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11. 发明授权

US5355087A Intracavity probe and interface device for MRI imaging and spectroscopy 失效
标题翻译：用于MRI成像和光谱学的腔内探针和界面装置
公开(公告)号：US5355087A
公开(公告)日：1994-10-11
申请号：US637658
申请日：1991-02-11
申请人： Theodore C. Claiborne , George J. Misic , Thomas R. Welch , Edward J. Rhinehart
发明人： Theodore C. Claiborne , George J. Misic , Thomas R. Welch , Edward J. Rhinehart
IPC分类号： G01R33/32 , A61B5/055 , A61F2/958 , G01R33/28 , G01R33/34 , G01R33/36 , G01R33/20
CPC分类号： B82Y15/00 , A61B5/055 , A61B5/4381 , A61M25/1002 , A61M25/1011 , G01R33/285 , G01R33/341 , G01R33/3628 , A61M2025/1013 , A61M2025/107 , A61M2025/1084 , G01R33/34084 , G01R33/3621 , G01R33/3657
摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatable inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft.
摘要翻译：可插入的探头和用于磁共振成像和光谱学的接口网络。优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。界面气囊包括由柔性外气囊包围的可充气内球囊。接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。

12. 发明授权

US06833705B2 Neurovascular coil system and interface and system therefor and method of operating same in a plurality of modes 失效
标题翻译：神经血管线圈系统及其接口及系统及其在多种模式中的操作方法
公开(公告)号：US06833705B2
公开(公告)日：2004-12-21
申请号：US10082818
申请日：2002-02-25
申请人： George J. Misic
发明人： George J. Misic
IPC分类号： G01V300
CPC分类号： G01R33/3664 , G01R33/3415 , G01R33/3678
摘要： A coil interface allows a neurovascular coil system to be coupled to a magnetic resonance (MR) system. The neurovascular coil system has an array of coils including a birdcage coil, a spine coil, and at least one neck coil, with the MR system being equipped with a number of receivers. The coil interface includes a plurality of input ports, a plurality of output ports, and an interface circuit. The plurality of input ports are for coupling to the coils of the neurovascular coil system, and the plurality of output ports for coupling to the receivers of the MR system. The interface circuit enables the input ports and output ports to be selectively interconnected, and thereby enables the neurovascular coil system to be selectively operated in (I) a neurovascular mode; (II) a high resolution brain mode; (III) a high speed brain mode; and (IV) a volume neck mode.
摘要翻译：线圈接口允许神经血管线圈系统耦合到磁共振（MR）系统。神经血管线圈系统具有包括鸟笼线圈，脊线圈和至少一个颈线圈的线圈阵列，MR系统配备有多个接收器。线圈接口包括多个输入端口，多个输出端口和接口电路。多个输入端口用于耦合到神经血管线圈系统的线圈，以及用于耦合到MR系统的接收器的多个输出端口。接口电路使得输入端口和输出端口能够选择性地互连，从而使得神经血管线圈系统能够以（I）神经血管模式选择性地操作; （二）高分辨率脑模式; （三）高速脑模式; 和（IV）体积颈部模式。

