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11. 发明授权

US09963677B2 Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses 有权
公开(公告)号：US09963677B2
公开(公告)日：2018-05-08
申请号：US12862409
申请日：2010-08-24
申请人： Ann M. Leen , Ulrike Gerdemann , Cliona M. Rooney , Juan Vera , John R. Wilson
发明人： Ann M. Leen , Ulrike Gerdemann , Cliona M. Rooney , Juan Vera , John R. Wilson
IPC分类号： A61K38/00 , C12N5/00 , C12N5/02 , C12N5/0783 , A61K39/12 , A61K39/155 , A61K39/245 , A61K39/00
CPC分类号： C12N5/0638 , A61K39/0011 , A61K39/12 , A61K39/155 , A61K39/245 , A61K2039/5158 , A61K2039/54 , A61K2039/572 , C12N5/0636 , C12N2501/23 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2502/11
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

12. 发明申请

US20170267973A1 METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY 审中-公开
公开(公告)号：US20170267973A1
公开(公告)日：2017-09-21
申请号：US15395662
申请日：2016-12-30
申请人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
发明人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
IPC分类号： C12N5/0783 , C12M1/04
CPC分类号： C12N5/0638 , C12M23/24 , C12N2501/2302 , C12N2502/11
摘要： An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.

13. 发明授权

US09567565B2 Methods of cell culture for adoptive cell therapy 有权
标题翻译：过继细胞治疗细胞培养方法
公开(公告)号：US09567565B2
公开(公告)日：2017-02-14
申请号：US14579373
申请日：2014-12-22
申请人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
发明人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
IPC分类号： C12N5/0783 , C12N5/02 , C12M1/04
CPC分类号： C12N5/0638 , C12M23/24 , C12N2501/2302 , C12N2502/11
摘要： An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
摘要翻译：培养用于细胞治疗应用的细胞的改进方法，其包括在存在抗原呈递细胞和/或饲养细胞的情况下生长期望的细胞，并且如果不包括生长表面，则中等体积与表面积比高达1ml / cm 2 的气体可渗透材料，如果生长表面由透气材料组成，则高达2ml / cm2。期望的细胞在生产周期开始时的表面密度小于0.5×10 6个细胞/ cm 2，并且所需细胞的表面密度加上抗原呈递细胞和/或饲养细胞的表面密度至少为约1.25×10 5个细胞/ cm 2。

14. 发明授权

US09545872B1 Dunnage bag hanger apparatus and method 有权
标题翻译：垫料袋衣架装置及方法
公开(公告)号：US09545872B1
公开(公告)日：2017-01-17
申请号：US14918480
申请日：2015-10-20
申请人： John R. Wilson , William M. Wilson
发明人： John R. Wilson , William M. Wilson
IPC分类号： B60P7/08 , B60P7/06 , B60P7/135 , B65D33/14
CPC分类号： B65D33/14 , B60P7/065 , B60P7/135
摘要： A dunnage bag hanger apparatus includes a dunnage bag hanger and a handle mounted applicator block operative to support and affix the dunnage bag hanger. The dunnage bag hanger is fabricated from three distinct and separate parts: a generally planar support substrate and two release papers covering adhesive patches or regions on the support substrate. The support substrate in one embodiment is a sheet that is further divided into two contact members separated by a resilient coupler. Each contact member preferably has a contact body, a hanging loop distal to the resilient coupler, and an adhesive coating. The two adhesive couplings are preferably on opposite sides of the support substrate sheet.
摘要翻译：垫料袋衣架装置包括衬垫袋悬挂器和手柄安装的施用器块，其可操作以支撑和固定衬垫袋衣架。衬垫袋衣架由三个不同和分开的部件制成：一般为平面的支撑衬底和两个在支撑衬底上覆盖粘合片或区域的剥离纸。一个实施例中的支撑衬底是进一步分为两个由弹性耦合器隔开的接触构件的片材。每个接触构件优选地具有接触体，远离弹性联接器的悬挂环和粘合剂涂层。两个粘合剂联接件优选地在支撑基板的相对侧上。

15. 发明授权

US08635717B2 Programmable automatic flushometer 有权
标题翻译：可编程自动电磁铁
公开(公告)号：US08635717B2
公开(公告)日：2014-01-28
申请号：US13242513
申请日：2011-09-23
申请人： John R. Wilson , Xu Wang
发明人： John R. Wilson , Xu Wang
IPC分类号： E03D1/00
CPC分类号： E03D5/105 , E03C1/057 , E03D3/02 , Y10T137/0318
摘要： Methods for communicating with an automatic flush valve device. The automatic flush device having a variety of operational modes which can be selected from to control the operation of the device. The communication from the automatic flush device providing a user with information regarding the status of the flush valve device.
摘要翻译：与自动冲洗阀装置通讯的方法。自动冲洗装置具有可以选择以控制装置的操作的各种操作模式。来自自动冲洗装置的通信向用户提供关于冲洗阀装置的状态的信息。

