专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06683115B2 &bgr;2-adrenergic receptor agonists 有权
标题翻译： β2-肾上腺素能受体激动剂
公开(公告)号：US06683115B2
公开(公告)日：2004-01-27
申请号：US09934982
申请日：2001-08-21
申请人： Edmund J. Moran , Seok-Ki Choi
发明人： Edmund J. Moran , Seok-Ki Choi
IPC分类号： A01N3302
CPC分类号： C07C215/60 , C07C2601/14 , C40B40/00
摘要： Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
摘要翻译：公开了作为β2肾上腺素能受体激动剂的多重联结化合物，并且可用于治疗和预防呼吸系统疾病如哮喘，支气管炎。它们也可用于治疗神经系统损伤和早产。

12. 发明授权

US06541669B1 &bgr;2-adrenergic receptor agonists 有权
标题翻译： β2-肾上腺素能受体激动剂
公开(公告)号：US06541669B1
公开(公告)日：2003-04-01
申请号：US09323943
申请日：1999-06-02
申请人： Edmund J. Moran , Seok-Ki Choi
发明人： Edmund J. Moran , Seok-Ki Choi
IPC分类号： C07C21100
CPC分类号： C07D213/74 , A61K47/55 , C07B2200/11 , C07C215/60 , C07C217/08 , C07C323/62 , C07D211/42 , C07D211/56 , C07D213/80 , C07D263/32 , C07D263/34 , C07D265/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/12 , C07K1/047 , C40B40/00 , G01N33/9406 , G01N2333/62 , G01N2333/70578 , G01N2333/726 , G01N2500/00
摘要： Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
摘要翻译：公开了作为β2肾上腺素能受体激动剂的多重联结化合物，并且可用于治疗和预防呼吸系统疾病如哮喘，支气管炎。它们也可用于治疗神经系统损伤和早产。

13. 发明授权

US07427639B2 β2-adrenergic receptor agonists 有权
标题翻译： β2-肾上腺素能受体激动剂
公开(公告)号：US07427639B2
公开(公告)日：2008-09-23
申请号：US11784148
申请日：2007-04-05
申请人： Edmund J. Moran , Seok-Ki Choi
发明人： Edmund J. Moran , Seok-Ki Choi
IPC分类号： A61K31/135 , A61K31/136 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/167
CPC分类号： A61K45/06 , A61K31/137 , A61K31/167 , A61K31/403 , A61K31/404 , A61K31/4164 , A61K31/4706 , C07C215/60 , C07C215/68 , C07C233/43 , C40B40/00
摘要： Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
摘要翻译：公开了作为β2肾上腺素能受体激动剂的多重联结化合物，并且可用于治疗和预防呼吸系统疾病如哮喘，支气管炎。它们也可用于治疗神经系统损伤和早产。

14. 发明授权

US07105701B2 β2-adrenergic receptor agonists 有权
标题翻译： β2-肾上腺素能受体激动剂
公开(公告)号：US07105701B2
公开(公告)日：2006-09-12
申请号：US11126124
申请日：2005-05-10
申请人： Edmund J. Moran , Seok-Ki Choi
发明人： Edmund J. Moran , Seok-Ki Choi
IPC分类号： C07C211/01 , A61K31/135 , A61K31/44 , C07D217/22
CPC分类号： C07D295/13 , C07B2200/11 , C07C215/08 , C07C215/16 , C07C215/60 , C07C217/10 , C07C217/16 , C07C217/20 , C07C217/34 , C07C323/62 , C07C2601/14 , C07D211/42 , C07D211/56 , C07D213/74 , C07D213/80 , C07D263/32 , C07D263/34 , C07D265/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/12 , C07K1/047 , C40B40/00 , G01N33/9406 , G01N2333/62 , G01N2333/70578 , G01N2333/726 , G01N2500/00
摘要： Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
摘要翻译：公开了作为β2-肾上腺素能受体激动剂的多重联结化合物，并且可用于治疗和预防呼吸系统疾病如哮喘，支气管炎。它们也可用于治疗神经系统损伤和早产。

15. 发明申请

US20090306134A1 Muscarinic receptor antagonists 审中-公开
标题翻译：毒蕈碱受体拮抗剂
公开(公告)号：US20090306134A1
公开(公告)日：2009-12-10
申请号：US12286528
申请日：2008-09-30
申请人： James Aggen , John H. Griffin , Mathai Mammen , Daniel Marquess , Edmund J. Moran , David Oare
发明人： James Aggen , John H. Griffin , Mathai Mammen , Daniel Marquess , Edmund J. Moran , David Oare
IPC分类号： A61K31/4545 , A61K31/54 , A61K31/5377 , A61K31/495 , A61K31/445 , C07D413/12 , C07D403/06 , C07D401/06 , C07D211/00
CPC分类号： A61K31/40 , C07C211/32 , C07C2603/32 , C07D207/08 , C07D209/48 , C07D211/46 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D519/00 , G01N33/566
摘要： Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.
摘要翻译：公开了作为毒蕈碱受体拮抗剂的多重联结化合物。含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。每个配体彼此独立地是毒蕈碱受体拮抗剂或变构调节剂，只要至少一种所述配体是毒蕈碱受体拮抗剂即可。本发明的多重联结化合物可用于治疗和预防慢性阻塞性肺疾病，慢性支气管炎，肠易激综合征，尿失禁等疾病。

