专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20050137168A1 Heterocyclyl substituted 1-alkoxy acetic acid amides 失效
标题翻译：杂环取代的1-烷氧基乙酰胺
公开(公告)号：US20050137168A1
公开(公告)日：2005-06-23
申请号：US11009464
申请日：2004-12-10
申请人： Luca Gobbi , Katrin Zbinden , Peter Mohr , Ulrike Obst
发明人： Luca Gobbi , Katrin Zbinden , Peter Mohr , Ulrike Obst
IPC分类号： C07D209/46 , C07D209/48 , C07D213/64 , C07D213/74 , C07D213/76 , C07D231/12 , C07D235/16 , C07D249/08 , C07D263/32 , C07D271/06 , C07D401/04 , C07D401/12 , C07D413/12 , A61K31/695 , A61K31/4035 , A61K31/4152 , A61K31/421 , A61K31/4245 , A61K31/44
CPC分类号： C07D401/04 , C07D209/46 , C07D209/48 , C07D213/64 , C07D213/74 , C07D213/76 , C07D231/12 , C07D235/16 , C07D249/08 , C07D263/32 , C07D271/06 , C07D401/12 , C07D413/12
摘要： The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新的杂环基取代的1-烷氧基乙酸衍生物，其中R 1至R 6和A如描述中所定义，并且在以及其生理上可接受的盐。这些化合物抑制由因子VIIa和组织因子诱导的凝血因子Xa，IXa和凝血酶的形成，并且可以用作药物。

12. 发明授权

US06890947B2 Indolyl derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US06890947B2
公开(公告)日：2005-05-10
申请号：US10659664
申请日：2003-09-10
申请人： Alfred Binggeli , Beat Wirz , Uwe Grether , Hans Hilpert , Roland Humm , Hans Iding , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr
发明人： Alfred Binggeli , Beat Wirz , Uwe Grether , Hans Hilpert , Roland Humm , Hans Iding , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr
IPC分类号： A61K31/405 , A61P3/06 , A61P3/10 , A61P9/10 , C07D413/06 , C07D413/14 , C07D417/06 , A61K31/404 , C07D209/04
CPC分类号： C07D413/06 , C07D417/06
摘要： Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R8, A, A1 and n have the significance indicated in the specification.
摘要翻译：提供了式I化合物及其药学上可接受的盐和酯，其中R 1至R 8，A，A 1和N 2 具有说明书中指出的意义。

13. 发明申请

US20050096353A1 Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents 失效
标题翻译：吲哚基和二氢吲哚衍生物，其制备和用作药剂
公开(公告)号：US20050096353A1
公开(公告)日：2005-05-05
申请号：US10978144
申请日：2004-10-29
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
IPC分类号： C07D401/12 , C07D403/12 , A61K31/4439 , A61K31/405 , C07D209/18 , C07D43/02
CPC分类号： C04B35/632 , C07D401/12 , C07D403/12
摘要： This invention relates to compounds of the formula wherein one of R6, R7 and R8 is and X, Y1 to Y4, R1 to R14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译：本发明涉及下式的化合物，其中R 6，R 7和R 8之一是和X，Y 1， R 1至R 4，R 1至R 14和n如说明书中所定义，并且与所有对映异构体和药学上可接受的盐本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。

