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11. 发明授权

US07425568B2 Compounds, which are potent inhibitors of Na+ /Ca2+ exchange mechanism and are useful in the treatment of arrhythmias 失效
标题翻译：化合物，它们是Na + / Ca2 +交换机制的有效抑制剂，可用于治疗心律失常
公开(公告)号：US07425568B2
公开(公告)日：2008-09-16
申请号：US10482396
申请日：2002-07-10
申请人： Tuula Koskelainen , Leena Otsomaa , Arto Karjalainen , Pekka Kotovuori , Jukka Tenhunen , Sirpa Rasku , Pentti Nore , Eija Tiainen , Olli Törmäkangas
发明人： Tuula Koskelainen , Leena Otsomaa , Arto Karjalainen , Pekka Kotovuori , Jukka Tenhunen , Sirpa Rasku , Pentti Nore , Eija Tiainen , Olli Törmäkangas
IPC分类号： A61K31/4433 , C07D405/12
CPC分类号： C07D405/12 , C07C217/14 , C07C217/54 , C07C217/90 , C07C2602/08 , C07D213/64 , C07D311/28 , C07D311/58 , C07D311/60 , C07D411/12
摘要： Therapeutically active compounds of formula (I): wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of the Na+/Ca2+ exchange mechanism.
摘要翻译：式（I）的治疗活性化合物：其中式（I）中所示的变量在本公开中定义; 及其药学上可接受的盐和酯。这些化合物是Na + / 2H 2 +交换机理的有效抑制剂。

12. 发明授权

US06875775B2 Triphenylalkene derivatives and their use as selective estrogen receptor modulators 有权
标题翻译：三苯基烯烃衍生物及其作为选择性雌激素受体调节剂的用途
公开(公告)号：US06875775B2
公开(公告)日：2005-04-05
申请号：US10408303
申请日：2003-04-08
申请人： Marja-Liisa Södervall , Arja Kalapudas , Lauri Kangas , Risto Lammintausta , Pirkko Härkönen , Kalervo Väänänen , Arto Karjalainen
发明人： Marja-Liisa Södervall , Arja Kalapudas , Lauri Kangas , Risto Lammintausta , Pirkko Härkönen , Kalervo Väänänen , Arto Karjalainen
IPC分类号： A61K31/4164 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/136 , A61K31/138 , A61K31/145 , A61K31/192 , A61K31/4453 , A61P5/30 , A61P5/32 , A61P9/02 , A61P13/02 , A61P15/02 , A61P15/12 , A61P19/10 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/28 , A61P43/00 , C07C43/225 , C07C43/23 , C07C59/68 , C07C211/10 , C07C211/53 , C07C215/16 , C07C217/18 , C07C217/20 , C07C323/12 , C07C323/25 , C07D211/14 , C07D233/61 , C07D295/092 , C07D521/00 , A61K31/445 , A61K31/415 , C07D211/32 , C07D233/00 , C07D211/21
CPC分类号： C07D295/088 , C07C43/225 , C07C43/23 , C07C59/68 , C07C211/10 , C07C215/16 , C07C217/20 , C07C323/12 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH3, OH; or where X is O, NH or S; and n is an integer from 1 to 4; and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, —CH2C≡CH or —CH2CH2OH; or R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring; or c) —Y—(CH2)nCH2—O—R6 where Y is O, NH or S and n is an integer from 1 to 4; and R6 is H, —CH2CH2OH, or —CH2CH2Cl; or d) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy; and R3 is H, halogen, OH or —OCH3; stereoisomers thereof and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds exhibit valuable pharmacological properties.
摘要翻译：本发明提供了新颖的选择性雌激素受体调节剂化合物，其通式如下：其中R1和R2是相同或不同的面积）H，卤素，OCH 3，OH; 或其中X为O，NH或S; n为1〜4的整数。和R 4和R 5相同或不同，为1至4个碳原子的烷基，H，-CH 2 C = CH或-CH 2 CH 2 OH; 或R 4和R 5形成含N的五元或六元环或杂芳环; orc）-Y-（CH2）nCH2-O-R6其中Y是O，NH或S，n是1至4的整数; 并且R 6是H，-CH 2 CH 2 OH或-CH 2 CH 2 Cl; 2,3-二羟基丙氧基，2-甲基磺酰基乙氧基，2-氯乙氧基，1-乙基-2-羟基乙氧基，2,2-二乙基-2-羟基乙氧基或羧基甲氧基; 和R 3是H，卤素，OH或-OCH 3;其立体异构体及其无毒的药学上可接受的盐和酯及其混合物，该化合物显示出有价值的药理学性质。

