专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US08400636B2 Blast injury dosimeter 有权
标题翻译：爆炸剂量计
公开(公告)号：US08400636B2
公开(公告)日：2013-03-19
申请号：US12383777
申请日：2009-03-27
申请人： Douglas H. Smith , Shu Yang , D. Kacy Cullen
发明人： Douglas H. Smith , Shu Yang , D. Kacy Cullen
IPC分类号： G01J3/46 , G01B11/30
CPC分类号： G01P15/06
摘要： A method for detecting blast induced pressure changes includes exposing a material, a contained solution, a membrane-bound solution, or a photonic crystal material, having a first optical property, to a pressure wave having a blast level. A change in the first optical property to a second optical property of the exposed material, contained solution, membrane-bound solution, or photonic crystal material is determined, and the extent of change corresponds to the blast level.
摘要翻译：用于检测炸药诱发的压力变化的方法包括将具有第一光学特性的材料，所含溶液，膜结合溶液或光子晶体材料暴露于具有爆炸级别的压力波。确定曝光材料，包含溶液，膜结合溶液或光子晶体材料的第一光学特性与第二光学特性的变化，并且变化程度对应于爆破级别。

12. 发明授权

US07972367B2 Device and method using integrated neuronal cells and an electronic device 有权
标题翻译：使用集成神经细胞和电子装置的装置和方法
公开(公告)号：US07972367B2
公开(公告)日：2011-07-05
申请号：US12194693
申请日：2008-08-20
申请人： Douglas H. Smith , Bryan Pfister , David F. Meaney
发明人： Douglas H. Smith , Bryan Pfister , David F. Meaney
IPC分类号： A61N1/00
CPC分类号： A61N1/04 , A61N1/05 , A61N1/326 , A61N1/36103
摘要： The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.
摘要翻译：本发明提供了与电子设备接口的集成神经细胞的装置及其制造方法。

13. 发明申请

US20110097719A1 Neprilysin Gene Polymorphism and Amyloid Beta Plaques in Traumatic Brain Injury 审中-公开
标题翻译：创伤性脑损伤中的Neprilysin基因多态性和淀粉样β噬菌斑
公开(公告)号：US20110097719A1
公开(公告)日：2011-04-28
申请号：US12808097
申请日：2008-12-10
申请人： Douglas H. Smith , William Stewart , Vicrtoria E. Johnson
发明人： Douglas H. Smith , William Stewart , Vicrtoria E. Johnson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention relates to methods of diagnosing risk of amyloid β deposition following traumatic brain injury. More particularly, the invention relates to the discovery of a specific single nucleotide polymorphism in the neprilysin gene that is linked to an increased risk of amyloid β deposition after traumatic brain injury
摘要翻译：本发明涉及诊断淀粉样蛋白和风险的方法。创伤性脑损伤后的沉积。更具体地，本发明涉及发现与升高的淀粉样蛋白和bgr的风险相关的neprilysin基因中的特定单核苷酸多态性; 创伤性脑损伤后沉积