14. 发明授权

US06326397B1 Retinoid antagonists and use thereof 有权
标题翻译：类视黄醇拮抗剂及其用途
公开(公告)号：US06326397B1
公开(公告)日：2001-12-04
申请号：US09307009
申请日：1999-05-07
申请人： Werner Bollag , Michael Klaus , Peter Mohr , Paola Panina-Bordignon , Michael Rosenberger , Francesco Sinigaglia
发明人： Werner Bollag , Michael Klaus , Peter Mohr , Paola Panina-Bordignon , Michael Rosenberger , Francesco Sinigaglia
IPC分类号： A01N5300
CPC分类号： C07C57/48 , C07C57/42
摘要： The present invention relates to novel retinoid antagonists of the formula I wherein the dotted bond can be either hydrogenated or form a double bond; and, when the dotted bond forms a double bond, R1 is lower alkyl and R2 is hydrogen; and, when the dotted bond is hydrogenated, R1 and R2 taken together are methylene to form a cis-substituted cyclopropyl ring; R3 is hydroxy or lower alkoxy; R4 is alkyl or alkoxy; and R5 and R6 are, independently, a C4-12 alkyl or a 5-12 cycloalkyl substituent containing from 1-3 rings which are either unsubstituted or substituted with from 1-3 lower alkyl groups, with the carbon atom of R5 and R6 being linked to the remainder of the molecule to form a quaternary carbon atom pharmaceutically acceptable salts of carbocylic acids of the formula I; as well as method for the treatment of osteoporosis and preneoplastic and neoplastic diseases, and a method for reducing or abolishing adverse events in subjects receiving retinoid agonist treatment by administering a retinoid antagonist.
摘要翻译：本发明涉及式I的新型类视黄醇拮抗剂，其中虚线键可以被氢化或形成双键; 并且当虚线键形成双键时，R 1为低级烷基且R 2为氢; 并且当点键被氢化时，R 1和R 2一起为亚甲基以形成顺式取代的环丙基环; R3是羟基或低级烷氧基; R4是烷基或烷氧基; 并且R 5和R 6独立地是C 1-4烷基或含有1-3个环的5-12个环烷基取代基，它们是未取代的或被1-3个低级烷基取代，R5和R6的碳原子是与分子的其余部分连接以形成式I的碳酸的药学上可接受的盐的季碳原子; 以及用于治疗骨质疏松症和肿瘤前和肿瘤性疾病的方法，以及通过施用类视黄醇拮抗剂减少或消除接受类视黄醇激动剂治疗的受试者的不良事件的方法。

15. 发明授权

US06043385A Vitamin D derivatives 有权
标题翻译：维生素D衍生物
公开(公告)号：US06043385A
公开(公告)日：2000-03-28
申请号：US203088
申请日：1998-12-01
申请人： Pierre Barbier , Franz Bauer , Peter Mohr , Marc Muller , Wolfgang Pirson
发明人： Pierre Barbier , Franz Bauer , Peter Mohr , Marc Muller , Wolfgang Pirson
IPC分类号： C07C401/00 , A61N45/00
CPC分类号： C07C401/00
摘要： The present invention relates to vitamin D derivatives of the formula I ##STR1## wherein X is C.dbd.CH.sub.2 or CH.sub.2 ;Y is hydrogen, fluorine or hydroxyZ is hydroxyn is 1 or 2R.sup.1 is lower alkyl,R.sup.2 is a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents, or is a phenyl group which is unsubstituted or substituted with a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents;and the dotted carbon-carbon bond in ring D is --C--C-- or --C.dbd.C--; or a pharmaceutically usable salt thereof.
摘要翻译：本发明涉及式I的维生素D衍生物，其中X为C = CH 2或CH 2; Y是氢，氟或羟基，Z是羟基，n是1或2，R 1是低级烷基，R 2是未取代或被一个或多个卤素或OH取代基取代的具有3-8个碳原子的支链烷基，或是苯基其未取代或被未取代或被一个或多个卤素或OH取代基取代的具有3-8个碳原子的支链烷基取代; 环D中的点状碳 - 碳键为-C-C-或-C = C-; 或其药学上可用的盐。

16. 发明授权

US5986131A RXR selective ligands 失效
标题翻译： RXR选择配体
公开(公告)号：US5986131A
公开(公告)日：1999-11-16
申请号：US953361
申请日：1997-10-17
申请人： Michael Klaus , Allen John Lovey , Peter Mohr , Michael Rosenberger
发明人： Michael Klaus , Allen John Lovey , Peter Mohr , Michael Rosenberger
IPC分类号： A61K31/07 , A61K31/16 , A61K31/20 , A61K31/23 , A61K31/38 , A61K31/381 , A61P3/02 , A61P17/10 , A61P35/00 , A61P35/02 , C07C47/45 , C07C47/548 , C07C59/64 , C07C61/16 , C07C63/00 , C07C403/20 , C07D211/70 , C07D333/24
CPC分类号： C07D333/24 , C07C403/14 , C07C403/20 , C07C47/45 , C07C47/548 , C07B2200/09 , C07C2101/16
摘要： Novel nonatetraenoic acid derivatives which selectively bind to retinoic acid X-receptors (RXR) and which have anti-acne acitvity and which potentiate the activity of retinoids having RAR.alpha. activity are disclosed.
摘要翻译：公开了选择性结合视黄酸X受体（RXR）并具有抗痤疮活性并且增强具有RARα活性的类视黄醇活性的新型非四烯酸衍生物。