13. 发明申请

US20060241147A1 Pyridine derivatives useful for inhibiting sodium/calcium exchange system 失效
标题翻译：用于抑制钠/钙交换系统的吡啶衍生物
公开(公告)号：US20060241147A1
公开(公告)日：2006-10-26
申请号：US10541677
申请日：2004-01-09
申请人： Leena Otsomaa , Tuula Koskelainen , Arto Karjalainen , Sirpa Rasku , Piero Pollesello , Jouko Levijoki
发明人： Leena Otsomaa , Tuula Koskelainen , Arto Karjalainen , Sirpa Rasku , Piero Pollesello , Jouko Levijoki
IPC分类号： A61K31/4433 , A61K31/444 , C07D405/14
CPC分类号： C07D213/75 , C07D405/12 , C07D405/14 , C07D411/12
摘要： Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na+/Ca2+ exchange mechanism.
摘要翻译：式（I）或（II）的治疗活性化合物：其中式（I）和（II）中的变量在描述中定义，及其药学上可接受的盐和酯。这些化合物是Na + / 2H 2 +交换机理的有效抑制剂。

14. 发明授权

US4275072A 2,6-Dichlorophenyl-substituted amino-imidazole derivatives and use as hypertensive agents 失效
标题翻译： 2,6-二氯苯基取代的氨基咪唑衍生物，用作高血压药
公开(公告)号：US4275072A
公开(公告)日：1981-06-23
申请号：US93247
申请日：1979-11-13
申请人： Arto Karjalainen , Kauko Kurkela
发明人： Arto Karjalainen , Kauko Kurkela
IPC分类号： C07D233/88 , A61K31/415 , C07D233/54
CPC分类号： C07D233/88
摘要： The 2,6-dichlorophenyl-substituted amino-imidazole derivatives 1-(2',6'-dichlorophenyl)-2-amino-4-methyl-imidazole, 2-(2',6'-dichloroanilino)-4-methyl-imidazole, their non-toxic, pharmaceutically acceptable, acid addition salts and mixtures thereof, exhibit excellent anti-hypertensive activity which makes the derivatives particularly suitable for treatment of high blood pressure in mammals.The derivatives may be prepared in either of two processes. The first process involves the sequential reaction of a known starting material with ammonia and a halogenated acetone which may be followed by separation of the formed isomers. The second process involves the decarboxylation of the novel intermediates 4-[1-(2',6'-dichlorophenyl)-2-amino)]-imidazoleacetic acid or 4-[2-(2',6'-dichloroanilino)]-imidazoleacetic acid or mixtures thereof. Such intermediates, their lower alkyl esters, their non-toxic, pharmaceutically acceptable acid addition salts or mixtures thereof may also be employed as a diuretic agent.The derivatives are employed in an effective amount and are typically combined with a pharmaceutical carrier. Administration of the derivatives may be accomplished either orally or parenterally.
摘要翻译： 2,6-二氯苯基取代的氨基咪唑衍生物1-（2'，6'-二氯苯基）-2-氨基-4-甲基咪唑，2-（2'，6'-二氯苯胺基）-4-甲基 - 咪唑，它们的无毒，药学上可接受的酸加成盐及其混合物表现出优异的抗高血压活性，这使得该衍生物特别适用于治疗哺乳动物的高血压。衍生物可以以两种方法中的任一种制备。第一种方法是将已知原料与氨和卤代丙酮进行顺序反应，然后分离所形成的异构体。第二种方法涉及新型中间体4- [1-（2'，6'-二氯苯基）-2-氨基）] - 咪唑乙酸或4- [2-（2'，6'-二氯苯胺基）] - 咪唑乙酸或其混合物。这样的中间体，它们的低级烷基酯，其无毒的，药学上可接受的酸加成盐或其混合物也可以用作利尿剂。衍生物以有效量使用，通常与药物载体组合。衍生物的施用可以口服或胃肠外实施。

