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11. 发明申请

US20130157996A1 TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS 有权
标题翻译： TRPM8拮抗剂及其在治疗中的应用
公开(公告)号：US20130157996A1
公开(公告)日：2013-06-20
申请号：US13529860
申请日：2012-06-21
申请人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
发明人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
IPC分类号： C07D498/04 , C07D401/14 , C07D213/81 , C07D487/04 , C07D413/12 , C07D401/12 , C07D471/04
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译：式I的化合物可用作TRPM8的拮抗剂。这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。这些疾病的实例包括但不限于偏头痛和神经性疼痛。式I的化合物具有以下结构：其中本文提供变量的定义。

12. 发明授权

US07612060B2 Triazoles and methods of use 有权
标题翻译：三唑和使用方法
公开(公告)号：US07612060B2
公开(公告)日：2009-11-03
申请号：US11247046
申请日：2005-10-11
申请人： Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
发明人： Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
IPC分类号： C07D403/00 , C07D401/00 , C07D413/00 , A01N43/46 , A61K31/535 , A61K31/497
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

13. 发明授权

US07096819B2 Inductive plasma processor having coil with plural windings and method of controlling plasma density 有权
公开(公告)号：US07096819B2
公开(公告)日：2006-08-29
申请号：US09821027
申请日：2001-03-30
申请人： Jian J. Chen , Robert G. Veltrop , Thomas E. Wicker
发明人： Jian J. Chen , Robert G. Veltrop , Thomas E. Wicker
IPC分类号： C23C16/00 , H01L21/00
CPC分类号： H01J37/32174 , H01J37/321
摘要： An inductive plasma processor includes a multiple winding radio frequency coil having plural electrically parallel, spatially concentric windings (1) having different amounts of RF power supplied to them, and (2) arranged to produce electromagnetic fields having different couplings to different regions of plasma in the chamber to control plasma flux distribution incident on a processed workpiece. The coil is powered by a single radio frequency generator via a single matching network. Input and output ends of each winding are respectively connected to input and output tuning capacitors. In a first embodiment, the location of maximum inductive coupling of the radio frequency to the plasma and the current magnitude in each winding are respectively mainly determined by values of the output and input capacitors. By adjusting all the input and output capacitors simultaneously, the current to a winding can be varied while the current to the other winding can be maintained constant as if these windings were completely de-coupled and independent. Therefore, the capacitors can control the plasma density in different radial and azimuthal regions. In another embodiment, a relatively low frequency drives the coil whereby each winding has a relatively short electrical length, causing substantially small standing wave current and voltage variations. The output capacitor for each winding adjusts current magnitude, to eliminate the need for the input capacitors and reduce operational complexity.

14. 发明授权

US06580868B2 High-resolution variable optical attenuator with mechanical adjustment 失效
公开(公告)号：US06580868B2
公开(公告)日：2003-06-17
申请号：US09812358
申请日：2001-03-19
申请人： Jian J. Chen , Jianhua Wang
发明人： Jian J. Chen , Jianhua Wang
IPC分类号： G02B600
CPC分类号： G02B26/02 , G02B6/266
摘要： A mechanically-adjustable variable optical attenuator includes a beam attenuator shaped as a concave quasi-cone. The beam attenuator has a sharp tip and a base, and can be rotationally symmetric with respect to a central axis extending between the tip and the base. The beam attenuator is positioned with its central axis perpendicular to the direction of the light beam to be attenuated. The extent of the beam attenuator obstructing the light beam is varied by moving the beam attenuator into and out of the light beam. The inwardly-curving, quasi-cone shape of the beam attenuator allows achieving a high resolution while limiting the beam attenuator size.

15. 发明授权

US08710043B2 TRPM8 antagonists and their use in treatments 有权
标题翻译： TRPM8拮抗剂及其在治疗中的应用
公开(公告)号：US08710043B2
公开(公告)日：2014-04-29
申请号：US13529860
申请日：2012-06-21
申请人： Jian J. Chen , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma
发明人： Jian J. Chen , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma
IPC分类号： C07D498/04 , C07D401/12 , C07D471/04 , C07D213/81
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译：式I的化合物可用作TRPM8的拮抗剂。这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。这些疾病的实例包括但不限于偏头痛和神经性疼痛。式I的化合物具有以下结构：其中本文提供变量的定义。

16. 发明授权

US08480991B2 Use of acid washing to provide purified silicon crystals 有权
标题翻译：使用酸洗提供纯化的硅晶体
公开(公告)号：US08480991B2
公开(公告)日：2013-07-09
申请号：US12670263
申请日：2008-07-23
申请人： Scott Nichol , Jian J. Chen
发明人： Scott Nichol , Jian J. Chen
IPC分类号： C01B33/02
CPC分类号： C30B9/10 , C01B33/037 , C30B29/06
摘要： A method for purifying silicon wherein silicon is crystallized from a solvent metal. The method comprises the steps of providing a molten liquid containing silicon, a solvent metal and impurities, cooling the molten liquid to form first silicon crystals and a first mother liquor, separating the first silicon crystals from the first mother liquor, contacting the first silicon crystals with compound which will dissolve the first mother liquor and separating the washed crystals from the wash solution.
摘要翻译：一种纯化硅的方法，其中硅从溶剂金属中结晶。该方法包括以下步骤：提供含有硅，溶剂金属和杂质的熔融液体，冷却熔融液体以形成第一硅晶体和第一母液，将第一硅晶体与第一母液分离，使第一硅晶体用化合物溶解第一母液并将洗涤的晶体与洗涤溶液分离。

