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11. 发明授权

US4925969A Process for preparing ethyl-alpha-amino-gamma-oxo-gamma-phenybutyrate derivatives 失效
标题翻译：制备乙基-γ-氨基-γ-氧代-γ-苯基丁酸酯衍生物的方法
公开(公告)号：US4925969A
公开(公告)日：1990-05-15
申请号：US324497
申请日：1989-03-16
申请人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
发明人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
IPC分类号： C07C227/08 , C07C233/46 , C07C271/06
CPC分类号： C07C233/46 , C07C227/08 , C07C271/06
摘要： Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.
摘要翻译：乙基-β-苯甲酸酯与（S） - 丙氨酸的碱金属盐或N6-三氟乙酰基-L-赖氨酸的碱金属盐反应形成相应的迈克尔加成产物，加入不少于等量的酸完成迈克尔加成以防止（S，S）形式的产物转化为（R，S）形式。

12. 发明授权

US4760162A Inorganic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanylchloride and process for preparing the same 失效
标题翻译： N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰氯的无机酸盐及其制备方法
公开(公告)号：US4760162A
公开(公告)日：1988-07-26
申请号：US900050
申请日：1986-08-25
申请人： Kazuhiko Yamada , Yoshifumi Yanagida , Satomi Takahashi , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Kazuhiko Yamada , Yoshifumi Yanagida , Satomi Takahashi , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： A61K31/215 , A61K31/22 , A61P9/12 , A61P43/00 , C07C227/18 , C07C229/36 , C07K5/02 , C07C101/10
CPC分类号： C07K5/0222
摘要： An inorganic acid salt of N-[1(S)-ethyoxycarbonyl-3-phenylpropyl]-L-alanylchloride having the formula (I): ##STR1## A process for preparing an inorganic acid salt of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanylchloride having the formula (I) ##STR2## which comprises reacting an inorganic acid salt of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine with phosphorous pentachloride in an inactive organic solvent. According to the present invention, ACEI can be economically and easily prepared.
摘要翻译：具有式（I）的N- [1（S） - 乙氧羰基-3-苯基丙基] -L-丙氨酰氯的无机酸盐：（I）制备N- [1 （I）的S） - 乙氧基羰基-3-苯基丙基] -L-丙氨酰氯，其包括使N- [1（S） - 乙氧基羰基-3-苯基丙基] -L- 丙二酸酯与五氯化磷在惰性有机溶剂中反应。根据本发明，ACEI可以经济地和容易地制备。

13. 发明授权

US4898822A Process for preparing optically active indoline-2-carboxylic acid 失效
标题翻译：光学活性二氢吲哚-2-羧酸的制备方法
公开(公告)号：US4898822A
公开(公告)日：1990-02-06
申请号：US846436
申请日：1986-03-31
申请人： Masanori Asada , Shigeki Hamaguchi , Hidetoshi Katsuki , Yoshio Nakamura , Hideyuki Takahashi , Kenji Takahara , Yoshio Shimada , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Masanori Asada , Shigeki Hamaguchi , Hidetoshi Katsuki , Yoshio Nakamura , Hideyuki Takahashi , Kenji Takahara , Yoshio Shimada , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C12P17/10 , C12P41/00
CPC分类号： C12P17/10 , C12P41/005 , Y10S435/83 , Y10S435/839 , Y10S435/843 , Y10S435/874 , Y10S435/897 , Y10S435/911 , Y10S435/921 , Y10S435/925
摘要： A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*].According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.
摘要翻译：通过光学拆分制备光学活性二氢吲哚-2-羧酸的方法，其包括使具有通式[（R，S）-I]的（R，S） - 二氢吲哚-2-羧酸的外消旋酯与具有立体选择性酯酶活性的酶或微生物的作用，其能够不对称地水解外消旋酯[（R，S）-I]，得到具有式[II *]的光学活性二氢吲哚-2-羧酸， ]以产生水解产物，即具有通式[I *]的光学活性二氢吲哚-2-羧酸[II *]和未反应的二氢吲哚-2-羧酸的光学活性酯，分离每种光学活性形式，此外，如果需要，水解得到的光学活性酯[I *]，得到酸[II *]的光学对映体。根据本发明的方法，可以以简单的方法制备具有高光学纯度的光学活性二氢吲哚-2-羧酸，产率高。

