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11. 发明授权

US07901877B2 Genetic markers and methods for detecting and treating cancers 有权
标题翻译：用于检测和治疗癌症的遗传标记和方法
公开(公告)号：US07901877B2
公开(公告)日：2011-03-08
申请号：US11907697
申请日：2007-10-16
申请人： Chin-Tarng Lin , Han-Chung Wu , Dah-Yeou Huang
发明人： Chin-Tarng Lin , Han-Chung Wu , Dah-Yeou Huang
IPC分类号： C12Q1/00 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides genetic markers, SOX5 and SPARC, for distant metastasis and poor prognosis of detection of the high risk potential for cancer patients. In addition, the present invention also provides a method to predict the risk potential for cancer patients with distant metastasis and poor prognosis. This method comprises obtaining a tissue sample from a patient; evaluating the expression levels of the SOX5 and/or SPARC genetic markers in the sample; and comparing the expression levels of genetic markers with those of non-cancerous tissues. The patient is determined to have the high risk of distant metastasis or poor prognosis when the expression level of SOX5 is higher, or when the expression level of SPARC is lower, than that of non-cancerous tissue. Furthermore, the identified genetic marker SOX5 and/or SPARC can also be used for cancer targeted therapy, because down regulation of SOX5 and/or up regulation of SPARC expression in NOD-SCID can retard tumor growth and inhibit cell proliferation, migration, invasion and metastasis.
摘要翻译：本发明提供用于远处转移的遗传标记物SOX5和SPARC，并且对癌症患者的高潜力检测的预后差。此外，本发明还提供了一种预测远端转移癌症患者和预后不良的潜在风险的方法。该方法包括从患者获得组织样品; 评估样品中SOX5和/或SPARC遗传标记的表达水平; 并比较遗传标记的表达水平与非癌组织的表达水平。当SOX5的表达水平较高时，或者当SPARC的表达水平低于非癌组织的表达水平时，患者被确定为具有远处转移的高风险或不良预后。此外，所鉴定的遗传标记SOX5和/或SPARC也可用于癌症靶向治疗，因为SOX5的下调和/或NOD-SCID中SPARC表达的上调可以延缓肿瘤生长并抑制细胞增殖，迁移，侵袭和转移。

12. 发明授权

US07238665B2 Peptide marker targeting to nasopharyngeal carcinoma cell and application thereof 有权
标题翻译：靶向鼻咽癌细胞的肽标记及其应用
公开(公告)号：US07238665B2
公开(公告)日：2007-07-03
申请号：US10796892
申请日：2004-03-09
申请人： Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee
发明人： Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee
IPC分类号： A61K38/04
CPC分类号： A61K9/1271 , A61K38/00 , A61K47/64 , C07K5/0808 , C07K7/08
摘要： The present invention provides a peptide marker targeting to nasopharyngeal carcinoma (NPC) cells and application thereof. The peptide binds specifically to the cell surface of NPC cells. After conjugated with liposome containing chemotherapeutic drugs, such peptides deliver chemotherapeutic drugs to the tumor cells specifically and destruct tumor cells without damaging normal tissues and organs. Furthermore, such peptide is applied as a detector in the development of NPC diagnosis kit.
摘要翻译：本发明提供靶向鼻咽癌（NPC）细胞的肽标记及其应用。肽特异性结合NPC细胞的细胞表面。在与含有脂质体的化学治疗药物缀合之后，这些肽特异性地向肿瘤细胞递送化学治疗药物并破坏肿瘤细胞而不损害正常的组织和器官。此外，这种肽作为NPC诊断试剂盒开发中的检测器使用。

13. 发明申请

US20110275105A1 Methods of inducing pluripotency 有权
标题翻译：诱发多能性的方法
公开(公告)号：US20110275105A1
公开(公告)日：2011-11-10
申请号：US12930154
申请日：2010-12-28
申请人： Han-Chung Wu , Tung-Ying Lu , Cheng-Fu Kao , John Yu , Ruei-Min Lu , Mei-Ying Liao , Hung-Chih Kuo
发明人： Han-Chung Wu , Tung-Ying Lu , Cheng-Fu Kao , John Yu , Ruei-Min Lu , Mei-Ying Liao , Hung-Chih Kuo
IPC分类号： C12N5/071 , C12N15/86 , C12Q1/02 , C12N15/85
CPC分类号： G01N33/5073 , C12N5/0696 , C12N2501/58 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00
摘要： Methods are provided for inducing non-pluripotent cells to become pluripotent. Methods also include identifying and isolating induced pluripotent (iPS) cells and uses thereof. Compositions and kits for carrying out the subject methods are also provided.
摘要翻译：提供用于诱导非多能细胞变为多能的方法。方法还包括鉴定和分离诱导多能（iPS）细胞及其用途。还提供了用于实施主题方法的组合物和试剂盒。

