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11. 发明授权

US07405825B2 Optical analysis system 失效
标题翻译：光学分析系统
公开(公告)号：US07405825B2
公开(公告)日：2008-07-29
申请号：US10539540
申请日：2003-12-19
申请人： Frank Jeroen Pieter Schuurmans , Michael Cornelis Van Beek , Levinus Pieter Bakker , Wouter Harry Jacinth Rensen , Bernardus Hendrikus Wilhelmus Hendriks , Robert Frans Maria Hendriks , Thomas Steffen
发明人： Frank Jeroen Pieter Schuurmans , Michael Cornelis Van Beek , Levinus Pieter Bakker , Wouter Harry Jacinth Rensen , Bernardus Hendrikus Wilhelmus Hendriks , Robert Frans Maria Hendriks , Thomas Steffen
IPC分类号： G01J3/32 , G01J3/457 , G02B26/02
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/10 , G01J3/28 , G01J3/36 , G01N21/274 , G01N21/31 , G01N2021/3196 , G01N2201/129
摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.
摘要翻译：用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。血液分析系统（40）包括根据本发明的光学分析系统（20）。

12. 发明授权

US10791932B2 Optical detection method and device for optical detection of the condition of joints 有权
公开(公告)号：US10791932B2
公开(公告)日：2020-10-06
申请号：US12992609
申请日：2009-05-20
申请人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
发明人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
IPC分类号： A61B5/00 , A61B5/02
摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

13. 发明申请

US20110066034A1 OPTICAL DETECTION METHOD AND DEVICE FOR OPTICAL DETECTION OF THE CONDITION OF JOINTS 审中-公开
标题翻译：光学检测方法和用于光学检测接头状态的装置
公开(公告)号：US20110066034A1
公开(公告)日：2011-03-17
申请号：US12992609
申请日：2009-05-20
申请人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
发明人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
IPC分类号： A61B6/00
摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.
摘要翻译：提供了一种光学检测方法，其中包括至少一个接头的主体部分（5）被照射光。在身体部分（5）的光的局部衰减被检测为在至少一个关节的位置处和身体部分（5）的至少另一部分的位置处的衰减测量（2）。并且其中进入和/或离开身体部分（5）的血液流动暂时至少部分被阻止，然后再次启动（3）。对于至少一个关节和身体部分（5）的至少一个其他部分的不同局部衰减测量在（I）之前，（II）期间和（III）之后的至少两次中进行，的血流。

14. 发明申请

US20090326385A1 OBTAINING OPTICAL TISSUE PROPERTIES 审中-公开
标题翻译：获得光学组织特性
公开(公告)号：US20090326385A1
公开(公告)日：2009-12-31
申请号：US12517249
申请日：2007-11-29
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Ruth Wilhelmine Ireen De Boer , Augustinus Laurentius Braun , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Ruth Wilhelmine Ireen De Boer , Augustinus Laurentius Braun , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/6848
摘要： This application describes a medical device (230) for obtaining optical tissue properties of a target material. The medical device (230) comprises an elongated body (231) having a longitudinal axis (232) and an optical fiber being integrated within the elongated body (231). The optical fiber has a second fiber end (242, 242a, 242b), which is arranged at a side wall (233) of the elongated body (231) and which provides a lateral field of view with respect to the longitudinal axis (232). According to an embodiment many optical fibers are integrated each having an optical outlet (242, 242a, 242b) around the elongated body (231). Using the outlets (242, 242a, 242b) to do diffuse optical tomography and also use optical fibers to do an optical inspection, one can get information on the presence of tumors in a volume around the medical device (230) and a tissue characterization in the vicinity of the medical device (230). Thereby, an optical biopsy may be carried out, wherein no real tissue is removed. According to another embodiment an optical detection system is integrated into a real biopsy needle (330) allowing inspection and taking real biopsy simultaneously.
摘要翻译：本申请描述了用于获得目标材料的光学组织性质的医疗装置（230）。医疗装置（230）包括具有纵向轴线（232）的细长主体（231）和整合在细长主体（231）内的光纤。光纤具有第二光纤端（242,242a，242b），其被布置在细长主体（231）的侧壁（233）处，并且相对于纵向轴线（232）提供横向视场，。根据实施例，许多光纤被集成为每个都具有围绕细长主体（231）的光学出口（242,242a，242b）。使用出口（242,242a，242b）进行漫射光学层析成像，并且还使用光纤进行光学检查，可以获得关于医疗装置周围的体积肿瘤的存在的信息（230）和组织表征医疗装置（230）的附近。因此，可以进行光学活检，其中不去除真实的组织。根据另一个实施例，光学检测系统被集成到实际的活检针（330）中，允许同时进行检查和进行实际的活检。

