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11. 发明申请

US20060287354A1 Azaindole compounds as kinase inhibitors 审中-公开
标题翻译： Azaindole化合物作为激酶抑制剂
公开(公告)号：US20060287354A1
公开(公告)日：2006-12-21
申请号：US10556227
申请日：2004-05-06
申请人： Laurent David , Peter Hansen
发明人： Laurent David , Peter Hansen
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to novel azaindole compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及作为激酶抑制剂的新型氮杂吲哚化合物，其制备中间体的方法和包含它们的药物组合物。

12. 发明申请

US20060207445A1 Juicer having an articulated arm carrying a pressing element 失效
标题翻译：榨汁机具有携带按压元件的铰接臂
公开(公告)号：US20060207445A1
公开(公告)日：2006-09-21
申请号：US11373124
申请日：2006-03-13
申请人： Cyril Durris , Laurent David , Marc Suberbie
发明人： Cyril Durris , Laurent David , Marc Suberbie
IPC分类号： B30B9/02
CPC分类号： A47J19/027
摘要： A juicer composed of: a housing provided to receive a rotatable element for extraction of juice; an arm that is mounted to the housing to pivot about an axis with respect to the housing; a pressing element for pressing a fruit half against the rotatable element; and a pivot element mounting the pressing element to the arm to pivot about a pivot axis with respect to the arm.
摘要翻译：一种榨汁机，由以下部件组成：一个壳体，用于接收用于提取果汁的可转动元件; 臂，其安装到壳体以相对于壳体绕轴线枢转; 用于将果半部压在可旋转元件上的按压元件; 以及枢轴元件，其将所述按压元件安装到所述臂以相对于所述臂绕枢转轴线枢转。

13. 发明申请

US20120022242A1 METHOD FOR PRODUCING AN ELONGATE POLYSACCHARIDE ELEMENT, IN PARTICULAR A CHITOSAN THREAD, AND POLYSACCCHARIDE THREAD OBTAINED 有权
标题翻译：生产优质多糖元素的方法，特别是芝士螺纹和多晶硅螺纹获得
公开(公告)号：US20120022242A1
公开(公告)日：2012-01-26
申请号：US13201489
申请日：2010-02-15
申请人： Alain Domard , Laurent David , Alexandra Montembault , Mylène Desorme
发明人： Alain Domard , Laurent David , Alexandra Montembault , Mylène Desorme
IPC分类号： C08B37/08 , B29C47/88 , D01F2/08 , B29C47/78 , D01D5/06
CPC分类号： D01F9/00 , B29C47/0014 , B29C47/8805 , B29C47/8895 , D01D5/06 , D01F2/24
摘要： The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element. The chitosan thread has a crystalline structure corresponding to the anhydrous allomorph and a rupture stress of at least 150 MPa after being immersed in demineralised water for fifteen hours. The apparatus (1) for the wet extrusion of polysaccharide thread (10) includes an extruder (2) with at least one extrusion die (3), an evaporation enclosure (4) placed immediately after the output (3a) of the extrusion die (3) and supplied with a hot air flow, a neutralisation unit (5), a washing unit (6), a drying unit (8) and a winding unit (9).
摘要翻译：本发明涉及一种用于生产细长多糖元件，特别是壳聚糖螺纹的方法，其包括通过挤出模挤出所述多糖的可渗透溶液的操作和使挤出溶液凝结的操作。可膨胀溶液是含有在大气压下不与水形成共沸物并且沸点大于150℃的醇的水醇溶液。凝结操作包括蒸发水，优选在醇上的步骤，产生主要为醇凝胶形式的凝胶化挤出细长元件，特别是通过将挤出的溶液经受热空气流。消除所述凝胶中所含的醇的至少一种操作使得可以获得细长多糖元件。壳聚糖螺纹具有对应于无水异构体的晶体结构，并且在浸入软化水中15小时后的破裂应力至少为150MPa。用于多糖螺纹（10）的湿挤压的装置（1）包括具有至少一个挤出模头（3）的挤出机（2），紧紧在挤出模头的输出（3a）之后放置的蒸发外壳（4）供给热风流，中和单元（5），清洗单元（6），干燥单元（8）和卷绕单元（9）。

