装置通过同步总线相互连接。主基站装置然后生成并广播由各个从基站装置接收的未来时间戳值。当主基站装置中的时间戳计数器达到发送值时，通过同步总线广播控制信号。然后，从基站设备检索时间戳值并将其各自的本地时间戳计数器重置为接收的值。以这种方式，基站装置同步。

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