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11. 发明申请

US20060173056A1 Proline derivatives and use thereof as drugs 审中-公开
公开(公告)号：US20060173056A1
公开(公告)日：2006-08-03
申请号：US11351118
申请日：2006-02-10
申请人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61K31/427 , A61K31/4025 , C07D417/02 , C07D403/02
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04
摘要： The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

12. 发明申请

US20050245538A1 Proline derivatives and use thereof as drugs 有权
标题翻译：脯氨酸衍生物和作为药物的用途
公开(公告)号：US20050245538A1
公开(公告)日：2005-11-03
申请号：US11142523
申请日：2005-06-02
申请人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61P1/02 , A61P3/04 , A61P3/10 , A61P13/08 , A61P17/00 , A61P31/18 , A61P35/04 , A61P37/06 , A61P43/00 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04 , C07D498/04 , A61K31/496 , A61K31/427 , A61K31/454 , C07D417/02
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04
摘要： The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
摘要翻译：本发明旨在提供由于DPP-IV抑制作用而具有治疗作用的化合物，并且作为药物产品令人满意。本发明人发现具有引入式（I）表示的脯氨酸的γ-位置的取代基的衍生物，其中每个符号如说明书中所定义，具有有效的DPP-IV抑制活性，并通过增加稳定性。

13. 发明授权

US5760032A Thienylazole compound and thienotriazolodiazepine compound 失效
标题翻译：噻吩唑化合物和噻吩并三唑并噻嗪类化合物
公开(公告)号：US5760032A
公开(公告)日：1998-06-02
申请号：US750025
申请日：1996-11-22
申请人： Hiroshi Kitajima , Syuji Ehara , Hideaki Sato , Minoru Moriwaki , Kenichi Onishi
发明人： Hiroshi Kitajima , Syuji Ehara , Hideaki Sato , Minoru Moriwaki , Kenichi Onishi
IPC分类号： C07D409/04 , C07D409/14 , C07D495/14 , A61K31/55 , C07D491/00 , C07D513/00 , C07D515/00
CPC分类号： C07D409/14 , C07D409/04 , C07D495/14
摘要： Thienylazole compounds (I) and thienotriazolodiazepine compounds (II) of the formulas ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen, halogen, C.sub.1 -C.sub.5 alkyl and the like; --A.dbd.B-- is --N.dbd.N-- and the like; R.sup.3 and R.sup.19 are hydrogen, C.sub.1 -C.sub.5 alkyl and the like; Y is --NHCO--, --NHCONH--, --NHCOO-- and the like; Z.sup.1 and Z.sup.2 are aryl, heteroaryl and the like; Ar is halogen-substituted phenyl and the like; and m is 0 or an integer of 1-5. The compounds of the present invention have CCK antagonistic action and gastrin antagonistic action, particularly potent antagonistic action against CCK-A receptor, and are useful as agents for the prophylaxis and treatment of central and peripheral nervous system diseases (e.g., anxiety, schizophrenia, and the like) and digestive diseases (e.g., pancreatitis, gastric ulcer, enterelcosis, irritable bowel syndrome, constipation, and the like).
摘要翻译： PCT No.PCT / JP95 / 01071 Sec。 371日期：1996年11月22日 102（e）日期1996年11月22日PCT归档1995年6月1日PCT公布。公开号WO95 / 32964 日期：1995年12月7日式（I）其中R 1和R 2为氢，卤素，C 1 -C 5烷基等的噻吩唑化合物（I）和噻吩并三唑并二氮杂化合物（Ⅱ） -A = B-是-N = N-等; R3和R19是氢，C1-C5烷基等; Y是-NHCO-，-NHCONH-，-NHCOO-等; Z 1和Z 2是芳基，杂芳基等; Ar是卤素取代的苯基等; m为0或1-5的整数。本发明的化合物具有CCK拮抗作用和胃泌素拮抗作用，特别是针对CCK-A受体的强效拮抗作用，可用作预防和治疗中枢和周围神经系统疾病（例如焦虑，精神分裂症和类似物）和消化疾病（例如胰腺炎，胃溃疡，入侵性肠易激综合征，便秘等）。

14. 发明授权

US5470185A Parking garage 失效
标题翻译：停车库
公开(公告)号：US5470185A
公开(公告)日：1995-11-28
申请号：US396059
申请日：1995-03-01
申请人： Takahiro Tsubota , Hiroshi Kitajima
发明人： Takahiro Tsubota , Hiroshi Kitajima
IPC分类号： E04H6/20 , E04H6/18 , E04H6/32 , E04H6/34
CPC分类号： E04H6/32
摘要： A parking garage in which parking zones are arranged at both sides of a self-running lane, and slat conveyers are arranged at the lane and the parking zones, such that a vehicle that has run on the lane is conveyed to one of the parking zones by the slat conveyers. At exit, a vehicle in one of the parking zones is conveyed to the self-running lane by the slat conveyers, and it runs by itself on the lane to exit the garage.
摘要翻译：在自行车道的两侧配置有停车场的停车库，在车道和停车区域设置板条输送机，使得在车道上行驶的车辆被输送到停车区域中的一个由板条输送机。在出口处，其中一个停车区内的车辆由板条输送机输送到自行车道，并且自行在车道上行驶以退出车库。