15. 发明申请

US20080285812A1 Personal Identification Method and Apparatus 审中-公开
标题翻译：个人识别方法和装置
公开(公告)号：US20080285812A1
公开(公告)日：2008-11-20
申请号：US11568719
申请日：2005-04-28
申请人： Wouter Harry Jacinth Rensen , Robert Frans Maria Hendriks , Michael Cornelis Van Beek , Antonius Hermanus Maria Akkermans
发明人： Wouter Harry Jacinth Rensen , Robert Frans Maria Hendriks , Michael Cornelis Van Beek , Antonius Hermanus Maria Akkermans
IPC分类号： G06K9/00
CPC分类号： G06K9/00033 , G06K2009/00932
摘要： The invention relates to a personal identification method and to a corresponding apparatus. Their elements are mainly a light source emitting a beam of light towards a target, a first imaging module receiving a return beam coming back from said target and displaying an image of the target of a first type, and a second imaging module also receiving said return beam and displaying an image of the target of a second type. An identification module allows to combine the information given by said image of a first type and said image of a second type and to identify, or not, a person according to a similarity criterion.
摘要翻译：本发明涉及个人识别方法和相应的装置。它们的元件主要是朝向目标发射光束的光源，第一成像模块接收从所述目标回来的返回光束并显示第一类型的目标的图像，以及第二成像模块，还接收所述返回并显示第二类型的目标的图像。识别模块允许组合由所述第一类型的图像和所述第二类型的图像给出的信息，并且根据相似性标准来识别或不识别人。

16. 发明申请

US20090015819A1 OPTICAL ANALYSIS SYSTEM, BLOOD ANALYSIS SYSTEM AND METHOD OF DETERMINING AN AMPLITUDE OF A PRINCIPAL COMPONENT 审中-公开
标题翻译：光学分析系统，血液分析系统和确定主成分的幅度的方法
公开(公告)号：US20090015819A1
公开(公告)日：2009-01-15
申请号：US10596563
申请日：2004-12-13
申请人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
发明人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , G01J3/28 , G01N21/274 , G01N21/64 , G01N21/6445 , G01N21/65 , G01N2021/3196 , G01N2021/6417 , G01N2021/655
摘要： The optical analysis system (20) is arranged to determine an amplitude of a principal component of an optical signal. The optical analysis system (20) comprises a multivariate optical element (5, 6) for weighing the optical signal by a spectral weighing function and a detector (7, 8) for detecting the weighed optical signal. The optical signal comprises the principal component and a further component which was not accounted for when designing the spectral weighing function. Therefore, the detected weighed optical signal comprises a part relating to the amplitude of the principal component and a further part relating to a further amplitude of the further component. The optical analysis system (20) further comprises a modulator element (13) for modulating the detected weighed optical signal. The difference between the modulated detected weighed optical signal and the detected weighed optical signal relates to the amplitude of the principal component and thus allows for determining the amplitude of the principal component in an accurate way. The blood analysis system (40) comprises such an optical analysis system (20). The method of determining an amplitude of an principal component makes use of the optical analysis system (20).
摘要翻译：光学分析系统（20）被布置成确定光信号的主分量的幅度。光学分析系统（20）包括用于通过光谱称重功能称量光信号的多元光学元件（5,6）和用于检测加权光信号的检测器（7,8）。光信号包括主分量和另外的分量，在设计光谱称重功能时不考虑。因此，检测到的加权光信号包括与主分量的振幅有关的部分，以及与另一分量的另一幅度相关的另一部分。光学分析系统（20）还包括用于调制检测到的称重光信号的调制器元件（13）。调制检测到的称重光信号与检测到的称重光信号之间的差异与主分量的振幅有关，因此允许以准确的方式确定主分量的振幅。血液分析系统（40）包括这样的光学分析系统（20）。确定主成分的振幅的方法利用光学分析系统（20）。

17. 发明申请

US20110201942A1 DEVICE AND METHOD FOR OPTICALLY EXAMINING THE INTERIOR OF A BODY PART 审中-公开
标题翻译：用于光学检查身体部分的内部的装置和方法
公开(公告)号：US20110201942A1
公开(公告)日：2011-08-18
申请号：US13125677
申请日：2009-10-21
申请人： Marius Iosif Boamfa , Wouter Harry Jacinth Rensen
发明人： Marius Iosif Boamfa , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/4528 , A61B5/6825
摘要： A device for optically examining the interior of a body part by transillumination is provided. The device comprises: an illumination unit (2) adapted for emitting polarized light (8) towards a body part (5) to be examined; and a detector unit (6) adapted for detecting light in transmission. A polarizer (10) is arranged in front of the detector unit (6).
摘要翻译：提供了通过透照光学检查身体部分的内部的装置。该装置包括：照明单元（2），适于向待检查的身体部分（5）发射偏振光（8）; 以及适于检测透射光的检测器单元（6）。偏振器（10）布置在检测器单元（6）的前面。