14. 发明授权

US06640438B2 Process and machine for uniting rotatable machine components 有权
标题翻译：用于结合可旋转机器部件的过程和机器
公开(公告)号：US06640438B2
公开(公告)日：2003-11-04
申请号：US09854060
申请日：2001-05-11
申请人： Alan Charles Webb , Peter Holland , Peter Standring , Douglas H. Smith , Larry L. Bahney
发明人： Alan Charles Webb , Peter Holland , Peter Standring , Douglas H. Smith , Larry L. Bahney
IPC分类号： B21D5310
CPC分类号： B60B27/001 , B23P11/005 , B60B35/18 , B60B2310/208 , B60B2310/228 , B60B2310/306 , B60B2310/316 , B60B2360/10 , B60B2360/102 , B60B2380/14 , F16C19/386 , F16C35/063 , F16C2326/02 , Y10T29/49533 , Y10T29/49535 , Y10T29/49536 , Y10T29/49682 , Y10T29/49696 , Y10T29/49776 , Y10T29/49918 , Y10T29/53065 , Y10T29/53104
摘要： A hub (2) includes a spindle (14) which projects through a housing (4) and rotates relative to the housing (4) on a bearing (6) that is located between the spindle (14) and the housing (4). The bearing (6) has two sets of raceways (28,40) that are oblique to the axis x, and in addition rolling elements (36) arranged in two rows between the sets of raceways (28,40). The inner raceways (28) that fit around the spindle (14) and have back faces (32), with the back face (32) for one of the races (26) being against a shoulder (18) from which the spindle (14) projects. Initially, the end of the spindle (14) projects straight beyond the back face (32) of the outer race—indeed, so that the races (26) can be installed over the spindle (14). But once the housing (4) and races (26) are in a position around the spindle (14), the projecting end portion of the spindle (14) is deformed radially and axially in a rotary forming operation such that it transforms into a formed end (20) that lies behind back face (32) of the race (26). With the two races (26) between the formed end (20) and the shoulder (18). During the rotary forming operation the hub (26) rotates, and the end of its spindle (14) is forced against a rotating forming tool and the force is monitored. The housing (4) is restrained and the torque transferred from the rotating hub (2) to the housing (4) is monitored.
摘要翻译：轮毂（2）包括主轴（14），该主轴突出通过壳体（4）并且相对于壳体（4）在位于主轴（14）和壳体（4）之间的轴承（6）上旋转。轴承（6）具有与轴线x倾斜的两组滚道（28,40），以及在滚道组（28,40）之间布置成两排的滚动元件（36）。安装在主轴（14）周围并且具有后表面（32）的内滚道（28），其中一个座圈（26）的后表面（32）抵靠在肩部（18）上，主轴）项目。最初，主轴（14）的端部直接突出超过外圈的背面（32），实际上，使得座圈（26）可以安装在主轴（14）上。但是，一旦壳体（4）和座圈（26）处于围绕心轴（14）的位置，则主轴（14）的突出端部在旋转成形操作中径向和轴向地变形，使得其转变成形成端部（20）位于座圈（26）的背面（32）之后。通过形成的端部（20）和肩部（18）之间的两个座圈（26）。在旋转成形操作期间，毂（26）旋转，并且其主轴（14）的端部被迫抵抗旋转成形工具，并且该力被监测。对壳体（4）进行限制，并且监测从旋转轮毂（2）传递到壳体（4）的扭矩。

15. 发明授权

US06264944B1 Mechanically elongated neuronal cells 有权
标题翻译：机械伸长的神经细胞
公开(公告)号：US06264944B1
公开(公告)日：2001-07-24
申请号：US09630461
申请日：2000-08-02
申请人： Douglas H. Smith
发明人： Douglas H. Smith
IPC分类号： A01N6300
CPC分类号： C12N5/0618 , A61K35/12 , C12M35/04 , C12N5/0619
摘要： Mechanically elongated neuronal cells and methods of mechanically producing elongated cells are provided. Also provided are methods for transplanting elongated neuronal cells into an animal for treatment of spinal cord injuries and other nerve injuries.
摘要翻译：提供机械拉长的神经元细胞和机械地生产细长细胞的方法。还提供了将细长的神经元细胞移植到用于治疗脊髓损伤和其它神经损伤的动物中的方法。

16. 发明授权

US06501382B1 Bearing with data storage device 有权
标题翻译：带数据存储设备
公开(公告)号：US06501382B1
公开(公告)日：2002-12-31
申请号：US09878485
申请日：2001-06-11
申请人： Kevin E. Rehfus , Douglas H. Smith
发明人： Kevin E. Rehfus , Douglas H. Smith
IPC分类号： G08B1314
CPC分类号： F16C41/008 , F16C19/364
摘要： A product with an automatic identification and data capture (AIDC) device associated with a physical measurement, authentication code or operating condition of the product is disclosed. A bearing with an embedded transponder is illustratively described. The transponder contains data specific to the manufactured bearing, such as physical measurements or identification numbers.
摘要翻译：公开了具有与产品的物理测量，认证代码或操作条件相关联的自动识别和数据捕获（AIDC）设备的产品。示例性地描述了具有嵌入式转发器的轴承。应答器包含特定于制造轴承的数据，例如物理测量或识别号码。

