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11. 发明授权

US5578457A Immunoassays with novel labeled carbamazepine hapten analogues 失效
标题翻译：新型标记卡马西平半抗原类似物的免疫测定
公开(公告)号：US5578457A
公开(公告)日：1996-11-26
申请号：US926202
申请日：1992-08-07
申请人： Barbara A. Brummond , Mohan S. Saini , Ignazio S. Ponticello
发明人： Barbara A. Brummond , Mohan S. Saini , Ignazio S. Ponticello
IPC分类号： C07D223/22 , C07D403/12 , G01N33/535 , G01N33/94 , G01N33/545 , C12N9/96
CPC分类号： C07D403/12 , C07D223/22 , G01N33/535 , G01N33/9486 , Y10S436/815
摘要： An immunoassay method and analytical elements for detecting carbamazepine drugs, for example, in body fluids, is described. The immunoassay method comprises:(A) contacting a liquid sample, containing carbamazepine, with a labeled carbamazepine analogue in the presence of antibodies for carbamazepine under conditions that promote the formation of carbamazepine/antibody immunocomplexes; and(B) determining the quantity of the drug in the liquid by measuring bound or unbound labeled drug analogue; characterized in that the labeled carbamazepine comprises:(1) a label, of the type used in immunoassays, having an amine or sulfhydryl group;(2) a carbamazepine nucleus; and(3) a linking chain linking the carboxamide group of the carbamazepine nucleus to the label, said linking chain having about 4 to about 40 atoms consisting of:(a) alkylene groups; and(b) heterocyclic ring groups, each group being joined into the linking group through chemical groups selected from(a) esters,(b) amides,(c) heteroatoms selected from --O--, --S--, and --NR--; wherein each R independently represents hydrogen or C.sub.1 to C.sub.6 alkyl; and(d) carbonyl groups.The elements of the invention are preferably dry, thin film analytical elements comprising a labeled carbamazepine analogue as described.
摘要翻译：描述了用于检测卡马西平药物（例如体液）的免疫测定方法和分析元件。免疫测定方法包括：（A）在促进形成卡马西平/抗体免疫复合物的条件下，在卡马西平抗体存在下，将含有卡马西平的液体样品与标记的卡马西平类似物接触; 和（B）通过测量结合或未结合的标记药物类似物来确定液体中药物的量; 其特征在于所述标记的卡马西平包括：（1）用于免疫测定中的具有胺或巯基的类型的标签; （2）卡马西平核; 所述连接链具有约4至约40个原子，由（a）亚烷基组成;和（3）连接卡马西平核的羧酰胺基团与标记物的连接链。每个基团通过选自（a）酯，（b）酰胺，（c）选自-O - ， - S - 和 - NR-的杂原子的化学基团连接到连接基团中; 其中每个R独立地表示氢或C1-C6烷基; 和（d）羰基。本发明的元件优选为干燥的薄膜分析元件，其包含如上所述的标记的卡马西平类似物。

12. 发明授权

US5434270A Weakly basic polymerizable monomers and polymers prepared therefrom 失效
标题翻译：弱碱性的可聚合单体和由其制备的聚合物
公开(公告)号：US5434270A
公开(公告)日：1995-07-18
申请号：US306341
申请日：1994-09-15
申请人： Ignazio S. Ponticello , Jerome C. Swartz , Tobias E. Ekeze
发明人： Ignazio S. Ponticello , Jerome C. Swartz , Tobias E. Ekeze
IPC分类号： C07D233/61 , C07D233/70 , C07D521/00 , C08F20/52 , C08F20/56
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Weakly basic ethylenically unsaturated polymerizable monomers and polymers have been prepared. The monomers are represented by the structure (I): ##STR1## wherein R is hydrogen or methyl, and R.sup.1 is alkylene of 1 to 3 carbon atoms. The resulting polymers are water-soluble and cationic at acidic pH, but water-insoluble and neutral in charge at basic pH. The polymers are useful for precipitating nucleic acids.
摘要翻译：已经制备了弱碱性烯键式不饱和可聚合单体和聚合物。单体由结构（I）表示：其中R是氢或甲基，R 1是1至3个碳原子的亚烷基。所得聚合物在酸性pH下为水溶性和阳离子性，但在碱性pH下为电荷，为水不溶性和中性。聚合物可用于沉淀核酸。

