专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US09226903B2 Transdermal therapeutic system comprising an adhesive layer method for siliconizing the back layer or the system and use of said back layer 有权
标题翻译：透皮治疗系统包括用于使背层或系统硅化的粘合剂层方法和所述背层的使用
公开(公告)号：US09226903B2
公开(公告)日：2016-01-05
申请号：US11661530
申请日：2005-09-06
申请人： Walter Mueller , Johannes Leonhard
发明人： Walter Mueller , Johannes Leonhard
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7069 , A61F13/02 , A61F13/023 , A61F13/0246 , A61F13/0253 , A61K9/7084
摘要： The invention relates to a transdermal therapeutic system which comprises a backing layer, an adhesive layer, a polymer layer and a removable protective layer. The adhesive layer is an organosiloxane layer and is anchored in the backing layer by siliconization.
摘要翻译：本发明涉及一种透皮治疗系统，其包括背衬层，粘合剂层，聚合物层和可除去的保护层。粘合剂层是有机硅氧烷层，并通过硅化将其锚定在背衬层中。

12. 发明授权

US09089527B2 Transdermal therapeutic system comprising ion pair microreservoirs 有权
标题翻译：包括离子对微储层的透皮治疗系统
公开(公告)号：US09089527B2
公开(公告)日：2015-07-28
申请号：US12515769
申请日：2007-11-16
申请人： Thomas Hille , Michael Horstmann , Walter Mueller
发明人： Thomas Hille , Michael Horstmann , Walter Mueller
IPC分类号： A61K9/00 , A61K31/439 , A61K31/19 , A61K9/70 , A61K31/195 , A61K31/4164 , A61K31/437 , A61K31/4439 , A61K31/445 , A61K31/485 , A61K31/505 , A61K31/535 , A61K31/60
CPC分类号： A61K31/19 , A61K9/7069 , A61K9/7092 , A61K31/195 , A61K31/4164 , A61K31/437 , A61K31/4439 , A61K31/445 , A61K31/485 , A61K31/505 , A61K31/535 , A61K31/60
摘要： The invention relates to a transdermal therapeutic system which comprises a back layer that is impermeable to the active substance, and a peelable protective layer that is impermeable to the active substance and at least one matrix layer consisting of polysiloxanes and/or polysiloxane derivatives and containing micro-reservoirs. Said micro-reservoirs contain at least one ion pair from a pharmacologically active substance and an additive and either the active substance is nucleophilic and the additive is electrophilic or the active substance is electrophilic and the additive is nucleophilic.
摘要翻译：本发明涉及一种透皮治疗系统，其包括对活性物质不可渗透的背层和对于活性物质是不可渗透的至少一个基质层和至少一个由聚硅氧烷和/或聚硅氧烷衍生物组成的基质层，并且含有微量水库所述微贮存器含有至少一个来自药理学活性物质和添加剂的离子对，活性物质是亲核的，并且添加剂是亲电子的或活性物质是亲电子的，并且添加剂是亲核的。

13. 发明授权

US09056026B2 Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy 有权
标题翻译：具有高活性物质利用率和给药精度的透皮治疗系统
公开(公告)号：US09056026B2
公开(公告)日：2015-06-16
申请号：US12515630
申请日：2007-11-09
申请人： Michael Horstmann , Walter Mueller
发明人： Michael Horstmann , Walter Mueller
IPC分类号： A61F13/02 , A61M35/00 , A61L15/44 , A61K9/70
CPC分类号： A61K9/7061 , A61F13/02 , A61F13/0233 , A61F13/0246 , A61K9/7053 , A61K9/7084 , A61K31/4468 , A61L15/44 , A61L2300/402
摘要： Transdermal therapeutic system for administering at least one active pharmaceutical ingredient which is involatile at room temperature with a daily dose not exceeding 30 mg, comprising a backing layer which is impermeable for the active ingredient and faces away from the skin, an adjoining polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2, and a protective layer which can be detached from the skin-contact layer and is impermeable for the active ingredient.
摘要翻译：用于施用至少一种在室温下不挥发的日剂量不超过30mg的至少一种活性药物成分的透皮治疗系统，其包含对活性成分不透过并背离皮肤的背衬层，邻接的聚合物层是远离皮肤并且基于至少80g / m 2的施用速率的聚异丁烯，与远离皮肤的聚合物层相邻并且基于具有施用率的丙烯酸酯共聚物的粘合性皮肤接触层不超过50g / m 2，以及可以从皮肤接触层分离并且对于活性成分是不可渗透的保护层。

