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    • 15. 发明申请
    • COLORED OR COLORABLE TOPICAL COMPOSITION FOAM
    • 有色或有色的主题组合泡沫
    • US20090175799A1
    • 2009-07-09
    • US12350642
    • 2009-01-08
    • Dov TAMARKINDoron FRIEDMANMeir EINI
    • Dov TAMARKINDoron FRIEDMANMeir EINI
    • A61K9/12
    • A61K8/046A61K31/47A61K2800/42A61K2800/45A61Q19/00
    • There is described a colored or colorable topical composition, comprising: a) a foamable base composition comprising, 1) a flowable carrier composition; 2) a color agent; wherein the color agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from the foamable composition and wherein the color agent is one or more agents selected from the group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a dye, a colorant and a coloring agent; b) a propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the base composition has a first color; and wherein the foam comprising the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and wherein the first color and the second color are visually different. There is also described a method of changing color, a method of administration, a use as a diagnostic and a kit.
    • 描述了一种有色或可着色的局部组合物,其包含:a)可发泡基质组合物,其包含:1)可流动的载体组合物; 2)着色剂; 其中所述着色剂有效地赋予,增加,减少或以其他方式影响由所述可发泡组合物产生的泡沫的颜色,并且其中所述着色剂是选自以下的一种或多种试剂:有色活性剂,着色指示剂, 彩色赋形剂,颜料,染料,着色剂和着色剂; b)以总组合物重量计约3%至约25%的浓度的推进剂; 其中所述基础组合物具有第一颜色; 并且其中包含着色或可着色的局部组合物的泡沫在从气溶胶容器分配时具有第二颜色,并且其中第一颜色和第二颜色在视觉上不同。 还描述了改变颜色,给药方法,用作诊断和试剂盒的方法。
    • 16. 发明申请
    • DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION
    • 用于输送可发泡组合物的装置
    • US20090068118A1
    • 2009-03-12
    • US12204771
    • 2008-09-04
    • Meir EINIDavid SCHUZHelen SHIFRINYohan HAZOTDov TAMARKIN
    • Meir EINIDavid SCHUZHelen SHIFRINYohan HAZOTDov TAMARKIN
    • A61K9/12A61M31/00
    • A61M31/00
    • A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
    • 用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体,所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器,其可操作地连接到所述组合物储存器,用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度,并且内径在约1.5mm至约3.5mm的范围内,其中所述长度和内径被选择为在操作期间提供至少约70%的可发泡组合物的输送 。 泡沫输送装置可以具有多个孔。