14. 发明申请

US20060062804A1 SARS-CoV-specific B-cell epitope and applications thereof 失效
标题翻译： SARS-CoV特异性B细胞表位及其应用
公开(公告)号：US20060062804A1
公开(公告)日：2006-03-23
申请号：US10945648
申请日：2004-09-21
申请人： Han-Chung Wu , I-Ju Liu , Chien-Yu Chiu
发明人： Han-Chung Wu , I-Ju Liu , Chien-Yu Chiu
IPC分类号： A61K39/12 , C12Q1/70 , C07H21/04 , C12N15/86 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , C12N2770/20022 , C12N2770/20034
摘要： Disclosed is SARS-CoV-specific B-cell epitope and applications thereof. The epitopes are peptides and can either be expressed in phages or synthesized to diagnose SARS patients accurately. High sensitivity and specificity of the serologic detection are achievable by using a plurality of SARS-CoV-specific B-cell epitope-based peptides. Therefore, the peptides can be applied to SARS diagnosis and have potentials to be immunogens for producing antibodies against SARS.
摘要翻译：公开了SARS-CoV特异性B细胞表位及其应用。表位是肽，可以在噬菌体中表达或合成，以准确诊断SARS患者。血清学检测的高灵敏度和特异性可以通过使用多个SARS-CoV特异性B细胞表位基于肽来实现。因此，该肽可以应用于SARS诊断，并且具有产生抗SARS抗体的免疫原的潜力。

15. 发明授权

US09541480B2 Capture, purification, and release of biological substances using a surface coating 有权
标题翻译：使用表面涂层捕获，纯化和释放生物物质
公开(公告)号：US09541480B2
公开(公告)日：2017-01-10
申请号：US14128354
申请日：2012-06-28
申请人： Ying-Chih Chang , Han-Chung Wu , Po-Yuan Tseng , Jen-Chia Wu
发明人： Ying-Chih Chang , Han-Chung Wu , Po-Yuan Tseng , Jen-Chia Wu
IPC分类号： G01N1/40 , G01N33/543 , G01N33/574 , C07K16/30 , C07K17/14
CPC分类号： G01N33/54386 , C07K16/30 , C07K17/14 , G01N1/405 , G01N33/54393 , G01N33/57492
摘要： This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
摘要翻译：本发明涉及用于捕获循环稀有细胞的表面涂层，其包含防止非特异性细胞结合的非结垢组合物和血清成分的吸附; 用于结合生物物质的生物活性组合物，例如循环肿瘤细胞; 具有或不具有结合非结垢和生物活性组合物的接头组合物。本发明还提供用于捕获和纯化生物物质的表面包衣，其包含可释放组合物以释放非特异性细胞和其它血清成分; 用于结合生物物质的生物活性组合物，例如循环肿瘤细胞; 具有或不具有结合可释放和生物活性组合物的接头组合物。本发明还公开了一种具有特定图案化微结构的新型微流体芯片，以产生流动扰动并增加生物物质的捕获率。

16. 发明授权

US09150655B2 Anti-C-met antibody and methods of use thereof 有权
标题翻译：抗C-met抗体及其使用方法
公开(公告)号：US09150655B2
公开(公告)日：2015-10-06
申请号：US13818283
申请日：2011-08-30
申请人： Han-Chung Wu , Ruei-Min Lu
发明人： Han-Chung Wu , Ruei-Min Lu
IPC分类号： C07K16/28 , A61K9/127 , A61K47/48 , A61K49/00 , A61K9/00 , A61K47/24 , A61K39/00
CPC分类号： C07K16/2869 , A61K9/0019 , A61K9/1271 , A61K47/24 , A61K47/6913 , A61K49/0058 , A61K49/0067 , A61K2039/505 , C07K16/2863 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.
摘要翻译：本文提供了与c-Met结合的抗体，以及相关组合物和使用方法。使用方法包括癌症治疗和诊断。在某些实施方案中，抗体结合哺乳动物细胞表面抗原（例如癌细胞表面抗原）。抗体还可以在与细胞结合时被内吞。可以由抗体靶向的细胞包括癌，如肺，肾，肝，胃，乳腺和脑等。

