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11. 发明授权

US6150533A N-aryloxyethyl-indoly-alkylamines for the treatment of depression 失效
标题翻译：用于治疗抑郁症的N-芳氧基乙基 - 吲哚烷基胺
公开(公告)号：US6150533A
公开(公告)日：2000-11-21
申请号：US287832
申请日：1999-04-07
申请人： Richard E. Mewshaw , James A. Nelson
发明人： Richard E. Mewshaw , James A. Nelson
IPC分类号： C07D209/34 , C07D403/12 , C07D235/04 , A61K31/404 , A61K31/4184 , C07D209/48 , C07D235/22 , A61N25/24
CPC分类号： C07D403/12 , C07D209/34
摘要： Compounds effective in treating disorders of the serotonin-affected neurological systems are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 is hydrogen, lower alkyl, phenyl, or substituted phenyl;X and Y together complete a lactam, imidazole, imidazolone, or thioimidazolone ring;Z is hydrogen, halogen, or lower alkoxy;W is hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or a trifluoromethyl group;and n=2 to 5; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了有效治疗血清素受影响的神经系统疾病的化合物，这些化合物具有下式：其中：R 1是氢，低级烷基，苯基或取代的苯基; X和Y一起完成内酰胺，咪唑，咪唑啉酮或硫代咪唑啉酮环; Z是氢，卤素或低级烷氧基; W是氢，卤素，低级烷氧基，低级烷基，氰基或三氟甲基; n = 2〜5; 或其药学上可接受的盐。

12. 发明授权

US6110956A N-aryloxyethylamine derivatives for the treatment of depression 失效
标题翻译： N-芳氧基乙胺衍生物用于治疗抑郁症
公开(公告)号：US6110956A
公开(公告)日：2000-08-29
申请号：US287416
申请日：1999-04-07
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： A61P25/24 , C07D209/14 , C07D403/12 , C07D405/12 , A61K31/404 , A61K31/4045 , C07D209/04 , C07D403/08
CPC分类号： C07D403/12 , C07D209/14 , C07D405/12
摘要： Compounds effective in treating disorders of the serotonin-affected neurological systems are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each, independently, hydrogen, halogen, CF.sub.3, lower alkyl, lower alkoxy, MeSO.sub.2, or together can form a 5-7 membered carbocyclic or heterocyclic ring;R.sub.3 is alkoxy, halogen, hydrogen or carbamoyl;R.sub.4 is hydrogen, hydroxy, lower alkyl, or lower alkoxy;R.sub.5 is hydrogen, lower alkyl, or halogen;R.sub.6 is hydrogen, lower alkyl, or phenyl;R.sub.7 is hydrogen, lower alkyl, lower alkoxy, halogen, CN, CF.sub.3, or hydroxy; andX is (CH.sub.2).sub.n,wherein n is 0 to 3; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了有效治疗受5-羟色胺影响的神经系统疾病的化合物，具有下式的化合物：其中：R 1和R 2各自独立地为氢，卤素，CF 3，低级烷基，低级烷氧基，MeSO 2或一起可形成 5-7元碳环或杂环; R3是烷氧基，卤素，氢或氨基甲酰基; R4是氢，羟基，低级烷基或低级烷氧基; R5是氢，低级烷基或卤素; R6是氢，低级烷基或苯基; R7是氢，低级烷基，低级烷氧基，卤素，CN，CF3或羟基; X为（CH 2）n，n为0〜3; 或其药学上可接受的盐。

13. 发明授权

US5541199A Chroman-2-ylmethylamino derivatives 失效
标题翻译：色满-2-基甲基氨基衍生物
公开(公告)号：US5541199A
公开(公告)日：1996-07-30
申请号：US460168
申请日：1995-06-02
申请人： Richard E. Mewshaw
发明人： Richard E. Mewshaw
IPC分类号： C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D493/02 , C07D498/02
CPC分类号： C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12
摘要： Compounds of the formula: ##STR1## in which n is one of the integers 1, 2, 3,or 4; m is one of the integers 0 or 1; R is ##STR2## or a pharmaceutically acceptable salt thereof, are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs.
摘要翻译：下式的化合物：其中n是整数1,2,3或4之一; m是整数0或1之一; R是或其药学上可接受的盐，是多巴胺合成和释放的抑制剂，可用于治疗精神分裂症，帕金森病，图雷特综合征，酒精成瘾，可卡因成瘾和成瘾到药物。

