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11. 发明授权

US09725512B2 HER3 antibodies binding to the beta-hairpin of HER3 有权
公开(公告)号：US09725512B2
公开(公告)日：2017-08-08
申请号：US14073149
申请日：2013-11-06
申请人： Hoffmann-La Roche Inc.
发明人： Birgit Bossenmaier , David Casagolda Vallribera , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , C07K14/195 , A61K47/48 , C07K14/71
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
摘要： The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.

12. 发明授权

US09725511B2 Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4 有权
公开(公告)号：US09725511B2
公开(公告)日：2017-08-08
申请号：US14073137
申请日：2013-11-06
申请人： Hoffmann-La Roche Inc.
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , A61K47/48 , A61K39/00
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.

13. 发明申请

US20150344586A1 Disulfide-Linked Multivalent MHC Class I Comprising Multi-function Proteins 审中-公开
标题翻译：包含多功能蛋白质的二硫键多价MHC I类
公开(公告)号：US20150344586A1
公开(公告)日：2015-12-03
申请号：US14745170
申请日：2013-12-18
申请人： HOFFMANN-LA ROCHE INC.
发明人： Guy Georges , Sabine Imhof-Jung , Hendrik Knoetgen , Martina Schmittnaegel
IPC分类号： C07K16/30 , C07K14/74 , C12N7/00
摘要： Herein is reported a disulfide-linked multivalent multi-function protein, characterized in that it comprises two or more antigen presenting domains, exactly one antibody Fc-region, and at least one antigen binding site, wherein the antigen presenting domain comprises in N- to C-terminal direction either (i) a β2-microglobulin, and (ii) the extracellular domains α1, α2, and α3 of a class I MHC molecule with a relative frequency of less than 1%, or (i) a T-cell response eliciting peptide, (ii) a β2-microglobulin, and (iii) the extracellular domains α1, α2, and α3 of a class I MHC molecule with a relative frequency of 1% or more, wherein the antigen binding site binds to a cancer cell surface antigen or a virus-infected cell surface antigen and wherein the antigen presenting domain has at least two non-naturally occurring cysteine residues which form an intrachain/interdomain disulfide bond.
摘要翻译：本文报道了二硫键连接的多价多功能蛋白质，其特征在于其包含两个或多个抗原呈递结构域，正好一个抗体Fc区和至少一个抗原结合位点，其中抗原呈递结构域包含N- 或（i）a-bgr; 2-微球蛋白，和（ii）相对频率小于1％的I类MHC分子的细胞外结构域α1，α2和α3，或（i）T末端方向 - 细胞响应引发肽，（ii）a＆bgr 2微球蛋白，和（iii）相对频率为1％以上的I类MHC分子的细胞外结构域α1，α2和α3，其中抗原结合位点与癌细胞表面抗原或病毒感染的细胞表面抗原结合，并且其中所述抗原呈递结构域具有至少两个形成链内/间域二硫键的非天然存在的半胱氨酸残基。

14. 发明申请

US20140302015A1 ANTIBODIES AGAINST HUMAN IL33R AND USES THEREOF 审中-公开
标题翻译：抗体对人IL33R的抗体及其用途
公开(公告)号：US20140302015A1
公开(公告)日：2014-10-09
申请号：US14302163
申请日：2014-06-11
申请人： Hoffmann-La Roche Inc.
发明人： Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
摘要： An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
摘要翻译：结合IL33R的抗体，其特征在于重链可变结构域包含SEQ ID NO：1的CDR3区，SEQ ID NO：2的CDR2区和SEQ ID NO：3的CDR1区，并且其中轻链可变区结构域包含SEQ ID NO：4的CDR3区，SEQ ID NO：5的CDR2区和SEQ ID NO：6的CDR1区或嵌合，人源化或T细胞表位缺失的抗体变体具有治疗的有利性质的炎性疾病。

