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11. 发明授权

US07829109B2 Catheter injectable depot compositions and uses thereof 失效
标题翻译：导管可注射药剂组合物及其用途
公开(公告)号：US07829109B2
公开(公告)日：2010-11-09
申请号：US10295603
申请日：2002-11-14
申请人： Guohua Chen , Paul R. Houston , Lothar Kleiner , John Spaltro
发明人： Guohua Chen , Paul R. Houston , Lothar Kleiner , John Spaltro
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
摘要翻译：提供导管可注射贮库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中具有小于或等于7重量％的混溶性的溶剂。％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

12. 发明申请

US20080269685A1 Solvent-cast microneedle arrays containing active 有权
标题翻译：含有活性的溶剂型微针阵列
公开(公告)号：US20080269685A1
公开(公告)日：2008-10-30
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61M37/00 , B29C43/14
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译：在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。第一溶液优选含有活性成分。

13. 发明申请

US20060193918A1 Solvent/polymer solutions as suspension vehicles 有权
公开(公告)号：US20060193918A1
公开(公告)日：2006-08-31
申请号：US11347562
申请日：2006-02-03
申请人： Catherine Rohloff , Guohua Chen , Andrew Luk , Rupal Ayer , Paul Houston , Michael Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine Rohloff , Guohua Chen , Andrew Luk , Rupal Ayer , Paul Houston , Michael Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61K38/19 , A61K38/22 , A61K38/48 , A61K9/14
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

14. 发明授权

US6113938A Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents 失效
标题翻译：具有膜塞的有益代理输送系统和用于控制有益药物输送的方法
公开(公告)号：US6113938A
公开(公告)日：2000-09-05
申请号：US121835
申请日：1998-07-24
申请人： Guohua Chen , Scott Lautenbach , Keith Dionne , Lawton Hom
发明人： Guohua Chen , Scott Lautenbach , Keith Dionne , Lawton Hom
IPC分类号： A61K9/00 , A61K9/52 , A61F2/02
CPC分类号： A61K9/0004
摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.
摘要翻译：用于有益药物的受控递送的渗透递送系统包括含有有益剂的植入物胶囊和在与水接触时溶胀的渗透剂，随着时间推移释放有益剂。渗透递送系统具有膜塞，其允许水从胶囊的外部通过塞子，同时防止胶囊内的组合物从胶囊中流出。通过在恒定直径的胶囊内改变膜塞的芯直径来控制从植入物胶囊输送有益剂的递送速率。膜塞具有可变的水渗透速率，这取决于膜塞被胶囊壁约束的程度。

15. 发明授权

US6063637A Sensors for sugars and other metal binding analytes 失效
标题翻译：糖和其他金属结合分析物的传感器
公开(公告)号：US6063637A
公开(公告)日：2000-05-16
申请号：US875047
申请日：1997-07-07
申请人： Frances H. Arnold , Zhibin Guan , Chao-Tsen Chen , Guohua Chen
发明人： Frances H. Arnold , Zhibin Guan , Chao-Tsen Chen , Guohua Chen
IPC分类号： A61B5/00 , G01N21/00 , G01N21/64 , G01N33/00 , G01N33/14 , G01N33/487
CPC分类号： A61B5/14539 , G01N27/4145 , A61B5/14532 , G01N21/64 , G01N33/143 , Y10T436/142222 , Y10T436/143333 , Y10T436/144444 , Y10T436/20 , Y10T436/200833 , Y10T436/203332
摘要： Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a proton or includes an exchangable ligand which is exchanged for the target molecule during the binding interaction between the metal complex and the target molecule. The result of the binding interaction is the release of a proton, hydroxide ion or ligand species generated during the ligand exchange. Measurement of the release of proton, hydroxide ion or other ligand species from the sensor (20, 50, 70) provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures (10, 12) to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton or hydroxide release are disclosed, as are detection systems in which Cl.sup.- release is used. Methods for monitoring the concentrations of sugars and related molecules using the metal based sensors (20, 50, 70) are also disclosed.
摘要翻译： PCT No.PCT / US97 / 03654 Sec。 371日期1997年7月7日 102（e）日期1997年7月7日PCT 1997年3月3日PCT公布。公开号WO97 / 33177 1997年9月12日发布的传感器（20,50,70）用于检测糖和其他分析物（靶分子）的存在。该传感器由结合目标分子并释放质子的金属络合物组成，或者包括在金属络合物和靶分子之间的结合相互作用期间与靶分子交换的可交换配体。结合相互作用的结果是在配体交换期间产生的质子，氢氧根离子或配体物质的释放。从传感器（20,50,70）释放质子，氢氧根离子或其他配体物质的测量提供了目标分子浓度的间接指示。金属络合物可以连接到支撑结构（10,12），以提供金属离子的锚定和定位，以增加糖/金属络合物相互作用的选择性。公开了使用pH作为质子或氢氧化物释放指示的检测系统，其中使用Cl-释放的检测系统也是如此。还公开了使用金属基传感器（20,50,70）监测糖和相关分子的浓度的方法。

16. 外观设计

USD1009519S1 Two seat recliner reversible sofa cover 有权
公开(公告)号：USD1009519S1
公开(公告)日：2024-01-02
申请号：US29777518
申请日：2021-04-06
申请人： Guohua Chen
设计人： Guohua Chen
摘要： FIG. 1 is a rear perspective view of a two seat recliner reversible sofa cover showing my new design;
FIG. 2 is front perspective view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a front elevation view thereof;
FIG. 5 is a left side elevation view thereof;
FIG. 6 is a right side elevation view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The dotted lines in the figures show stitching which is part of the claimed design.

