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    • 18. 发明授权
    • Sulphonation of phenols
    • US06936732B2
    • 2005-08-30
    • US10490361
    • 2002-09-18
    • Jonathan Simon HillBernard CapaiCarlo Neri
    • Jonathan Simon HillBernard CapaiCarlo Neri
    • C07C303/08C07C309/42C07C309/44C07C309/00
    • C07C303/08C07C309/42C07C309/44
    • A process for the preparation of sulphonated phenols of general formula (I) where R1 is hydrogen, a C1-C20 alkyl group which is unsubstituted or substituted by halogen, cyano, hydroxyl, C1-C20 alkoxy, C2-C20 alkoxycarbonyl, acyloxy and/or phenyl which is unsubstituted or substituted by C1-C4 alkyl, C1-C4 alkoxy and/or halogen, R2 is hydrogen, C1-C20 alkyl or benzoyl of general formula (II) where R3 and R4 independently of one another are each hydrogen, halogen, C1-C12 alkyl, C1-C12 alkoxy, C1-C4 haloalkyl, C3-C8 cycloalkyl, C4-C12 cycloalkylalkyl, cyano, hydroxyl, or hydroxyethyl or are each phenoxy, C7-C10 phenylalkyl or phenyl which is unsubstituted or substituted by C1-C4 alkyl, C1-C4 alkoxy and/or halogen, and R5 is hydrogen or the group SO3X where X can be hydrogen, a monovalent metal or a group —N(R6)3, where each of the three radicals R6 can be independently of one another hydrogen, C1-C6 alkyl or C1-C6 hydroxy alkyl, which process comprises reacting a phenol of general formula (III) where R1 and R2 are as defined above, with a halosulphonic acid in a solvent which is a mixture of a C5-C10 aliphatic or cycloaliphatic hydrocarbon and a dialkyl carbonate of general formula (IV) R7—O—CO—O—R8 where R7 and R8 each represent independently a C1-C4 alkyl group
    • 20. 发明授权
    • Process for the preparation of symmetrical diacylhydrazines
    • 制备对称二酰基肼的方法
    • US06444848B1
    • 2002-09-03
    • US09786789
    • 2001-03-09
    • Fabio BroussardCarlo NeriFlavio Somenzi
    • Fabio BroussardCarlo NeriFlavio Somenzi
    • C07C24100
    • C07C243/32C07C241/04C07C243/28C07C243/38
    • Process for the preparation of symmetrical diacylhydrazines having general formula (I): R1—CO—NH—NH—CO—R1 wherein R1 represents a linear or branched C1-C18 alkyl group; a linear or branched C2-C8 alkoxyalkyl group; a C2-C8 cyanoalkyl group; a C5-C8 cycloalkyl group, said cycloalkyl group optionally containing a heteroatom selected from oxygen, nitrogen and sulfur; a C6-C18 aryl group; a C7C20 arylalkyl group or alkylaryl group, said arylalkyl or alkylaryl groups optionally substituted with one or more hydroxyl groups, or with one or more linear or branched C1-C8 alkoxyl groups; comprising: (a) reacting an ester of a carboxylic acid having general formula (II): R1—CO—OR2 wherein R1 has the same meanings defined above and R2 represents a linear or branched C1-C18 alkyl group, with hydrazine, in its pure or hydrated state, obtaining a monoacylhydrazine having general formula (III): R1—CO—NH—NH2; (b) reacting the monoacylhydrazine having general formula (III) obtained in step (a), with a &bgr;-ketoester having general formula (IV): R3—CO—CH2—COOR4 wherein R3 represents a linear or branched C1-C18 alkyl group, or a C6-C18 aryl group and R4 represents a linear or branched C1-C18 alkyl group, obtaining the desired symmetrical diacylhydrazine having general formula (I).
    • 制备具有通式(I)的对称二酰肼的方法:R1-CO-NH-NH-CO-R1其中R1表示直链或支链C1-C18烷基; 直链或支链C 2 -C 8烷氧基烷基; C2-C8氰基烷基; C5-C8环烷基,所述环烷基任选地含有选自氧,氮和硫的杂原子; C 6 -C 18芳基; 任选被一个或多个羟基取代的所述芳基烷基或烷基芳基,或与一个或多个直链或支链C 1 -C 8烷氧基取代的C 7 -C 20芳烷基或烷基芳基; 其包括:(a)使其具有通式(II)的羧酸:R1-CO-OR2,其中R1具有与上述相同的含义并且R 2表示直链或支链C 1 -C 18烷基, 纯化或水合状态,得到具有通式(III)的单酰肼:R1-CO-NH-NH2; (b)使步骤(a)中获得的具有通式(III)的单酰基肼与具有通式(IV)的β-酮酯反应:R3-CO-CH2-COOR4,其中R3表示直链或支链C1-C18烷基 ,或C 6 -C 18芳基,R 4表示直链或支链C 1 -C 18烷基,得到具有通式(I)的所需对称二酰基肼。