17. 发明申请

US20080249106A1 Novel B1 bradykinin receptor antagonists 审中-公开
标题翻译：新型B1缓激肽受体拮抗剂
公开(公告)号：US20080249106A1
公开(公告)日：2008-10-09
申请号：US12082076
申请日：2008-04-08
申请人： Benny C. Askew , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
发明人： Benny C. Askew , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
IPC分类号： A61K31/496 , C07D249/06 , A61K31/4192 , A61K31/454 , C07D401/08 , C07D403/08
CPC分类号： C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
摘要： The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译：本发明包括新颖的化合物及其药学上可接受的衍生物，用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。

18. 发明授权

US06904223B1 Tilted-translation variable optical attenuator 失效
标题翻译：倾斜变换光衰减器
公开(公告)号：US06904223B1
公开(公告)日：2005-06-07
申请号：US10408073
申请日：2003-04-04
申请人： Zuyun Fang , Jianhua Wang , Jian J. Chen
发明人： Zuyun Fang , Jianhua Wang , Jian J. Chen
IPC分类号： G02B6/00 , G02B6/26
CPC分类号： G02B6/266
摘要： In a preferred embodiment, a motorized variable optical attenuator comprises an input fiber collimator; an output fiber collimator disposed substantially along the first collimator; and a right-angle reflector movable relative to the input collimator and the output collimator along a translation direction forming a non-zero angle with a direction of a light beam emitted by the input collimator. The reflector comprises two mutually-perpendicular reflective surfaces for sequentially reflecting the light beam emitted by the input collimator to the output collimator. A variable attenuation imparted by the attenuator on the light beam is determined by a position of the reflector relative to the input collimator and the output collimator, along the translation direction. The reflector preferably comprises a right-angle prism adhered to a nut mounted on a threaded axle driven by a stepper motor. The attenuator can achieve stable, ripple-free attenuation characteristics at insertion losses beyond −40 dB.
摘要翻译：在优选实施例中，电动可变光衰减器包括输入光纤准直器; 基本上沿着所述第一准直仪设置的输出光纤准直器; 以及直角反射体，其相对于输入准直器和输出准直器沿着与由输入准直仪发射的光束的方向成非零角度的平移方向移动。反射器包括两个相互垂直的反射表面，用于将由输入准直仪发射的光束顺序反射到输出准直器。由衰减器在光束上赋予的可变衰减由反射器相对于输入准直仪和输出准直器沿平移方向的位置确定。反射器优选地包括附接到安装在由步进马达驱动的螺纹轴上的螺母的直角棱镜。衰减器可以在插入损耗超过-40 dB时实现稳定的无纹波衰减特性。

19. 发明授权

US06872281B1 Chamber configuration for confining a plasma 有权
公开(公告)号：US06872281B1
公开(公告)日：2005-03-29
申请号：US09676269
申请日：2000-09-28
申请人： Jian J. Chen , Mukund Srinivasan , Eric H. Lenz
发明人： Jian J. Chen , Mukund Srinivasan , Eric H. Lenz
IPC分类号： H05H1/46 , B01J19/08 , C23F4/00 , H01J37/32 , H01L21/205 , H01L21/3065 , C23C16/00 , C23F1/00
CPC分类号： H01J37/32871 , H01J37/32082 , H01J37/32623
摘要： A plasma confining assembly for minimizing unwanted plasma formations in regions outside of a process region in a process chamber is disclosed. The plasma confining assembly includes a first confining element and second confining element positioned proximate the periphery of the process region. The second confining element is spaced apart from the first confining element. The first confining element includes an exposed conductive surface that is electrically grounded and the second confining element includes an exposed insulating surface, which is configured for covering a conductive portion that is electrically grounded. The first confining element and the second confining element substantially reduce the effects of plasma forming components that pass therebetween. Additionally, the plasma confining assembly may include a third confining element, which is formed from an insulating material and disposed between the first confining element and the second confining element, and proximate the periphery of the process region. The third confining element further reduces the effects of plasma forming components that pass between the first confining element and the second confining element.

20. 发明授权

US06527912B2 Stacked RF excitation coil for inductive plasma processor 有权
公开(公告)号：US06527912B2
公开(公告)日：2003-03-04
申请号：US09821752
申请日：2001-03-30
申请人： Jian J. Chen , Robert G. Veltrop , Thomas E. Wicker
发明人： Jian J. Chen , Robert G. Veltrop , Thomas E. Wicker
IPC分类号： H05H1100
CPC分类号： H01J37/321
摘要： A radio frequency excitation coil of an inductive plasma processor includes a planar turn connected in series with a segment of the coil stacked above a portion of the planar turn. The stacked segment is placed around a region having weak radio frequency coupling to plasma due to azimuthal asymmetries in the chamber and/or the excitation coil. In a single winding embodiment, the stacked segment is close to an interconnection gap between two adjacent planar turns and extends in both directions from the gap to compensate low radio frequency coupling to plasma in the gap region. In an embodiment including two electrically parallel spatially concentric windings, the stacked segment extends beyond one side of an interconnection gap of two adjacent turns, and is aligned with the planar turn such that one end of the stacked segment is directly connected to an end of the planar turn via a straight, short stub. Terminals of the coil are connected to RF excitation circuitry terminals in a housing above the coil by leads extending smoothly and gradually without sharp bends between the coil terminals and the excitation circuitry terminals. Ends of the planar turn and the stacked segment are connected by a lead extending smoothly and gradually without sharp bends between its ends.

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