16. 发明授权

US07173039B2 Protein kinase inhibitors 有权
标题翻译：蛋白激酶抑制剂
公开(公告)号：US07173039B2
公开(公告)日：2007-02-06
申请号：US11178736
申请日：2005-07-11
申请人： John H. Griffin , Yu-Hua Ji , Edmund J. Moran , Jonathan W. Wray
发明人： John H. Griffin , Yu-Hua Ji , Edmund J. Moran , Jonathan W. Wray
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10
CPC分类号： C07D231/38 , C07C43/23 , C07C46/00 , C07C50/38 , C07C217/34 , C07C225/22 , C07C229/60 , C07C2602/08 , C07D231/14 , C07D235/06 , C07D239/42 , C07D239/94 , C07D243/24 , C07D271/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07F9/3873 , C07F9/3882 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/6561
摘要： Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.
摘要翻译：公开了抑制或调节蛋白激酶活性的化合物和含有这些化合物的药物组合物。所公开的化合物含有两个或更多个通过一个或多个连接基团共价连接在一起的配体部分。这些化合物可用于治疗由蛋白激酶介导的疾病或医学病症。

17. 发明授权

US06750241B2 Protein kinase inhibitors 有权
标题翻译：蛋白激酶抑制剂
公开(公告)号：US06750241B2
公开(公告)日：2004-06-15
申请号：US10093068
申请日：2002-03-06
申请人： John H. Griffin , Yu-Hua Ji , Edmund J. Moran , Jonathan W. Wray
发明人： John H. Griffin , Yu-Hua Ji , Edmund J. Moran , Jonathan W. Wray
IPC分类号： C07D20934
CPC分类号： C07D231/38 , C07C43/23 , C07C46/00 , C07C50/38 , C07C217/34 , C07C225/22 , C07C229/60 , C07C2602/08 , C07D231/14 , C07D235/06 , C07D239/42 , C07D239/94 , C07D243/24 , C07D271/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07F9/3873 , C07F9/3882 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/6561
摘要： Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.
摘要翻译：公开了抑制或调节蛋白激酶活性的化合物和含有这些化合物的药物组合物。所公开的化合物含有两个或更多个通过一个或多个连接基团共价连接在一起的配体部分。这些化合物可用于治疗由蛋白激酶介导的疾病或医学病症。

18. 发明申请

US20090111737A1 Novel antibacterial agents 审中-公开
标题翻译：新型抗菌剂
公开(公告)号：US20090111737A1
公开(公告)日：2009-04-30
申请号：US12082666
申请日：2008-04-11
申请人： Burton G. Christensen , Edmund J. Moran , John H. Griffin , J. Kevin Judice , YongQi Mu , John L. Pace , Mathai Mammen , James Aggen
发明人： Burton G. Christensen , Edmund J. Moran , John H. Griffin , J. Kevin Judice , YongQi Mu , John L. Pace , Mathai Mammen , James Aggen
IPC分类号： A61K38/14 , C07K7/00 , A61P43/00
CPC分类号： C07D477/12 , C07D499/32 , C07D499/44 , C07D501/56
摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
摘要翻译：本发明涉及作为抗菌剂的新型多结合化合物（试剂）。本发明的多相结合化合物包含2-10个配体，其通过连接体或连接体共价连接，其中所述各单体（即，未连接）状态的所述配体具有结合涉及细胞壁生物合成和代谢的酶的能力用于合成细菌细胞壁和/或细菌细胞表面的前体因而干扰细胞壁的合成和/或代谢。特别地，本发明的多相结合化合物包含通过接头或接头共价连接的2-10个配体，其中每个所述配体具有能够结合青霉素结合蛋白的配体结构域，转肽酶，转肽酶的底物， β-内酰胺酶，pencillinase酶，头孢菌素酶，转糖基酶或转糖基酶酶底物; 优选地，配体选自β-内酰胺或糖肽类抗菌剂。

19. 发明授权

US07037912B2 Protein kinase inhibitors 有权
公开(公告)号：US07037912B2
公开(公告)日：2006-05-02
申请号：US10824005
申请日：2004-04-14
申请人： John H. Griffin , Yu-Hua Ji , Edmund J. Moran , Jonathan W. Wray
发明人： John H. Griffin , Yu-Hua Ji , Edmund J. Moran , Jonathan W. Wray
IPC分类号： C07D239/46 , C07D239/26 , C07D403/12 , C07D31/506 , A61P3/10
CPC分类号： C07D231/38 , C07C43/23 , C07C46/00 , C07C50/38 , C07C217/34 , C07C225/22 , C07C229/60 , C07C2602/08 , C07D231/14 , C07D235/06 , C07D239/42 , C07D239/94 , C07D243/24 , C07D271/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07F9/3873 , C07F9/3882 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/6561
摘要： Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.

20. 发明授权

US07456203B2 Muscarinic receptor antagonists 有权
标题翻译：毒蕈碱受体拮抗剂
公开(公告)号：US07456203B2
公开(公告)日：2008-11-25
申请号：US10425368
申请日：2003-04-29
申请人： James Aggen , John H. Griffin , Mathai Mammen , Daniel Marquess , Edmund J. Moran , David Oare
发明人： James Aggen , John H. Griffin , Mathai Mammen , Daniel Marquess , Edmund J. Moran , David Oare
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/40 , C07C211/32 , C07C2603/32 , C07D207/08 , C07D209/48 , C07D211/46 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D519/00 , G01N33/566
摘要： Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.
摘要翻译：公开了作为毒蕈碱受体拮抗剂的多重联结化合物。含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。每个配体彼此独立地是毒蕈碱受体拮抗剂或变构调节剂，只要至少一种所述配体是毒蕈碱受体拮抗剂即可。本发明的多重联结化合物可用于治疗和预防慢性阻塞性肺疾病，慢性支气管炎，肠易激综合征，尿失禁等疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式