14. 发明授权

US4716235A Process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline 失效
标题翻译：制备N- [1（S） - 乙氧基羰基-3-苯基丙基] -L-丙氨酰-L-脯氨酸的方法
公开(公告)号：US4716235A
公开(公告)日：1987-12-29
申请号：US900051
申请日：1986-08-25
申请人： Satomi Takahashi , Kenji Inoue , Yoshifumi Yanagida , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Satomi Takahashi , Kenji Inoue , Yoshifumi Yanagida , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C07K14/81 , C07D207/16 , C07K1/02 , C07K5/02 , C07K5/06 , C07K14/435 , C07D207/09
CPC分类号： C07K5/0222
摘要： A process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline, which comprises reacting N-carboxyanhydride of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine with L-proline in the presence of a base. According to the process, enalapril can be prepared economically, easily and effectively.
摘要翻译：制备N- [1（S） - 乙氧基羰基-3-苯丙基] -L-丙氨酰-L-脯氨酸的方法，其包括使N- [1（S） - 乙氧基羰基-3-苯基丙基] -L-脯氨酸的N-羧酸酐 - 丙氨酸与L-脯氨酸在碱的存在下。根据该过程，依那普利可以经济，容易和有效地制备。

15. 发明授权

US4863859A Process for preparing optically active glycerol derivatives 失效
标题翻译：光学活性甘油衍生物的制备方法
公开(公告)号：US4863859A
公开(公告)日：1989-09-05
申请号：US822494
申请日：1986-01-27
申请人： Shigeki Hamaguchi , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Shigeki Hamaguchi , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C12P11/00 , C12P41/00
CPC分类号： C12P41/004 , C12P11/00
摘要： A process for preparing optically active glycerol derivatives by a biochemical resolution which comprises (i) subjecting an ester having the general formula [(R,S)-I]: ##STR1## wherein X is a halogen atom, R is an aliphatic hydrocarbon group of C.sub.1 to C.sub.8 and R' is an aromatic hydrocarbon group or an aliphatic hydrocarbon group of C.sub.1 to C.sub.2, to the action of enzymes derived from either microorganisms or animal organs, wherein said enzymes have a stereo selective esterase activity to asymmetrically hydrolyze the ester having the general formula [(R,S)-I] to give a mixture of an optically active alcohol having the general formula (II)*: ##STR2## wherein X and R' are as above and an optically active ester having the general formula (I)*: ##STR3## wherein X, R and R' are as above, and (ii) obtaining the optically active alcohol having the general formula (II)* and the optically active ester having the general formula (I)* by separating operations.In accordance with the present invention, there can be provided a process for preparing optically active glycerol derivatives, wherein the optically active ester having the general formula (I)* and the optically active alcohol having the general formula (II)* can be easily obtained.
摘要翻译：一种通过生化分解制备光学活性甘油衍生物的方法，其包括（i）使具有通式[（R，S）-I]的酯：其中X为卤素原子，R是C1至C8的脂族烃基，R'是C1至C2的芳族烃基或脂族烃基，来自微生物或动物器官的酶的作用，其中所述酶具有立体声选择性酯酶活性以不对称地水解具有通式[（R，S）-I]的酯，得到具有通式（II）的光学活性醇的混合物：其中X和R （I）*：其中X，R和R'如上所述，和（ii）获得具有通式（I）的光学活性酯，其具有通式（I） II）*和具有通式（I）*的光学活性酯通过分离操作。根据本发明，可以提供一种制备光学活性甘油衍生物的方法，其中可以容易地获得具有通式（I）*的光学活性酯和具有通式（II）*的光学活性醇。