17. 发明授权

US09268799B1 System and method for restoring data from a remote repository 有权
标题翻译：从远程存储库恢复数据的系统和方法
公开(公告)号：US09268799B1
公开(公告)日：2016-02-23
申请号：US13928843
申请日：2013-06-27
申请人： Feng Qi , Pei Mao , Guohua Chen
发明人： Feng Qi , Pei Mao , Guohua Chen
IPC分类号： G06F17/30
CPC分类号： G06F11/1469 , G06F11/1451 , G06F2201/835
摘要： A method includes receiving a request to restore a memory of a client and determining a selected full session from a plurality of full sessions, each full session comprising a respective copy of data received from the memory of the client and a respective backup time stamp. The selected full session includes a most recent full backup having a respective backup time stamp prior to a selected restore time. The method further includes copying the selected full session to a restore session and determining a selected incremental session from a plurality of incremental sessions. Each incremental session includes a respective incremental backup time stamp, and respective changes to the data received from the memory of the client. The method further includes modifying the restore session in a cloud computing environment based on the selected incremental session, and transmitting the modified restore session across a network to the client.
摘要翻译：一种方法包括接收请求以恢复客户端的存储器并且从多个完整会话确定所选择的完整会话，每个完整会话包括从客户端的存储器接收的相应的数据副本和相应的备份时间戳。所选的完整会话包括在选择的恢复时间之前具有各自的备份时间戳的最新的完整备份。该方法还包括将所选择的完整会话复制到恢复会话并且从多个增量会话确定所选择的增量会话。每个增量会话包括相应的增量备份时间戳，以及对从客户机的存储器接收到的数据的相应改变。该方法还包括基于所选择的增量会话在云计算环境中修改恢复会话，以及通过网络将修改的恢复会话发送到客户端。

18. 发明授权

US09114238B2 Solvent-cast microprotrusion arrays containing active ingredient 有权
标题翻译：含有活性成分的溶剂滴注微阵列
公开(公告)号：US09114238B2
公开(公告)日：2015-08-25
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61M5/00 , A61M37/00 , A61K9/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译：在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。第一溶液优选含有活性成分。

19. 发明申请

US20120100740A1 ELECTRIC TERMINAL FOR LEADING A LINE THROUGH A WALL 有权
标题翻译：用于通过墙壁引导线的电气端子
公开(公告)号：US20120100740A1
公开(公告)日：2012-04-26
申请号：US13265038
申请日：2010-04-13
申请人： Heinz Reibke , Rudolf Merz , Guohua Chen , Dennis Sprenger
发明人： Heinz Reibke , Rudolf Merz , Guohua Chen , Dennis Sprenger
IPC分类号： H01R13/621
CPC分类号： H01R13/74 , H01R4/30 , H01R11/12
摘要： The invention relates to an electric terminal for leading a conductor through a wall, comprising a first terminal piece (1) to be mounted on one side of the wall, and a second terminal piece (2) to be mounted on the other side of the wall. The first terminal piece (1) has a first connecting element (5) and a holding element (7) for positioning the first connecting element (5), while the second terminal piece (2) has a busbar (4) to be electrically connected to the first connecting element (5). According to the invention, the first connecting element (5) in such an electric terminal for leading a conductor through a wall can be connected to the conductor and/or the busbar (4) in a particularly simple fashion because the first connecting element (5) is positioned in the first terminal piece (1) by the holding element (7).
摘要翻译：本发明涉及一种用于将导体引导通过壁的电端子，其包括将安装在壁的一侧的第一端子件（1）和安装在壁的另一侧上的第二端子件（2）壁。第一端子件（1）具有用于定位第一连接元件（5）的第一连接元件（5）和保持元件（7），而第二端子件（2）具有电连接的汇流条（4）到第一连接元件（5）。根据本发明，用于引导导体穿过壁的这种电端子中的第一连接元件（5）可以以特别简单的方式连接到导体和/或母线（4），因为第一连接元件（5））通过保持元件（7）定位在第一端子件（1）中。

20. 发明申请

US20110276028A1 METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY 有权
标题翻译：使用微阵列阵列进行直接递送帕拉霉素激素的方法和装置
公开(公告)号：US20110276028A1
公开(公告)日：2011-11-10
申请号：US13101071
申请日：2011-05-04
申请人： Parminder Singh , Danir Bairamov , Guohua Chen , Robert Wade Worsham
发明人： Parminder Singh , Danir Bairamov , Guohua Chen , Robert Wade Worsham
IPC分类号： A61M5/00
CPC分类号： A61K9/0021 , A61K38/29 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/36 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
摘要翻译：提供了以脉动方式经皮给药甲状旁腺激素（PTH）的方法和药物递送系统，其中药物递送系统包括每个包含PTH的微阵列阵列。

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