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11. 发明授权

US08049017B2 Preparation of isoxazolin-3-ylacylbenzenes 有权
标题翻译：异恶唑啉-3-基酰基苯的制备
公开(公告)号：US08049017B2
公开(公告)日：2011-11-01
申请号：US13039137
申请日：2011-03-02
申请人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Miβlitz , Ernst Baumann
发明人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Miβlitz , Ernst Baumann
IPC分类号： C07D261/04
CPC分类号： C07C249/06 , C07C201/10 , C07C201/12 , C07C205/44 , C07C209/62 , C07C251/48 , C07C253/00 , C07C255/50 , C07C315/04 , C07C319/14 , C07D261/04 , C07D413/10 , C07C323/09 , C07C317/24 , C07C317/32 , C07C205/06 , C07C211/52
摘要： A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.
摘要翻译：描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体并描述了制备中间体的新方法。

12. 发明授权

US07663001B2 Preparation of isoxazolin-3-ylacylbenzene 有权
标题翻译：异恶唑啉-3-基酰基苯的制备
公开(公告)号：US07663001B2
公开(公告)日：2010-02-16
申请号：US11684630
申请日：2007-03-11
申请人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Miβlitz , Ernst Baumann
发明人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Miβlitz , Ernst Baumann
IPC分类号： C07C239/08
CPC分类号： C07C249/06 , C07C201/10 , C07C201/12 , C07C205/44 , C07C209/62 , C07C251/48 , C07C253/00 , C07C255/50 , C07C315/04 , C07C319/14 , C07D261/04 , C07D413/10 , C07C323/09 , C07C317/24 , C07C317/32 , C07C205/06 , C07C211/52
摘要： A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.
摘要翻译：描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体并描述了制备中间体的新方法。

13. 发明授权

US06548677B1 Method of producing 2-alkyl-3-(4,5-dihydroisoxazole-3-yl)-halobenzenes 有权
标题翻译： 2-烷基-3-（4,5-二氢异恶唑-3-基） - 卤代苯的制备方法
公开(公告)号：US06548677B1
公开(公告)日：2003-04-15
申请号：US09856037
申请日：2001-05-17
申请人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
发明人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
IPC分类号： C07D26118
CPC分类号： C07D261/04
摘要： A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.
摘要翻译：一种制备式I化合物的新方法，其中n为0,1或2; R 1，R 2为C 1 -C 6 - 烷基; R 3，R 4，R 5为氢或C 1 -C 6烷基，或者R 4和R 5一起形成 R 6是Cl，Br，其包含从式II的1,2-二烷基苯开始的合成序列，随后卤化以得到3,6-二卤代-1,2-二烷基苯，卤代烷基化得到苄基溴，氧化得到苯甲醛，肟化，与烯烃的反应得到异恶唑，转化成硫醚，如果合适，氧化得到式I的磺酰基或磺酰基衍生物。

14. 发明授权

US06603017B2 Preparation of 2-alkyl-3-(4,5-dihydroisoxazol-3-yl) halobenzenes 有权
标题翻译： 2-烷基-3-（4,5-二氢异恶唑-3-基）卤代苯的制备
公开(公告)号：US06603017B2
公开(公告)日：2003-08-05
申请号：US10141236
申请日：2002-05-09
申请人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
发明人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
IPC分类号： C07D26118
CPC分类号： C07D261/04
摘要： A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.
摘要翻译：一种制备式I化合物的新方法，其中n为0,1或2; R 1，R 2为C 1 -C 6 - 烷基; R 3，R 4，R 5为氢或C 1 -C 6烷基，或者R 4和R 5一起形成 R 6是Cl，Br，其包含从式II的1,2-二烷基苯开始的合成序列，随后卤化以得到3,6-二卤代-1,2-二烷基苯，卤代烷基化得到苄基溴，氧化得到苯甲醛，肟化，与烯烃的反应得到异恶唑，转化成硫醚，如果合适，氧化得到式I的磺酰基或磺酰基衍生物。

