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11. 发明申请

US20090157166A1 Medical Devices Having Porous Component For Controlled Diffusion 有权
标题翻译：具有控制扩散的多孔成分的医疗器械
公开(公告)号：US20090157166A1
公开(公告)日：2009-06-18
申请号：US12333909
申请日：2008-12-12
申请人： Anurag Singhal , Robert A. Herrmann , Yixin Xu , Young-Ho Song
发明人： Anurag Singhal , Robert A. Herrmann , Yixin Xu , Young-Ho Song
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L29/14 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含以下内容：（a）具有一个或多个凹陷的基底，其含有至少一种治疗剂，和（b）设置在基底上的多孔膜，一个或多个凹陷，其调节化学物质在含治疗剂的凹陷和装置的外部之间的运输。基板和多孔膜由各自具有不同热膨胀系数的不同材料形成。此外，衬底和多孔膜中的一个至少部分地围绕另一个。本发明的其它方面涉及制造这种医疗装置的方法，以及使用这种医疗装置的治疗方法。

12. 发明授权

US07501179B2 Block copolymer particles 有权
标题翻译：嵌段共聚物颗粒
公开(公告)号：US07501179B2
公开(公告)日：2009-03-10
申请号：US11314557
申请日：2005-12-21
申请人： Young-Ho Song , Eric D. Welch , Scott T. Bluni
发明人： Young-Ho Song , Eric D. Welch , Scott T. Bluni
IPC分类号： B32B5/66
CPC分类号： A61K9/1635 , A61K9/1682 , A61K47/32 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998 , Y10T428/31935
摘要： Block copolymer particles, and related compositions and methods, are disclosed.
摘要翻译：嵌段共聚物颗粒以及相关的组合物和方法。

13. 发明申请

US20070160640A1 Halofuginone delivering vascular medical devices 审中-公开
标题翻译：输送血管医疗器械的卤代酮
公开(公告)号：US20070160640A1
公开(公告)日：2007-07-12
申请号：US11330448
申请日：2006-01-12
申请人： Eun-Hyun Jang , Young-Ho Song , Robert Herrmann , Anurag Singhal , Brad Pires , Andrew Saati
发明人： Eun-Hyun Jang , Young-Ho Song , Robert Herrmann , Anurag Singhal , Brad Pires , Andrew Saati
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416
摘要： A medical device comprising halofuginone is provided. The medical device is adapted for implantation or insertion into a blood vessel and it provides a cumulative, in vivo, 14 day release that lies between 0.02 μg and 0.2 μg of halofuginone per mm2 of stent surface area.
摘要翻译：提供了包含卤夫酮的医疗装置。该医疗装置适于植入或插入血管，并且其提供累积的体内14天释放，其位于每平方米支架表面积的0.02微克和0.2杯卤伏酮之间。

14. 发明申请

US20050037048A1 Medical devices containing antioxidant and therapeutic agent 审中-公开
标题翻译：含抗氧化剂和治疗剂的医疗器械
公开(公告)号：US20050037048A1
公开(公告)日：2005-02-17
申请号：US10638920
申请日：2003-08-11
申请人： Young-Ho Song
发明人： Young-Ho Song
IPC分类号： A61L27/54 , A61L29/16 , A61L31/16 , A61F2/00
CPC分类号： A61L31/143 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/802
摘要： An medical device which comprises (a) a medical device substrate and (b) a therapeutic-agent-containing region over the substrate that comprises a therapeutic agent and an antioxidant. Exemplary medical devices are implantable or insertable medical devices, such as catheters, guide wires, balloons, filters, stents, stent grafts, vascular grafts, vascular patches and shunts. Also described are methods of making devices such as those above, which methods comprise: (a) providing a solution comprising (i) solvent, (ii) the therapeutic agent, and (iii) the antioxidant; (b) providing the medical device substrate; (c) contacting the solution with the medical device substrate; and (d) removing the solvent from the solution to form the therapeutic-agent-containing region.
摘要翻译：一种医疗装置，其包括（a）医疗装置基板和（b）包含治疗剂和抗氧化剂的基材上的含治疗剂的区域。示例性医疗装置是可植入或可插入的医疗装置，例如导管，导丝，球囊，过滤器，支架，支架移植物，血管移植物，血管斑块和分流器。还描述了制造诸如上述装置的方法，所述方法包括：（a）提供包含（i）溶剂，（ii）治疗剂和（iii）抗氧化剂的溶液; （b）提供医疗装置基板; （c）使溶液与医疗装置基板接触; 和（d）从溶液中除去溶剂以形成含治疗剂的区域。

15. 发明申请

US20070196451A1 Extendable rolled delivery system 审中-公开
标题翻译：可扩展轧制系统
公开(公告)号：US20070196451A1
公开(公告)日：2007-08-23
申请号：US11358117
申请日：2006-02-22
申请人： Anurag Singhal , Robert Herrmann , Eun-Hyun Jang , Young-Ho Song
发明人： Anurag Singhal , Robert Herrmann , Eun-Hyun Jang , Young-Ho Song
IPC分类号： A61M31/00 , A61K9/70
CPC分类号： A61M25/0082 , A61M25/0074 , A61M31/00
摘要： The present invention relates to a device and method for delivery of a patch, graft, implant, therapeutic agent, or other device onto tissue using a rolled delivery mechanism. In one embodiment, a rolled delivery mechanism is provided for delivering a patch to tissue when the rolled delivery mechanism is unrolled. In another embodiment, a rolled delivery mechanism is provided for delivering therapeutic agent to a target tissue.
摘要翻译：本发明涉及一种用于使用轧制递送机构将补片，移植物，植入物，治疗剂或其它装置递送到组织上的装置和方法。在一个实施例中，提供了一种轧制递送机构，用于在轧制的递送机构展开时将补片递送到组织。在另一个实施方案中，提供了用于将治疗剂递送至靶组织的卷绕递送机构。

