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11. 发明申请

US20100048581A1 THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
标题翻译：噻唑化合物可用作激酶抑制剂
公开(公告)号：US20100048581A1
公开(公告)日：2010-02-25
申请号：US12519597
申请日：2007-12-19
申请人： Anne Marinier , Claude A. Quesnelle , Marco Dodier , Stephan Roy , Patrice Gill , Mark D. Wittman , David R. Langley
发明人： Anne Marinier , Claude A. Quesnelle , Marco Dodier , Stephan Roy , Patrice Gill , Mark D. Wittman , David R. Langley
IPC分类号： A61K31/444 , C07D401/14 , A61K31/4365 , A61K31/496 , A61P35/00
CPC分类号： C07D417/14 , C07D495/04
摘要： The invention provides compounds of formula I [INSERT CHEMICAL STRUCTURE HERE] (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译：本发明提供式I化合物[其中的化学结构]（I）及其药学上可接受的盐。式I噻唑基化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和用于治疗阿尔茨海默氏病。

12. 发明授权

US07470713B2 Imidazole based kinase inhibitors 有权
标题翻译：基于咪唑的激酶抑制剂
公开(公告)号：US07470713B2
公开(公告)日：2008-12-30
申请号：US11062271
申请日：2005-02-18
申请人： Anne Marinier , Stephan Roy , Alain Martel
发明人： Anne Marinier , Stephan Roy , Alain Martel
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/04
摘要： The present invention provides compounds having formula I and their use for the treatment of cancer.
摘要翻译：本发明提供具有式I的化合物及其用于治疗癌症的用途。

13. 发明授权

US06414179B1 Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors 有权
标题翻译： α-和β-取代的三氟甲基酮作为磷脂酶抑制剂
公开(公告)号：US06414179B1
公开(公告)日：2002-07-02
申请号：US09816574
申请日：2001-03-23
申请人： Jacques Banville , Anne Marinier , Yonghua Gai , Serge Plamondon , Stephan Roy , Neelakantan Balasubramanian
发明人： Jacques Banville , Anne Marinier , Yonghua Gai , Serge Plamondon , Stephan Roy , Neelakantan Balasubramanian
IPC分类号： C07C26100
CPC分类号： C07D303/48 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/695 , C07C217/22 , C07C317/18 , C07C323/12 , C07C323/52
摘要： Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, R1, R2, R3, R4, Ra and Rb are as defined in the specification.
摘要翻译：提供了细胞溶质磷脂酶A2酶的抑制剂，其可用于控制多种炎性疾病。本发明的抑制剂具有通式，X，Z，R 1，R 2，R 3，R 4，R a和R b如本说明书中所定义。

14. 发明申请

US20140057894A1 PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS 有权
标题翻译：作为MELANOCORTIN-4受体调节剂的吡唑并吡啶和吡唑并吡啶衍生物
公开(公告)号：US20140057894A1
公开(公告)日：2014-02-27
申请号：US13981834
申请日：2012-01-26
申请人： Michel Bouvier , Anne Marinier , Rejean Ruel , Patricia René , Yves Chantigny , Philippe Dagneau , Stéphane Gingras
发明人： Michel Bouvier , Anne Marinier , Rejean Ruel , Patricia René , Yves Chantigny , Philippe Dagneau , Stéphane Gingras
IPC分类号： C07D471/04 , C07D487/04 , G01N33/50
CPC分类号： C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/74 , G01N2333/72 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein is a compound of Formula I: wherein X, R1, R2, and R3 are as defend herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described.
摘要翻译：本文公开了式I的化合物：其中X，R 1，R 2和R 3与本文保护，或其药学上可接受的盐，以允许药物穿透细胞膜; 或前体药物，或者该化合物用可检测标记或其亲和标签进行标记。还公开了药物组合物，治疗由黑皮质素-4受体介导的病症的方法，以及使用所述化合物治疗肥胖症的方法。

15. 发明授权

US06319948B1 Retinoid antagonists and uses thereof 有权
公开(公告)号：US06319948B1
公开(公告)日：2001-11-20
申请号：US09732850
申请日：2000-12-08
申请人： Kenneth M. Tramposch , Xina Nair , Anne Marinier , Fred Christopher Zusi
发明人： Kenneth M. Tramposch , Xina Nair , Anne Marinier , Fred Christopher Zusi
IPC分类号： A61K31192
摘要： Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and possess the above-mentioned property in addition to their use as antiinflammatory agents for chronic skin inflammatory diseases, as agents for the treatment of rheumatic diseases and as agents for the treatment of various tumors as well as non-malignant proliferative skin conditions.

16. 发明授权

US06194601B1 5,6-dihydronaphthalenyl derivatives having retinoid-like activity 失效
标题翻译：具有类视黄醇样活性的5,6-二氢萘基衍生物
公开(公告)号：US06194601B1
公开(公告)日：2001-02-27
申请号：US09397975
申请日：1999-09-16
申请人： Anne Marinier , Yong-Jiang Hei , Philippe Lapointe , Jean-Paul Daris
发明人： Anne Marinier , Yong-Jiang Hei , Philippe Lapointe , Jean-Paul Daris
IPC分类号： C07C6976
CPC分类号： C07C63/66 , C07C65/19 , C07C69/76
摘要： The 5,6-dihydronaphthalenyl derivatives of the formulae possess potent retinoid-like activity against dermatological diseases with a substantially reduced irritancy profile when administered topically.
摘要翻译： 5,6-二氢萘基衍生物，对局部皮肤病具有强烈的类视黄醇样活性，当局部给药时，具有显着降低的刺激性。