13. 发明授权

US06396273B2 Magnetic resonance imaging receiver/transmitter coils 失效
标题翻译：磁共振成像接收器/发射器线圈
公开(公告)号：US06396273B2
公开(公告)日：2002-05-28
申请号：US09776132
申请日：2001-02-02
申请人： George J. Misic
发明人： George J. Misic
IPC分类号： G01V300
CPC分类号： G01R33/3415
摘要： A magnetic resonance imaging receiver/transmitter coil system for providing images for regions of interest includes a first phased array formed of a plurality of electrically conductive members and defining an array volume and a second phased array formed of a second plurality of electrically conductive members and disposed at least partially within the defined array volume. At least one of the first and second phased arrays is adapted to apply a magnetic field to the defined array volume. At least one of the first and second phased arrays is further adapted to receive said applied magnetic field. The first phased array is extendible to define a further array volume and is provided with a switch for electrically coupling and decoupling an extension to effectively extend the length of the first phased array and thereby define the further array volume. In this manner the length of the first phased array is effectively extended to approximately twice its unextended length.
摘要翻译：用于为感兴趣区域提供图像的磁共振成像接收器/发射器线圈系统包括由多个导电构件形成并限定阵列体积的第一相控阵列和由第二多个导电构件形成的第二相控阵列，至少部分地在定义的阵列卷内。第一和第二相控阵列中的至少一个适于将磁场施加到限定的阵列体积。所述第一和第二相控阵列中的至少一个进一步适于接收所述施加的磁场。第一相控阵可扩展以限定另一个阵列体积，并设置有用于电耦合和解耦延伸的开关，以有效地延长第一相控阵列的长度，从而限定另外的阵列体积。以这种方式，第一相控阵列的长度有效地延伸到其未延伸长度的大约两倍。

14. 发明授权

US6040697A Magnetic resonance imaging receiver/transmitter coils 失效
公开(公告)号：US6040697A
公开(公告)日：2000-03-21
申请号：US979842
申请日：1997-11-26
申请人： George J. Misic
发明人： George J. Misic
IPC分类号： G01R33/3415 , G01V3/00
CPC分类号： G01R33/3415
摘要： A magnetic resonance imaging receiver/transmitter coil system for providing images for regions of interest includes a first phased array formed of a plurality of electrically conductive members and defining an array volume and a second phased array formed of a second plurality of electrically conductive members and disposed at least partially within the defined array volume. At least one of the first and second phased arrays is adapted to apply a magnetic field to the defined array volume. At least one of the first and second phased arrays is further adapted to receive said applied magnetic field. The first phased array is extendible to define a further array volume and is provided with a switch for electrically coupling and decoupling an extension to effectively extend the length of the first phased array and thereby define the further array volume. In this manner the length of the first phased array is effectively extended to approximately twice its unextended length.

15. 发明授权

US5348010A Intracavity probe and interface device for MRI imaging and spectroscopy 失效
标题翻译：用于MRI成像和光谱学的腔内探针和界面装置
公开(公告)号：US5348010A
公开(公告)日：1994-09-20
申请号：US949918
申请日：1992-09-24
申请人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack , Theodore C. Claiborne , George J. Misic , Thomas R. Welch , Edward J. Rhinehart
发明人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack , Theodore C. Claiborne , George J. Misic , Thomas R. Welch , Edward J. Rhinehart
IPC分类号： A61B5/055 , A61F2/958 , A61M25/095 , G01R33/34 , G01R33/36 , A61B5/55
CPC分类号： G01R33/341 , A61B5/055 , A61B5/4381 , A61M25/1011 , G01R33/34084 , A61M2025/1013 , A61M25/1002 , G01R33/34007 , G01R33/3657
摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatabe inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft. An interface network is also provided which receives the interconnecting cable of the pickup probe and includes impedance matching means, tuning means, and decoupling means for interfacing the probe with a magnetic resonance imaging scanner. In addition, the interface includes an electronic circuit for automatically adjusting the control voltage of a varactor diode in a Pi network which comprises the tuning means.
摘要翻译：可插入的探头和用于磁共振成像和光谱学的接口网络。优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。界面气囊包括由柔性外气囊包围的发泡内气囊。接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。还提供接口网络，其接收拾取探针的互连电缆，并且包括阻抗匹配装置，调谐装置和用于将探针与磁共振成像扫描器对接的去耦装置。此外，该接口包括用于在包括调谐装置的Pi网络中自动调节变容二极管的控制电压的电子电路。