15. 发明授权

US06716989B2 Preparation of 2-alkyl-3-(4,5-dihydroisoxazol-3-yl) halobenzenes 有权
标题翻译： 2-烷基-3-（4,5-二氢异恶唑-3-基）卤代苯的制备
公开(公告)号：US06716989B2
公开(公告)日：2004-04-06
申请号：US10462903
申请日：2003-06-18
申请人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
发明人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
IPC分类号： C07D26118
CPC分类号： C07D261/04
摘要： A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.
摘要翻译：一种制备式I化合物的新方法，其中n为0,1或2; R 1，R 2为C 1 -C 6 - 烷基; R 3，R 4，R 5，或者R 4和R 5一起形成键; R 6是Cl，Br，其包含从式II的1,2-二烷基苯开始的合成序列，随后卤化得到3,6-二卤代-1,2-二烷基苯，卤代烷基化得到苄基溴，氧化得到苯甲醛，肟化，与烯烃反应得到异恶唑，转化成硫醚，如果合适，氧化得到亚硫酰基或磺酰基衍生物的式I。

16. 发明授权

US5422335A Herbicides containing substituted 2-aminothiophenes 失效
公开(公告)号：US5422335A
公开(公告)日：1995-06-06
申请号：US70389
申请日：1993-06-07
申请人： Helmut Hagen , Gerhard Nilz , Helmut Walter , Andreas Landes
发明人： Helmut Hagen , Gerhard Nilz , Helmut Walter , Andreas Landes
IPC分类号： A01N25/32 , A01N35/06 , A01N39/02 , A01N43/10 , C07D333/38 , C07D333/68 , C07D333/70 , C07D409/04 , C07D409/12 , C07D417/12 , A01N43/12 , A01N47/24 , C07D333/54
CPC分类号： C07D409/04 , A01N25/32 , C07D333/38 , C07D333/68 , C07D409/12 , C07D417/12
摘要： A herbicidal composition containing one or more substituted 2-aminothiophenes of the formula I ##STR1## where R.sup.1 and R.sup.2 together from a C.sub.4 -alkylene chain to which a benzene ring may be fused,R.sup.3 is --CN or CX--R.sup.6, where R.sup.6 is hydroxyl, C.sub.1 -C.sub.4 -alkoxy or amino,R.sup.4 is hydrogen or a phenyl group which may carry one or two nitro radicals,--PO(OR.sup.8).sub.2, --CX--R.sup.9, --SO.sub.2 R.sup.10, --CX--N(H) --CO--R.sup.8 or --CX--N(R.sup.7)--SO.sub.2 --R.sup.11,whereR.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl groupR.sup.9 is C.sub.1 -C.sub.20 -alkyl, partially or completely halogenated C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.6 -cycloalkyl, or amino, C.sub.1 -C.sub.4 -alkylamino, C.sub.3 -C.sub.8 -cycloalkylamino, phenyl or phenylamino, where the aromatic moiety may carry at least one of nitro and halogen;R.sup.10 is C.sub.1 -C.sub.4 -alkyl or phenyl, which may carry one C.sub.1 -C.sub.4 -alkyl radical;R.sup.11 is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl, where the heterocyclic structures may carry one C.sub.1 -C.sub.4 -group;R.sup.5 is hydrogen;orR.sup.4 and R.sup.5 together form a group .dbd.CR.sup.12 R.sup.13 or --CO--W--CO--, where R.sup.12 is hydrogen, amino, C.sub.1 -C.sub.4 -alkylamino or C.sub.3 -C.sub.8 -cycloalkylamino;R.sup.13 is amino, C.sub.3 -C.sub.8 -cycloalkylamino, phenyl or pyridyl, where the two last mentioned substituents may carry at least one halogen or nitro radicals;W is an ethylene or ethenylene bridge, or a 6-membered 1,2-C-bonded aromatic bridge where these bridge members may carry, on each substitutable carbon atom, at least one halogena 5-membered or 6-membered 1,2-C-bonded cycloalkylene or cycloalkenylene bridge,and the basic salts of the compounds I in which R.sup.3 is hydroxycarbonyl or hydroxythiocarbonyl, and the acidic salts of the compounds I which contain a basic nitrogen atom, as antagonistic compoundsand one or more herbicidal active ingredients from the group consisting ofthe cyclohexenone derivatives of the formula III ##STR2##

