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11. 发明授权

US08706206B2 Human fatigue assessment device and human fatigue assessment method 有权
标题翻译：人体疲劳评估装置及人体疲劳评估方法
公开(公告)号：US08706206B2
公开(公告)日：2014-04-22
申请号：US13142604
申请日：2010-10-26
申请人： Etsuko Kanai , Masami Funakura , Yasuyoshi Watanabe , Masaaki Tanaka , Yoshihito Shigihara , Kei Mizuno
发明人： Etsuko Kanai , Masami Funakura , Yasuyoshi Watanabe , Masaaki Tanaka , Yoshihito Shigihara , Kei Mizuno
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/16 , A61B5/024 , A61B5/0261 , A61B5/0476 , A61B5/048 , A61B5/14551 , A61B5/18 , A61B5/4035
摘要： A human fatigue assessment device capable of performing highly accurate fatigue assessment is provided. The human fatigue assessment device includes: a physiological signal measuring unit which measures a pulse wave signal of a user; a feature value extracting unit which extracts first feature values each of which is obtained from a systolic posterior component of the pulse wave signal measured by the physiological signal measuring unit; a storage unit in which the first feature values extracted by the feature value extracting unit are stored; and a fatigue determining unit which determines whether or not the user is fatigued, using the first feature values extracted by the feature value extracting unit, in which the fatigue determining unit compares a first feature value among the first feature values extracted by the feature value extracting unit and at least one of the first feature values stored in the storage unit, to determine whether or not the user is fatigued.
摘要翻译：提供能够进行高精度疲劳评估的人体疲劳评估装置。人体疲劳评估装置包括：生理信号测量单元，其测量用户的脉搏波信号; 特征值提取单元，其提取从生理信号测量单元测量的脉搏波信号的收缩后分量获得的第一特征值; 存储由特征值提取单元提取的第一特征值的存储单元; 以及疲劳确定单元，其使用由特征值提取单元提取的第一特征值来确定用户是否疲劳，其中疲劳确定单元比较由特征值提取单元提取的第一特征值中的第一特征值单元和存储在存储单元中的第一特征值中的至少一个，以确定用户是否疲劳。

12. 发明授权

US08349447B2 Antifouling composite material 有权
标题翻译：防污复合材料
公开(公告)号：US08349447B2
公开(公告)日：2013-01-08
申请号：US12084986
申请日：2006-12-28
申请人： Tsuruo Nakayama , Youhei Jikjhara , Yasuyoshi Watanabe , Nobukazu Motojima
发明人： Tsuruo Nakayama , Youhei Jikjhara , Yasuyoshi Watanabe , Nobukazu Motojima
IPC分类号： B32B5/16
CPC分类号： C08J7/045 , C08K3/22 , C08K9/06 , C09D5/1618 , C09D7/62 , D06M13/5135 , D06M15/277 , D06M23/08 , D06M2400/01 , Y10T428/254 , Y10T428/259 , Y10T428/31663 , Y10T442/218 , Y10T442/2287
摘要： An inorganic fine particle layer containing inorganic fine particles and a binder component is formed on a surface of a substrate by chemical bonding. The inorganic fine particles are coated with silane monomer each having an unsaturated bond. The content of the binder component is in the range of 0.1% by mass to 40% by mass to the content of the inorganic fine particles.
摘要翻译：通过化学键合在基板的表面上形成含有无机微粒和粘合剂成分的无机微粒层。无机细颗粒涂覆有各自具有不饱和键的硅烷单体。粘合剂成分的含量相对于无机微粒的含量为0.1质量％〜40质量％。