15. 发明授权

US07482340B2 Pyridine derivatives useful for inhibiting sodium/calcium exchange system 失效
标题翻译：用于抑制钠/钙交换系统的吡啶衍生物
公开(公告)号：US07482340B2
公开(公告)日：2009-01-27
申请号：US10541677
申请日：2004-01-09
申请人： Leena Otsomaa , Tuula Koskelainen , Arto Karjalainen , Sirpa Rasku , Piero Pollesello , Jouko Levijoki
发明人： Leena Otsomaa , Tuula Koskelainen , Arto Karjalainen , Sirpa Rasku , Piero Pollesello , Jouko Levijoki
IPC分类号： A61K31/54 , A61K31/535 , A61K31/44
CPC分类号： C07D213/75 , C07D405/12 , C07D405/14 , C07D411/12
摘要： Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na+/Ca2+ exchange mechanism.
摘要翻译：式（I）或（II）的治疗活性化合物：其中式（I）和（II）中的变量在描述中定义，及其药学上可接受的盐和酯。这些化合物是Na + / Ca2 +交换机制的有效抑制剂。

16. 发明申请

US20080287685A1 Detomidine Hydrochloride Crystallization Method 有权
标题翻译：盐酸地西铵结晶法
公开(公告)号：US20080287685A1
公开(公告)日：2008-11-20
申请号：US11911181
申请日：2006-04-13
申请人： Arto Karjalainen , Seppo Parhi
发明人： Arto Karjalainen , Seppo Parhi
IPC分类号： C07D233/58
CPC分类号： C07D233/64
摘要： A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with
摘要翻译：提供了一种分离盐酸吗咪烷（I）为结晶盐的方法。该方法包括在式（II）化合物的催化剂存在下，在含有盐酸的水溶液中氢化，通过蒸馏浓缩溶液，任选地向浓缩溶液中加入盐酸，冷却浓缩溶液并回收结晶的盐酸迪卡尼定。该产品可直接从水溶液中回收

17. 发明授权

US07642279B2 Atipamezole hydrochloride crystallization method 有权
标题翻译：盐酸阿替美唑结晶法
公开(公告)号：US07642279B2
公开(公告)日：2010-01-05
申请号：US11913776
申请日：2006-06-16
申请人： Seppo Parhi , Arto Karjalainen
发明人： Seppo Parhi , Arto Karjalainen
IPC分类号： A01N43/50 , C07D233/00
CPC分类号： C07D233/64
摘要： A method of isolating atipamezole hydrocloride as a crystalline salt is provided.
摘要翻译：提供了一种分离作为结晶盐的阿替美唑氢氯化物的方法。

18. 发明申请

US20080275252A1 Atipamezole Hydrochloride Crystallization Method 有权
标题翻译：阿非匹唑盐酸盐结晶法
公开(公告)号：US20080275252A1
公开(公告)日：2008-11-06
申请号：US11913776
申请日：2006-06-16
申请人： Seppo Parhi , Arto Karjalainen
发明人： Seppo Parhi , Arto Karjalainen
IPC分类号： C07D233/64
CPC分类号： C07D233/64
摘要： A method of isolating atipamezole hydrochloride as a crystalline salt is provided.
摘要翻译：提供分离盐酸阿替咪唑为结晶盐的方法。