13. 发明授权

US5298403A Labeled drug hapten analogues for immunoassays 失效
标题翻译：标记的药物半抗原类似物用于免疫测定
公开(公告)号：US5298403A
公开(公告)日：1994-03-29
申请号：US851439
申请日：1992-03-16
申请人： Susan J. Danielson , Barbara A. Brummond , Marsha D. B. Oenick , Ignazio S. Ponticello , David A. Hilborn
发明人： Susan J. Danielson , Barbara A. Brummond , Marsha D. B. Oenick , Ignazio S. Ponticello , David A. Hilborn
IPC分类号： G01N33/532 , G01N33/94 , C07D235/30 , C12N9/02 , C12N9/08 , C12Q1/00
CPC分类号： G01N33/948 , G01N33/532 , G01N33/94
摘要： The invention is directed to labeled drug hapten analogues comprising:(A) a label, of the type used in immunoassays, having an amine or sulfhydryl group;(B) a drug hapten nucleus selected from barbiturates or hydantoins and(C) a linking chain linking the 3-position of the drug hapten nucleus to the label through a carbonyl bridge.
摘要翻译：本发明涉及标记的药物半抗原类似物，包括：（A）在免疫测定中使用的具有胺或巯基的类型的标记; （B）选自巴比妥酸盐或乙内酰脲的药物半抗原核，（C）通过羰基桥连接药物半抗原核的3位与衔接标记的连接链。

14. 发明授权

US5286450A Bilirubin assay using crosslinkable polymers 失效
标题翻译：使用可交联聚合物的胆红素测定
公开(公告)号：US5286450A
公开(公告)日：1994-02-15
申请号：US892073
申请日：1992-06-01
申请人： Stephen C. Hasselberg , Ignazio S. Ponticello , David M. Taylor
发明人： Stephen C. Hasselberg , Ignazio S. Ponticello , David M. Taylor
IPC分类号： G01N33/52 , G01N33/72 , G01N21/77 , G01N33/00
CPC分类号： G01N33/526 , Y10T436/146666 , Y10T436/25125
摘要： A colorimetric assay for the determination of conjugated or unconjugated bilirubin in biological fluids can be carried out with an improved analytical element. The element includes a support having thereon a gelatin-free mordant layer with a positively-charged interactive mordant having at least one binding site for bilirubin, a radiation-blocking layer, and a porous spreading layer. The interactive mordant is dispersed in a binder material of crosslinkable copolymers which include a monomer capable of reaction with a crosslinking agent to crosslink the copolymer.
摘要翻译：可以用改进的分析元件进行用于测定生物液体中的共轭或非共轭胆红素的比色测定。该元件包括其上具有无明胶的媒染剂层的带有带正电荷的交替媒染剂的载体，其具有至少一个胆红素结合位点，辐射阻挡层和多孔扩散层。交联媒染剂分散在可交联共聚物的粘合剂材料中，其包括能够与交联剂反应以交联共聚物的单体。

15. 发明授权

US3939130A Polymers of monomers containing active methylene groups and other ethylenically unsaturated monomers 失效
标题翻译：含有活性亚甲基和其它烯属不饱和单体的单体的聚合物
公开(公告)号：US3939130A
公开(公告)日：1976-02-17
申请号：US497803
申请日：1974-08-15
申请人： Ignazio S. Ponticello
发明人： Ignazio S. Ponticello
IPC分类号： C08F12/22 , C08F16/36 , C08F20/26 , G03C1/04 , C08F28/00 , C08G75/00
CPC分类号： G03C1/04 , C08F12/22 , C08F16/36 , C08F20/26
摘要： Disclosed herein is a polymer comprisingA. from about 1 to 100% by weight of a polymerized monomer containing at least one active methylene group and having the formula ##EQU1## wherein n is 0 or 1, R is hydrogen or methyl, R' is substituted or unsubstituted arylenethylene having the structure ##EQU2## wherein Ar is arylene, R.sup.2 is hydrogen, alkyl, aryl, or cycloalkyl, R.sup.3 is alkoxy or amino when n is equal to 0, and R.sup.3 is alkyl, alkoxy, amino, cycloalkyl or aryl when n is equal to 1; andB. from 0 to about 99% by weight of at least one additional polymerized ethylenically unsaturated monomer.
摘要翻译：本文公开了一种聚合物，其包含约1至100重量％的包含至少一个活性亚甲基并且具有式R OO的聚合单体的聚合物;平行CH 2 = C-R 1）n C-CH 2 -C 其中n为0或1，R为氢或甲基，R'为具有结构-Ar-CH 2 -CH 2 - 的取代或未取代的芳亚乙烯基，其中Ar为亚芳基，R 2为氢，烷基，芳基或环烷基，R 3 当n等于0时，是烷氧基或氨基，当n等于1时，R 3是烷基，烷氧基，氨基，环烷基或芳基; 和B为0至约99重量％的至少一种另外的聚合烯属不饱和单体。