13. 发明申请

US20120263645A1 RADIOLABELED COMPOUND DIRECTABLE IN VIVO TO TARGET TISSUE AND USE THEREOF 审中-公开
标题翻译：无菌化合物直接导向目标组织及其用途
公开(公告)号：US20120263645A1
公开(公告)日：2012-10-18
申请号：US13517296
申请日：2010-12-22
申请人： Yasuyoshi Watanabe , Koki Hasegawa
发明人： Yasuyoshi Watanabe , Koki Hasegawa
IPC分类号： C07K19/00 , A61P35/00 , C12Q1/68 , G01N33/53 , G01N33/569 , A61K51/08 , C12P21/00
CPC分类号： G01N33/5088 , A61K51/083 , A61N2005/1021 , C07K7/06 , C07K14/57563 , C07K14/605 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/33 , C07K2319/41 , C07K2319/43 , C07K2319/50 , G01N33/60 , G01N2500/00
摘要： The present invention provides a clinically usable radiolabeled compound that is precisely directable in vivo to a target tissue. The compound of the present invention has a first polypeptide or an analogue thereof, and a second polypeptide bonded to an N-terminus of the first polypeptide or the analogue thereof. In the compound, the first polypeptide is a polypeptide that specifically binds with a protein expressed in a target tissue, the second polypeptide has an amino acid region that has a high affinity for a radioactive metal nuclide, and the radioactive metal nuclide that has a high affinity for the amino acid region is held in the amino acid region.
摘要翻译：本发明提供临床可用的放射性标记化合物，其在体内可精确地指向靶组织。本发明的化合物具有第一多肽或其类似物，以及与第一多肽或其类似物的N末端键合的第二多肽。在化合物中，第一多肽是与靶组织中表达的蛋白质特异性结合的多肽，第二多肽具有对放射性金属核素具有高亲和力的氨基酸区域，并且具有高的放射性金属核素对氨基酸区域的亲和性保持在氨基酸区域。

14. 发明授权

US5530938A Non-volatile memory card device having flash EEPROM memory chips with designated spare memory chips and the method of rewriting data into the memory card device 失效
标题翻译：具有指定备用存储器芯片的快闪EEPROM存储芯片的非易失性存储卡装置以及将数据重写到存储卡装置中的方法
公开(公告)号：US5530938A
公开(公告)日：1996-06-25
申请号：US14430
申请日：1993-02-05
申请人： Katsumi Akasaka , Kenichi Sato , Yasuyoshi Watanabe
发明人： Katsumi Akasaka , Kenichi Sato , Yasuyoshi Watanabe
IPC分类号： G06F12/16 , G06F11/14 , G06F12/00 , G06F12/02 , G11C16/02 , G11C16/10 , G11C17/00 , G06F13/00
CPC分类号： G11C16/102 , G06F12/0246 , G11C16/105 , G06F11/1435
摘要： A memory card device and method of rewriting the same which require no separate memory for saving all data in a chip containing data to be rewritten, and in which data are not lost due to a power source failure that may occur during writing operation. Each of a plurality of chips which constitute a memory card is provided with; a logic address, a control region containing a write start number and a write completion number, and a data region. An erased chip is prepared within the memory card device. A write start number in a chip containing data to be rewritten is written, for example, into the erased chip by performing incrementing operation. Data in the data region which is not to be rewritten in a chip containing data to be rewritten are copied into the erased chip and new rewrite data are written into the erased chip. A write completion number in the chip containing data to be rewritten is written, for example, into the erased chip by performing incrementing operation on the write completion number. Finally, the chip which contained data to be rewritten is erased.
摘要翻译：一种存储卡装置及其重写方法，其不需要单独的存储器来保存包含要重写的数据的芯片中的所有数据，并且其中数据不会由于写入操作期间可能发生的电源故障而丢失。提供构成存储卡的多个芯片中的每一个; 逻辑地址，包含写入起始号和写入完成号的控制区以及数据区。擦除的芯片在存储卡装置内准备好。包含要重写的数据的芯片中的写入开始号例如通过执行递增操作被写入擦除的芯片。在包含要重写的数据的芯片中不要重写的数据区域中的数据被复制到擦除的芯片中，并且将新的重写数据写入擦除的芯片。包含要重写的数据的芯片中的写入完成号例如通过对写入完成号执行增量操作而写入擦除的芯片。最后，包含要重写的数据的芯片被擦除。

15. 发明授权

US4920122A Pharmaceutical composition and method for the treatment of infantile autism 失效
标题翻译：用于治疗婴幼儿自闭症的药物组合物和方法
公开(公告)号：US4920122A
公开(公告)日：1990-04-24
申请号：US210312
申请日：1988-06-23
申请人： Hiroshi Naruse , Masashi Takesada , Osamu Hayaishi , Yasuyoshi Watanabe
发明人： Hiroshi Naruse , Masashi Takesada , Osamu Hayaishi , Yasuyoshi Watanabe
IPC分类号： C07D475/04 , A61K31/40 , A61K31/505 , A61K31/519 , A61P25/00 , A61P25/18 , A61P43/00
CPC分类号： A61K31/505
摘要： A pharmaceutical composition for the treatment of infantile autism which contains tetrahydrobiopterin or a derivative thereof as a major effective ingredient and 5-hydroxytryptophan and/or L-DOPA as an optional auxiliary effective ingredient is provided.