17. 发明授权

US07851500B2 Aminopyrazole kinase inhibitors 有权
标题翻译：氨吡唑激酶抑制剂
公开(公告)号：US07851500B2
公开(公告)日：2010-12-14
申请号：US12521061
申请日：2008-01-04
申请人： Marco Dodier , Claude A. Quesnelle , Anne Marinier
发明人： Marco Dodier , Claude A. Quesnelle , Anne Marinier
IPC分类号： C07D403/02 , A01N43/56
CPC分类号： C07D487/04 , C07D401/12 , C07D401/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐。式（I）化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂。

18. 发明授权

US5945561A Retinoid-like compounds 失效
标题翻译：类视黄醇样化合物
公开(公告)号：US5945561A
公开(公告)日：1999-08-31
申请号：US66206
申请日：1998-04-24
申请人： John E. Starrett, Jr. , Kenneth M. Tramposch , Xina Nair , Peter R. Reczek , Anna Ericsson , Anne Marinier , Alain Martel , Fred C. Zusi
发明人： John E. Starrett, Jr. , Kenneth M. Tramposch , Xina Nair , Peter R. Reczek , Anna Ericsson , Anne Marinier , Alain Martel , Fred C. Zusi
IPC分类号： C07C63/66 , C07C65/19 , C07C65/28 , C07C69/00 , C07C69/76 , C07C323/61 , C07D213/55 , C07D307/54 , C07C63/36
CPC分类号： C07C69/00 , C07C323/61 , C07C63/66 , C07C65/19 , C07C65/28 , C07C69/76 , C07D213/55 , C07D307/54 , C07C2103/00 , C07C2103/24
摘要： Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined in the specification exhibit retinoid-like properties and are particularly useful in the prevention of post-surgical adhesions.
摘要翻译：某些具有通式的新的取代的（5,6） - 二氢蒽基化合物其中A，n，p，R1，R2，R3，R4，R5，R6，R7和R8如本说明书中所定义，表示类视黄醇样物质，特别适用于预防手术后粘连。

19. 发明授权

US5747463A Malonate derivatives of glycolipids as cell adhesion inhibitors 失效
标题翻译：糖脂的丙二酸酯衍生物作为细胞粘附抑制剂
公开(公告)号：US5747463A
公开(公告)日：1998-05-05
申请号：US725147
申请日：1996-10-02
申请人： Anne Marinier , Alain Martel
发明人： Anne Marinier , Alain Martel
IPC分类号： C07H15/04 , A61K31/70 , C07H15/00
CPC分类号： C07H15/04
摘要： There is provided a novel series of malonate derivatives of glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid: R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ; R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each are independently hydrogen, unsubstituted or substituted (lower)alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from the group consisting of halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy provided that one of R.sup.2, R.sup.3, R.sup.4 and R.sup.6 substituents is --(CH.sub.2).sub.p --CH(CO.sub.2 R.sup.7).sub.2 ; m is an integer of 0 or 1; n is an integer of from 5 to 14 inclusive; p is an integer of from 2 to 6 inclusive; and R.sup.7 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt; or a solvate or hydrate thereof which are inhibitors of selectin-mediated cellular adhesion and are useful in the treatment or prevention of inflammatory diseases and other pathological conditions in mammals.
摘要翻译：提供了一种新型的式I糖脂化合物的丙二酸酯衍生物，其中R是脂肪酸的酰基残基：R 1是 - （CH = CH）m - （CH 2）n -CH 3; R2，R3，R4，R5和R6各自独立地为氢，未取代或取代的（低级）烷酰基，芳基烷基或芳基羰基，其中所述取代基选自卤素，C 1-4烷基，三氟甲基，羟基和C 1-4烷氧基条件是R2，R3，R4和R6取代基之一为 - （CH2）p-CH（CO2R7）2; m为0或1的整数; n为5〜14的整数， p为2〜6的整数，和R7是氢，可水解的酯基或阳离子，以形成无毒的药学上可接受的盐; 或其选择素介导的细胞粘附抑制剂的溶剂化物或水合物，并且可用于治疗或预防哺乳动物的炎性疾病和其它病理状况。

20. 发明授权

US09018395B2 Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators 有权
标题翻译：吡唑并吡啶和吡唑并嘧啶衍生物作为黑皮质素-4受体调节剂
公开(公告)号：US09018395B2
公开(公告)日：2015-04-28
申请号：US13981834
申请日：2012-01-26
申请人： Michel Bouvier , Anne Marinier , Réjean Ruel , Patricia René , Yves Chantigny , Philippe Dagneau , Stéphane Gingras
发明人： Michel Bouvier , Anne Marinier , Réjean Ruel , Patricia René , Yves Chantigny , Philippe Dagneau , Stéphane Gingras
IPC分类号： C07D231/56 , C07D487/00 , C07D471/04 , C07D487/04 , G01N33/74 , G01N33/50
CPC分类号： C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/74 , G01N2333/72 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein is a compound of Formula I: wherein X, R1, R2, and R3 are as defend herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described.
摘要翻译：本文公开了式I的化合物：其中X，R 1，R 2和R 3与本文保护，或其药学上可接受的盐，以允许药物穿透细胞膜; 或前体药物，或者该化合物用可检测标记或其亲和标签进行标记。还公开了药物组合物，治疗由黑皮质素-4受体介导的病症的方法，以及使用所述化合物治疗肥胖症的方法。

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