17. 发明授权

US5512683A Alkyl or alkoxy substituted S-heterocyclic retinoids 失效
标题翻译：烷基或烷氧基取代的S-杂环类视黄醇
公开(公告)号：US5512683A
公开(公告)日：1996-04-30
申请号：US324836
申请日：1994-10-18
申请人： Michael Klaus , Peter Mohr
发明人： Michael Klaus , Peter Mohr
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61P17/00 , A61P37/06 , C07D333/54 , C07D335/06 , C07D337/08 , C07D337/04
CPC分类号： C07D333/54 , C07D335/06 , C07D337/08
摘要： Compounds of the formula ##STR1## in which X is --S--, --SO-- or --SO.sub.2 --; R.sup.1 is C.sub.7-10 -alkyl or C.sub.7-10 -alkoxy; R.sup.2 is a residue of the formula ##STR2## R.sup.3 is carboxy or lower-alkoxycarbonyl; and n is an integer of 1, 2 or 3; and salts of carboxylic acids of formula I can be used for the treatment of autoimmune diseases and diseases having a strong immunological component, such as psoriasis.
摘要翻译：其中X是-S-，-SO-或-SO 2 - 的式I的化合物; R1是C7-10-烷基或C7-10-烷氧基; R 2是下式的残基：R 3是羧基或低级烷氧基羰基; n为1,2或3的整数; 式I的羧酸盐可用于治疗具有强免疫组分的自身免疫性疾病和疾病，例如牛皮癣。

18. 发明授权

US5300522A Condensed heterocyclic compounds and pharmaceutical use thereof 失效
标题翻译：缩合杂环化合物及其药物用途
公开(公告)号：US5300522A
公开(公告)日：1994-04-05
申请号：US931612
申请日：1992-08-18
申请人： Michael Klaus , Peter Mohr , Ekkehard Weiss
发明人： Michael Klaus , Peter Mohr , Ekkehard Weiss
IPC分类号： A61K31/335 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/38 , A61K31/382 , A61K31/385 , A61K31/42 , A61K31/423 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/55 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D215/06 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/48 , C07D223/16 , C07D241/42 , C07D241/52 , C07D243/12 , C07D263/56 , C07D281/10 , C07D311/58 , C07D313/08 , C07D315/00 , C07D317/46 , C07D317/54 , C07D317/60 , C07D319/18 , C07D321/10 , C07D327/04 , C07D327/06 , C07D335/06 , C07D337/02 , C07D337/08 , C07D339/00 , C07D339/06 , C07D339/08 , C07D417/12 , A61K31/34 , C07D307/80
CPC分类号： C07D223/16 , C07D215/06 , C07D215/12 , C07D215/48 , C07D241/52 , C07D243/12 , C07D281/10 , C07D311/58 , C07D315/00 , C07D317/54 , C07D317/60 , C07D319/18 , C07D321/10 , C07D327/04 , C07D327/06 , C07D335/06 , C07D337/08 , C07D339/00 , C07D339/06 , C07D339/08 , C07D417/12
摘要： The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen. acyl, lower-alkyl or --CHO, --CH.sub.2 OR.sup.10, --COR.sup.7 or OR.sup.13 ; R.sup.2, R.sup.3 and R.sup.4 are, independently, hydrogen, lower-alkyl, lower-alkoxy or halogen; R.sup.5 and R.sup.5 are, independently, hydrogen or lower-alkyl; R.sup.7 is hydroxy, lower-alkoxy or NR.sup.8 R.sup.9 ; R.sup.8 and R.sup.9 are, independently, hydrogen or lower-alkyl; X and Y are, independently, >CR.sup.14 R.sup.15, --O--, --S--, >SO, >SO.sub.2 or >NR.sup.18 ; R.sup.10 and R.sup.18 are, independently, hydrogen, lower-alkyl or acyl; M is --C(R.sup.11).dbd.C(R.sup.12)--, --CONH-- or --NH--CO--; R.sup.11, R.sup.12, R.sup.14 and R.sup.15 are, independently, hydrogen or lower-alkyl, R.sup.13 is hydrogen, lower-alkoxycarbonyl or lower- alkyl, which can be substituted by amino, mono-alkylamino, di-alkylamino, morpholino, thiomorpholino or piperazino; and n is 1, 2, 3 or 4; with the proviso that at least one of X and Y comprises a hetero atom and that n is 1, 3 or 4 when X contains a hetero atom, Y is >C(CH.sub.3).sub.2 and R.sup.1 is lower-alkyl or --CH.sub.2 OR.sup.10 or --COR.sup.7, or a salt of a compound of formula I, when R.sup.1 is carboxy.The compounds of formula I are useful in the treatment and prophylaxis of neoplasms, dermatoses and ageing of the skin.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是氢。酰基，低级烷基或-CHO，-CH 2 OR 10，-COR 7或OR 13; R2，R3和R4独立地是氢，低级烷基，低级烷氧基或卤素; R5和R5独立地是氢或低级烷基; R7是羟基，低级烷氧基或NR8R9; R8和R9独立地是氢或低级烷基; X和Y独立地为> CR14R15，-O - ， - S - ，> SO，SO2或NR18; R 10和R 18独立地是氢，低级烷基或酰基; M是-C（R 11）= C（R 12） - ， - CONH-或-NH-CO-; R11，R12，R14和R15独立地为氢或低级烷基，R13为氢，低级烷氧基羰基或低级烷基，其可被氨基，单烷基氨基，二烷基氨基，吗啉代，硫代吗啉代或哌嗪基取代; n为1,2,3或4; 条件是X和Y中的至少一个包含杂原子，当X含有杂原子时，n为1,3或4，Y为> C（CH 3）2且R 1为低级烷基或-CH 2 OR 10或 - COR7或式I化合物的盐，当R 1为羧基时。式I化合物可用于治疗和预防皮肤赘生物，皮肤病和老化。