16. 发明申请

US20120101266A1 18F-LABELED AZIDE COMPOUND, REAGENT FOR 18F-LABELING AND METHOD FOR 18F-LABELING OF ALKYNE COMPOUND USING SAME 失效
标题翻译： 18F标记的AZIDE化合物，18F标记试剂和使用其的18K标记的烷基化合物的方法
公开(公告)号：US20120101266A1
公开(公告)日：2012-04-26
申请号：US13320421
申请日：2010-05-14
申请人： Yasuyoshi Watanabe , Masaaki Suzuki , Hisashi Doi , Takeshi Kuboyama , Satoshi Obika , Takeshi Imanichi
发明人： Yasuyoshi Watanabe , Masaaki Suzuki , Hisashi Doi , Takeshi Kuboyama , Satoshi Obika , Takeshi Imanichi
IPC分类号： C07H1/00 , C07D249/06 , C07D249/04
CPC分类号： A61K51/0453 , A61K51/0491 , C07B59/005 , C07B2200/05 , C07C247/16 , C07D249/06
摘要： [OBJECT]The present invention provides an 18F-labeled azide compound usable in the Huisgen reaction which enables 18F-labeling although only a small quantity of alkyne compound is available as a counterpart substrate, more specifically the 18F-labeled azide compound enabling the PET to be applied to peptides or oligonucleotides and enabling the 18F-labeling of any sites of oligonucleotide other than the 5′ end or 3′ end thereof, a reagent for 18F-labeling, and a method for 18F-labeling of an alkyne compound using the same.[SOLVING MEANS]An 18F-labeled azide compound according to the present invention is expressed by the following structural formula 1.[SELECTED DRAWING] None
摘要翻译：本发明提供了可用于Huisgen反应的18F标记的叠氮化合物，其能够进行18F标记，尽管只有少量的炔化合物可用作对应的底物，更具体地说，18F-标记的叠氮化合物使PET能够应用于肽或寡核苷酸，并且使得除了5'末端或3'末端以外的寡核苷酸的任何位点的18F标记，用于18F标记的试剂和使用其的18E-标记的炔化合物的方法。 [解决方案]根据本发明的18F标记的叠氮化合物由以下结构式1表示。[选择的图]无

17. 发明申请

US20110237774A1 METHOD FOR INTRODUCING DOTA 审中-公开
标题翻译：引言DOTA的方法
公开(公告)号：US20110237774A1
公开(公告)日：2011-09-29
申请号：US13123137
申请日：2009-10-09
申请人： Koki Hasegawa , Yasuyoshi Watanabe
发明人： Koki Hasegawa , Yasuyoshi Watanabe
IPC分类号： C07K1/113 , C07H1/00
CPC分类号： C07K1/13 , A61K49/0002 , A61K51/10 , C07K1/1072 , C07K14/605 , C07K14/645 , C07K14/655 , Y02P20/55
摘要： The invention provides a method for introducing 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid (DOTA) into a compound such as a peptide. The method comprises a first step for preparing a mixed liquid of DOTA having no protecting group and dimethylsulfoxide, and a second step for contacting the mixed liquid with the compound carried on a solid-phase carrier.
摘要翻译：本发明提供了将1,4,7,10-四氮杂环十二烷-N，N'，N“，N” - 四乙酸（DOTA）引入化合物如肽中的方法。该方法包括：制备没有保护基和二甲基亚砜的DOTA的混合液的第一步骤，以及使混合液与载持在固相载体上的化合物接触的第二步骤。