14. 发明授权

US4709025A Beta-lactams substituted at C-4 with substituted aminooxymethyl 失效
标题翻译：在C-4被取代的氨氧基甲基取代的β-内酰胺
公开(公告)号：US4709025A
公开(公告)日：1987-11-24
申请号：US4529
申请日：1987-01-20
申请人： Richard E. Mewshaw , Thomas J. Commons
发明人： Richard E. Mewshaw , Thomas J. Commons
IPC分类号： C07D417/12 , A61K31/425 , A61K31/55 , C07D417/14
CPC分类号： C07D417/12
摘要： This invention provides novel antibacterial beta-lactams of the formula: ##STR1## in which R is alkyl of 1 to 6 carbon atoms, carboxyalkyl of 2 to 6 carbon atoms or alkoxycarbonylalkyl wherein the alkyl and alkoxy moieties contain, independently, 1 to 6 carbon atoms;R.sup.1 is alkylideneamino of 2 to 6 carbon atoms, alkanoylamino of 2 to 6 carbon atoms, carboxyalkylideneamino of 2 to 6 carbon atoms, alkylsulfonylamino of 1 to 6 carbon atoms, alkoxycarbonylalkylsulfonylamino of 3 to 13 carbon atoms, or N,N-cyclodialkanoylamino of 4 to 6 carbon atoms;or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供新的抗菌β-内酰胺，其结构式为：其中R是1至6个碳原子的烷基，2至6个碳原子的羧基烷基或烷氧基羰基，其中烷基和烷氧基部分独立地包含1至6个碳原子 R 1是2至6个碳原子的亚烷基氨基，2至6个碳原子的烷酰基氨基，2至6个碳原子的羧基亚烷基氨基，1至6个碳原子的烷基磺酰基氨基，3至13个碳原子的烷氧基羰基烷基磺酰基氨基，或4个N，N-二环烷酰基氨基至6个碳原子; 或其药学上可接受的盐。

15. 发明授权

US06489342B2 Aryloxy piperidinyl indoles for treating depression 失效
标题翻译：芳氧基哌啶基吲哚用于治疗抑郁症
公开(公告)号：US06489342B2
公开(公告)日：2002-12-03
申请号：US10002340
申请日：2001-11-15
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： A61K31454
CPC分类号： C07D401/14
摘要： This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having the formula: wherein R1 is H or alkyl; R2, R3, and R4 are H, alkyl, or halogen; X is H, halogen, CN, or C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 1 or 2; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了芳氧基吲哚衍生物，其可用于治疗受血清素受影响的神经系统疾病如抑郁和焦虑影响的疾病，具有下式的化合物：其中R1是H或烷基; R2，R3和R4是H，烷基或卤素; X是H，卤素，CN或C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

16. 发明授权

US06313126B1 Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression 失效
标题翻译：用于治疗抑郁症的芳基哌嗪基 - 环己基吲哚衍生物
公开(公告)号：US06313126B1
公开(公告)日：2001-11-06
申请号：US09476254
申请日：1999-12-30
申请人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
发明人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
IPC分类号： A61K31496
CPC分类号： C07D401/08 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物，其包括：R 1，R 2和R 3各自独立地为氢，卤素，CF 3，烷基，烷氧基，MeSO 2或一起可以形成5-7元碳环或杂环; R 4为氢，卤素或烷基; R 5为氢，烷基，烷基芳基或芳基; R 6为氢，卤素，CF 3，CN，脲或烷氧基; X 1，X 2和X 3为碳或 X1，X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。

17. 发明授权

US06291683B1 N-arloxyethyl-alkylamines for the treatment of depression 失效
标题翻译： N-芳氧基乙基 - 烷基胺用于治疗抑郁症
公开(公告)号：US06291683B1
公开(公告)日：2001-09-18
申请号：US09593267
申请日：2000-06-13
申请人： Richard E. Mewshaw , Dahui Zhou
发明人： Richard E. Mewshaw , Dahui Zhou
IPC分类号： A61K31405
CPC分类号： C07D401/12 , C07D209/14 , C07D405/12
摘要： Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了可用于减轻抑郁症状的化合物，其具有下式：其中：R 1是氢，低级烷基或芳基; R 2是氢，低级烷基，苯基或取代的苯基; X和Y各自独立地是氢，低级烷基，低级烷氧基或卤素，或与它们所连接的碳原子一起结合形成环戊基，环己基，苯基，吡咯基，吡喃基，吡啶基，二氢呋喃基，呋喃基，二恶烷基，恶唑基或异恶唑基; Z是氢，卤素或低级烷氧基; 条件是当X，Y或Z表示低级烷氧基时，它们不存在于邻位; W是氢，卤素，低级烷基，氰基或三氟甲基; andn是2-5; 其药学上可接受的盐。

