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11. 发明授权

US5384322A Nitrogen-containing bicyclic compounds and pharmaceutical compositions thereof 失效
标题翻译：含氮双环化合物及其药物组合物
公开(公告)号：US5384322A
公开(公告)日：1995-01-24
申请号：US129651
申请日：1993-09-30
申请人： Michel Vincent , Georges Remond , Bernard Portevin , Yolande Herve , Jean Lepagnol , Guillaume de Nanteuil
发明人： Michel Vincent , Georges Remond , Bernard Portevin , Yolande Herve , Jean Lepagnol , Guillaume de Nanteuil
IPC分类号： A61K31/40 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/55 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D209/42 , C07D209/52 , C07D215/48 , C07D217/26 , C07D277/06 , C07D401/06 , C07D403/06 , C07D417/06 , C07D453/06 , C07D487/08 , A61K31/46
CPC分类号： C07D403/06 , C07D209/42 , C07D209/52 , C07D217/26 , C07D417/06 , C07D453/06
摘要： The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,B represents, with the nitrogen atom to which it is bound, a heterocycle,R.sub.1 represents alkoxy, benzyloxy, phenoxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted cycloalkyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid, medicinal products containing the same.
摘要翻译：本发明涉及式（I）化合物：其中：A表示与其结合的氮原子和碳原子一起形成杂环，B表示与其原子相同的氮原子 R 1表示烷氧基，苄氧基，苯氧基，取代或未取代的烷基，取代或未取代的烯基或取代或未取代的环烷基，它们的对映异构体，非对映异构体和差向异构体，以及它们与药学上可接受的酸的加成盐，相同。

12. 发明授权

US5190923A Peptide compounds containing a cyclic amide structure 失效
标题翻译：含有环状结构的肽类化合物
公开(公告)号：US5190923A
公开(公告)日：1993-03-02
申请号：US710283
申请日：1991-06-04
申请人： Michel Vincent , Georges Remond , Bernard Portevin , Yolande Herve , Jean Lepagnol
发明人： Michel Vincent , Georges Remond , Bernard Portevin , Yolande Herve , Jean Lepagnol
IPC分类号： A61K38/00 , A61P25/28 , C07K5/08 , C07K5/097
CPC分类号： C07K5/0821 , A61K38/00 , Y10S514/824 , Y10S514/878 , Y10S514/879
摘要： The invention relates to compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, cyclic amide as defined in the description,B represents, with the nitrogen and carbon atoms to which it is linked, saturated polycyclic structure as defined in the description,R represents hydrogen, optionally substituted lower alkyl, optionally substituted (4-imidazolyl)methyl, (3-pyrazolyl)methyl or optionally substituted (2-pyridyl)methyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid.Medicinal products.
摘要翻译：本发明涉及式（I）化合物：其中：A表示与其连接的碳原子和氮原子，描述中定义的环酰胺，B表示与氮和与其连接的碳原子，如描述中所定义的饱和多环结构，R表示氢，任选取代的低级烷基，任选取代的（4-咪唑基）甲基，（3-吡唑基）甲基或任选取代的（2-吡啶基）甲基，它们的对映异构体，非对映异构体和差向异构体以及它们与药学上可接受的酸的加成盐。药用产品。

