专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20050222062A1 Decoy for treating and/or preventing th2 cytokine-associated allergic disease, gata3 mutant protein and medicinal compositions containing the same 审中-公开
标题翻译：用于治疗和/或预防th2细胞因子相关过敏性疾病，gata3突变蛋白和含有其的药物组合物的诱饵
公开(公告)号：US20050222062A1
公开(公告)日：2005-10-06
申请号：US10512262
申请日：2003-04-24
申请人： Ken-ichi Arai , Shoichiro Miyatake , Naofumi Takemoto
发明人： Ken-ichi Arai , Shoichiro Miyatake , Naofumi Takemoto
IPC分类号： A61K38/00 , A61P11/06 , A61P37/02 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/113 , G01N33/68 , A61K48/00 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C07K14/4702 , C12N2310/13 , G01N33/6863 , G01N33/6872
摘要： The present invention provides GATA3 decoys and GATA3 mutant proteins which can specifically suppress Th2 cytokine production and pharmaceutical compositions comprising such decoys and mutant proteins. This suppression is achieved by inhibiting binding of the GATA3 protein to the low affinity GATA3 binding sequence within the Th2 cytokine gene cluster, which causes suppression of the chromatin remodeling required for stable and sufficient expression of Th2 cytokines.
摘要翻译：本发明提供可特异性抑制Th2细胞因子产生的GATA3诱饵和GATA3突变蛋白，以及包含这种诱饵和突变蛋白的药物组合物。通过抑制GATA3蛋白与Th2细胞因子基因簇内的低亲和性GATA3结合序列的结合来实现该抑制，这导致抑制Th2细胞因子的稳定和充分表达所需的染色质重塑。

12. 发明授权

US06780597B1 NF-AT derived polypeptides that bind calcineurin and uses thereof 失效
标题翻译：结合钙调神经磷酸酶的NF-AT衍生多肽及其用途
公开(公告)号：US06780597B1
公开(公告)日：2004-08-24
申请号：US09550115
申请日：2000-04-14
申请人： Ken-ichi Arai , Jie Liu
发明人： Ken-ichi Arai , Jie Liu
IPC分类号： G01N3353
CPC分类号： G01N33/6872 , G01N2500/00
摘要： Calcineurin (CN)-binding regions in the N-terminal domain derived from NF-ATx is disclosed. Also disclosed are CN-binding polypeptide compositions, DNA segments encoding these polypeptides, and methods of use. The CN-binding polypeptides bind to CN, suppressing the interaction between NF-AT and CN. The CN-binding polypeptide compositions can be used for treating pharmacological intervention with Ca2+-dependent signaling events. The CN-binding polypeptide or DNA segments encoding them can be used to assay and screen candidates of pharmaceuticals, in particular, in the evaluation and characterization of immunosuppressants specifically interfering with the interaction between NF-AT and CN.
摘要翻译：公开了衍生自NF-ATx的N-末端结构域中的钙调神经磷酸（CN）结合区。还公开了CN结合多肽组合物，编码这些多肽的DNA区段和使用方法。 CN结合多肽与CN结合，抑制NF-AT和CN之间的相互作用。 CN结合多肽组合物可用于治疗具有Ca 2+依赖性信号传导事件的药物干预。 CN结合多肽或编码它们的DNA片段可用于测定和筛选药物的候选物，特别是在特异性干扰NF-AT和CN之间的相互作用的免疫抑制剂的评价和表征中。

13. 发明授权

US5382469A Ceramic-titanium nitride electrostatic chuck 失效
标题翻译：陶瓷 - 氮化钛静电吸盘
公开(公告)号：US5382469A
公开(公告)日：1995-01-17
申请号：US72233
申请日：1993-06-03
申请人： Yoshihiro Kubota , Makoto Kawai , Shinji Kojima , Ken-ichi Arai
发明人： Yoshihiro Kubota , Makoto Kawai , Shinji Kojima , Ken-ichi Arai
IPC分类号： B23Q3/15 , C04B35/117 , H01L21/683 , H02N13/00 , B32B18/00
CPC分类号： H01L21/6831 , C04B35/117 , Y10T279/23 , Y10T428/26
摘要： Proposed is a ceramic-made electrostatic chuck consisting of two insulating ceramic layers and a metallic electrode layer integrally sandwiched between the two insulating layers, which has a very quick response characteristic to turning-on and -off of the electric voltage applied to the electrodes without affecting the very high electrostatic attracting force. This improvement can be obtained by forming the insulating ceramic layers from a specific ceramic material consisting of a highly resistive ceramic material such as alumina and the like and titanium nitride admixed with the former in an amount not exceeding 5% by weight but sufficient to impart the insulating ceramic layers with a volume resistivity in the range from 1.times.10.sup.8 to 1.times.10.sup.13 ohm.cm at 20.degree. C.
摘要翻译：提出了一种由两个绝缘陶瓷层和一体地夹在两个绝缘层之间的金属电极层组成的陶瓷制静电卡盘，其对施加到电极的电压的导通和断开具有非常快的响应特性，而没有影响非常高的静电吸引力。这种改进可以通过从由高电阻陶瓷材料如氧化铝等组成的特定陶瓷材料和与前者混合的氮化钛以不超过5重量％的量形成绝缘陶瓷层而获得，但足以使在20℃下体积电阻率为1×10 8至1×10 13欧姆·厘米的绝缘陶瓷层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式