15. 发明授权

US4912519A Laser speckle velocity-measuring apparatus 失效
标题翻译：激光斑点速度测量仪
公开(公告)号：US4912519A
公开(公告)日：1990-03-27
申请号：US207864
申请日：1988-06-17
申请人： Tomio Yoshida , Nobuo Nakatsuka , Hiroshi Kitajima , Tsukasa Yamashita
发明人： Tomio Yoshida , Nobuo Nakatsuka , Hiroshi Kitajima , Tsukasa Yamashita
IPC分类号： G01P3/80
CPC分类号： G01P3/806
摘要： There is provided a laser speckle velocity-measuring apparatus comprising: a semiconductor laser to irradiate the light to a moving object; first and second photo sensing devices whose light receiving points are arranged in the moving direction of the objects at a predetermined distance so as to be away from each other; a clock signal generating and control circuit for determining a clock frequency of the clock signal so that the number of clocks of the clock signal is always set to a constant value when the delay time of the photo sensing signal of the second photo sensing device for the photo sensing signal of the first photo sensing device is measured by the clock signals; and an arithmetic operating circuit for counting the clock signals and calculating the length, moving distance, or velocity of the object on the basis of the count value. With this apparatus, the detecting time of the length or velocity of the moving object can be reduced and the measuring processes can be performed in a real-time manner.
摘要翻译：提供了一种激光散斑速度测量装置，包括：将光照射到移动物体的半导体激光器; 第一和第二感光装置，其光接收点沿物体的移动方向以预定距离布置成彼此远离; 时钟信号发生和控制电路，用于确定时钟信号的时钟频率，使得当第二感光装置的感光信号的延迟时间用于时钟信号的延迟时间时，时钟信号的时钟数总是设置为恒定值第一感光装置的感光信号由时钟信号测量; 以及算术运算电路，用于根据计数值对时钟信号进行计数并计算物体的长度，移动距离或速度。利用该装置，可以减少移动物体的长度或速度的检测时间，并且可以实时地进行测量处理。

16. 发明申请

US20080167307A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof 失效
标题翻译：含有噻唑环的羧酸衍生物及其药物用途
公开(公告)号：US20080167307A1
公开(公告)日：2008-07-10
申请号：US11667006
申请日：2005-11-04
申请人： Takashi Tozawa , Osamu Tsuruta , Hiroshi Kitajima , Yoshiyuki Aoki , Naoko Ando , Hiroki Tamakawa
发明人： Takashi Tozawa , Osamu Tsuruta , Hiroshi Kitajima , Yoshiyuki Aoki , Naoko Ando , Hiroki Tamakawa
IPC分类号： A61K31/5377 , C07D277/20 , C07D295/00 , C07D213/02 , C07D239/24 , A61K31/506 , A61K31/496 , A61K31/435 , A61P9/00 , A61K31/498 , A61K31/4523 , A61K31/501 , C07D237/06 , C07D221/00 , C07D241/36 , A61K31/426
CPC分类号： C07D277/36
摘要： According to the present invention, a compound represented by the following formula (I) having a superior PPARα agonist action and concurrently showing a hypolipidemic action can be provided, and further, a compound useful as a synthetic intermediate for the compound can be provided.
摘要翻译：根据本发明，可以提供具有优异的PPARααA激动剂作用并同时显示降血脂作用的下式（I）表示的化合物，此外，可用作合成中间体可以提供化合物。

17. 发明申请

US20050051857A1 Semiconductor device 审中-公开
标题翻译：半导体器件
公开(公告)号：US20050051857A1
公开(公告)日：2005-03-10
申请号：US10901997
申请日：2004-07-30
申请人： Takaaki Kawahara , Kazuyoshi Torii , Hiroshi Kitajima
发明人： Takaaki Kawahara , Kazuyoshi Torii , Hiroshi Kitajima
IPC分类号： H01L21/316 , H01L21/28 , H01L21/336 , H01L29/49 , H01L29/51 , H01L29/78 , H01L29/76
CPC分类号： H01L21/28185 , H01L21/28088 , H01L21/28194 , H01L21/28202 , H01L21/28211 , H01L29/4966 , H01L29/513 , H01L29/517 , H01L29/518 , H01L29/6659 , H01L29/7833
摘要： A semiconductor device of the present invention comprises: a silicon substrate; a gate insulating film on the silicon substrate; and a gate electrode on the gate insulating film, wherein the gate insulating film includes: a first insulating film; a second insulating film on the first insulating film; and a metal nitride film on the second insulating film. The metal nitride film may be either AlN or Hf3N4. The metal nitride film may include nitrides of two or more different metals.
摘要翻译：本发明的半导体器件包括：硅衬底; 硅基板上的栅极绝缘膜; 以及栅极绝缘膜上的栅极电极，其中所述栅极绝缘膜包括：第一绝缘膜; 第一绝缘膜上的第二绝缘膜; 和第二绝缘膜上的金属氮化物膜。金属氮化物膜可以是AlN或Hf3N4。金属氮化物膜可以包括两种或更多种不同金属的氮化物。

