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    • 14. 发明授权
    • Trans-.DELTA..sup.2 -pge alkylsulphonyl amides
    • 经DELTA 2-pge烷基磺酰胺
    • US4390548A
    • 1983-06-28
    • US257102
    • 1981-04-24
    • Takashi YamatoHirofumi EndoKimiichiro MatsumotoHajimu Miyake
    • Takashi YamatoHirofumi EndoKimiichiro MatsumotoHajimu Miyake
    • A61K31/557A61K31/5575A61P43/00C07C67/00C07C401/00C07C405/00C07C143/75A61K31/18
    • C07C405/0041C07C405/0033Y02P20/55
    • Prostaglandin analogues of the formula: ##STR1## (wherein R.sup.1 represents an alkyl group containing from 1 to 4 carbon atoms, R.sup.2 represents a single bond or an alkylene group containing from 1 to 5 carbon atoms, R.sup.3 represents a hydrogen atom, an alkyl or alkoxy group containing from 1 to 8 carbon atoms, a cycloalkyl or cycloalkyloxy group containing from 4 to 7 carbon atoms and being unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atom, trifluoromethyl group or alkyl group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom or a hydroxy-protecting group which may be removed under acidic conditions, X represents an ethylene group or a cis-vinylene group, the double bonds between the carbon atoms in positions 2 and 3 and between the carbon atoms in positions 13 and 14 are both in trans-configuration, and the wavy line attached to the carbon atom in position 15 represents .alpha.- or .beta.-configuration or a mixture thereof, provided that, when R.sup.2 represents a single bond, R.sup.3 does not represent an alkoxy group, a cycloalkoxy group or a phenoxy group) and cyclodextrin clathrates thereof are useful compounds: those in which R.sup.4 represents a hydrogen atom possess selective prostaglandin-like properties.
    • 具有下式的前列腺素类似物:其中R 1表示含有1至4个碳原子的烷基,R 2表示单键或含有1至5个碳原子的亚烷基,R 3表示氢原子,烷基或 含有1至8个碳原子的烷氧基,含有4至7个碳原子的环烷基或环烷氧基,未被取代或被至少一个含有1至8个碳原子的烷基取代,或未取代或取代的苯基或苯氧基 通过至少一个卤素原子,三氟甲基或含有1至4个碳原子的烷基,R 4表示氢原子或可在酸性条件下除去的羟基保护基,X表示亚乙基或顺式 - 亚乙烯基 位置2和3之间的碳原子之间以及位置13和14之间的碳原子之间的双键都是反式构型,并且连接在p中的碳原子上的波浪线 环状15表示α-或β-构型或其混合物,条件是当R 2表示单键时,R 3不表示烷氧基,环烷氧基或苯氧基)和环糊精包合物是有用的化合物: 其中R4表示氢原子,具有选择性前列腺素样特性。
    • 16. 发明授权
    • Position detecting sensor
    • 位置检测传感器
    • US07005848B2
    • 2006-02-28
    • US10464647
    • 2003-06-19
    • Takashi SuzukiSatoru TagawaTakayoshi TsuzukiHirofumi Endo
    • Takashi SuzukiSatoru TagawaTakayoshi TsuzukiHirofumi Endo
    • G01B7/14
    • G01D5/145
    • A position detecting sensor includes a magnet, a magnetic detecting element, and a yoke adjacent to or near the magnet. A detected member is positioned at one side of the position detecting sensor so as to be adjacent to or away from the position detecting sensor. The magnet is oriented to generate a magnetic line of flux which flows in a direction complying with an extending direction of the detected member. The magnetic detecting element is positioned in an area in which a magnetic flux density generated by the magnet is relatively low when the detected member is positioned away from the position detecting sensor and a magnetic flux density is relatively high when the detected member is positioned adjacent to the position detecting sensor.
    • 位置检测传感器包括磁体,磁检测元件和与磁体相邻或靠近磁体的磁轭。 检测到的构件位于位置检测传感器的一侧,以便与位置检测传感器相邻或远离。 磁体被定向以产生沿着与所检测到的构件的延伸方向一致的方向流动的磁通线。 当检测到的构件位于远离位置检测传感器的位置时,磁检测元件位于其中由磁体产生的磁通密度相对较低的区域中,并且当检测到的构件位于邻近位置时磁通密度相对较高 位置检测传感器。