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11. 发明申请

US20090112004A1 SYNTHESIS OF QUATERNARY SALT COMPOUNDS 有权
标题翻译：季铵化合物的合成
公开(公告)号：US20090112004A1
公开(公告)日：2009-04-30
申请号：US12256114
申请日：2008-10-22
申请人： David C. Palmer , Sergio Casco-Cancian , Tong Xiao , Kirl L. Sorgi , Armin Roessler , Anita Vladislavic , Roger Faessler
发明人： David C. Palmer , Sergio Casco-Cancian , Tong Xiao , Kirl L. Sorgi , Armin Roessler , Anita Vladislavic , Roger Faessler
IPC分类号： C07D309/12 , C07C235/56 , C07C233/66
CPC分类号： C07D333/36 , C07D209/42 , C07D295/135 , C07D307/14 , C07D307/68 , C07D307/85 , C07D309/04 , C07D309/14 , C07D311/58 , C07D311/92 , C07D313/08 , C07D333/70 , C07D335/02 , C07D405/12 , C07D407/12 , C07D409/12
摘要： The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
摘要翻译：本发明涉及一种降低环境影响的方法，用于制备作为CCR2拮抗剂的苯基氨基取代的季盐化合物。

12. 发明授权

US08309720B2 Process for the preparation of substituted pyrimidine derivatives 有权
标题翻译：制备取代嘧啶衍生物的方法
公开(公告)号：US08309720B2
公开(公告)日：2012-11-13
申请号：US12459229
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
IPC分类号： C07D211/06 , C07D211/30
CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26
摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
摘要翻译：本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法，以及H4调节剂合成中的中间体。

13. 发明授权

US07795426B2 Processes for the preparation of cyclopropyl-amide derivatives 有权
标题翻译：制备环丙基 - 酰胺衍生物的方法
公开(公告)号：US07795426B2
公开(公告)日：2010-09-14
申请号：US11553154
申请日：2006-10-26
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： C07D413/10
CPC分类号： C07D295/192
摘要： The present invention relates to processes for the preparation of cyclopropyl-amine derivatives of formula (II), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译：本发明涉及制备本说明书中定义的式（II）的环丙基 - 胺衍生物的方法，其用于治疗由组胺受体介导的病症和病症。

14. 发明申请

US20100197689A1 NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES 审中-公开
标题翻译：制备哌嗪和二氮杂萘衍生物的新方法
公开(公告)号：US20100197689A1
公开(公告)日：2010-08-05
申请号：US12762912
申请日：2010-04-19
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： A61K31/5377 , C07D413/10 , A61P11/06 , A61P11/02 , A61P17/04
CPC分类号： C07D295/192 , C07D207/06 , C07D211/14 , C07D295/182 , C07D413/04
摘要： The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译：本发明涉及用于制备用于治疗由组胺受体介导的病症和病症的取代哌嗪基和二氮杂苯甲酰基苯甲酰胺的新方法。

15. 发明授权

US5977302A Liquid phase process for the preparation of GnRH peptides 有权
标题翻译：用于制备GnRH肽的液相方法
公开(公告)号：US5977302A
公开(公告)日：1999-11-02
申请号：US195049
申请日：1998-11-18
申请人： David C. Palmer , Ahmed Abdel-Magid , Michael S. Breslav , Urs P. Eggmann , Bruce Harris , Mark L. Haslego , Kirk L. Sorgi
发明人： David C. Palmer , Ahmed Abdel-Magid , Michael S. Breslav , Urs P. Eggmann , Bruce Harris , Mark L. Haslego , Kirk L. Sorgi
IPC分类号： C07K5/09 , C07K5/103 , C07K5/107 , C07K7/23 , C07K7/06
CPC分类号： C07K5/0815 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K7/23 , Y02P20/55
摘要： A liquid phase process for preparing GnRH peptide analogs of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)-AA.sub.5 -AA.sub.6 AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2Formula 1which comprises:(a) reacting a peptide of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -Xwhere T is (P.sub.2)AA4 orP.sub.2 and X is AA.sub.7 --OH or is --OH, with a peptide of the formula:X'-AA.sub.8 -Pro-AA.sub.10 -NH.sub.2or acid-addition salt form thereof, where X' is AA.sub.7 when X is absent and X' selected from P-Ala, Gly, GABA, the D- and L- isomers of Ala, amino isobutyric acid, 6-amino-hexanoic acid, Ser, Thr, His, Tyr, Asn, and Gln' is absent when X is AA.sub.7 --OH;in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2(b) removing the P.sub.2 protecting group at the N-terminus, and(c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula:G-AA.sub.1 -(R.sub.1)D-Phe-AA.sub.3 -T'or acid-addition salt form thereof, where T' is AA.sub.4 --OH when T is absent and is absent when T is P2-AA.sub.4, in a liquid reaction medium to obtain a GnRH peptide of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2.
摘要翻译：用于制备下式的GnRH肽类似物的液相方法：G-AA1-（A）D-Phe-AA3-AA4-（R2）-AA5-AA6AA7-AA8-Pro-AA10-NH2式1，其包含：（a ）使下式的肽与下式的肽反应：其中T是（P2）AA4或P2，X是AA7-OH或-OH的式（T-（R2）AA5-AA6-X）肽与下式的肽反应：X'-AA8-Pro -AA10-NH2或其酸加成盐形式，其中当X不存在时X'为AA 7，X'选自P-Ala，Gly，GABA，Ala的D-和L-异构体，氨基异丁酸，当X是AA7-OH时，氨基己酸，Ser，Thr，His，Tyr，Asn和Gln'不存在; 在液体反应介质中，在肽偶联剂和强有机胺碱的存在下，得到下式的产物：（（R 2）AA 5 -A AA 6 -A AA 7 -A AA 8 -Pro-AA 10 -NH 2（b） P2保护基团，和（c）使步骤（b）的产物或其酸加成盐与下式的肽反应：G-AA1-（R1）D-Phe-AA3-T' 或其酸加成盐形式，其中当T不存在时T'为AA4-OH，当T为P2-AA4时不存在，在液体反应介质中得到G-AA1 - （A）的GnRH肽， D-Phe-AA3-AA4-（R2）AA5-AA6-AA7-AA8-Pro-AA10-NH2。

