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11. 发明申请

US20100286564A1 TEST MEDIA CASSETTE FOR BODILY FLUID TESTING DEVICE 有权
公开(公告)号：US20100286564A1
公开(公告)日：2010-11-11
申请号：US12840352
申请日：2010-07-21
申请人： Jeffrey N. Roe , Steven N. Roe
发明人： Jeffrey N. Roe , Steven N. Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/1411 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/150419 , A61B5/150473 , A61B5/150503 , A61B5/150633 , A61B5/150702 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/157 , A61B10/0045 , A61B2562/0295 , G01N33/48 , G01N33/48764 , G01N2001/028 , G01N2035/00019 , Y10T436/25
摘要： A bodily fluid sampling device includes a piercing device and a sensor enclosed in a housing. A cassette, which contains test media, is positioned proximal to the sensor so that the sensor is able to analyze a bodily fluid sample collected on the test media. The cassette includes a supply portion from which unused test media is supplied and a storage portion in which contaminated test media is stored after exposure to the bodily fluid. The cassette is adapted to collect a series of bodily fluid samples without requiring disposal of the test media.

12. 发明授权

US07828749B2 Blood and interstitial fluid sampling device 有权
公开(公告)号：US07828749B2
公开(公告)日：2010-11-09
申请号：US11562496
申请日：2006-11-22
申请人： Joel S. Douglas , Jeffrey N. Roe , Ryszard Radwanski , Henry M. Grage , Michael S. Sanchez
发明人： Joel S. Douglas , Jeffrey N. Roe , Ryszard Radwanski , Henry M. Grage , Michael S. Sanchez
IPC分类号： A61B5/00 , B65D81/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150083 , A61B5/150183 , A61B5/15019 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150343 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150946 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15136 , A61B5/1519 , A61B5/15196
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.

13. 发明申请

US20100106058A1 BLOOD AND INTERSTITIAL FLUID SAMPLING DEVICE 有权
标题翻译：血液和间质液体取样装置
公开(公告)号：US20100106058A1
公开(公告)日：2010-04-29
申请号：US12644528
申请日：2009-12-22
申请人： Joel S. Douglas , Jeffrey N. Roe , Ryszard Radwanski , Henry M. Grage , Michael S. Sanchez
发明人： Joel S. Douglas , Jeffrey N. Roe , Ryszard Radwanski , Henry M. Grage , Michael S. Sanchez
IPC分类号： A61B5/151 , A61B17/34
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150083 , A61B5/150183 , A61B5/15019 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150343 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150946 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15136 , A61B5/1519 , A61B5/15196
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译：用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。该装置的尺寸优选为一只手中的手持式并且用一只手可操作。该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。

14. 发明授权

US07670301B2 Integrated disposable for automatic or manual blood dosing 失效
标题翻译：集成一次性用于自动或手动血液给药
公开(公告)号：US07670301B2
公开(公告)日：2010-03-02
申请号：US11950457
申请日：2007-12-05
申请人： Jeffrey N. Roe
发明人： Jeffrey N. Roe
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00
CPC分类号： A61B5/15142 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150442 , A61B5/150534 , A61B5/15105 , A61B5/15107 , A61B2562/0295
摘要： An integrated sampling device defines a first opening and a second opening. The first opening is connected to a channel for drawing fluid automatically towards a test media upon incision by an incision portion. The second opening is positioned over the test media allowing manual sampling of fluid if the channel fails to draw a sufficient amount of fluid onto the test media.
摘要翻译：集成采样装置限定第一开口和第二开口。第一开口连接到用于通过切口部分切开时自动向测试介质抽取流体的通道。第二个开口定位在测试介质上方，如果通道不能将足够量的流体吸入到测试介质上，则允许对流体进行手动取样。

15. 发明申请

US20100045993A1 METHOD OF DETECTING ANALYTE 有权
标题翻译：检测分析仪的方法
公开(公告)号：US20100045993A1
公开(公告)日：2010-02-25
申请号：US12195997
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： G01N21/00
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。该方法包括检测系统中两个或更多个区域的第一区域的光学性质，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应于分析物浓度的变化。下一步骤检测系统中两个或更多个区域的第二区域的光学性质，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应化合物浓度的变化，其中化合物是除分析物以外的物质。检测到的第一区域的光学特性和第二区域的检测光学特性用于实施例中以将分析物对第一区域的检测光学性质的影响与化合物的影响分开，其中化合物是干扰复合。