14. 发明申请

US20100119585A1 TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING THE ACTIVE SUBSTANCE BUPRENORPHINE 有权
标题翻译：用于管理活性物质保护素的透皮治疗系统
公开(公告)号：US20100119585A1
公开(公告)日：2010-05-13
申请号：US12515848
申请日：2007-11-07
申请人： Thomas Hille , Michael Horstmann , Walter Mueller
发明人： Thomas Hille , Michael Horstmann , Walter Mueller
IPC分类号： A61K31/485 , A61K9/70 , A61P25/00
CPC分类号： A61K31/485 , A61K9/7053 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K47/12 , A61M37/00
摘要： The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and is characterized by a considerably increased utilization of the active substance.
摘要翻译：本发明涉及一种用于施用活性物质丁丙诺啡的透皮治疗系统。所述系统包含至少一种羧酸，其确定丁丙诺啡在基质层中的溶解度，同样可以被吸收。根据本发明的透皮治疗系统用于治疗疼痛，其特征在于活性物质的利用率显着增加。

15. 发明授权

US4257334A Apparatus and method for regulating the distribution of granulate 失效
标题翻译：调节颗粒分布的装置和方法
公开(公告)号：US4257334A
公开(公告)日：1981-03-24
申请号：US30934
申请日：1979-04-17
申请人： Walter Mueller
发明人： Walter Mueller
IPC分类号： B65G53/46 , F23K3/02
CPC分类号： B65G53/46
摘要： Apparatus and method for the independently regulated distribution of granulate to a plurality of points of consumption. A container (1), at least partially filled with granulate (10) to be distributed, includes a plurality of container apertures (4) each covered by a slide (5). A rotatable shaft (2) longitudinally disposed in front of apertures (4) is driven by a drive (3) at controllable rates. Granulate (10) adheres by friction to the surface of shaft (2) when rotated and is conveyed via the shaft to a plurality of troughs (6) where the granulate is collected. The granulate then flows through feed tubes (7) to air injectors (8) where it is entrained into an airstream and propelled to a plurality of points of consumption. The method according to the present invention includes the steps of: Storing granulate in a container having slide controlled apertures; rotating a shaft in the vicinity of these apertures; conveying granulate along the surface of the shaft; receiving the conveyed granulate into a plurality of troughs, each trough corresponding to an aperture; and conducting the granulate at each trough through an associated air injector to distribution pipes for conduction to a plurality of points of consumption.
摘要翻译：将颗粒独立调节分配到多个消费点的装置和方法。至少部分地填充有要分配的颗粒（10）的容器（1）包括多个容纳孔（4），每个容器孔（4）都被滑动件（5）覆盖。纵向设置在孔（4）前面的可旋转轴（2）以可控速率由驱动器（3）驱动。颗粒（10）在旋转时通过摩擦粘附到轴（2）的表面，并且经由轴被输送到多个槽（6），其中收集颗粒。颗粒然后通过进料管（7）流入空气喷射器（8），在那里它被夹带到气流中并推进到多个消耗点。根据本发明的方法包括以下步骤：将颗粒储存在具有滑动控制孔的容器中; 旋转这些孔附近的轴; 沿着轴的表面输送颗粒; 将输送的颗粒接收到多个槽中，每个槽对应于孔; 并且通过相关联的空气喷射器在每个槽处进行颗粒传送到多个消耗点。

16. 发明授权

US10322093B2 Method for producing a transdermal therapeutic system which contains a D2 agonist 有权
公开(公告)号：US10322093B2
公开(公告)日：2019-06-18
申请号：US10936620
申请日：2004-09-07
申请人： Walter Mueller , James V. Peck
发明人： Walter Mueller , James V. Peck
IPC分类号： A61K9/70 , A61K31/381
摘要： A substantially solvent-free matrix layer containing (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.