16. 发明授权

US5445951A Regioselective enzymatic deacylation of sucrose esters in anhydrous organic media 失效
标题翻译：蔗糖酯在无水有机介质中的区域选择性酶脱酰基
公开(公告)号：US5445951A
公开(公告)日：1995-08-29
申请号：US133725
申请日：1993-10-07
申请人： David C. Palmer , Fernand Terradas
发明人： David C. Palmer , Fernand Terradas
IPC分类号： C12P19/12
CPC分类号： C12P19/12
摘要： A process for the preparation of partially acylated derivatives of sucrose by the enzyme catalyzed deacylation of sucrose esters, wherein said process comprises treating a sucrose ester selected from the group consisting of sucrose octaacylate, sucrose heptaacylate, and sucrose hexaacylate in an anhydrous organic medium, with an enzyme or combination of enzymes capable of catalyzing the deacylation of said sucrose ester to produce a partially deacylated sucrose derivative having free hydroxyl group(s) in pre-selected position(s), and recovering the resulting partially deacylated sucrose derivative.
摘要翻译：一种通过酶催化蔗糖酯脱酰基来制备部分酰化的蔗糖衍生物的方法，其中所述方法包括在无水有机介质中处理选自蔗糖八酸酯，蔗糖七酸酯和蔗糖六酰化物的蔗糖酯，能够催化所述蔗糖酯脱酰基以产生在预先选择的位置具有游离羟基的部分脱酰基蔗糖衍生物的酶或酶的组合，以及回收所得的部分脱酰基蔗糖衍生物。

17. 发明授权

US08835633B2 Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives 有权
标题翻译：苯并咪唑-2-基嘧啶衍生物的制备方法
公开(公告)号：US08835633B2
公开(公告)日：2014-09-16
申请号：US13427767
申请日：2012-03-22
申请人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号： C07D401/14 , C07D403/04
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译：本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。

18. 发明申请

US20140067406A1 FACILITATING A TRANSACTION AMONG A SURGICAL PROVIDER, AN ITEM PROVIDER, AND A PAYOR 审中-公开
标题翻译：促进外科提供者，项目提供者和付款人的交易
公开(公告)号：US20140067406A1
公开(公告)日：2014-03-06
申请号：US13599696
申请日：2012-08-30
申请人： Eugene A. Hyatt , Todd A. Rielly , David C. Palmer , Richard B. Mills , Martin W. Smith
发明人： Eugene A. Hyatt , Todd A. Rielly , David C. Palmer , Richard B. Mills , Martin W. Smith
IPC分类号： G06Q50/22
CPC分类号： G06Q50/22 , G06F19/328 , G06Q30/0283
摘要： Methods and systems using a computer system for facilitating a transaction among a surgical provider, a medical device provider, and a payor are disclosed. A cost to provide medical devices needed for an identified procedure is estimated. Revenue to an entity that controls the computer system may also be estimated. Medical devices actually used in the surgical procedure are identified. A request may be submitted to the payor for reimbursement of costs associated with the devices actually used.
摘要翻译：公开了使用计算机系统促进手术提供者，医疗装置提供者和付款者之间交易的方法和系统。估计为确定的程序所需的医疗设备的费用。还可以估计对控制计算机系统的实体的收入。确定在外科手术中实际使用的医疗装置。可以向付款人提交请求以偿还与实际使用的设备相关的费用。

19. 发明申请

US20120184740A1 Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives 审中-公开
标题翻译：苯并咪唑-2-基嘧啶衍生物的制备方法
公开(公告)号：US20120184740A1
公开(公告)日：2012-07-19
申请号：US13427798
申请日：2012-03-22
申请人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号： C07D401/14
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译：本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。

20. 发明授权

US08168829B2 Synthesis of quaternary salt compounds 有权
标题翻译：季盐化合物的合成
公开(公告)号：US08168829B2
公开(公告)日：2012-05-01
申请号：US12256114
申请日：2008-10-22
申请人： David C. Palmer , Sergio Casco-Cancian , Tong Xiao , Kirk L. Sorgi , Armin Roessler , Anita Vladislavic , Roger Faessler
发明人： David C. Palmer , Sergio Casco-Cancian , Tong Xiao , Kirk L. Sorgi , Armin Roessler , Anita Vladislavic , Roger Faessler
IPC分类号： C07C211/00
CPC分类号： C07D333/36 , C07D209/42 , C07D295/135 , C07D307/14 , C07D307/68 , C07D307/85 , C07D309/04 , C07D309/14 , C07D311/58 , C07D311/92 , C07D313/08 , C07D333/70 , C07D335/02 , C07D405/12 , C07D407/12 , C07D409/12
摘要： The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
摘要翻译：本发明涉及一种降低环境影响的方法，用于制备作为CCR2拮抗剂的苯基氨基取代的季盐化合物。

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