13. 发明授权

US5098888A New heterocyclic tripeptide compounds 失效
标题翻译：新型间苯二酚化合物
公开(公告)号：US5098888A
公开(公告)日：1992-03-24
申请号：US536193
申请日：1990-06-11
申请人： Michel Vincent , Georges Remond , Bernard Portevin , Yolande Herve , Jean Lepagnol , Catherine Biton
发明人： Michel Vincent , Georges Remond , Bernard Portevin , Yolande Herve , Jean Lepagnol , Catherine Biton
IPC分类号： A61K38/04 , A61K31/41 , A61K31/435 , A61K38/00 , A61P25/00 , A61P25/28 , C07D209/52 , C07D403/14 , C07D453/00 , C07K1/02 , C07K1/06 , C07K1/08 , C07K1/113 , C07K5/06 , C07K5/08 , C07K5/097
CPC分类号： C07K5/0821 , C07D209/52 , C07D453/00 , A61K38/00
摘要： The invention relates to the compounds of general formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, a cycloamide group,B represents, with the carbon and nitrogen atoms to which it is linked, a saturated polycyclic structure,R represents a hydrogen atom, alower alkyl group or a substituted or unsubstituted 4-imidazolylmethyl group,their diastereoisomers, enantiomers and epimers, as well as their addition salts with a pharmaceutically acceptable acid.Medicinal products.
摘要翻译：本发明涉及通式（I）的化合物：其中：A表示与其连接的碳原子和氮原子一起形成环氨基，B表示碳原子和氮原子其连接的是饱和多环结构，R表示氢原子，低级烷基或取代或未取代的4-咪唑基甲基，它们的非对映异构体，对映体和差向异构体，以及它们与药学上可接受的酸的加成盐。药用产品。

14. 发明申请

US20050100650A1 Granules and powders for instant drinks which are prepared using an extrusion cooking method 审中-公开
标题翻译：使用挤压蒸煮法制备的速溶饮料颗粒和粉末
公开(公告)号：US20050100650A1
公开(公告)日：2005-05-12
申请号：US10491477
申请日：2002-10-03
申请人： Jean Lepagnol , Laura Barsotti , Arnaud Vannier-Moreau , Eric Prudhomme
发明人： Jean Lepagnol , Laura Barsotti , Arnaud Vannier-Moreau , Eric Prudhomme
IPC分类号： A23G1/00 , A23G1/56 , A23L1/30 , A23L2/38 , A23L2/39 , A23K1/00
CPC分类号： A23G1/56 , A23G1/0016 , A23L2/38 , A23L2/39 , A23L25/30 , A23L33/105 , A23G2200/14 , A23G2200/04
摘要： Preparation by means of extrusion cooking of granules or powders from nuts and/or oleaginous fruits and/or oil seeds, which are optionally and partially defatted and/or dried in toto, the granules and powders being intended in particular for instant drinks. More specifically, the extrusion cooking method which is used in order to prepare the highly-nutritional granules or powders allows for the introduction of a high weight percentage (>/=40%) of the vegetable raw materials and for the concentration of the active ingredients and natural nutriments thereof.
摘要翻译：通过将来自坚果和/或含油果实和/或油种子的颗粒或粉末通过挤压蒸煮来制备，其任选地和部分地脱脂和/或干燥，颗粒和粉末特别用于速溶饮料。更具体地说，为了制备高营养颗粒或粉末而使用的挤出烹饪方法允许引入植物原料的高重量百分比（> 40％）和活性成分的浓度及其天然营养。

15. 发明授权

US5646132A 2(1H)-quinolone compounds 失效
标题翻译： 2（1H） - 喹诺酮化合物
公开(公告)号：US5646132A
公开(公告)日：1997-07-08
申请号：US499946
申请日：1995-07-10
申请人： Alex Cordi , Patrice Desos , Jean Lepagnol
发明人： Alex Cordi , Patrice Desos , Jean Lepagnol
IPC分类号： A61K31/675 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07F9/576 , C07F9/60
CPC分类号： C07F9/5765 , C07F9/60
摘要： Compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino, or a group ##STR3## in which R.sub.6 and R.sub.7 are as defined above, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base, and medicinal product containing the same are useful as inhibitor of the pathological phenomena associated with hyperactivation of the excitating amino acid-dependant pathways of neurotransmission.
摘要翻译：式（I）化合物：其中：R 1，R 2和R 3相同或不同，表示氢或卤素或烷基，硝基，氰基或氨基磺酰基，或者当其中两个位于（C 3 -C 7）环烷基环或取代或未取代的苯环，R 4表示氢，直链或支链（C 1 -C 6）烷基，取代或未取代的苯基或取代或未取代的苯基基团其中R6和R7相同或不同，表示氢或取代或未取代的直链或支链（C1-C6）烷基，R5表示氢，羟基，直链或支链（C1-C6）烷氧基，苯氧基（C1-C6）烷基，取代或未取代的直链或支链（C1-C6）烷基，取代或未取代的苯基或取代或未取代的氨基，或其中R6和R7为它们的异构体以及它们与药物的加成盐可接受的酸或碱，以及含有它们的药物可用作与神经传递的兴奋性氨基酸依赖性途径的高活化相关的病理现象的抑制剂。