18. 发明申请

US20090153852A1 OPTICAL FIBER FOR SPECTROSCOPIC ANALYSIS SYSTEM 审中-公开
标题翻译：光纤光谱分析系统
公开(公告)号：US20090153852A1
公开(公告)日：2009-06-18
申请号：US11568198
申请日：2005-04-12
申请人： Wouter Harry Jacinth Rensen
发明人： Wouter Harry Jacinth Rensen
IPC分类号： G01J3/00 , G02B6/26 , G02B6/02
CPC分类号： G01J3/02
摘要： The present invention provides an optical fiber for connecting a probe head and a base station of a spectroscopic analysis system for analyzing the molecular composition of a volume of interest. The optical fiber comprises a core for transmission of excitation radiation from the base station to the probe head and a first cladding for transmission of multi-mode return radiation from the probe head to a spectroscopic analysis unit of the base station. Preferably, the first cladding is surrounded by a second cladding and therefore provides a multi-mode wave guide by itself. Appropriately designing the dimensions of the core, the first cladding and the second cladding provides an optimal collection and coupling efficiency of the optical fiber. Coating of the distal end facet of the optical fiber with multi-layer optical filters allows an effective separation of elastically and inelastically scattered radiation which is of advantage for the spectroscopic analysis.
摘要翻译：本发明提供了用于连接用于分析感兴趣体积的分子组成的光谱分析系统的探针头和基站的光纤。光纤包括用于从基站传输到探头的激发辐射的核心和用于将多模返回辐射从探头传输到基站的光谱分析单元的第一包层。优选地，第一包层被第二包层包围，因此本身提供多模式波导。适当地设计芯的尺寸，第一包层和第二包层提供了光纤的最佳收集和耦合效率。使用多层光学滤光器对光纤的远端面进行涂覆，可有效地分离弹性和非弹性散射的辐射，这对于光谱分析是有利的。

19. 发明授权

US07924140B2 Biometrics-based identification method and apparatus 有权
标题翻译：基于生物识别的识别方法和装置
公开(公告)号：US07924140B2
公开(公告)日：2011-04-12
申请号：US11577375
申请日：2005-10-20
申请人： Robert Frans Maria Hendriks , Wouter Harry Jacinth Rensen , Antonius Hermanus Maria Akkermans
发明人： Robert Frans Maria Hendriks , Wouter Harry Jacinth Rensen , Antonius Hermanus Maria Akkermans
IPC分类号： G05B19/00
CPC分类号： G06K9/0012 , G06K9/00013 , G06K9/00899 , G06K2009/00932
摘要： The invention relates to an identification method carried out as follows. A surface structure and an inner structure of a body member are measured (ST1-ST4, ST7) so as to obtain a surface-structure measurement result (FPM) and an inner-structure measurement result (BVPM), respectively. The surface-structure measurement result (FPM) is compared (ST5) with a surface-structure reference result (FPR) that distinguishes an individual from other individuals. The inner-structure measurement result (BVPM) is compared (ST8) with an inner-structure reference result (BVPR) that is associated with the same individual and that distinguishes the individual from other individuals. The body member may be, for example, a finger. In that case, the surface structure comprises a fingerprint and the inner structure comprises a blood-vessel pattern.
摘要翻译：本发明涉及如下进行的识别方法。测量体部件的表面结构和内部结构（ST1-ST4，ST7），以获得表面结构测量结果（FPM）和内部结构测量结果（BVPM）。比较表面结构测量结果（FPM）（ST5）与区分个体与其他个体的表面结构参考结果（FPR）。比较内部结构测量结果（BVPM）（ST8）与与同一个人相关联的内部结构参考结果（BVPR），并将个体与其他个体区分开。身体构件可以是例如手指。在这种情况下，表面结构包括指纹，内部结构包括血管图案。

20. 发明申请

US20130310697A1 DEVICE AND METHOD FOR DETERMINING A DISEASE ACTIVITY 有权
标题翻译：用于确定疾病活动的装置和方法
公开(公告)号：US20130310697A1
公开(公告)日：2013-11-21
申请号：US13989800
申请日：2011-11-25
申请人： Wouter Harry Jacinth Rensen , Pieter Klaas De Bokx
发明人： Wouter Harry Jacinth Rensen , Pieter Klaas De Bokx
IPC分类号： A61B5/00
CPC分类号： A61B5/0082 , A61B5/0075 , A61B5/022 , A61B5/0261 , A61B5/4528 , A61B5/4842 , A61B5/6825 , A61B5/6829
摘要： A system and method to determine a disease activity as a single value by way of optical measurements in order to facilitate an analysis of a current disease status and a future course of disease, thus assisting a doctor's diagnosis or decision on a therapy. A blood perfusion is varied in an area of interest, the area of interest is irradiated with light of at least two wavelengths, an intensity of light reflected and/or transmitted by the area of interest is detected, features are derived from detected intensity curves of at least two predetermined wavelengths under at least two different perfusion conditions, and the disease activity is determined using these features.
摘要翻译：通过光学测量法将疾病活动确定为单一值的系统和方法，以便于分析当前疾病状况和未来疾病进程，从而帮助医生诊断或决定治疗。在感兴趣的区域中改变血液灌注，用至少两个波长的光照射感兴趣的区域，检测由感兴趣区域反射和/或透射的光的强度，特征是从检测到的强度曲线在至少两个不同灌注条件下至少两个预定波长，并且使用这些特征确定疾病活动。

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