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11. 发明申请

US20060189856A1 Oxygen enhancing membrane systems for implantable devices 有权
公开(公告)号：US20060189856A1
公开(公告)日：2006-08-24
申请号：US11410555
申请日：2006-04-25
申请人： James Petisce , Mark Tapsak , Peter Simpson , Victoria Carr-Brendel , James Brauker
发明人： James Petisce , Mark Tapsak , Peter Simpson , Victoria Carr-Brendel , James Brauker
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

12. 发明申请

US20050115832A1 Electrode systems for electrochemical sensors 有权
标题翻译：电化学传感器用电极系统
公开(公告)号：US20050115832A1
公开(公告)日：2005-06-02
申请号：US10897312
申请日：2004-07-21
申请人： Peter Simpson , James Petisce , Victoria Carr-Brendel , James Brauker
发明人： Peter Simpson , James Petisce , Victoria Carr-Brendel , James Brauker
IPC分类号： G01N20060101 , G01N27/26 , G01N27/416
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

13. 发明授权

US5549675A Method for implanting tissue in a host 失效
标题翻译：在组织中植入组织的方法
公开(公告)号：US5549675A
公开(公告)日：1996-08-27
申请号：US180018
申请日：1994-01-11
申请人： Steven Neuenfeldt , James Brauker , Robert Clarke , Victoria Carr-Brendel
发明人： Steven Neuenfeldt , James Brauker , Robert Clarke , Victoria Carr-Brendel
IPC分类号： C12M1/00 , A61F2/02 , A61K9/00 , A61L27/00 , A61L27/38 , C12N5/06
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38 , Y10S623/902
摘要： A method for implanting cells into a host tissue is provided. The method comprises the steps of: creating an implant assembly for holding cells including wall means for forming a porous boundary between the host tissue and the implanted cells in the device, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response; implanting the assembly without the cells into a host tissue; and accessing an interior of the assembly to add the cells thereto.
摘要翻译：提供了将细胞植入宿主组织的方法。该方法包括以下步骤：创建用于保持细胞的植入物组件，其包括用于在所述装置中的宿主组织和植入细胞之间形成多孔边界的壁装置，边界的孔径足以将植入的细胞与免疫响应; 将没有细胞的组件植入宿主组织中; 以及访问组件的内部以将单元格添加到其中。

14. 发明申请

US20060200022A1 Optimized sensor geometry for an implantable glucose sensor 审中-公开
公开(公告)号：US20060200022A1
公开(公告)日：2006-09-07
申请号：US11416058
申请日：2006-05-02
申请人： James Brauker , Victoria Carr-Brendel , Paul Neale , Laura Martinson
发明人： James Brauker , Victoria Carr-Brendel , Paul Neale , Laura Martinson
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/415 , A61B5/418 , A61B2562/187
摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

15. 发明申请

US20060224108A1 Optimized sensor geometry for an implantable glucose sensor 审中-公开
公开(公告)号：US20060224108A1
公开(公告)日：2006-10-05
申请号：US11416346
申请日：2006-05-02
申请人： James Brauker , Victoria Carr-Brendel , Paul Neale , Laura Martinson
发明人： James Brauker , Victoria Carr-Brendel , Paul Neale , Laura Martinson
IPC分类号： A61M31/00 , A61K9/22
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/415 , A61B5/418 , A61B2562/187
摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

16. 发明申请

US20060211921A1 Optimized sensor geometry for an implantable glucose sensor 有权
公开(公告)号：US20060211921A1
公开(公告)日：2006-09-21
申请号：US11415631
申请日：2006-05-02
申请人： James Brauker , Victoria Carr-Brendel , Paul Neale , Laura Martinson
发明人： James Brauker , Victoria Carr-Brendel , Paul Neale , Laura Martinson
IPC分类号： A61B5/00
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/415 , A61B5/418 , A61B2562/187
摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

17. 发明申请

US20050251083A1 Biointerface with macro-and micro-architecture 有权
标题翻译：具有宏观和微观架构的生物界面
公开(公告)号：US20050251083A1
公开(公告)日：2005-11-10
申请号：US11055779
申请日：2005-02-09
申请人： Victoria Carr-Brendel , Peter Simpson , James Brauker
发明人： Victoria Carr-Brendel , Peter Simpson , James Brauker
IPC分类号： A61F13/00 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：本文公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并连接到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观结构共同协调管理和操纵体内异物反应的高级别组织结构和低水平细胞组织，从而增加接近装置 - 组织界面的新生血管形成，干扰屏障细胞层形成并提供良好的组织锚定，同时减少运动神经的影响，并破坏FBC的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传送或测量装置中的分析物浓度的装置，和/或其组合。

18. 发明申请

US20050027463A1 System and methods for processing analyte sensor data 有权
公开(公告)号：US20050027463A1
公开(公告)日：2005-02-03
申请号：US10633367
申请日：2003-08-01
申请人： Paul Goode , James Brauker , Apurv Kamath , Victoria Carr-Brendel
发明人： Paul Goode , James Brauker , Apurv Kamath , Victoria Carr-Brendel
IPC分类号： A61B5/00 , G01D18/00 , G01N31/00 , G01N33/487
CPC分类号： A61B5/1468 , A61B5/0031 , A61B5/1433 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/4839 , A61B5/743 , A61B2560/0223 , A61B2560/04 , A61B2562/085 , G01N33/48707 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

19. 发明申请

US20050203360A1 SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR 有权
标题翻译：连续分析传感器信号处理
公开(公告)号：US20050203360A1
公开(公告)日：2005-09-15
申请号：US11007920
申请日：2004-12-08
申请人： James Brauker , Victoria Carr-Brendel , Paul Goode , Apurv Kamath , James Thrower , Ben Xavier
发明人： James Brauker , Victoria Carr-Brendel , Paul Goode , Apurv Kamath , James Thrower , Ben Xavier
IPC分类号： A61B5/00 , A61B5/05 , G01N20060101
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/14503 , A61B5/1451 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/7275 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61M5/1723 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： Abstract of the DisclosureSystems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.
摘要翻译：用于动态和智能地估计来自连续分析物传感器的分析物数据的系统和方法，包括接收数据流，选择多种算法中的一种，以及采用所选择的算法来估计分析物值。附加数据处理包括评估所选择的估计算法，基于统计学，临床或生理参数分析估计分析物值的变化，将估计的分析物值与相应的测量分析物值进行比较，以及向用户提供输出。估计可用于补偿时间滞后，匹配传感器数据与相应的参考数据，警告即将到来的临床风险，替换错误的传感器数据信号，并提供更及时的分析物信息，鼓励主动行为和抢占临床风险。

20. 发明申请

US20050043598A1 Systems and methods for replacing signal artifacts in a glucose sensor data stream 有权
标题翻译：用于替换葡萄糖传感器数据流中的信号伪影的系统和方法
公开(公告)号：US20050043598A1
公开(公告)日：2005-02-24
申请号：US10648849
申请日：2003-08-22
申请人： Paul Goode , James Brauker , Apurv Kamath , James Thrower , Victoria Carr-Brendel
发明人： Paul Goode , James Brauker , Apurv Kamath , James Thrower , Victoria Carr-Brendel
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/7203 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7225 , A61B5/7257 , A61B5/726 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2562/0247 , A61B2562/0271 , A61B2562/08
摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
摘要翻译：用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号估计算法。

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