16. 发明申请

US20080161724A1 INTEGRATED DISPOSABLE FOR AUTOMATIC OR MANUAL BLOOD DOSING 失效
标题翻译：一体化用于自动或手动血液灌装
公开(公告)号：US20080161724A1
公开(公告)日：2008-07-03
申请号：US11950457
申请日：2007-12-05
申请人： Jeffrey N. Roe
发明人： Jeffrey N. Roe
IPC分类号： A61B5/157
CPC分类号： A61B5/15142 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150442 , A61B5/150534 , A61B5/15105 , A61B5/15107 , A61B2562/0295
摘要： An integrated sampling device defines a first opening and a second opening. The first opening is connected to a channel for drawing fluid automatically towards a test media upon incision by an incision portion. The second opening is positioned over the test media allowing manual sampling of fluid if the channel fails to draw a sufficient amount of fluid onto the test media.
摘要翻译：集成采样装置限定第一开口和第二开口。第一开口连接到用于通过切口部分切开时自动向测试介质抽取流体的通道。第二个开口定位在测试介质上方，如果通道不能将足够量的流体吸入到测试介质上，则允许对流体进行手动取样。

17. 发明授权

US06522903B1 Glucose measurement utilizing non-invasive assessment methods 失效
标题翻译：使用非侵入性评估方法进行葡萄糖测量
公开(公告)号：US06522903B1
公开(公告)日：2003-02-18
申请号：US09693202
申请日：2000-10-19
申请人： Herbert L. Berman , Jeffrey N. Roe , Robert N. Blair
发明人： Herbert L. Berman , Jeffrey N. Roe , Robert N. Blair
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14514 , A61B5/14521 , A61B5/14532
摘要： This involves non-invasive glucose measurement processes for determining blood glucose level in the human body. After achieving a static level of glucose at a surface of the skin over some period of time, the glucose may then be measured by a variety of different processes. A sample of the glucose may also first be extracted from the skin and this sample may then be measured. Clearly, these processes are especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. These procedures may be used for other analyte materials that are found in appropriate regions of the outer skin.
摘要翻译：这涉及用于测定人体血糖水平的非侵入性葡萄糖测量方法。在一段时间内在皮肤表面达到静止水平的葡萄糖之后，可以通过多种不同的方法测量葡萄糖。也可以首先从皮肤中提取葡萄糖样品，然后可以测量该样品。显然，这些方法特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。这些方法可用于在外皮的适当区域中发现的其它分析物质。

18. 发明授权

US06445938B1 Method for determining blood glucose levels from a single surface of the skin 失效
标题翻译：从皮肤的单个表面测定血糖水平的方法
公开(公告)号：US06445938B1
公开(公告)日：2002-09-03
申请号：US09668222
申请日：2000-09-22
申请人： Herbert L. Berman , Jeffrey N. Roe
发明人： Herbert L. Berman , Jeffrey N. Roe
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/245 , G01N21/552
摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。该装置使用衰减全反射（ATR）红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

19. 发明授权

US6106780A Synchronized analyte testing system 有权
公开(公告)号：US6106780A
公开(公告)日：2000-08-22
申请号：US228814
申请日：1999-01-11
申请人： Joel S. Douglas , Karen R. Drexler , Jeffrey N. Roe
发明人： Joel S. Douglas , Karen R. Drexler , Jeffrey N. Roe
IPC分类号： G01N33/49 , A61B5/00 , C12Q1/54 , G01D3/02 , G01N21/01 , G01N21/78 , G01N21/86 , G01N27/28 , G01N27/327 , G01N31/22 , G01N33/48 , G01N33/487 , G01N33/52 , G01N33/66 , G01N35/00 , G01N37/00 , G01N21/00
CPC分类号： G01N33/528 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/150259 , A61B5/150305 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/15186 , A61B5/157 , A61B5/415 , C12Q1/54 , G01D3/022 , G01N21/8483 , G01N33/48757 , G01N33/48771 , G01N33/525 , G01N33/66 , A61B2560/0431 , A61B2562/0295 , A61B2562/085 , A61B5/150503 , G01N2035/00138 , Y10S435/808 , Y10S435/817
摘要： An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.

20. 发明授权

US6071250A Methods and apparatus for expressing body fluid from an incision 有权
公开(公告)号：US6071250A
公开(公告)日：2000-06-06
申请号：US238140
申请日：1999-01-28
申请人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
IPC分类号： A61B5/00 , A61B5/15 , A61B10/00 , A61B17/00
CPC分类号： A61B5/14532 , A61B10/0045 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15186 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.

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