17. 发明授权

US5216171A 2-amino-4-trichloropyridine derivatives 失效
标题翻译： 2-氨基-4-三氯吡啶衍生物
公开(公告)号：US5216171A
公开(公告)日：1993-06-01
申请号：US681254
申请日：1991-04-08
申请人： Helmut Hagen , Hans Ziegler , Juergen Pfister , Gerhard Nilz , Gisela Lorenz , Juergen Dressel
发明人： Helmut Hagen , Hans Ziegler , Juergen Pfister , Gerhard Nilz , Gisela Lorenz , Juergen Dressel
IPC分类号： C05G3/08 , C07D213/74 , C07D213/75 , C07D213/76 , C07D401/04 , C07F9/58
CPC分类号： C07D213/74 , C07D213/75 , C07D213/76 , C07D401/04 , C07F9/588 , Y02P60/218 , Y10S106/90
摘要： 2-Amino-4-trichloromethylpyridines of the general formula I ##STR1## where R.sup.1 is hydrogen or C.sub.1 -C.sub.8 -alkyl,R.sup.2 is C.sub.1 -C.sub.8 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, C.sub.2 -C.sub.4 -alkenyl or phenyl, benzyl or phenylsulfonyl,--CX--R.sup.3, --SO.sub.2 R.sup.3 or --PX(OR.sup.4).sub.2 orR.sup.1 and R.sup.2 together form .dbd.CR.sup.5 R.sup.6 or --CO--Z--CO--,X is oxygen or sulfur,R.sup.3 is C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.6 -alkenyl, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, morpholino, piperidino, pyrazolidino or C.sub.1 -C.sub.8 -alkylcarbonylamino, substituted or unsubstituted phenylamino or benzylamino,R.sup.4 is C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -haloalkyl or substituted or unsubstituted phenyl,R.sup.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl, or substituted or unsubstituted phenyl,R.sup.6 is substituted or unsubstituted phenyl,Z is substituted or unsubstituted ethylene which may be part of a substituted or unsubstituted cycloalkyl or cycloalkylene radical, substituted or unsubstituted ethenylene which may be part of a substituted or unsubstituted aromatic or heteroaromatic ring, and Z is not part of an unsubstituted phenyl radical, agriculturally useful salts thereof, processes for their preparation and the use thereof as nitrification inhibitors.
摘要翻译：通式I的2-氨基-4-三氯甲基吡啶其中R1是氢或C1-C8-烷基，R2是C1-C8-烷基，C5-C8-环烷基，C2-C4-烯基或苯基，苄基或苯基磺酰基，-CX-R3，-SO2R3或-PX（OR4）2或R1和R2一起形成= CR5R6或-CO-Z-CO-，X是氧或硫，R3是C1-C20-烷基，C2- C 1 -C 6 - 烯基，氨基，C 1 -C 6 - 烷基氨基，二-C 1 -C 6烷基氨基，吗啉代，哌啶子基，吡唑烷基或C 1 -C 8烷基羰基氨基，取代或未取代的苯基氨基或苄基氨基，R 4是C 1 -C 8烷基，卤代烷基或取代或未取代的苯基，R 5是氢，C 1 -C 4烷基或取代或未取代的苯基，R 6是取代或未取代的苯基，Z是可以是取代或未取代的环烷基或环亚烷基的一部分的取代或未取代的乙烯取代或未取代的亚乙烯基，其可以是取代或未取代的芳族或杂芳族环的一部分，Z不是未取代的苯基的一部分，农业其文化上有用的盐，其制备方法及其作为硝化抑制剂的用途。

18. 发明授权

US5196573A Process for the preparation of sulfonated anthranilic acids 失效
标题翻译：磺化邻氨基苯甲酸的制备方法
公开(公告)号：US5196573A
公开(公告)日：1993-03-23
申请号：US888444
申请日：1992-05-28
申请人： Manfred Patsch , Klaus Pandl , Jacques Dupuis , Helmut Hagen
发明人： Manfred Patsch , Klaus Pandl , Jacques Dupuis , Helmut Hagen
IPC分类号： C07C309/46 , C07C309/48
CPC分类号： C07C309/48 , C07C309/46
摘要： A process for the preparation of 4-sulfonated anthranilic acids by sulfonation of ortho-nitrotoluenes with chlorosulfonic acid or oleum followed by oxidation of the methyl group and, finally, reduction of the nitro group.
摘要翻译：通过用氯磺酸或发烟硫酸磺化邻 - 硝基甲苯，然后氧化甲基，最后还原硝基来制备4-磺化邻氨基苯甲酸的方法。