17. 发明授权

US06457869B1 Wheel mounting with axle-mounted sensor 有权
标题翻译：车轮安装带车轴传感器
公开(公告)号：US06457869B1
公开(公告)日：2002-10-01
申请号：US09665199
申请日：2000-09-18
申请人： Douglas H. Smith , Lloyd William Sparrow , Geoffrey William Branfield
发明人： Douglas H. Smith , Lloyd William Sparrow , Geoffrey William Branfield
IPC分类号： F16C1900
CPC分类号： F16C41/007 , B60B27/001 , F16C19/386 , F16C33/7883 , F16C2326/02 , F16J15/326 , G01P3/443
摘要： A wheel mounting includes an axle provided with a spindle, a hub located around the spindle, and an antifriction bearing located between the spindle and the hub for enabling the hub to rotate on the spindle with minimal friction. The axle also has a cylindrical ring seat located beyond its spindle and a shoulder located between the spindle and the ring seat. The ring seat has a stop located along it. The bearing has a cone located around the spindle, with its back face being against the shoulder, a cup located in the hub, and tapered rollers located between tapered raceways on the cone and cup. Beyond the large end of its raceway the cup is fitted with an excitor ring having a radial wall at the inboard end of the bearing. The ring seat carries a mounting ring having an axial wall provided with a formation that bears against the stop on the seat and an end edge that is against the back face of the inboard cone. Indeed, the axial wall is compressed between the back face of the inboard cone and the stop, so that the formation on the axial wall bears tightly against the stop on the ring seat. This fixes the mounting ring firmly in position axially with respect to the radial wall on the excitor ring. The mounting ring carries a sensor which is presented toward the radial wall of the excitor ring. The sensor produces a pulsating signal when the excitor ring rotates, and the frequency of that signal reflects the angular velocity of the hub.
摘要翻译：车轮安装包括设置有主轴的轴，围绕主轴定位的轮毂和位于主轴和轮毂之间的减摩轴承，用于使轮毂能够以最小的摩擦在主轴上旋转。该轴还具有位于其主轴之外的圆柱形环座和位于主轴和环座之间的肩部。环座位于其上。轴承具有位于主轴周围的锥体，其背面抵靠肩部，位于轮毂中的杯子和位于锥体和杯子上的锥形滚道之间的锥形滚子。在其滚道的大端之外，该杯装配有在轴承内侧具有径向壁的激振环。环座承载安装环，该安装环具有轴向壁，该轴向壁设置有抵靠座椅上的止挡件的结构以及抵靠内侧锥体的后表面的端部边缘。实际上，轴向壁在内侧锥体的后表面和止动件之间被压缩，使得轴向壁上的形成紧紧地抵靠在环形座上的止动件上。这将固定环相对于激励环上的径向壁轴向固定在适当的位置上。安装环带有一个向激发环的径向壁呈现的传感器。当激励环旋转时，传感器产生脉动信号，该信号的频率反映了轮毂的角速度。

18. 发明授权

US06365153B2 Mechanically elongated neuronal cells and methods for producing and using these cells 有权
标题翻译：机械伸长的神经元细胞和用于产生和使用这些细胞的方法
公开(公告)号：US06365153B2
公开(公告)日：2002-04-02
申请号：US09800395
申请日：2001-03-06
申请人： Douglas H. Smith
发明人： Douglas H. Smith
IPC分类号： A01N6300
CPC分类号： C12N5/0618 , A61K35/12 , C12M35/04 , C12N5/0619
摘要： Mechanically elongated neuronal cells and methods of mechanically producing elongated cells are provided. Also provided are methods for transplanting elongated neuronal cells into an animal for treatment of spinal cord injuries and other nerve injuries.
摘要翻译：提供机械拉长的神经元细胞和机械地生产细长细胞的方法。还提供了将细长的神经元细胞移植到用于治疗脊髓损伤和其它神经损伤的动物中的方法。

19. 发明授权

US5837544A Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase 失效
标题翻译：使用包含janus激酶的嵌合受体诱导细胞增殖的方法
公开(公告)号：US5837544A
公开(公告)日：1998-11-17
申请号：US485293
申请日：1995-06-07
申请人： Daniel J. Capon , Huan Tian , Douglas H. Smith , Genine A. Winslow , Miriam Siekevitz
发明人： Daniel J. Capon , Huan Tian , Douglas H. Smith , Genine A. Winslow , Miriam Siekevitz
IPC分类号： A61K38/00 , C07K14/705 , C07K14/715 , C07K14/73 , C12N9/12 , C12N15/12 , C12N5/10 , C12N1/38
CPC分类号： C12N9/1205 , C07K14/705 , C07K14/70514 , C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention is directed to novel chimeric proliferation receptor proteins and DNA sequences encoding these proteins where the chimeric proteins are characterized in three general categories. In one category, the novel chimeric proteins comprise at least three domains, namely, an extracellular inducer-responsive clustering domain capable of binding an extracellular inducer that transmits a signal to a proliferation signaling domain, a transmembrane domain and a proliferation signaling domain that signals a host cell to divide. In the second category, the novel chimeric proteins comprise at least two domains, namely, an intracellular inducer-responsive clustering domain capable of binding an intracellular inducer and a proliferation signaling domain that signals the cell to divide. In yet a third category, a novel hybrid chimeric protein receptor is contemplated that contains an intracellular or extracellular inducer domain, a transmembrane domain, a proliferation signaling domain and an effector signaling domain in a single chain molecule. Whether the binding domain is intracellular or extracellular, the binding of inducer to these novel chimeric receptor proteins induces the clustering of the binding domains to each other and further signals the cell to proliferate, and optionally, signal an effector function. The present invention further relates to expression vectors containing the nucleic acids encoding the novel chimeric receptors, cells expressing the novel chimeric receptors and therapeutic methods of using cells expressing these novel receptors for the treatment of cancer, infectious disease and autoimmune diseases, for example.
摘要翻译：本发明涉及嵌合增殖受体蛋白和编码这些蛋白的DNA序列，其中嵌合蛋白的特征在于三个一般类别。在一个类别中，新型嵌合蛋白质包含至少三个结构域，即能够结合将信号传递给增殖信号转导域的细胞外诱导物 - 响应性聚簇结构域，跨膜结构域和增殖信号转导域，宿主细胞分裂。在第二类中，新的嵌合蛋白包含至少两个结构域，即能够结合细胞内诱导物的细胞内诱导物 - 响应聚簇结构域和信号细胞分裂的增殖信号转导域。在三分之一类别中，预期在单链分子中含有细胞内或细胞外诱导物结构域，跨膜结构域，增殖信号结构域和效应子信号结构域的新型杂合嵌合蛋白受体。结合结构域是细胞内还是细胞外，诱导物与这些新型嵌合受体蛋白的结合诱导结合结构域彼此聚集，并进一步使细胞信号增殖，并且任选地发送效应子功能。本发明还涉及含有编码新型嵌合受体的核酸，表达新型嵌合受体的细胞和使用表达这些新受体的细胞治疗癌症，感染性疾病和自身免疫疾病的治疗方法的表达载体。