18. 发明授权

US5879648A Apparatus for disinfecting containers 失效
标题翻译：消毒容器的设备
公开(公告)号：US5879648A
公开(公告)日：1999-03-09
申请号：US955243
申请日：1997-10-21
申请人： Hiroaki Hada , Tadao Akai , Kazuo Abe , Hiroshi Kitajima , Michio Ueda
发明人： Hiroaki Hada , Tadao Akai , Kazuo Abe , Hiroshi Kitajima , Michio Ueda
IPC分类号： B65B55/10 , A61L2/20 , A61L2/22 , A61L2/16
CPC分类号： A61L2/20 , A61L2/22
摘要： An apparatus for disinfecting containers comprises a disinfection chamber 12 surrounding a required section of a container transport path, partition means for dividing the interior of the disinfection chamber 12 into a preheating zone 35, an exposure zone 36 and a drying zone 37 as arranged downstream from an upstream side of the transport path, antiseptic supply means for supplying hydrogen peroxide gas or mist to the exposure zone 36, and means for supplying hot air to the preheating zone 35 and the drying zone 37.
摘要翻译：用于消毒容器的装置包括围绕容器输送路径的所需部分的消毒室12，用于将消毒室12的内部分成预热区35的分隔装置，暴露区36和干燥区37，输送路径的上游侧，向曝光区域36供给过氧化氢气体或雾的防腐剂供给单元，以及向预热区域35和干燥区域37供给热空气的单元。

19. 发明授权

US5838058A Semiconductor substrate and semiconductor device employing the same 失效
标题翻译：半导体衬底和采用该半导体衬底的半导体器件
公开(公告)号：US5838058A
公开(公告)日：1998-11-17
申请号：US767039
申请日：1996-12-11
申请人： Hiroshi Kitajima , Akiyoshi Kobayashi
发明人： Hiroshi Kitajima , Akiyoshi Kobayashi
IPC分类号： C30B29/06 , H01L21/02 , H01L21/027 , H01L21/265 , H01L21/266 , H01L21/336 , H01L21/822 , H01L29/04 , H01L29/10 , H01L29/93
CPC分类号： H01L21/26586 , H01L21/266 , H01L21/822 , H01L29/045 , H01L29/1079 , H01L29/1083 , H01L29/6659
摘要： In the vicinity of the (100) plane, planar channeling by (100) type crystal planes, which are (011) plane and (011) plane according to the (100) surface plane, degrades uniformity of ion implantation. Therefore, a major surface of the substrate is established at a plane perpendicular to a crystal orientation forming an angle greater than or equal to 3.5.degree. with two planes perpendicularly intersecting the (100) plane. Namely, in consideration of fluctuation in setting to an ion implantation device and ion implantation angle, the substrate having surface orientation within a range 104 is employed. Also, by limiting the orientation to be less than or equal to 10.degree. from the (100) plane, ion implantation can be performed perpendicularly to the substrate without modifying the process condition. The result of the foregoing is a semiconductor substrate which will never cause planar channeling even when ion implantation is performed in a perpendicular direction to the surface of a semiconductor substrate of silicon.
摘要翻译：在（100）面附近，根据（100）表面平面通过（100）型晶面（（0 + E，ovs 1 + EE 1）面和（011）面）进行平面沟道降低均匀性的离子注入。因此，在垂直于晶体取向的平面上形成基板的主表面，形成大于或等于3.5°的角度，其中两个垂直于（100）平面相交的平面。也就是说，考虑到离子注入装置的设定波动和离子注入角度，采用表面取向在104范围内的基板。此外，通过将取向从（100）面限制为10°，可以在不改变工艺条件的情况下垂直于衬底进行离子注入。上述结果是即使在与硅的半导体衬底的表面垂直的方向上进行离子注入也不会引起平面沟道的半导体衬底。

20. 发明授权

US5833831A Method and system for generating electrolyzed water 失效
标题翻译：生成电解水的方法和系统
公开(公告)号：US5833831A
公开(公告)日：1998-11-10
申请号：US798716
申请日：1997-02-12
申请人： Hiroshi Kitajima , Hidemitsu Aoki
发明人： Hiroshi Kitajima , Hidemitsu Aoki
IPC分类号： C02F1/46 , B08B3/08 , C02F1/04 , C02F1/461 , H01L21/00 , H01L21/304 , H01L21/306 , C25B15/00 , C25B1/00
CPC分类号： H01L21/67086 , B08B3/08 , C02F1/045 , C02F1/4618 , H01L21/67057 , C02F2201/4611 , C02F2201/46115 , C02F2201/4618 , C02F2201/46185 , C02F2201/4619 , C02F2209/04 , C02F2209/06 , C02F2209/42 , H01L21/00
摘要： In a method for generating electrolyzed water, pre-electrolyzed solution is added in water to be electrolyzed at least at the beginning of electrolyzing processing.
摘要翻译：在电解水生成方法中，至少在电解处理开始时，将预先电解的溶液加入到水中进行电解。

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