16. 发明授权

US5543311A Labeled carbamazepine hapten analogues for competitive enzyme immunoassays 失效
标题翻译：标记的卡马西平半抗原类似物用于竞争性酶免疫测定
公开(公告)号：US5543311A
公开(公告)日：1996-08-06
申请号：US926203
申请日：1992-08-07
申请人： Barbara A. Brummond , Mohan S. Saini , Ignazio S. Ponticello
发明人： Barbara A. Brummond , Mohan S. Saini , Ignazio S. Ponticello
IPC分类号： C07D223/22 , C07D403/12 , G01N33/535 , G01N33/94 , C12N9/96
CPC分类号： C07D403/12 , C07D223/22 , G01N33/535 , G01N33/9486
摘要： A labeled carbamazepine analogue is described comprising:(A) a label, of the type used in immunoassays, having an amine or sulfhydryl group such as horseradish peroxidase;(B) a carbamazepine nucleus; and(C) a linking chain linking the carboxamide group of the carbamazepine nucleus to the label, said linking chain having about 4 to about 40 atoms consisting of:(1) C.sub.2 to C.sub.6 alkylene groups; and(2) 5 to 7 membered heterocyclic ring groups, each group being joined into the linking group through chemical groups selected from(a) esters,(b) amides(c) heteroatoms selected from --O--, --S--, and --NR--; wherein R represents hydrogen or C.sub.1 to C.sub.6 alkyl; and(d) carbonyl.The new labeled analogues are useful in immunoassay elements and processes for detection of carbamazepine drugs, for example, in body fluids.
摘要翻译：描述了标记的卡马西平类似物，其包含：（A）在免疫测定中使用的具有胺或巯基的类型的标签，例如辣根过氧化物酶; （B）卡马西平核; 和（C）连接卡马西平核的羧酰胺基团与标记物的连接链，所述连接链具有约4至约40个原子，由以下组成：（1）C2至C6亚烷基; 每个基团通过选自（a）酯，（b）酰胺（c）选自-O - ， - S - 和 - 的杂原子的化学基团连接到连接基团中， NR-; 其中R表示氢或C1至C6烷基; 和（d）羰基。新的标记的类似物可用于免疫测定元件和用于检测卡马西平药物（例如体液）的方法。

17. 发明授权

US5429931A Multilayer analytical element containing crosslinked binder and method for the determination of ethanol 失效
标题翻译：含有交联粘合剂的多层分析元素和乙醇测定方法
公开(公告)号：US5429931A
公开(公告)日：1995-07-04
申请号：US66291
申请日：1993-05-24
申请人： Richard L. Detwiler , Stephen C. Hasselberg , Ignazio S. Ponticello
发明人： Richard L. Detwiler , Stephen C. Hasselberg , Ignazio S. Ponticello
IPC分类号： C12Q1/32 , G01N21/78 , G01N33/497 , G01N33/52 , G01N33/00
CPC分类号： G01N33/526 , G01N33/4972 , Y10T436/17 , Y10T436/204165
摘要： A multilayer analytical element has been prepared for accurate and rapid colorimetric determination of ethanol in aqueous specimens using alcohol dehydrogenase and an oxidized nicotinamide coenzyme. The element includes at least one reagent layer beneath a porous spreading layer. This reagent layer has a crosslinked polymeric binder prepared, in part, with a polymerizable monomer having a halomethylcarbonyl, haloethylcarbonyl, halomethylsulfonyl or haloethylsulfonyl group. Alcohol dehydrogenase is in a layer of the element for reaction with the analyte.
摘要翻译：已经制备了一种多层分析元件，用于使用醇脱氢酶和氧化烟酰胺辅酶精确和快速的比色测定含水样品中的乙醇。该元件包括在多孔扩散层下面的至少一个试剂层。该试剂层具有部分由具有卤代甲基羰基，卤代乙基羰基，卤代甲基磺酰基或卤代乙基磺酰基的可聚合单体制备的交联聚合物粘合剂。醇脱氢酶位于用于与分析物反应的元件的层中。