19. 发明授权

US5055622A Novel tetrahydronaphthalene and indane derivatives 失效
标题翻译：新四氢萘并靛酚衍生物
公开(公告)号：US5055622A
公开(公告)日：1991-10-08
申请号：US581352
申请日：1990-09-12
申请人： Michael Klaus , Peter Loeliger , Peter Mohr , Ekkehard Weiss
发明人： Michael Klaus , Peter Loeliger , Peter Mohr , Ekkehard Weiss
IPC分类号： A61K31/01 , A61K31/015 , A61K31/02 , A61K31/035 , A61K31/045 , A61K31/12 , A61K31/215 , C07C13/45 , C07C13/465 , C07C13/48 , C07C15/24 , C07C15/52 , C07C15/58 , C07C25/24 , C07C25/28 , C07C35/32 , C07C35/36 , C07C39/23 , C07C43/215 , C07C43/23 , C07C45/72 , C07C49/683 , C07C49/697 , C07C49/747 , C07C69/157 , C07C205/06
CPC分类号： C07C205/06 , A61K31/015 , A61K31/035 , C07C13/465 , C07C13/48 , C07C25/24 , C07C35/32 , C07C35/36 , C07C39/23 , C07C43/215 , C07C43/23 , C07C45/72 , C07C49/683 , C07C49/697 , C07C49/747 , C07C2102/08 , C07C2102/10
摘要： Novel Styryl-tetrahydromaphthalene and indane derivatives useful for treating neoplasms and dermatoses.

20. 发明授权

US4870219A Novel tetrahydronaphthalene and indane derivatives 失效
标题翻译：新四氢萘和茚满衍生物
公开(公告)号：US4870219A
公开(公告)日：1989-09-26
申请号：US49916
申请日：1987-05-15
申请人： Michael Klaus , Peter Loeliger , Peter Mohr , Ekkehard Weiss
发明人： Michael Klaus , Peter Loeliger , Peter Mohr , Ekkehard Weiss
IPC分类号： A61K31/01 , A61K31/015 , A61K31/02 , A61K31/035 , A61K31/045 , A61K31/12 , A61K31/215 , C07C13/45 , C07C13/465 , C07C13/48 , C07C15/24 , C07C15/52 , C07C15/58 , C07C25/24 , C07C25/28 , C07C35/32 , C07C35/36 , C07C39/23 , C07C43/215 , C07C43/23 , C07C45/72 , C07C49/683 , C07C49/697 , C07C49/747 , C07C69/157 , C07C205/06
CPC分类号： C07C205/06 , A61K31/015 , A61K31/035 , C07C13/465 , C07C13/48 , C07C25/24 , C07C35/32 , C07C35/36 , C07C39/23 , C07C43/215 , C07C43/23 , C07C45/72 , C07C49/683 , C07C49/697 , C07C49/747 , C07C2102/08 , C07C2102/10
摘要： Novel styryl-tetrahydromaphythalene and indane derivatives useful for treating neoplasms and dermatoses.
摘要翻译：用于治疗赘生物和皮肤病的新型苯乙烯基 - 四氢萘和二氢化茚衍生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式