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11. 发明授权

US07634359B2 Computerized system and method for building a system of test components for a healthcare orderable procedure 有权
标题翻译：计算机化系统和方法，用于构建医疗可订购程序的测试组件系统
公开(公告)号：US07634359B2
公开(公告)日：2009-12-15
申请号：US11028379
申请日：2005-01-03
申请人： Mark A. Hoffman , Kevin M. Power , Ginger H. Kuhns , Nicholas Smith
发明人： Mark A. Hoffman , Kevin M. Power , Ginger H. Kuhns , Nicholas Smith
IPC分类号： G06F1/00
CPC分类号： G06Q50/22 , G06F19/00 , G06Q10/067 , G06Q10/10 , G06Q50/24 , Y10S707/99943
摘要： A computerized system and method of building a system of test components for an orderable healthcare procedure is provided. An orderable healthcare procedure is received and associated with a discrete ontology concept. An ontology is traversed for the discrete ontology concept to identify test components related to the discrete ontology concept. The test components related to the discrete ontology concept are identified.
摘要翻译：提供了一种用于建立可订购医疗程序的测试组件系统的计算机化系统和方法。收到有序的医疗程序并与离散本体概念相关联。遍历离散本体概念的本体来识别与离散本体概念相关的测试组件。确定与离散本体概念相关的测试组件。

12. 发明申请

US20050026963A1 Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5 有权
标题翻译：代谢型谷氨酸受体-5的杂芳基取代的吡唑调节剂
公开(公告)号：US20050026963A1
公开(公告)日：2005-02-03
申请号：US10497122
申请日：2002-12-13
申请人： Nicholas Cosford , Chixu Chen , Brian Eastman , Dehua Huang , Benito Munoz , Petpiboon Prasit , Nicholas Smith
发明人： Nicholas Cosford , Chixu Chen , Brian Eastman , Dehua Huang , Benito Munoz , Petpiboon Prasit , Nicholas Smith
IPC分类号： A61K31/4155 , A61K31/424 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/506 , A61K45/00 , A61P3/04 , A61P17/06 , A61P21/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/34 , A61P29/00 , A61P43/00 , C07D231/38 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： C07D231/38 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： Pyrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, circadian rhythm disorders, and other diseases.
摘要翻译：直接或通过桥连与杂芳基相连接的杂芳基部分的吡唑化合物是可用于治疗精神病和情绪障碍（例如精神分裂症，焦虑症，抑郁症）的mGluR5调节剂，双相情感障碍和恐慌，以及治疗疼痛，昼夜节律紊乱和其他疾病。

13. 发明申请

US20190336249A1 Orthodontic Device 审中-公开
公开(公告)号：US20190336249A1
公开(公告)日：2019-11-07
申请号：US16504269
申请日：2019-07-07
申请人： Nicholas Smith
发明人： Nicholas Smith
IPC分类号： A61C7/14 , A61C7/20 , A61C7/28 , C01B32/158
摘要： Systems, methods and apparatus are provided through which in some implementations an orthodontic apparatus includes a plurality of brackets, wherein each of the plurality of brackets includes a carbon-nanotube forest upon a carbon-nanotube bonding substrate that is adhered to a lingual bracket bonding surface, forming a plurality of carbon-nanotube bonding substrates.

14. 发明申请

US20070135431A1 INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的组织脱乙酰酶的抑制剂
公开(公告)号：US20070135431A1
公开(公告)日：2007-06-14
申请号：US11608726
申请日：2006-12-08
申请人： Nicholas Smith , Celine Bonnefous , Joseph Payne , Timothy Hoffman , Paul Wash , Christian Hassig , Shawn Scranton
发明人： Nicholas Smith , Celine Bonnefous , Joseph Payne , Timothy Hoffman , Paul Wash , Christian Hassig , Shawn Scranton
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4439 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07C327/30 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/76 , C07D295/096 , C07D295/26 , C07D413/12
摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开了具有以下结构式的羰基化合物：或其盐，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，中枢神经系统疾病，神经变性使用本发明的化合物，疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地热病，炎性病症，心血管病症和血管发生在发病机理中发挥作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

15. 发明申请

US20070027184A1 Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease 审中-公开
标题翻译：多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
公开(公告)号：US20070027184A1
公开(公告)日：2007-02-01
申请号：US11496784
申请日：2006-07-27
申请人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
发明人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
IPC分类号： A61K31/47 , C07D215/12 , C07D319/14 , A61K31/36
CPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开的是本文所述的式VII的磺酰胺化合物。公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地中海贫血，炎性病症，心血管疾病以及使用本发明化合物的血管发生在发病机理中起作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