20. 发明授权

US5741899A Chimeric receptors comprising janus kinase for regulating cellular pro liferation 失效
标题翻译：包含janus激酶调节细胞增殖的嵌合受体
公开(公告)号：US5741899A
公开(公告)日：1998-04-21
申请号：US481003
申请日：1995-06-07
申请人： Daniel J. Capon , Huan Tian , Douglas H. Smith , Genine A. Winslow , Miriam Siekevitz
发明人： Daniel J. Capon , Huan Tian , Douglas H. Smith , Genine A. Winslow , Miriam Siekevitz
IPC分类号： A61K38/00 , C07K14/705 , C07K14/715 , C07K14/73 , C12N9/12 , C12N15/12 , C12N15/62 , C07K19/00 , C12N5/10
CPC分类号： C12N9/1205 , C07K14/705 , C07K14/70514 , C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention is directed to novel chimeric proliferation receptor proteins and DNA sequences encoding these proteins where the chimeric proteins are characterized in three general categories. In one category, the novel chimeric proteins comprise at least three domains, namely, an extracellular inducer-responsive clustering domain capable of binding an extracellular inducer that transmits a signal to a proliferation signaling domain, a transmembrane domain and a proliferation signaling domain that signals a host cell to divide. In the second category, the novel chimeric proteins comprise at least two domains, namely, an intracellular inducer-responsive clustering domain capable of binding an intracellular inducer and a proliferation signaling domain that signals the cell to divide. In yet a third category, a novel hybrid chimeric protein receptor is contemplated that contains an intracellular or extracellular inducer domain, a transmembrane domain, a proliferation signaling domain and an effector signaling domain in a single chain molecule. Whether the binding domain is intracellular or extracellular, the binding of inducer to these novel chimeric receptor proteins induces the clustering of the binding domains to each other and further signals the cell to proliferate, and optionally, signal an effector function. The present invention further relates to expression vectors containing the nucleic acids encoding the novel chimeric receptors, cells expressing the novel chimeric receptors and therapeutic methods of using cells expressing these novel receptors for the treatment of cancer, infectious disease and autoimmune diseases, for example.
摘要翻译：本发明涉及嵌合增殖受体蛋白和编码这些蛋白的DNA序列，其中嵌合蛋白的特征在于三个一般类别。在一个类别中，新型嵌合蛋白质包含至少三个结构域，即能够结合将信号传递给增殖信号转导域的细胞外诱导物 - 响应性聚簇结构域，跨膜结构域和增殖信号转导域，宿主细胞分裂。在第二类中，新的嵌合蛋白包含至少两个结构域，即能够结合细胞内诱导物的细胞内诱导物 - 响应聚簇结构域和信号细胞分裂的增殖信号转导域。在三分之一类别中，预期在单链分子中含有细胞内或细胞外诱导物结构域，跨膜结构域，增殖信号结构域和效应子信号结构域的新型杂合嵌合蛋白受体。结合结构域是细胞内还是细胞外，诱导物与这些新型嵌合受体蛋白的结合诱导结合结构域彼此聚集，并进一步使细胞信号增殖，并且任选地发送效应子功能。本发明还涉及含有编码新型嵌合受体的核酸，表达新型嵌合受体的细胞和使用表达这些新受体的细胞治疗癌症，感染性疾病和自身免疫疾病的治疗方法的表达载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式