18. 发明授权

US5284948A Drug hapten analogues for immunoassays 失效
标题翻译：药物半抗原类似物用于免疫测定
公开(公告)号：US5284948A
公开(公告)日：1994-02-08
申请号：US851435
申请日：1992-03-16
申请人： Ignazio S. Ponticello , Marsha D. B. Oenick , Susan J. Danielson , David A. Hilborn
发明人： Ignazio S. Ponticello , Marsha D. B. Oenick , Susan J. Danielson , David A. Hilborn
IPC分类号： G01N33/535 , C07D403/12 , G01N33/532 , G01N33/94 , C07D403/00 , C07D233/72 , C07D239/02
CPC分类号： C07D403/12 , G01N33/532 , G01N33/94 , G01N33/948
摘要： The invention is directed to new drug hapten analogues comprising:(A) an active ester group;(B) a drug hapten nucleus selected from a hydantoin nucleus or a barbiturate nucleus and(C) a linking chain linking the 3-position of the drug hapten nucleus to the active ester group.
摘要翻译：本发明涉及新的药物半抗原类似物，其包括：（A）活性酯基; （B）选自乙内酰脲核或巴比妥酸核的药物半抗原核和（C）连接药物半抗原核的3位与活性酯基的连接链。

19. 发明授权

US5149416A Polymeric electrophoresis media 失效
标题翻译：聚合电泳介质
公开(公告)号：US5149416A
公开(公告)日：1992-09-22
申请号：US812885
申请日：1991-12-20
申请人： Hans W. Osterhoudt , Ignazio S. Ponticello , Kenneth G. Christy, Jr. , David B. LaTart
发明人： Hans W. Osterhoudt , Ignazio S. Ponticello , Kenneth G. Christy, Jr. , David B. LaTart
IPC分类号： C08F220/54 , G01N27/447
CPC分类号： G01N27/44747 , C08F220/54
摘要： Preformed, water-soluble, acrylamide based copolymers comprising a minor proportion of a comonomer, which comonomer contains a site for a crosslinking reaction with a selected crosslinking agent by a reaction that does not involve a free-radical vinyl addition mechanism, which copolymers have M.sub.w and M.sub.n values within selected ranges, can be conveniently and safely used to prepare electrophoresis gel media in situ.
摘要翻译：包含少量共聚单体的预成型的水溶性丙烯酰胺基共聚物，该共聚单体含有通过不涉及自由基乙烯基加成机理的反应与所选择的交联剂进行交联反应的位点，该共聚物具有＆选择范围内的Mw和＆amp; Upbar＆Mn值可以方便，安全地用于原位制备电泳凝胶介质。

20. 发明授权

US5077187A Photographic elements silver halide containing a specific polymer and water soluble dye layer 失效
标题翻译：摄影元素含有特定聚合物和水溶性染料层的卤化银
公开(公告)号：US5077187A
公开(公告)日：1991-12-31
申请号：US592765
申请日：1990-10-04
申请人： Ronda E. Factor , Ignazio S. Ponticello
发明人： Ronda E. Factor , Ignazio S. Ponticello
IPC分类号： C08F220/28 , C08F220/60 , G03C1/835 , G03C8/56
CPC分类号： G03C1/835 , C08F220/28 , C08F220/60 , G03C8/56
摘要： Polymers comprising recurring units represented by the structure: ##STR1## where R.sup.1, R.sup.2, D, J, Y, a, b, and c are as defined herein are useful for controlling wandering of filter dyes in photographic elements.
摘要翻译：包含由以下结构表示的重复单元的聚合物：其中R 1，R 2，D，J，Y，a，b和c如本文所定义，可用于控制照相元件中滤光染料的漂移。

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