19. 发明授权

US06615709B1 Method for detecting contamination and/or damaging of a face that runs through a nip or nips in a calendar for paper 失效
标题翻译：检测污染物和/或破坏通过砑光机中的辊隙或辊隙的纸张的方法
公开(公告)号：US06615709B1
公开(公告)日：2003-09-09
申请号：US09554640
申请日：2000-05-17
申请人： Eero Suomi , Tapio Mäenpää , Arto Karjalainen
发明人： Eero Suomi , Tapio Mäenpää , Arto Karjalainen
IPC分类号： B30B1122
CPC分类号： D21G1/008 , G01H1/003
摘要： The invention concerns a method for detecting a contamination and damaging of a face (10) that runs through a nip or nips (N1 . . . N10) in a calendar for paper. In the method vibrations occurring in connection with the constructions (18, 100) of a calendar are detected and processed. The vibrations are detected by at least one vibration detector (40; 41 . . . 46; 41a. . . 46a, 41b. . . 46b) fitted in connection with the bearing supports of calendar rolls (11 . . . 16) or in connection with constructions (18, 100) related to said bearing supports. By the way of these vibration detectors the calendar roll(s) (11 . . . 16) is/are identified from which the vibration derives. In the method , it is possible to observe the rotation of all of the rolls to be monitored and to measure vibration from any suitable point whatsoever, for example from the frame (100) of the machine, by employing at least one vibration detector (40), the time (Tr) of the cycle of the vibration signal obtained from said detector(s) being compared with the numbers of revolutions of the rolls to be monitored. In this way, the source of the disturbance is determined, and action is taken in order to eliminate the disturbance.
摘要翻译：本发明涉及一种用于检测通过纸张日历中的辊隙或压痕（N1 ... N10）的面（10）的污染和损坏的方法。在该方法中，检测并处理与日历的结构（18,100）有关的振动。至少一个振动检测器（40; 41 ... 46; 41a ... 46a，41b ... 46b）通过与日历辊（11 ... 16）的轴承支撑件相配合或者在与与所述轴承支撑件相关的结构（18,100）的连接。通过这些振动检测器的方式，确定了振动来自的日历辊（11 ... 16）。在该方法中，可以观察所有要被监视的辊的旋转，并且通过使用至少一个振动检测器（40）来测量来自任何适当点的振动，例如来自机器的框架（100）），将从所述检测器获得的振动信号的周期的时间（Tr）与待监测的辊的转数进行比较。以这种方式确定干扰的来源，并采取行动以消除干扰。

20. 发明授权

US06270628B1 Method for detecting contamination and/or damage in a face running through a nip in a paper machine or in a paper finishing machine 失效
标题翻译：用于检测通过造纸机或纸张整理机中的辊隙的表面污染和/或损坏的方法
公开(公告)号：US06270628B1
公开(公告)日：2001-08-07
申请号：US09331475
申请日：1999-08-12
申请人： Eero Suomi , Tapio Mäenp{umlaut over (aa)} , Arto Karjalainen
发明人： Eero Suomi , Tapio Mäenp{umlaut over (aa)} , Arto Karjalainen
IPC分类号： D21F1100
CPC分类号： D21G9/0045 , G01H1/12 , Y10S162/10
摘要： A method for detecting contamination on or damage to a web-contacting face in a paper machine or a paper finishing machine, including the steps of detecting vibrations of the web-contacting face over a period of time by means of a plurality of detectors arranged in association with the machine and determining the location of the contamination on or damage to the web-contacting face based on the time the vibrations were detected.
摘要翻译：一种用于检测造纸机或造纸机中的纸幅接触面的污染或损坏的方法，包括以下步骤：通过多个检测器布置在一段时间内检测卷筒纸接触面的振动与机器相关联，并且基于检测到振动的时间确定污染物对纸幅接触面的位置或损坏位置。

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