14. 发明申请

US20110280829A1 Low Molecular Weight Sulphated Polysaccharides as Candidates for Anti-Angiogenic Therapy 审中-公开
标题翻译：低分子量硫酸多糖作为抗血管生成治疗的候选者
公开(公告)号：US20110280829A1
公开(公告)日：2011-11-17
申请号：US13146897
申请日：2010-01-07
申请人： Laurent David , Laetitia Frank , Rosa Siali , Jean Huet
发明人： Laurent David , Laetitia Frank , Rosa Siali , Jean Huet
IPC分类号： A61K38/21 , A61K31/737 , A61K31/704 , A61K33/24 , A61K31/7064 , A61P7/00 , A61P35/00 , A61P19/02 , A61P17/00 , A61P27/02 , A61P27/06 , A61P35/02 , A61K38/19 , A61K38/22 , C07H5/10
CPC分类号： C08B37/0003 , C08B37/006
摘要： Low molecular weight sulphated L-fucose polysaccharide fraction having a molecular weight ranging from 11 to 30 kDa when measured with TEST A, a sulphate content ranging from 10 and 50% w/w relative to the total weight of the fraction, a fucosis content ranging from 30 and 70% w/w relative to the total weight of the fraction, and a polydispersity index ranging from 1 and 2, wherein the fraction is obtainable by free radical depolymerisation of a crude fucan of vegetal origin; process for manufacturing same; pharmaceutical composition and medicament containing same and their use for inhibiting neovascularisation.
摘要翻译：当用TEST A测量时，分子量为11至30kDa的低分子量硫酸化L-岩藻糖多糖级分，相对于级分总重量为10-50％w / w的硫酸盐含量，范围为相对于级分的总重量为30％和70％w / w，并且多分散指数为1和2，其中所述级分可通过植物来源的粗制石蜡的自由基解聚获得; 制造工艺相同; 药物组合物和含有它们的药物及其用于抑制新血管形成的用途。

15. 发明申请

US20120040463A1 HOLLOW, NOTABLY MULTI-MEMBRANE FIBERS, METHOD FOR PREPARATION THEREOF BY SPINNING AND DEVICE FOR APPLYING SAID METHOD 审中-公开
标题翻译：中空纤维，多孔膜纤维，其纺丝方法及用于施用方法的装置
公开(公告)号：US20120040463A1
公开(公告)日：2012-02-16
申请号：US12676560
申请日：2008-09-05
申请人： Alain Domard , Laurent David , Rocío Nohemí Rivas Araiza
发明人： Alain Domard , Laurent David , Rocío Nohemí Rivas Araiza
IPC分类号： C12N5/07 , B29C55/22 , D01D5/06
CPC分类号： D01D5/24 , B01D69/087 , B01D69/088 , D01D5/06 , D01F2/28 , D01F4/00 , D01F9/00 , D01F9/04
摘要： The present invention relates to a method for preparing fibers, notably of polysaccharide or collagen, by wet spinning under coagulation, said method notably comprising: a step for extruding a coagulable macromolecular assembly solution through a normal die; at least one partial coagulation cycle comprising a coagulation step on the one hand and a step for interrupting the coagulation on the other hand; and a step for receiving, notably by winding up, the obtained hollow fiber. The invention also relates to multi-membrane hollow fibers consisting of a same macromolecular assembly which may be spun by coagulation, notably a natural or modified natural polysaccharide in the physical hydrogel or partly dehydrated state. Said fibers including at least over their length two superposed coaxial membranes separated from each other by an inter-membrane space. The invention also relates to the spinning device for applying said method.
摘要翻译：本发明涉及通过在凝固下湿法纺丝制备纤维，特别是多糖或胶原纤维的方法，所述方法特别包括：通过正常模具挤出可凝结的大分子装配溶液的步骤; 至少一个部分凝固循环一方面包括凝固步骤和另一方面中断凝固的步骤; 以及用于接收，特别是通过卷绕所获得的中空纤维的步骤。本发明还涉及由可以通过凝结而纺出的相同的大分子组合物组成的多膜中空纤维，特别是物理水凝胶或部分脱水状态的天然或改性天然多糖。所述纤维至少在其长度上包括通过膜间间隔彼此分离的两个重叠的同轴膜。本发明还涉及用于应用所述方法的纺丝装置。