18. 发明申请

US20070249816A1 Methods for carbon istope labeling synthesis by rhodium-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide 审中-公开
标题翻译：通过使用叠氮化物和碳 - 同位素一氧化物的铑促进的通过异氰酸酯的羰基化的碳同位素标记合成方法
公开(公告)号：US20070249816A1
公开(公告)日：2007-10-25
申请号：US10582761
申请日：2004-12-13
申请人： Bengt Langstrom , Julien Barletta , Hisashi Doi , Masaaki Suzuki , Ryoji Noyori , Yasuyoshi Watanabe , Farhad Karimi
发明人： Bengt Langstrom , Julien Barletta , Hisashi Doi , Masaaki Suzuki , Ryoji Noyori , Yasuyoshi Watanabe , Farhad Karimi
IPC分类号： C07D213/84 , C07C233/02 , C07D205/04
CPC分类号： A61K51/04 , C07B59/00 , C07B2200/05 , C07C263/00 , C07C269/02 , C07C273/1827 , C07C265/12 , C07C271/28 , C07C275/28
摘要： Methods and reagents for rhodium-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
摘要翻译：提供了使用碳同位素标记的一氧化碳通过异氰酸酯进行铑促进羰基化的方法和试剂。所得碳同位素标记的化合物可用作放射性药物，特别用于正电子发射断层扫描（PET）。还提供了用于PET研究的相关工具包。

19. 发明授权

US6087395A Isocarbacyclin derivatives as apoptosis inhibitors 失效
标题翻译：异卡环素衍生物作为凋亡抑制剂
公开(公告)号：US6087395A
公开(公告)日：2000-07-11
申请号：US173758
申请日：1998-10-16
申请人： Yasuyoshi Watanabe , Atsuo Hazato , Masaaki Suzuki , Yumiko Watanabe , Takumi Sato
发明人： Yasuyoshi Watanabe , Atsuo Hazato , Masaaki Suzuki , Yumiko Watanabe , Takumi Sato
IPC分类号： C07C59/54 , C07C69/732 , A01N37/08 , A01N43/00 , C07C62/06
CPC分类号： C07C69/732 , C07C59/54
摘要： The present invention provides an apoptosis inhibitor containing a 15R-isocarbacyclin derivative or a 15-deoxy-isocarbacyclin derivative, which can be manufactured easily and economically by means of chemical synthesis.
摘要翻译：本发明提供含有15R-异卡波环素衍生物或15-脱氧 - 异卡波环素衍生物的细胞凋亡抑制剂，其可通过化学合成而容易且经济地制备。

20. 发明授权

US5847193A Labelled compound 失效
标题翻译：标记化合物
公开(公告)号：US5847193A
公开(公告)日：1998-12-08
申请号：US620320
申请日：1996-03-22
申请人： Yasuyoshi Watanabe , Hironori Omura , Yuji Furuya , Bengt Langstrom , Gunnar Antoni
发明人： Yasuyoshi Watanabe , Hironori Omura , Yuji Furuya , Bengt Langstrom , Gunnar Antoni
IPC分类号： A61K51/04 , C07C255/11 , C07C255/27 , C12P13/04
CPC分类号： A61K51/0406 , A61K2123/00
摘要： The present invention provides a labelled .beta.-cyano-L-alanine and a .gamma.-cyano-.alpha.-aminobutyric acid, of which cyano group carbon is labelled with radionuclide .sup.11 C or .sup.14 C, or stable isotope .sup.13 C. The present invention also provides a labelled amino acids such as asparagine, asparatic acid, DABA, GABA, glutamine and glutamic acid synthesized by using the labelled .beta.-cyano-L-alanine and the .gamma.-cyano-.alpha.-aminobutyric acid as an intermediate. The labelled amino acids are useful for in vivo imaging of tumors and brain functions.
摘要翻译：本发明提供了标记的β-氰基-L-丙氨酸和γ-氰基-α-氨基丁酸，其中氰基碳被放射性核素11C或14C或稳定同位素13C标记。本发明还提供了通过使用标记的β-氰基-L-丙氨酸和γ-氰基-α-氨基丁酸作为中间体合成的标记的氨基酸，例如天冬酰胺，天冬氨酸，DABA，GABA，谷氨酰胺和谷氨酸。标记的氨基酸可用于肿瘤和脑功能的体内成像。

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