16. 发明授权

US5258717A Geometrically isolated multiple port volume MRI receiving coil comprising multiple quadrature coils 失效
标题翻译：几何隔离多端口体积MRI接收线圈，包括多个正交线圈
公开(公告)号：US5258717A
公开(公告)日：1993-11-02
申请号：US743489
申请日：1991-08-09
申请人： George J. Misic , Eric D. Reid
发明人： George J. Misic , Eric D. Reid
IPC分类号： A61B5/055 , G01R33/34 , G01R33/3415 , G01R33/36 , G01R33/20
CPC分类号： G01R33/34046 , G01R33/3415
摘要： A magnetic resonance imaging receiving coil having an improved signal-to-noise ratio comprising two or more separate quadrature volume coils, each intercepting the two quadrature components of the magnetic resonance signal within its own sensitive volume, and the two or more quadrature coils being magnetically isolated from each other by overlap geometry along the axis normal to the plane of the magnetic resonance rotating field. The coils are connected to independent image processing channels of a data acquisition system, the outputs of the processing channels being combined to form an overall image.
摘要翻译：具有改善的信噪比的磁共振成像接收线圈包括两个或更多个分离的正交体积线圈，每个线圈在其自身的灵敏体积内截获磁共振信号的两个正交分量，并且两个或更多个正交线圈是磁性的通过与磁共振旋转场的平面垂直的轴的重叠几何形状彼此隔离。线圈连接到数据采集系统的独立图像处理通道，组合处理通道的输出以形成整体图像。

17. 发明授权

US5196796A Anatomically conformal quadrature MRI surface coil 失效
标题翻译：解剖一致性MRI表面线圈
公开(公告)号：US5196796A
公开(公告)日：1993-03-23
申请号：US740920
申请日：1991-08-06
申请人： George J. Misic , Eric D. Reid
发明人： George J. Misic , Eric D. Reid
IPC分类号： A61B5/055 , G01R33/34 , G01R33/341 , G01R33/36
CPC分类号： G01R33/3678 , A61B5/0555 , G01R33/341 , G01R33/34084
摘要： A quadrature surface probe comprising two individual mirror image coil loops arranged so that the magnetic field vectors of the respective coil loops are substantially perpendicular. An area of overlap between the first and second coil loops is adjusted to minimize the mutual coupling between the individual coils. Also disclosed is the method of manufacturing the quadrature surface probe.
摘要翻译：包括两个单独的镜像线圈环的正交表面探针，其布置成使得各个线圈环的磁场矢量基本上垂直。调整第一和第二线圈环之间的重叠区域以最小化各个线圈之间的相互耦合。还公开了制造正交表面探针的方法。

18. 发明授权

US4797617A Nuclear magnetic resonance radio frequency antenna 失效
标题翻译：核磁共振射频天线
公开(公告)号：US4797617A
公开(公告)日：1989-01-10
申请号：US933152
申请日：1986-11-21
申请人： George J. Misic , Aarne Lillo , John L. Patrick , G. Neil Holland
发明人： George J. Misic , Aarne Lillo , John L. Patrick , G. Neil Holland
IPC分类号： G01R33/34 , G01R33/36 , G01R33/20
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/3628 , G01R33/3657
摘要： A nuclear magnetic resonance radio frequency coil. The disclosed coil provides high frequency resonance signals for perturbing a magnetic field within the coil. The coil is impedance matched and tuned with adjustable capacitors. A balanced configuration is achieved with a co-axial cable chosen to phase shift an energization signal coupled to the coil. The preferred coil is a thin metallic foil having a shorting conductor, four wing conductors, and uniquely shaped parallel cross conductors connecting the shorting and wing conductors. When mounted to an rf transmissive plastic substrate and energized the coil produces a homogenous field within a region of interest the size of a patient head. A semicircular balanced feedbar arrangement is used to minimize undesired field contributions.
摘要翻译：核磁共振射频线圈。所公开的线圈提供用于扰乱线圈内的磁场的高频谐振信号。线圈阻抗匹配并用可调电容器调谐。使用同轴电缆实现平衡配置，以使相耦合到线圈的通电信号相移。优选的线圈是具有短路导体，四个机翼导体和连接短路和翼导体的独特成形的平行十字导体的薄金属箔。当安装到rf透射塑料基板并通电时，线圈在患者头部的尺寸的感兴趣区域内产生均匀的场。使用半圆平衡馈线布置来最小化不期望的场贡献。