16. 发明申请

US20050064011A1 Implantable or insertable medical devices containing phenolic compound for inhibition of restenosis 审中-公开
标题翻译：含有酚类化合物的植入式或可插入医疗器械用于抑制再狭窄
公开(公告)号：US20050064011A1
公开(公告)日：2005-03-24
申请号：US10955368
申请日：2004-09-30
申请人： Young-Ho Song , Andrew Carter
发明人： Young-Ho Song , Andrew Carter
IPC分类号： A61L27/54 , A61L29/16 , A61L31/16 , A61F2/00
CPC分类号： A61L29/085 , A61L27/54 , A61L29/16 , A61L31/10 , A61L31/143 , A61L31/16 , A61L2300/216 , A61L2300/606 , A61L2300/608 , A61L2300/802 , C08L53/02
摘要： A vascular medical device is provided, which contains at least one phenolic compound. The medical device also contains at least one polymeric region, which regulate the release of the phenolic compound from the device. The polymeric region, in turn, contains at least one polymer species. In some embodiments, for example, the polymeric region contains a vinyl aromatic polymer species (e.g., a styrene homopolymer or copolymer). In other embodiments, for example, the polymeric region contains an alkene polymer species (e.g., an isobutylene homopolymer or copolymer). In still other embodiments, for example, the polymeric region contains a biostable polymer having at least one Tg below 25° C. (e.g., a homopolymer or copolymer containing one or more polyalkene polymer blocks).
摘要翻译：提供了含有至少一种酚类化合物的血管医疗装置。医疗装置还包含至少一个聚合物区域，其调节酚类化合物从该装置的释放。聚合物区域又包含至少一种聚合物种类。在一些实施方案中，例如，聚合物区域含有乙烯基芳族聚合物物质（例如苯乙烯均聚物或共聚物）。在其它实施方案中，例如，聚合物区域含有烯烃聚合物物质（例如，异丁烯均聚物或共聚物）。在其它实施方案中，例如，聚合物区域含有至少一个Tg低于25℃的生物稳定聚合物（例如含有一个或多个聚烯烃聚合物嵌段的均聚物或共聚物）。

17. 发明申请

US20130108668A1 Therapeutic Polymeric Nanoparticles Comprising Epothilone and Methods of Making and Using Same 审中-公开
公开(公告)号：US20130108668A1
公开(公告)日：2013-05-02
申请号：US13523030
申请日：2012-06-14
申请人： Maria Figueiredo , David Dewitt , Young-Ho Song
发明人： Maria Figueiredo , David Dewitt , Young-Ho Song
IPC分类号： A61K9/14 , A61K31/4178
CPC分类号： A61K31/427 , A61K9/146 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/4178 , A61K47/34
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 0.2 to about 20 weight percent of epothilone, e.g. epothilone B; and about 50 to about 99 weight percent biocompatible polymer.

18. 发明授权

US08388678B2 Medical devices having porous component for controlled diffusion 有权
标题翻译：具有用于受控扩散的多孔成分的医疗装置
公开(公告)号：US08388678B2
公开(公告)日：2013-03-05
申请号：US12333909
申请日：2008-12-12
申请人： Anurag Singhal , Robert A. Herrmann , Yixin Xu , Young-Ho Song
发明人： Anurag Singhal , Robert A. Herrmann , Yixin Xu , Young-Ho Song
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L29/14 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含以下内容：（a）具有一个或多个凹陷的基底，其含有至少一种治疗剂，和（b）设置在基底上的多孔膜，一个或多个凹陷，其调节化学物质在含治疗剂的凹陷和装置的外部之间的运输。基板和多孔膜由各自具有不同热膨胀系数的不同材料形成。此外，衬底和多孔膜中的一个至少部分地围绕另一个。本发明的其它方面涉及制造这种医疗装置的方法，以及使用这种医疗装置的治疗方法。

19. 发明申请

US20090123517A1 MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME 有权
标题翻译：用于释放治疗药物的医疗装置及其制备方法
公开(公告)号：US20090123517A1
公开(公告)日：2009-05-14
申请号：US12109677
申请日：2008-04-25
申请人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhai , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
发明人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhai , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
IPC分类号： A61F2/82 , A61L27/00
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

20. 发明申请

US20070141339A1 Block copolymer particles 有权
公开(公告)号：US20070141339A1
公开(公告)日：2007-06-21
申请号：US11314557
申请日：2005-12-21
申请人： Young-Ho Song , Eric Welch , Scott Bluni
发明人： Young-Ho Song , Eric Welch , Scott Bluni
IPC分类号： B32B5/16 , B32B15/02
CPC分类号： A61K9/1635 , A61K9/1682 , A61K47/32 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998 , Y10T428/31935
摘要： Block copolymer particles, and related compositions and methods, are disclosed.

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