18. 发明授权

US5684039A Chroman-2-ylmethylamino derivatives 失效
标题翻译：色满-2-基甲基氨基衍生物
公开(公告)号：US5684039A
公开(公告)日：1997-11-04
申请号：US684610
申请日：1996-07-19
申请人： Richard E. Mewshaw
发明人： Richard E. Mewshaw
IPC分类号： A61K31/353 , C07D311/58 , A61K31/35
CPC分类号： C07D311/58 , A61K31/353
摘要： Compounds of the formula: ##STR1## in which R is a straight or branched chain alkyl group of 1 to 6 carbon atoms, hydroxyalkyl of 1 to 6 carbon atoms or a cycloalkyl group of 3 to 8 carbon atoms; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs.
摘要翻译：其中R是1至6个碳原子的直链或支链烷基，1至6个碳原子的羟基烷基或3至8个碳原子的环烷基的下式的化合物：或其药学上可接受的盐是多巴胺合成和释放的抑制剂，可用于治疗精神分裂症，帕金森病，图雷特氏综合征，酒精成瘾，可卡因成瘾和对药物的成瘾。

19. 发明授权

US5401769A Dibenzofuranyl N-alkyl carbamates 失效
标题翻译：二苯并呋喃基N-烷基氨基甲酸酯
公开(公告)号：US5401769A
公开(公告)日：1995-03-28
申请号：US190402
申请日：1994-02-02
申请人： Thomas J. Commons , Richard E. Mewshaw , Donald P. Strike
发明人： Thomas J. Commons , Richard E. Mewshaw , Donald P. Strike
IPC分类号： C07D307/91 , A61K31/34
CPC分类号： C07D307/91
摘要： A compound of formula A: ##STR1## wherein R.sup.1 and R.sup.2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO.sub.2 H, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, alkoxycarbonyloxy, mono or dialkylaminocarbonyl, or mono or dialkylaminocarbonyloxy; R.sup.3 is hydrogen or alkyl; R.sup.4 is alkyl, cycloalkylalkyl or phenylalkyl or substituted phenylalkyl, and the substituent on the benzene ring is alkyl, alkoxy, halo, nitro, cyano, trifluoromethyl or phenyl, are anti-cholesterolemic agents.
摘要翻译：式A的化合物：其中R 1和R 2独立地是氢，氟，氯，溴，碘，三氟甲基，氰基，硝基，烷基，烷氧基，-CO 2 H，烷基羰基，烷基羰基氧基，烷氧基羰基，或二烷基氨基羰基，或单或二烷基氨基羰基氧基; R3是氢或烷基; R4是烷基，环烷基烷基或苯基烷基或取代的苯基烷基，苯环上的取代基是烷基，烷氧基，卤素，硝基，氰基，三氟甲基或苯基，是抗胆固醇血症药。

20. 发明授权

US5250537A 5,6,7,8,9,10-hexahydro-7 ,10-iminocyclohept[b]indole,-6,7,8,9,10-hexahydro-7,11-imino-5H-cyclooct[ b]indole and substituted derivatives 失效
标题翻译： 5,6,7,8,9,10-六氢-7,10-亚氨基环辛烯，-6,7,8,9,10-六氢-7,11-亚氨基-5H-环辛烷并取代的衍生物
公开(公告)号：US5250537A
公开(公告)日：1993-10-05
申请号：US850761
申请日：1992-03-13
申请人： Richard E. Mewshaw , Carl Kaiser , Mary E. Abreu
发明人： Richard E. Mewshaw , Carl Kaiser , Mary E. Abreu
IPC分类号： C07D471/18 , A61K31/435 , C07D471/20
CPC分类号： C07D471/18
摘要： 5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited liability to produce concomitant adverse extrapyramidal symptoms. These compounds are also useful for treating other central nervous system and cardiovascular disorders.
摘要翻译： 5,6,7,8,9,10-六氢-7,10-亚氨基环庚三烯并[b]吲哚，6,7,8,9,10,11-六氢-7,11-亚氨基-5H-环辛[b] 吲哚和取代的衍生物在治疗精神病方面是有效的，有限责任以产生伴随的锥体外系症状。这些化合物也可用于治疗其他中枢神经系统和心血管疾病。

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