17. 发明授权

US08394758B2 Tumor-targeting peptides and uses thereof 有权
标题翻译：肿瘤靶向肽及其用途
公开(公告)号：US08394758B2
公开(公告)日：2013-03-12
申请号：US12607334
申请日：2009-10-28
申请人： Han-Chung Wu , De-Kuan Chang , Chien-Yu Chiu
发明人： Han-Chung Wu , De-Kuan Chang , Chien-Yu Chiu
IPC分类号： A61K38/00 , A61K38/04 , A61K51/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： G01N33/586 , A61K47/6911 , C07K7/08 , G01N33/57484
摘要： Tumor targeting peptides and uses thereof in tumor diagnosis and treatment.
摘要翻译：肿瘤靶向肽及其在肿瘤诊断和治疗中的应用。

18. 发明申请

US20120014945A1 Anti-Dengue Virus Antibodies 有权
标题翻译：抗登革热病毒抗体
公开(公告)号：US20120014945A1
公开(公告)日：2012-01-19
申请号：US13182771
申请日：2011-07-14
申请人： Han-Chung Wu , Pi-Chun Li , Mei-Ying Liao , Chien-Yu Chiu
发明人： Han-Chung Wu , Pi-Chun Li , Mei-Ying Liao , Chien-Yu Chiu
IPC分类号： A61K39/42 , C12Q1/70 , G01N33/53 , C07K16/08 , A61P31/12
CPC分类号： G01N33/56983 , A61K2039/505 , C07K16/1081 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N2333/185 , Y02A50/386 , Y02A50/53
摘要： Provided herein are monoclonal antibodies specific to dengue virus as well as their antigen-binding fragments, and functional variants. Also disclosed are uses thereof for treating or diagnosing dengue virus infection.
摘要翻译：本文提供了对登革热病毒及其抗原结合片段和功能变体特异性的单克隆抗体。还公开了其用于治疗或诊断登革热病毒感染的用途。

19. 发明授权

US07612957B1 Voice coil driving auto-focus lens module 失效
标题翻译：音圈驱动自动对焦镜头模组
公开(公告)号：US07612957B1
公开(公告)日：2009-11-03
申请号：US12422718
申请日：2009-04-13
申请人： Han-Chung Wu , Chin-Yi Chou , San-Woei Shyu
发明人： Han-Chung Wu , Chin-Yi Chou , San-Woei Shyu
IPC分类号： G02B7/02
CPC分类号： G02B7/08
摘要： A voice coil driving auto-focus lens module is disclosed. The voice coil driving auto-focus lens module includes a base, two conductive plates, an insulation spacer, four permanent magnets, a lens holder, an optical lens, a spring set, a coil, and a top cover. The lens holder, the optical lens and the coil form a lens set that moves synchronously while the permanent magnets are fixed on an outer circle of a leaf spring. The spring set includes a coil spring and a leaf spring. By resultant spring force due to extension or compression of the coil spring as well as the leaf spring, together with the electromagnetic force, the lens module moves fast, focuses stably and the tilt of the lens module is reduced.
摘要翻译：公开了一种音圈驱动自动对焦透镜模块。音圈驱动自动对焦透镜模块包括基座，两个导电板，绝缘垫片，四个永磁体，透镜架，光学透镜，弹簧组件，线圈和顶盖。透镜架，光学透镜和线圈形成同时移动的透镜组，同时将永磁体固定在板簧的外圆上。弹簧组包括螺旋弹簧和板簧。由于由于螺旋弹簧以及板簧的延伸或压缩而产生的弹簧力，与电磁力一起，透镜模块快速移动，稳定地聚焦，并且减少了透镜模块的倾斜。

20. 发明授权

US08674070B2 Cancer-targeting peptides and uses thereof in cancer therapy 有权
标题翻译：癌症靶向肽及其在癌症治疗中的应用
公开(公告)号：US08674070B2
公开(公告)日：2014-03-18
申请号：US13201749
申请日：2010-02-19
申请人： Han-Chung Wu , Chien-Yu Chiu
发明人： Han-Chung Wu , Chien-Yu Chiu
IPC分类号： A61K38/04 , A61K38/10 , A61K38/00
CPC分类号： C07K7/08
摘要： Cancer-targeting peptides and uses thereof in cancer therapy.
摘要翻译：癌症靶向肽及其在癌症治疗中的应用。

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