19. 发明授权

US5175265A Azo dyes with a diazo component of the 4-amino-7-nitrobenzisothiazole series and a coupling compound from the aminopyrazole or hydroxypyridone series 失效
标题翻译：具有4-氨基-7-硝基苯并噻唑系列的DIAZO组分的AZO染料和来自氨基吡唑或羟基吡啶酮系列的偶联化合物
公开(公告)号：US5175265A
公开(公告)日：1992-12-29
申请号：US488868
申请日：1990-03-05
申请人： Guenter Hansen , Helmut Hagen , Helmut Reichelt
发明人： Guenter Hansen , Helmut Hagen , Helmut Reichelt
IPC分类号： C09B29/40 , C09B29/00 , C09B29/42 , C09B29/48
CPC分类号： C09B29/3656 , C09B29/0081 , C09B29/3634
摘要： Benzisothiazole-azo dyes useful for dyeing synthetic fiber materials have the formula ##STR1## where X is hydrogen, chlorine, bromine, cyano or nitro and K is a radical of the formula ##STR2## where R.sup.1 is substituted or unsubstituted C.sub.1 -C.sub.12 -alkyl, substituted or unsubstituted phenyl, C.sub.3 -C.sub.5 -alkenyl or C.sub.5 -C.sub.7 -cycloalkyl,R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.3 is hydrogen or methyl andR.sup.4 is hydrogen, cyano, carbamoyl or C.sub.1 -C.sub.4 -alkoxycarbonyl.
摘要翻译：可用于染色合成纤维材料的苯并异噻唑 - 偶氮染料具有式“IMAGE”，其中X是氢，氯，溴，氰基或硝基，K是下式的基团：其中R 1是取代或未取代的C 1 -C 12烷基取代或未取代的苯基，C 3 -C 5 - 烯基或C 5 -C 7 - 环烷基，R 2是氢或C 1 -C 4烷基，R 3是氢或甲基，R 4是氢，氰基，氨基甲酰基或C 1 -C 4 - 烷氧基羰基。

20. 发明授权

US5167695A Derivatives of quinoline fused to a five-membered heterocyclic ring 失效
标题翻译：融合成五元杂环的喹啉衍生物
公开(公告)号：US5167695A
公开(公告)日：1992-12-01
申请号：US527831
申请日：1990-05-24
申请人： Gunter Brill , Helmut Hagen , Karl-Otto Westphalen , Bruno Wuerzer
发明人： Gunter Brill , Helmut Hagen , Karl-Otto Westphalen , Bruno Wuerzer
IPC分类号： A01N43/52 , A01N43/76 , C07D471/04 , C07D498/04
CPC分类号： C07D471/04
摘要： Quinoline derivatives fused to a five-membered heterocyclic ring and of the formula ##STR1## where R.sup.1 is hydrogen, halogen, carboxyl or substituted or unsubstituted alkyl,Y is nitrogen or C--R.sup.2, whereR.sup.2 is hydrogen, halogen, hydroxyl, alkoxy, alkylthio, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted benzyl, phenethyl, phenyl or naphthyl, or a substituted or unsubstituted 5- or 6-membered heterocyclic ring with one or two heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen,X is oxygen or N--R.sup.3, R.sup.3 being hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl or subsituted or unsubstituted benzyl,processes for their manufacture and their use for combating unwanted plant growth.
摘要翻译：与五元杂环稠合的喹啉衍生物，其中R1是氢，卤素，羧基或取代或未取代的烷基，Y是氮或C-R2，其中R2是氢，卤素，羟基，烷氧基，烷硫基，取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的苄基，苯乙基，苯基或萘基，或取代或未取代的具有一个或两个选自氧，硫的杂原子的5或6元杂环和氮，X为氧或N-R 3，R 3为氢，取代或未取代的烷基，烯基，炔基，环烷基或取代或未取代的苄基，其制备方法及其用于防治不想要的植物生长。

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