15. 发明授权

US12023378B2 Covalently linked antigen-antibody conjugates 有权
公开(公告)号：US12023378B2
公开(公告)日：2024-07-02
申请号：US16667464
申请日：2019-10-29
申请人： Hoffmann-La Roche Inc.
发明人： Joerg Benz , Ulrich Brinkmann , Stefan Dengl , Sebastian Dziadek , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann
IPC分类号： A61K39/385 , A61K39/00 , A61K47/68 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/28 , C07K16/40 , C07K16/44 , C07K16/46 , G01N33/68
CPC分类号： A61K39/385 , A61K47/6835 , A61K47/6879 , A61K47/6897 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/2896 , C07K16/40 , C07K16/44 , C07K16/468 , G01N33/6857 , A61K2039/6056 , A61K2039/627 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/624 , C07K2317/94
摘要： Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

16. 发明授权

US11680110B2 Three-dimensional structure-based humanization method 有权
公开(公告)号：US11680110B2
公开(公告)日：2023-06-20
申请号：US16633423
申请日：2018-07-27
申请人： Hoffmann-La Roche Inc.
发明人： Johannes Auer , Guy Georges , Stefan Klostermann , Wolfgang Schaefer
IPC分类号： C07K16/46 , C07K16/24 , C07K16/28
CPC分类号： C07K16/464 , C07K16/244 , C07K16/2866 , C07K2317/24 , C07K2317/565
摘要： Herein is reported a method for the humanization of non-human antibodies using a structure-based scoring matrix. With the scoring matrix it is possible to determine (the requirement for and) the suitability of specific (back)mutations of amino acid residues at defined positions of a selected human germline sequence. The scoring matrix takes into account the topology, the three-dimensional structure and the interactions of the respective residue and change. Thereby the influence on antigen binding of a specific amino acid residue change can be determined.

17. 发明授权

US11286300B2 Humanized anti-human CD19 antibodies and methods of use 有权
公开(公告)号：US11286300B2
公开(公告)日：2022-03-29
申请号：US15763868
申请日：2016-09-30
申请人： Hoffmann-La Roche Inc.
发明人： Claudia Ferrara Koller , Guy Georges , Alexander Haas , Hubert Kettenberger , Ekkehard Moessner , Tilman Schlothauer , Michael Molhoj , Laurent Lariviere
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K16/28 , C07K1/00
摘要： Herein is reported an antibody that specifically binds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.

18. 发明授权

US11273223B2 Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles 有权
公开(公告)号：US11273223B2
公开(公告)日：2022-03-15
申请号：US15930579
申请日：2020-05-13
申请人： Hoffmann-La Roche Inc.
发明人： Ulrich Brinkmann , Guy Georges , Olaf Mundigl , Jens Niewoehner
IPC分类号： A61K47/54 , C07K16/28 , C07K16/44 , C07K16/46 , C07K16/40 , C07K16/16 , C07K16/26 , A61K47/60 , A61K47/68 , A61K47/64
摘要： Herein is reported a bispecific antibody comprising a first binding specificity that specifically binds to a haptenylated payload and a second binding specificity that specifically binds to a blood brain barrier receptor.

19. 发明申请

US20210139571A1 HUMANIZED ANTI-TAU(PS422) ANTIBODIES AND METHODS OF USE 有权
公开(公告)号：US20210139571A1
公开(公告)日：2021-05-13
申请号：US17023963
申请日：2020-09-17
申请人： Hoffmann-La Roche Inc.
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.

20. 发明申请

US20210079080A1 ANTI-VEGF ANITBODIES AND METHODS OF USE 有权
公开(公告)号：US20210079080A1
公开(公告)日：2021-03-18
申请号：US16912950
申请日：2020-06-26
申请人： Hoffmann-La Roche Inc.
发明人： Stefan Dengl , Sebastian Fenn , Guy Georges , Joerg Moelleken , Francesca Ros , Esther Koenigsberger
IPC分类号： C07K16/22 , A61K39/395
摘要： The present invention relates to anti-VEGF antibodies and methods of their production and their use.

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