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    • 16. 发明授权
    • Process for production of fluoroalkane carboxamide derivatives
    • 氟代烷酰胺衍生物的制备方法
    • US5484933A
    • 1996-01-16
    • US282562
    • 1994-07-29
    • Sumio NishidaYuzuru Sanemitsu
    • Sumio NishidaYuzuru Sanemitsu
    • C07D277/46C07D277/18
    • C07D277/46
    • There is disclosed a process for the production of a fluoroalkanecarboxamide derivative of the formula (I): ##STR1## wherein R.sup.1 is a halogen atom, an alkyl group substituted with at least one halogen atom or an alkoxyl group substituted with at least one halogen atom; R.sup.2 is a hydrogen atom or a halogen atom; and R.sup.3 is a methyl group, an ethyl group, a chlorine atom or a bromine atom; X and Y are the same or different and each of them represents a hydrogen atom, a chlorine atom, a fluorine atom or a trifluoromethyl group, with the proviso that X and Y do not simultaneously represent a hydrogen atom or a chlorine atom, which comprises the steps of:(a) reacting an iminothiazoline compound of the formula (II): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are each as defined above, or a salt thereof with a fluoroolefin of the formula (III):XYC.dbd.CF.sub.2 (III)wherein X and Y are each as defined above, in the presence of a primary or secondary amine; and(b) reacting the resultant reaction mixture with water.
    • 公开了制备式(I)的氟烷烃甲酰胺衍生物的方法:其中R1是卤素原子,被至少一个卤素原子取代的烷基或至少被取代的烷氧基的式 一个卤素原子; R2是氢原子或卤素原子; 且R 3为甲基,乙基,氯原子或溴原子; X和Y相同或不同,它们各自表示氢原子,氯原子,氟原子或三氟甲基,条件是X和Y不同时表示氢原子或氯原子,其包括 步骤:(a)使式(II)的亚氨基噻唑啉化合物:其中R 1,R 2和R 3各自如上所定义,或其盐与式(III)的氟代烯烃反应: XYC = CF 2(III)其中X和Y各自如上所定义,在伯胺或仲胺的存在下; 和(b)使所得反应混合物与水反应。