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11. 发明申请

US20110289146A1 METHOD AND APPARATUS ALLOWING SCAN OF DATA STORAGE DEVICE FROM REMOTE SERVER 有权
标题翻译：从远程服务器允许数据存储设备扫描的方法和设备
公开(公告)号：US20110289146A1
公开(公告)日：2011-11-24
申请号：US12785131
申请日：2010-05-21
申请人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
发明人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
IPC分类号： G06F15/167 , G06F12/00
CPC分类号： G06F21/57 , G06F21/56
摘要： A method and device allowing a scan of a data storage device from a remote server are disclosed. In some embodiments, a computing device may include an out-of-band (OOB) configured to compute a first hash value for data stored in one or more sectors of a data storage device at a first time; receive, using communication circuitry, a request to transmit a portion of the data stored in the one or more sectors of the data storage device at a second time, the second time being subsequent to the first time; compute a second hash value for the data stored in the one or more sectors of the data storage device at the second time; and transmit, using the communication circuitry, the requested portion of the data, only if the second hash value does not match the first hash value.
摘要翻译：公开了允许从远程服务器扫描数据存储设备的方法和设备。在一些实施例中，计算设备可以包括带外（OOB），其被配置为在第一时间对存储在数据存储设备的一个或多个扇区中的数据计算第一散列值; 接收使用通信电路的请求，以在第二时间之后的第二时间第二时间发送存储在数据存储装置的一个或多个扇区中的数据的一部分的请求; 在第二次计算存储在数据存储设备的一个或多个扇区中的数据的第二哈希值; 并且仅当所述第二散列值与所述第一散列值不匹配时，才使用所述通信电路来发送所请求的数据部分。

12. 再颁专利

USRE41996E1 Composition and methods for enhancing receptor-mediated cellular internalization 有权
标题翻译：用于增强受体介导的细胞内化的组合物和方法
公开(公告)号：USRE41996E1
公开(公告)日：2010-12-14
申请号：US11821513
申请日：2007-06-21
申请人： Daniel R. Deaver , David A. Edwards , Robert S. Langer
发明人： Daniel R. Deaver , David A. Edwards , Robert S. Langer
IPC分类号： A61F2/02 , A61F13/02 , A61K9/48 , A61K9/20 , A61K9/14
CPC分类号： A61K9/0046 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/0073 , A61K9/06 , A61K31/56 , A61K31/573 , A61K31/715 , A61K47/38 , A61K48/00 , A61K48/0008 , A61K48/0083 , Y10S977/906
摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
摘要翻译：公开了用于改善一种或多种化合物的细胞内化的组合物和方法。组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。该组合物还包括或者与增效剂一起施用，其量可以有效地最大程度地使受体的表达或结合，并增强化合物进入细胞的RME。这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。组合物经口，鼻，阴道，直肠和眼部局部应用。增强剂与组合物一起施用或分开施用，全部或优选局部施用。待递送的化合物也可以是增强剂。

13. 发明授权

US06977087B2 Aerodynamically light particles for pulmonary drug delivery 失效
标题翻译：用于肺部药物递送的空气动力学轻微颗粒
公开(公告)号：US06977087B2
公开(公告)日：2005-12-20
申请号：US10090418
申请日：2002-03-01
申请人： David A. Edwards , Giovannia Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovannia Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K31/56 , A61K31/568 , A61K38/28
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/56 , A61K31/568 , A61K38/28
摘要： Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.
摘要翻译：提供用于递送至肺系统的改善的空气动力学轻微颗粒，以及其制备和给药方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚（氨基酸）侧链上的直链α-羟基酸聚酯主链组成集团在聚酯骨干。在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂，并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。

14. 发明授权

US06399102B1 Aerodynamically light particles for pulmonary drug delivery 有权
公开(公告)号：US06399102B1
公开(公告)日：2002-06-04
申请号：US09562988
申请日：2000-05-01
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

15. 发明授权

US5985320A Materials and methods for enhancing cellular internalization 失效
标题翻译：用于增强细胞内化的材料和方法
公开(公告)号：US5985320A
公开(公告)日：1999-11-16
申请号：US810275
申请日：1997-03-03
申请人： David A. Edwards , Daniel R. Deaver , Robert S. Langer
发明人： David A. Edwards , Daniel R. Deaver , Robert S. Langer
IPC分类号： A61K9/06 , A61K9/00 , A61K9/127 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/55 , A61K39/395 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K48/00 , A61K49/00
CPC分类号： A61K9/0043 , A61K47/38 , A61K9/0034 , A61K47/10 , A61K47/26 , A61K47/36 , Y10S436/829
摘要： Compositions and methods for delivering agents across cell membranes are disclosed. The compositions include an agent to be delivered, a viscous material, such as a hydrogel, lipogel or viscous sol, and, optionally, a carrier that includes a ligand that binds to or interacts with cell surface receptors. The agent to be delivered binds to or otherwise interacts with cell surface receptors, is attached, either covalently or ionically to a molecule that binds to or interacts with a cell surface receptor, or is associated with the carrier. Agents to be delivered include bioactive compounds and diagnostic agents. The compositions have an apparent viscosity roughly equal to the viscosity of the cytosol in the cell to which the agent is to be delivered. The rate of cellular internalization is higher when the viscosity of the viscous material and that of the cytosol in the cell are approximately the same, relative to when they are not the same. The compositions enhance cellular entry of bioactive agents and diagnostic materials when administered vaginally, nasally, rectally ocularly, orally, or to the respiratory or pulmonary system.
摘要翻译：公开了用于递送细胞膜的药剂的组合物和方法。组合物包括待递送的试剂，粘性物质，例如水凝胶，脂凝胶或粘稠溶胶，以及任选的包含与细胞表面受体结合或与细胞表面受体相互作用的配体的载体。待递送的药剂与细胞表面受体结合或以其他方式相互作用，与结合细胞表面受体或与细胞表面受体相关的分子共价或离子地连接。待递送的试剂包括生物活性化合物和诊断剂。组合物的表观粘度大致等于试剂要递送的细胞中细胞溶胶的粘度。当粘性物质和细胞质中的细胞溶胶的粘度相差不大时，细胞内化速率较高。当阴道，鼻，直肠眼，口服或呼吸或肺部系统施用时，组合物增强生物活性剂和诊断材料的细胞进入。