16. 发明申请

US20100310631A1 FILAMENT BASED ON HYALURONIC ACID IN THE FORM OF FREE ACID AND METHOD FOR OBTAINING IT 有权
标题翻译：基于免疫酸形式的羟丙酸纤维和获得其的方法
公开(公告)号：US20100310631A1
公开(公告)日：2010-12-09
申请号：US12680257
申请日：2008-09-26
申请人： Alain Domard , Laurent David , Florence Dupasquier
发明人： Alain Domard , Laurent David , Florence Dupasquier
IPC分类号： A61K9/70 , B29C47/00 , D02G3/22 , D02G3/36 , A61K38/22 , A61K38/18 , A61K38/20 , A61K38/21 , A61P31/04 , A61P31/10
CPC分类号： A61K9/70 , A61K47/36 , A61L27/20 , C08J7/04 , C08J7/065 , C08J2305/08 , D01D5/06 , D01F9/00 , D01F11/00 , Y10T428/2913 , Y10T428/2933 , Y10T428/298
摘要： The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
摘要翻译：本发明涉及通过以游离酸形式，特别是可溶于水的方式湿法纺丝基于透明质酸的连续长丝来制备方法。根据本发明的制备方法包括以下步骤：a）制备透明质酸或透明质酸盐，优选透明质酸钠溶液的可纺丝水溶液; b）将所述溶液挤出到挤出模头; c）通过将挤出的溶液通入乙酸浴中形成长丝，浓缩至80％以上，拉伸和干燥。本发明还涉及一种基于游离酸形式的透明质酸的长丝，所述长丝在水和生理液体中具有溶胀性质，而且在某些条件下可溶于水。

17. 发明申请

US20090118336A1 PYRAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS 审中-公开
标题翻译：吡唑衍生物及其作为PI3K抑制剂使用
公开(公告)号：US20090118336A1
公开(公告)日：2009-05-07
申请号：US12299369
申请日：2007-05-02
申请人： Laurent David , Kevin Michael Foote , Annea Lisius
发明人： Laurent David , Kevin Michael Foote , Annea Lisius
IPC分类号： A61K31/4439 , C07D401/14 , C07D417/14 , C07D401/04
CPC分类号： C07D401/04 , C07D417/14
摘要： The invention concerns pyrazole derivatives of Formula I or pharmaceutically-acceptable salts thereof, wherein each of R, Ring A, m, R1, R2 and R3 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.
摘要翻译：本发明涉及式I的吡唑衍生物或其药学上可接受的盐，其中R，环A，m，R 1，R 2和R 3中的每一个具有上文在描述中定义的任何含义; 其制备方法，含有它们的药物组合物及其在治疗中的用途，例如用于治疗由PI3K酶和/或mTOR激酶介导的疾病。

18. 发明授权

US06722392B1 Assembly comprising a tube and a sleeve 失效
标题翻译：组件包括管和套筒
公开(公告)号：US06722392B1
公开(公告)日：2004-04-20
申请号：US10030148
申请日：2002-05-02
申请人： Laurent David , Michael Mittelstaedt
发明人： Laurent David , Michael Mittelstaedt
IPC分类号： F16L1108
CPC分类号： F16B11/006 , Y10T428/139
摘要： The invention concerns an assembly comprising a tube in composite material including carbon fibers embedded in a resin, an extremity of which is equipped with a sleeve in plastic material such as polyamide, optionally equipped with a jointing thread. According to the invention, the tube comprises at least one layer of composite material, and the sleeve is obtained by overmolding injection of material on the tube. Preferably, the composite material constituting the tube comprises two adjacent layers of carbon fibers embedded in carbon, the inner layer being a layer whose fibers are substantially longitudinal, whereas the outer layer comprises helically arranged fibers.
摘要翻译：本发明涉及一种组件，其包括复合材料管，其包括嵌入在树脂中的碳纤维，其末端配备有诸如聚酰胺的塑料材料的套筒，任选地装有接合线。根据本发明，管包括至少一层复合材料，并且通过在管上注射材料进行包覆模制而获得套筒。优选地，构成管的复合材料包括嵌入碳中的两个相邻的碳纤维层，内层是其纤维基本上纵向的层，而外层包括螺旋布置的纤维。