16. 发明授权

US4814506A Process for preparing 3 halogeno-2-hydroxypropyltrimethylammonium halide 失效
标题翻译：制备3卤代-2-羟丙基三甲基卤化铵的方法
公开(公告)号：US4814506A
公开(公告)日：1989-03-21
申请号：US088331
申请日：1987-08-21
申请人： Kazuhiko Katayama , Shigeki Hamaguchi , Yoshikazu Kogame , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Kazuhiko Katayama , Shigeki Hamaguchi , Yoshikazu Kogame , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C07C215/08 , C07C209/74 , C07C215/40 , C07C85/06
CPC分类号： C07C213/08 , C07C215/40
摘要： A process for preparing 3-halogeno-2-hydroxy-propyltrimethylammonium halide or especially one having the (S)-configuration, which comprises reacting 2,3-dihydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is obtained by reacting (R)-3-halogeno-1,2-propanediol with trimethylamine, with a halogenating reagent.According to the present invention, 3-halogeno-2-hydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is a useful intermediate for the synthesis of carnitine or especially (l)-carnitine, can be obtained economically, efficiently and easily.
摘要翻译：制备3-卤代-2-羟基 - 丙基三甲基卤化铵的方法，特别是具有（S） - 构型的方法，其包括使2,3-二羟基丙基三甲基卤化铵或具有（S） - 构型的反应，其通过使（ R）-3-卤代-1,2-丙二醇与三甲胺，与卤化试剂反应。根据本发明，可以经济，有效和容易地获得3-卤代-2-羟丙基三甲基卤化铵或具有（S） - 构型的化合物，其是合成肉碱或特别是（l） - 肉碱的有用中间体。

17. 发明授权

US4649197A Sulfate of 5,6,7,8-tetrahydro-L-erythro-biopterin and process for preparing the same 失效
标题翻译： 5,6,7,8-四氢-L-赤式生物蝶呤的硫酸盐及其制备方法
公开(公告)号：US4649197A
公开(公告)日：1987-03-10
申请号：US712813
申请日：1985-03-18
申请人： Hayashi Uchino , Masaaki Azuma , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Hayashi Uchino , Masaaki Azuma , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： A61K31/505 , A61K31/519 , A61P25/00 , A61P25/24 , A61P25/26 , A61P43/00 , C07D475/04
CPC分类号： C07D475/04
摘要： A sulfate of tetrahydrobiopterin having the formula (I): ##STR1## and a process for preparing the same, which comprises crystallizing tetrahydrobiopterin from an aqueous medium containing sulfuric acid. The sulfate of the (6R)-form of (1) has a high crystallinity and the process easily gives a sulfate of the (6R)-form
摘要翻译：具有式（I）的四氢生物蝶呤的硫酸盐：其中包括使其从含有硫酸的水性介质中结晶出四氢生物蝶呤的方法。（6R）型硫酸盐（1

18. 发明授权

US4595752A Process for preparing 5,6,7,8-tetrahydro-6-(L-erythro-1',2'-dihydroxypropyl)pterin 失效
标题翻译：制备5,6,7,8-四氢-6-（L-赤式-1'，2'-二羟丙基）蝶呤的方法
公开(公告)号：US4595752A
公开(公告)日：1986-06-17
申请号：US703976
申请日：1985-02-21
申请人： Masaaki Azuma , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Masaaki Azuma , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： B01J23/00 , B01J23/40 , C07B61/00 , C07D475/04
CPC分类号： C07D475/04
摘要： A process for preparing tetrahydrobiopterin which is rich in the (6R)-form, which comprises hydrogenating L-erythrobiopterin in a basic medium in the presence of a platinum group catalyst. According to the process, tetrahydrobiopterin improved in (6R)/(6S) ratio can be easily obtained in the high yield.
摘要翻译：一种富含（6R）形式的四氢生物喋呤的方法，其包括在铂族催化剂存在下在碱性介质中氢化L-赤藓红素。根据该方法，可以以高产率容易地获得（6R）/（6S）比例的四氢生物喋呤。