17. 发明授权

US09308202B2 Transdermal therapeutic system for administering the active substance buprenorphine 有权
标题翻译：用于施用活性物质丁丙诺啡的透皮治疗系统
公开(公告)号：US09308202B2
公开(公告)日：2016-04-12
申请号：US12515848
申请日：2007-11-07
申请人： Thomas Hille , Michael Horstmann , Walter Mueller
发明人： Thomas Hille , Michael Horstmann , Walter Mueller
IPC分类号： A61K31/485 , A61K9/70
CPC分类号： A61K31/485 , A61K9/7053 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K47/12 , A61M37/00
摘要： The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and is characterized by a considerably increased utilization of the active substance.
摘要翻译：本发明涉及一种用于施用活性物质丁丙诺啡的透皮治疗系统。所述系统包含至少一种羧酸，其确定丁丙诺啡在基质层中的溶解度，同样可以被吸收。根据本发明的透皮治疗系统用于治疗疼痛，其特征在于活性物质的利用率显着增加。

18. 发明授权

US07413747B2 Transdermal therapeutic system for treating Parkinsonism 有权
标题翻译：用于治疗帕金森综合征的透皮治疗系统
公开(公告)号：US07413747B2
公开(公告)日：2008-08-19
申请号：US11931666
申请日：2007-10-31
申请人： Walter Mueller , James V. Peck
发明人： Walter Mueller , James V. Peck
IPC分类号： A61F13/02 , A61F13/00 , A61L15/16 , A61K9/14
CPC分类号： A61K9/7061 , A61K9/7023 , A61K9/703 , A61K9/7038 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/381
摘要： A transdermal therapeutic system (TTS) comprises a silicone-based polymer adhesive system having distributed therein (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol free base in an amount of about 5% to 40% by weight. The adhesive system comprises a silicone adhesive and an additive having increased solubility for the active substance, in an amount effective to increase dissolving capacity of the matrix for the active substance.
摘要翻译：透皮治疗系统（TTS）包括其中分布有（ - ）-5,6,7,8-四氢-6- [丙基 - [2-（2-噻吩基）乙基]氨基] - 1-萘酚游离碱的量为约5％至40％重量。粘合剂体系包含硅氧烷粘合剂和对活性物质具有增加的溶解度的添加剂，其量可以有效地增加基质对活性物质的溶解能力。

19. 发明申请

US20080026043A1 Transdermal Therapeutic System Comprising an Adhesive Layer Method for Siliconizing the Back Layer or the System and Use of Said Back Layer 有权
标题翻译：透皮治疗系统包括用于硅胶化背层或系统的粘合层方法和所述背层的使用
公开(公告)号：US20080026043A1
公开(公告)日：2008-01-31
申请号：US11661530
申请日：2005-09-06
申请人： Walter Mueller , Johannes Leonhard
发明人： Walter Mueller , Johannes Leonhard
IPC分类号： A61K9/70 , A61K47/30 , C08F283/12
CPC分类号： A61K9/7069 , A61F13/02 , A61F13/023 , A61F13/0246 , A61F13/0253 , A61K9/7084
摘要： The invention relates to a transdermal therapeutic system which comprises a backing layer, an adhesive layer, a polymer layer and a removable protective layer. The adhesive layer is an organosiloxane layer and is anchored in the backing layer by siliconization.
摘要翻译：本发明涉及一种透皮治疗系统，其包括背衬层，粘合剂层，聚合物层和可除去的保护层。粘合剂层是有机硅氧烷层，并通过硅化将其锚定在背衬层中。

20. 发明申请

US20050033065A1 Transdermal therapeutic system which contains a D2 agonist and which is provided for treating parkinsonism, and a method for the production thereof 审中-公开
标题翻译：含有D2激动剂并用于治疗帕金森综合征的经皮治疗系统及其制备方法
公开(公告)号：US20050033065A1
公开(公告)日：2005-02-10
申请号：US10936620
申请日：2004-09-07
申请人： Walter Mueller , James Peck
发明人： Walter Mueller , James Peck
IPC分类号： A61K9/70 , A61K31/381 , A61P25/16 , A61P43/00 , C07D333/12
CPC分类号： A61K9/7061 , A61K9/7023 , A61K9/703 , A61K9/7038 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/381
摘要： A substantially solvent-free matrix layer containing (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.
摘要翻译：含有（ - ） - 5,6,7,8-四氢-6- [丙基 - [2-（2-噻吩基）乙基]氨基] -1-萘酚的基本上无溶剂的基质层是通过将活性物质粘合剂溶液，将得到的含活性物质的粘合剂溶液涂布到合适的片材上，并在干燥过程中除去溶剂，得到基本上无溶剂的基质层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式