16. 发明申请

US20060217420A1 4-Ring imidazole derivatives as modulators of metabotropic glutamate receptor-5 审中-公开
标题翻译： 4-环咪唑衍生物作为代谢型谷氨酸受体-5的调节剂
公开(公告)号：US20060217420A1
公开(公告)日：2006-09-28
申请号：US10552107
申请日：2004-03-30
申请人： Nicholas Cosford , Dehua Huang , Nicholas Smith , Essa Hsinyi Hu
发明人： Nicholas Cosford , Dehua Huang , Nicholas Smith , Essa Hsinyi Hu
IPC分类号： A61K31/444 , C07D403/14
CPC分类号： C07D233/64 , C07D401/04 , C07D401/14 , C07D471/04
摘要： Imidazole compounds of Formula (I): (where A, B, R11, R12, W, X, Y and Z are as defined herein) wherein the imidazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, which are MgluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases, and pharmaceutical compositions and methods of treating these diseases.
摘要翻译：式（I）的咪唑化合物（其中A，B，R 11，R 12，W，X，Y和Z如本文所定义），其中咪唑是直接或桥接，其中i）杂芳基部分，其含有与杂芳基的连接点相邻的N，和ii）另一杂芳基或芳基环，其中至少一个环进一步被另一个环取代，用于治疗精神病和情绪障碍（例如精神分裂症，焦虑症，抑郁症，双相性精神障碍和恐慌）以及治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律和睡眠的MgluR5调节剂疾病 - 如转移工作诱导的睡眠障碍和时滞，药物成瘾，药物滥用，药物戒断，肥胖症等疾病，以及治疗这些疾病的药物组合物和方法。

17. 发明申请

US20050138249A1 Inter-process communication mechanism 有权
标题翻译：进程间通信机制
公开(公告)号：US20050138249A1
公开(公告)日：2005-06-23
申请号：US10885240
申请日：2004-07-07
申请人： Mark Galbraith , Harry Fearnhamm , Nicholas Smith , Bruce Mathewson
发明人： Mark Galbraith , Harry Fearnhamm , Nicholas Smith , Bruce Mathewson
IPC分类号： G06F15/167 , G06F11/30 , G06F13/00 , G06F15/163 , G06F15/17 , G06F15/80
CPC分类号： G06F15/17
摘要： A data processing apparatus comprises at least one source processor core (110), at least two destination processor cores (120), a message handler (130) and a bus arrangement (150) providing a data communication path between the source core, the destination cores and the message handler. The message handler (130) has plurality of message-handling modules (132-1 to 132-3). At least one of the message-handling modules has a message receipt indicator that is modifiable by each of the destination processor cores to indicate that a message has been received at its destination. This message-handling module also has a transmission completion detector operable to detect, in dependence upon a message receipt indicator value that a message has been received by all of the at least two destination processor cores and to initiate transmission of an acknowledgement signal to the source processor core.
摘要翻译：数据处理装置包括至少一个源处理器核心（110），至少两个目的处理器核心（120），消息处理器（130）和总线装置（150），其提供源核心，目的地之间的数据通信路径内核和消息处理程序。消息处理器（130）具有多个消息处理模块（132-1至132-3）。消息处理模块中的至少一个具有可由每个目的处理器核心修改以指示在其目的地已经接收到消息的消息接收指示符。该消息处理模块还具有传输完成检测器，其可操作用于根据消息接收指示符值来检测消息已被所有至少两个目的处理器核心中的所有接收器接收并且发起确认信号到源处理器核心。