19. 发明授权

US4460780A Process for preparation of optically active thiol compounds 失效
标题翻译：光学活性硫醇化合物的制备方法
公开(公告)号：US4460780A
公开(公告)日：1984-07-17
申请号：US457377
申请日：1983-01-12
申请人： Takehisa Ohashi , Masami Shimazaki , Kenji Nomura , Yasushi Nose , Kiyoshi Watanabe
发明人： Takehisa Ohashi , Masami Shimazaki , Kenji Nomura , Yasushi Nose , Kiyoshi Watanabe
IPC分类号： C07D207/16 , C07D277/06
CPC分类号： C07D277/06 , C07D207/16
摘要： An improved process for preparation of an optically active N-(3-mercapto-2-D-methylpropanoyl)-L-amino acid represented by formula (I): ##STR1## from an N-(3-chloro-2-D-methylpropanoyl)-L-amino acid represented by formula (II): ##STR2## (Y in (I) and (II): CH.sub.2 or sulfur; Q in (II): hydrogen, Na, K or NH.sub.4),which is characterized by reacting the compound (II) with an alkali trithiocarbonate, of which the molar ratio to the compound (II) is not less than 1.5, in an aqueous medium at a temperature of from about 60.degree. C. to about 90.degree. C., and hydrolyzing the resulting product with an acid.It is preferable to use sodium trithiocarbonate as the alkali trithiocarbonate, mineral acid as the acid, or water or aqueous alcohol as an aqueous medium.
摘要翻译：由式（I）表示的光学活性N-（3-巯基-2-D-甲基丙酰基）-L-氨基酸的改进方法：从N-（3-氯-2 （II）表示的（ⅰ）和（II）中的Y：CH 2或硫;（II）中的Q：氢，Na，K或 NH4），其特征在于使化合物（II）与碱性三硫代碳酸酯反应，其中化合物（II）的摩尔比不小于1.5，在水介质中在约60℃至约60℃至约90℃，并用酸水解所得产物。优选使用三硫代碳酸钠作为碱式三硫代碳酸酯，无机酸作为酸，或水或含水醇作为水性介质。

20. 发明授权

US08581123B2 Touch panel 有权
标题翻译：触控面板
公开(公告)号：US08581123B2
公开(公告)日：2013-11-12
申请号：US13242515
申请日：2011-09-23
申请人： Masao Ozeki , Takashi Shimada , Kiyoshi Watanabe
发明人： Masao Ozeki , Takashi Shimada , Kiyoshi Watanabe
IPC分类号： G06F3/042 , G06F3/044
CPC分类号： G06F3/044 , G06F2203/04111
摘要： A touch panel includes a plurality of first and second transparent electrodes extending in first and second directions on one side of a transparent substrate. One of a couple of adjacent electrodes of the first electrodes and a couple of adjacent electrodes of the second electrodes at each of crossing portions has no interruption while the adjacent electrodes of the other couple are interrupted. A transparent interlayer insulting film is disposed as an upper layer on the one couple at each of the crossing portions. A metal bridge electrode is an upper layer on the interlayer insulting film to connect between the adjacent electrodes of the other couple. Each of the coupling portions has a greater length than the bridge portion.
摘要翻译：触摸面板包括在透明基板的一侧上在第一和第二方向上延伸的多个第一和第二透明电极。在每个交叉部分，第一电极的一对相邻电极和第二电极的一对相邻电极之间没有中断，而另一对的相邻电极被中断。透明的层间绝缘膜在每个交叉部分设置在一对上的上层。金属桥电极是层间绝缘膜上的上层，用于连接另一对的相邻电极之间。每个联接部分具有比桥接部分更大的长度。

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