19. 发明授权

US08989841B2 Interface devices for use with intracavity probes for high field strength magnetic resonance systems 有权
标题翻译：用于高场强磁共振系统的腔内探头的接口装置
公开(公告)号：US08989841B2
公开(公告)日：2015-03-24
申请号：US13018849
申请日：2011-02-01
申请人： George J. Misic
发明人： George J. Misic
IPC分类号： A61B5/055 , G01R33/28 , G01R33/36 , G01R33/34
CPC分类号： G01R33/285 , A61B5/055 , G01R33/34084 , G01R33/3628
摘要： An interface device enables an intracavity probe to be used with a magnetic resonance (MR) system for the purpose of obtaining images or spectra of a region of interest within a cavity of a patient. The probe includes a shaft, a balloon at one end thereof, and a coil loop within the balloon. The coil loop preferably includes two drive capacitors and a tuning capacitor, all of which in series. A junction node between the drive capacitors serves as a ground for electrically balancing the coil loop. Diametrically opposite the junction node, the tuning capacitor enables the coil loop to resonate at the operating frequency of the MR system. Across each drive capacitor is connected an output cable having an electrical length of SL+n(λ/4). The output cables terminate in a plug that is used to connect the coil loop to the interface device.
摘要翻译：接口装置能够使腔内探针与磁共振（MR）系统一起使用，以获得患者空腔内感兴趣区域的图像或光谱。探针包括轴，其一端处的气囊和气囊内的线圈环。线圈环优选地包括两个串联的驱动电容器和调谐电容器。驱动电容器之间的结节点用作电平衡线圈回路的接地。调谐电容与连接节点完全相反，使得线圈环能够在MR系统的工作频率下谐振。在每个驱动电容器之间连接一个电长度为SL + n（λ/ 4）的输出电缆。输出电缆端接在用于将线圈环连接到接口设备的插头中。

20. 发明授权

US07632245B1 Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure 有权
标题翻译：用于在磁共振程序期间将流体输送到患者体内的装置，系统和方法
公开(公告)号：US07632245B1
公开(公告)日：2009-12-15
申请号：US10921083
申请日：2004-08-18
申请人： Kevin P. Cowan , Frederick W. Trombley, III , David M. Reilly , David M. Griffiths , George J. Misic , Keith Callan
发明人： Kevin P. Cowan , Frederick W. Trombley, III , David M. Reilly , David M. Griffiths , George J. Misic , Keith Callan
IPC分类号： A61M5/19
CPC分类号： A61M5/14526 , A61M5/007 , A61M2039/0009 , A61M2205/3362
摘要： A device for injection of a fluid into a patient includes a container adapted to hold the fluid and defining an outlet through which the fluid can exit the container. A pressurizing mechanism is in connection with the container for pressurizing the fluid, and an actuator is in fluid connection with the outlet. The actuator has a first state in which fluid is prevented from flowing through the outlet and a second state in which fluid can flow through the outlet. The injection device further includes a flow regulator to control the flow rate of fluid in fluid connection with the outlet. The container, the pressurizing mechanism, the actuator and the flow regulator can be MR compatible, thereby making the device suitable for use in or near the bore of an MR scanner.
摘要翻译：用于向患者注射流体的装置包括适于保持流体并限定出口的容器，流体可通过该出口离开容器。加压机构与用于对流体加压的容器连接，并且致动器与出口流体连接。致动器具有防止流体流过出口的第一状态和流体可以流过出口的第二状态。注射装置还包括流量调节器以控制与出口流体连接的流体的流速。容器，加压机构，致动器和流量调节器可以是MR兼容的，从而使得该装置适合于在MR扫描器的孔中或附近使用。

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