16. 发明授权

US4886799A Acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone 失效
标题翻译：衍生自2,3-二氢-3-苯基-2-苯并呋喃酮的乙酰胺
公开(公告)号：US4886799A
公开(公告)日：1989-12-12
申请号：US244132
申请日：1988-09-14
申请人： Gilbert Lavielle , Jean Lepagnol
发明人： Gilbert Lavielle , Jean Lepagnol
IPC分类号： B64G1/40 , B64G1/42
CPC分类号： B64G1/42 , B64G1/402 , B64G1/401
摘要： The invention relates to new acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone, of general formula I ##STR1## in which: R.sub.1 denotes a hydrogen or halogen atom,R.sub.2 and R.sub.3, which may be identical or different, each denote a hydrogen atom or a linear or branched alkyl radical containing 1 to 4 carbon atoms, a benzyl radical optionally substituted with a halogen atom, with an alkoxy radical containing 1 to 4 carbon atoms or with an alkyl radical having 1 to 4 carbon atoms, or a 3,4-methylene-dioxybenzyl radical, or form, together with the nitrogen to which they are attached, a 4-morpholinyl radical or a 1-piperazinyl radical.
摘要翻译：本发明涉及衍生自通式I（I）的2,3-二氢-3-苯基-2-苯并呋喃酮的新型乙酰胺，其中：R1表示氢或卤素原子，R2和R3可以是相同或不同，各自表示氢原子或含有1至4个碳原子的直链或支链烷基，任选被卤素原子取代的苄基，含有1至4个碳原子的烷氧基或具有1个至4个碳原子，或3,4-亚甲基 - 二氧苄基，或与其连接的氮一起形成4-吗啉基或1-哌嗪基。

17. 发明授权

US4725581A New peptide compounds having a lactone or cycloamide structure 失效
标题翻译：具有内酯或环酰胺结构的新肽化合物
公开(公告)号：US4725581A
公开(公告)日：1988-02-16
申请号：US892345
申请日：1986-08-01
申请人： Michel Vincent , Georges Remond , Jean Lepagnol
发明人： Michel Vincent , Georges Remond , Jean Lepagnol
IPC分类号： A61K38/00 , A61K38/04 , A61K38/22 , A61P5/00 , A61P25/00 , A61P25/28 , C07K1/06 , C07K1/113 , C07K5/06 , C07K5/08 , C07K5/097 , A61K37/02 , C07K5/02
CPC分类号： C07K5/0821
摘要： New peptide compounds having a lactone or cycloamide structure and containing a saturated bicyclic structure, pharmaceutically-acceptable acid addition salts thereof, method for the preparation thereof, pharmaceutical compositions containing the same, and use thereof for the stimulation of cyclic AMP in the cerebral tissue and consequently increasing the metabolic capacities of the brain, thereby making them of interest in the treatment of diseases of the central nervous system or disorders approximating normal or pathological aging, are disclosed.
摘要翻译：具有内酯或环酰胺结构并含有饱和双环结构的新肽化合物，其药学上可接受的酸加成盐，其制备方法，含有该化合物的药物组合物及其在脑组织中刺激环AMP的用途和从而增加脑的代谢能力，从而使它们对中枢神经系统疾病的治疗或接近正常或病理衰老的病症感兴趣。