18. 发明申请

US20050034017A1 Cross-triggering of processing devices 有权
标题翻译：交叉触发处理设备
公开(公告)号：US20050034017A1
公开(公告)日：2005-02-10
申请号：US10633363
申请日：2003-08-04
申请人： Cedric Airaud , Nicholas Smith , Paul Kimelman , Ian Field , Man Yiu , David McHale , Andrew Swaine
发明人： Cedric Airaud , Nicholas Smith , Paul Kimelman , Ian Field , Man Yiu , David McHale , Andrew Swaine
IPC分类号： G06F11/28 , G06F9/48 , G06F11/07 , G06F11/27 , G06F11/30 , H05K10/00
CPC分类号： G06F11/366 , G06F11/2242 , G06F11/3632 , G06F11/3636
摘要： A data processing apparatus controls cross-triggering of diagnostic processes on a plurality of processing devices. The data processing apparatus comprises a routing module having a plurality of broadcast channels, one or more of the broadcast channels being operable to indicate the occurrence of a diagnostic event on one or more of the plurality of processing devices. The data processing apparatus also comprises an mapping module associated with a corresponding processing device. The interface module programmably asserts diagnostic event signals from the associated processing device to one or more of the plurality of broadcast channels and programmably retrieves diagnostic events signals from processing devices other than the associated processing device from one or more of the plurality of broadcast channels. The retrieved diagnostic event data is used to facilitate triggering of a diagnostic process on the associated processing device in dependence upon said retrieved diagnostic event data.
摘要翻译：数据处理装置控制多个处理装置上的诊断处理的交叉触发。数据处理装置包括具有多个广播信道的路由模块，一个或多个广播信道可操作以指示在多个处理设备中的一个或多个上发生诊断事件。数据处理装置还包括与对应的处理装置相关联的映射模块。接口模块可编程地将来自相关联的处理设备的诊断事件信号断言成多个广播信道中的一个或多个，并且可编程地从多个广播信道中的一个或多个处理装置处理除相关联的处理设备之外的处理设备的诊断事件信号。所检索的诊断事件数据用于根据所检索的诊断事件数据来便利触发关联处理设备上的诊断过程。

19. 发明授权

US08800173B2 Shoelace protector and methods thereof 有权
标题翻译：鞋带保护器及其方法
公开(公告)号：US08800173B2
公开(公告)日：2014-08-12
申请号：US13215417
申请日：2011-08-23
申请人： Nicholas Smith
发明人： Nicholas Smith
IPC分类号： A43C11/00 , A43B11/00 , A43C7/00 , A43C5/00
CPC分类号： A43C5/00 , A43C7/00 , Y10T24/3711 , Y10T24/3726 , Y10T24/3742
摘要： A shoelace protector can include a fastening member, enclosure and upper section. The fastening member can be inserted into to an eyelet of a shoe to properly support the shoelace protector. The shoelace can be strung into the fastening member and through the enclosure. The enclosure can surround the shoe lace on an exterior portion of the shoe. The shoelace can then be placed through the upper section. The upper section can provide a narrow slit such that the shoelace can be fit therethrough. Two or more shoelace protectors can be fitted into the eyelets of the shoe. The protectors can be positioned on the lower eyelets such that the bend created by the eyelet on the shoelace can be protected during use.
摘要翻译：鞋带保护器可以包括紧固构件，外壳和上部。紧固构件可以插入到鞋的孔眼中以适当地支撑鞋带保护器。鞋带可以穿入紧固件并穿过外壳。外壳可以在鞋的外部部分上围绕鞋带。然后鞋带可以通过上部放置。上部可以提供狭窄的狭缝，使得鞋带可以穿过其中。鞋子的孔眼中可以安装两个或更多的鞋带保护装置。保护器可以定位在下眼圈上，使得鞋带上的孔眼产生的弯曲可以在使用过程中得到保护。

20. 发明授权

US08001097B2 Computerized system and method for building a system of test components for a healthcare orderable procedure 有权
标题翻译：计算机化系统和方法，用于构建医疗可订购程序的测试组件系统
公开(公告)号：US08001097B2
公开(公告)日：2011-08-16
申请号：US12626270
申请日：2009-11-25
申请人： Mark A. Hoffman , Kevin M. Power , Ginger H. Kuhns , Nicholas Smith
发明人： Mark A. Hoffman , Kevin M. Power , Ginger H. Kuhns , Nicholas Smith
IPC分类号： G06F7/00
CPC分类号： G06Q50/22 , G06F19/00 , G06Q10/067 , G06Q10/10 , G06Q50/24 , Y10S707/99943
摘要： A computerized system and method of building a system of test components for an orderable healthcare procedure is provided. An orderable healthcare procedure is received and associated with a discrete ontology concept. An ontology is traversed for the discrete ontology concept to identify test components related to the discrete ontology concept. The test components related to the discrete ontology concept are identified.
摘要翻译：提供了一种用于建立可订购医疗程序的测试组件系统的计算机化系统和方法。收到有序的医疗程序并与离散本体概念相关联。遍历离散本体概念的本体来识别与离散本体概念相关的测试组件。确定与离散本体概念相关的测试组件。

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