16. 发明授权

US08518692B2 Gas permeable cell culture device and method of use 有权
标题翻译：透气细胞培养装置及其使用方法
公开(公告)号：US08518692B2
公开(公告)日：2013-08-27
申请号：US12499633
申请日：2009-07-08
申请人： John R. Wilson
发明人： John R. Wilson
IPC分类号： C12M1/12
CPC分类号： C12M23/24 , C12M23/08 , C12M23/34 , C12M23/40
摘要： Gas permeable devices and methods are disclosed that provide highly efficient cell culture. Gas compartments, made up at least in part of gas permeable material, are dispersed within the culture device in locations that allow cells to remain within a fixed distance from a gas transmission location as the device scales in the horizontal direction. Gas permeable walls of the gas compartment(s) allow gas exchange with the ambient gas. Such an arrangement provides many advantages including the ability to eliminate the need for a gas-liquid interface, allow cell culture to proceed in the static mode (i.e. absent the need for media or gas to be pumped through the device), allow the scale of the device to increase in both the horizontal direction and vertical direction, reduce the rate of media evaporation, allow uncomplicated and low cost device fabrication, and provide the capacity for reduced feeding frequency.
摘要翻译：公开了提供高效细胞培养的透气装置和方法。构成至少部分透气材料的气体隔室在培养装置中分散在允许细胞在水平方向上缩放时允许细胞与气体传输位置保持在一定距离内的位置。气体隔室的气体可渗透壁允许与环境气体的气体交换。这种布置提供了许多优点，包括消除对气 - 液界面的需要的能力，允许细胞培养以静态模式进行（即，不需要将介质或气体泵送通过装置），允许该装置在水平方向和垂直方向上增加，降低了介质蒸发速率，允许不复杂和低成本的器件制造，并提供减少馈电频率的能力。

17. 发明授权

US08415144B2 Cell culture methods and devices utilizing gas permeable materials 有权
标题翻译：使用透气材料的细胞培养方法和装置
公开(公告)号：US08415144B2
公开(公告)日：2013-04-09
申请号：US11505122
申请日：2006-08-16
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12M1/22 , C12M1/00 , C12M3/00
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.
摘要翻译：公开了用于细胞培养的透气装置和方法，包括细胞培养装置和在高度含有培养基的方法以及某些气体可渗透的表面积与中等体积比。这些装置和方法允许提高细胞培养效率并提高效率。

18. 发明授权

US08234724B2 Automatic dual flush activation 有权
标题翻译：自动双冲激活
公开(公告)号：US08234724B2
公开(公告)日：2012-08-07
申请号：US11863195
申请日：2007-09-27
申请人： John R. Wilson , Peter J. Jahrling
发明人： John R. Wilson , Peter J. Jahrling
IPC分类号： E03D1/00
CPC分类号： E03D3/12 , E03D5/105 , Y10S4/03
摘要： A multi flush volume flush valve is in communication with an automatic flush control. The flush control determines the presence of a user and the amount of time the user uses the toilet. The usage time is compared to a predetermined time value to determine the appropriate flush volume based on an assumption regarding usage time and flush volume needs. The comparative value statistically adjusts to the restroom traffic.
摘要翻译：多冲洗量冲洗阀与自动冲洗控制通信。冲洗控制确定用户的存在和用户使用厕所的时间量。将使用时间与预定时间值进行比较，以基于关于使用时间和冲洗量需求的假设来确定适当的冲洗量。比较值统计调整为卫生间流量。

19. 发明授权

US08201282B2 High efficiency urinal system 有权
标题翻译：高效小便器系统
公开(公告)号：US08201282B2
公开(公告)日：2012-06-19
申请号：US12422030
申请日：2009-04-10
申请人： John R. Wilson
发明人： John R. Wilson
IPC分类号： E03D13/00
CPC分类号： E03D13/00
摘要： A flush mechanism for use in a urinal. The flush mechanism includes a flush reservoir pivotally mounted within a flush frame. The flush mechanism receives water from an inlet above the flush reservoir. The flush reservoir is pivotable from a fill position to a flush position whereby the water is dispensed to a manifold within the urinal for flushing of the urinal. The flow of water into the flush reservoir and the actuation of the flush reservoir may be directed by a controller.
摘要翻译：用于小便器的冲洗机构。冲洗机构包括枢转地安装在冲洗框架内的冲水容器。冲洗机构从冲洗水池上方的入口接收水。冲洗容器可从填充位置枢转到冲洗位置，由此将水分配到小便器内的歧管以便冲洗小便器。进入冲洗水箱的水流和冲洗水箱的启动可由控制器引导。

20. 发明申请

US20120011644A1 Programmable Automatic Flushometer 有权
标题翻译：可编程自动闪灯
公开(公告)号：US20120011644A1
公开(公告)日：2012-01-19
申请号：US13242513
申请日：2011-09-23
申请人： John R. Wilson , Xu Wang
发明人： John R. Wilson , Xu Wang
IPC分类号： E03D1/00
CPC分类号： E03D5/105 , E03C1/057 , E03D3/02 , Y10T137/0318
摘要： Methods for communicating with an automatic flush valve device. The automatic flush device having a variety of operational modes which can be selected from to control the operation of the device. The communication from the automatic flush device providing a user with information regarding the status of the flush valve device.
摘要翻译：与自动冲洗阀装置通讯的方法。自动冲洗装置具有可以选择以控制装置的操作的各种操作模式。来自自动冲洗装置的通信向用户提供关于冲洗阀装置的状态的信息。

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