18. 发明授权

US06232319B1 Substituted tetrahydropyridin derivatives, method of preparation and pharmaceutical compositions containing them 失效
标题翻译：取代的四氢吡啶衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US06232319B1
公开(公告)日：2001-05-15
申请号：US09319341
申请日：1999-06-04
申请人： Christian Marazano , Delphine Compere , Bhupesh Chandra Das , Jean Lepagnol
发明人： Christian Marazano , Delphine Compere , Bhupesh Chandra Das , Jean Lepagnol
IPC分类号： A61K31435
CPC分类号： C07D211/70
摘要： The invention relates to compounds of general formula (I): in which R, R1, R2, X and Y are as defined in the description, their geometrical and/or optical isomers, and their addition salts with a pharmaceutically-acceptable acid or base, as well as to medicaments containing the same.
摘要翻译：本发明涉及通式（I）的化合物：其中R，R 1，R 2，X和Y如说明书中所定义，它们的几何和/或光学异构体及其与药学上可接受的酸或碱的加成盐，以及含有该药物的药物。

19. 发明授权

US5536709A 2(1H)-quinolone compounds 失效
标题翻译： 2（1H） - 喹诺酮化合物
公开(公告)号：US5536709A
公开(公告)日：1996-07-16
申请号：US297793
申请日：1994-08-30
申请人： Alex Cordi , Patrice Desos , Jean Lepagnol
发明人： Alex Cordi , Patrice Desos , Jean Lepagnol
IPC分类号： A61K31/675 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07F9/576 , C07F9/60 , C07D215/227 , C07F9/38
CPC分类号： C07F9/5765 , C07F9/60
摘要： Compound of formula (I): ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino; or a group ##STR3## in which R.sub.6 and R.sub.7 are as defined above, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base, and medicinal product containing the same are useful as inhibitor of the pathological phenomena associated with hyperactivation of the excitating amino acid-dependant pathways of neurotransmission.
摘要翻译：式（I）化合物：其中R 1，R 2和R 3相同或不同，表示氢或卤素或烷基，硝基，氰基或氨基磺酰基，或者当它们中的两个位于（C 3 -C 7）环烷基环或取代或未取代的苯环，R 4表示氢，直链或支链（C 1 -C 6）烷基，取代或未取代的苯基或基团其中R6和R7相同或不同，表示氢或取代或未取代的直链或支链（C1-C6）烷基，R5代表氢，羟基，直链或支链（C1-C6）烷氧基，苯氧基，直链或支链（C1-C6）烷硫基，取代或未取代的直链或支链（C1-6）烷基，取代或未取代的苯基或取代或未取代的氨基; 或其中R 6和R 7如上所定义的基团，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用作与超活化相关的病理现象的抑制剂兴奋性氨基酸依赖的神经传递途径。

20. 发明授权

US5506237A Bicyclic nitrogen compounds 失效
标题翻译：双环氮化合物
公开(公告)号：US5506237A
公开(公告)日：1996-04-09
申请号：US216794
申请日：1994-03-23
申请人： Guillaume De Nanteuil , Bernard Protevin , Georges Remond , Jean Lepagnol , Veronique Heidet
发明人： Guillaume De Nanteuil , Bernard Protevin , Georges Remond , Jean Lepagnol , Veronique Heidet
IPC分类号： A61K31/40 , A61K31/401 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/47 , A61P9/00 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D209/42 , C07D401/06 , C07D403/06 , C07D409/08 , C07D413/06 , C07D417/06 , C07D453/02 , C07D453/06
CPC分类号： C07D409/08 , C07D209/42 , C07D453/06
摘要： The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is attached, a heterocycle,B represents, with the nitrogen atom to which it is attached, a heterocycle,n is equal to 1, 2, 3 or 4,R represents phenyl substituted by at least one halogen or alkyl, hydroxyl, alkoxy, trifluoromethyl, nitro, amino, cyano, carboxyl or alkoxycarbonyl, benzyl, thienyl or pyridyl. The compounds may be used as medicaments.
摘要翻译：本发明涉及式（I）化合物：其中：A表示与其连接的碳原子和氮原子一起形成杂环，B表示与其原子的氮原子羟基，烷氧基，三氟甲基，硝基，氨基，氰基，羧基或烷氧基羰基，苄基，噻吩基或吡啶基，其中R表示被至少一个卤素取代的苯基，。这些化合物可以用作药物。

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