19. 发明授权

US09567406B2 Method for obtaining an elongate polysaccharide element, in particular a chitosan thread 有权
标题翻译：用于获得细长多糖元件，特别是壳聚糖螺纹的方法
公开(公告)号：US09567406B2
公开(公告)日：2017-02-14
申请号：US13582537
申请日：2011-03-04
申请人： Laurent David , Alexandra Montembault , Mylène Desorme
发明人： Laurent David , Alexandra Montembault , Mylène Desorme
IPC分类号： D01F9/00 , C08B37/00 , D01D5/06 , D01F9/04 , B32B27/02
CPC分类号： C08B37/0024 , B32B27/02 , D01D5/06 , D01F9/00 , D01F9/04 , Y10T428/2975 , Y10T442/431
摘要： A method for obtaining an elongate polysaccharide element, in particular a chitosan thread, includes extruding a hydroalcoholic extrusible solution containing a polyalcohol of said polysaccharide through an extrusion die, coagulating the extruded solution by neutralization, and at least one operation of removing the polyalcohol. The ratio of water to polyalcohol in the extrusible solution is determined such as to obtain in the elongate element a polysaccharide with the crystalline structure thereof mainly in the form of an anhydrous allomorph. Since the polysaccharide used to prepare the extrusible solution has a weight-average molar mass Mw0, the polysaccharide in the elongate element obtained preferably has a weight-average molar mass Mw1 comprised between Mw0 and 0.7 Mw0. Since the purpose is to obtain a chitosan thread, the latter has properties of mechanical strength and flexibility that allow the thread to be tied into overhand knots and to be woven without breaking.
摘要翻译：用于获得细长多糖元件，特别是壳聚糖丝线的方法包括通过挤出模头挤出含有所述多糖的多元醇的水醇可渗溶溶液，通过中和凝结挤出的溶液，以及至少一种除去多元醇的操作。确定可挤出溶液中的水与多元醇的比例，以便在细长元件中获得其结晶结构的多糖主要是无水异构体形式的多糖。由于用于制备可膨胀溶液的多糖具有重均摩尔质量Mw0，所获得的细长元件中的多糖优选具有Mw0至0.7Mw0之间的重均摩尔质量Mw1。由于目的是获得一种壳聚糖螺纹，后者具有机械强度和柔韧性的特性，允许将螺纹捆扎成过度的结，并且不会断裂。

20. 发明授权

US09315772B2 Crosslinked hyaluronan hydrogels for 3D cell culture 有权
标题翻译：用于3D细胞培养的交联透明质酸水凝胶
公开(公告)号：US09315772B2
公开(公告)日：2016-04-19
申请号：US13704384
申请日：2011-06-22
申请人： Jean-Pierre Vannier , Laurent David , Didier Lecerf , Virginie Dulong , Berenice Coquerel , Elise Demange
发明人： Jean-Pierre Vannier , Laurent David , Didier Lecerf , Virginie Dulong , Berenice Coquerel , Elise Demange
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N5/0062 , C12N2533/80 , C12N2537/10
摘要： The present invention relates to a new method for treating or processing a cross-linked hyaluronan hydrogel prior to its use in applications involving three-dimensional cell culture. The invention also relates to cross-linked hyaluronan hydrogels prepared by such a method and to their use in 3D cell culture, stem cell/tissue engineering, drug discovery, toxicology testing, and broad cell biology applications.
摘要翻译：本发明涉及一种用于在涉及三维细胞培养物的应用中用于治疗或加工交联的透明质酸水凝胶的新方法。本发明还涉及通过这种方法制备的交联透明质酸水凝胶及其在3D细胞培养，干细胞/组织工程，药物发现，毒理学测试和广泛细胞生物学应用中的应用。

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