16. 发明授权

US5874064A Aerodynamically light particles for pulmonary drug delivery 失效
公开(公告)号：US5874064A
公开(公告)日：1999-02-23
申请号：US739308
申请日：1996-10-29
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K47/32
CPC分类号： A61K9/0075 , A61K31/137 , A61K9/1647
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 .mu.m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

17. 发明授权

US08846607B2 Particles for treatment of pulmonary infection 有权
标题翻译：用于治疗肺部感染的颗粒
公开(公告)号：US08846607B2
公开(公告)日：2014-09-30
申请号：US11720595
申请日：2005-10-19
申请人： David A. Edwards , Jennifer Fiegel , Jean Sung
发明人： David A. Edwards , Jennifer Fiegel , Jean Sung
IPC分类号： A61K9/14 , A61P31/06 , A61P11/00 , A61K38/12 , A61K9/00 , A61K9/16
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , Y10S514/924
摘要： Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine.
摘要翻译：已经开发了治疗或减少呼吸道感染传播的制剂，特别是慢性或耐药性感染，特别是结核病（TB），严重急性呼吸综合征（SARS），脑膜炎球菌性脑膜炎，呼吸道合胞病毒（RSV），流感和小痘。制剂包括纳米颗粒的微粒，纳米颗粒或骨料形式的药物或疫苗，以及任选的可以通过吸入递送的载体。通过吸入器给药可以通过绕过胃和肝来避开与口服或可注射药物相关的问题，并将药物直接送入肺部。在一个实施方案中，含有该试剂的颗粒是大的多孔气溶胶颗粒（LPPs）。在另一个实施方案中，颗粒是纳米颗粒，其可以作为具有微米直径的多孔纳米颗粒聚集体施用，其在施用后分散到纳米颗粒中。任选地，包覆纳米颗粒，例如用表面活性剂或蛋白质涂层。制剂可以粉末形式施用或作为溶液给药或通过肠内或非肺部非肠道途径给药。制剂优选作为肺制剂施用。在用于治疗结核病的优选实施方案中，疫苗是在室温下稳定的BCG疫苗，或者是针对TB有效的抗生素，例如卷曲霉素或PA-824，其以非常高的百分比加载到微粒或纳米颗粒中。在一个实施方案中，用递送抗生素和疫苗的制剂治疗患者。

18. 发明授权

US08628754B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率地传送大量治疗性气溶胶
公开(公告)号：US08628754B2
公开(公告)日：2014-01-14
申请号：US13334236
申请日：2011-12-22
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译：用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。颗粒能够携带。试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合试剂与颗粒混合并与颗粒共同传送。还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。还包括递送这些可呼吸组合物的方法。

19. 发明授权

US08489686B2 Method and apparatus allowing scan of data storage device from remote server 有权
标题翻译：允许从远程服务器扫描数据存储设备的方法和装置
公开(公告)号：US08489686B2
公开(公告)日：2013-07-16
申请号：US12785131
申请日：2010-05-21
申请人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
发明人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
IPC分类号： G06F15/16
CPC分类号： G06F21/57 , G06F21/56
摘要： A method and device allowing a scan of a data storage device from a remote server are disclosed. In some embodiments, a computing device may include an out-of-band (OOB) configured to compute a first hash value for data stored in one or more sectors of a data storage device at a first time; receive, using communication circuitry, a request to transmit a portion of the data stored in the one or more sectors of the data storage device at a second time, the second time being subsequent to the first time; compute a second hash value for the data stored in the one or more sectors of the data storage device at the second time; and transmit, using the communication circuitry, the requested portion of the data, only if the second hash value does not match the first hash value.
摘要翻译：公开了允许从远程服务器扫描数据存储设备的方法和设备。在一些实施例中，计算设备可以包括带外（OOB），其被配置为在第一时间对存储在数据存储设备的一个或多个扇区中的数据计算第一散列值; 接收使用通信电路的请求，以在第二时间之后的第二时间第二时间发送存储在数据存储装置的一个或多个扇区中的数据的一部分的请求; 在第二次计算存储在数据存储设备的一个或多个扇区中的数据的第二哈希值; 并且仅当所述第二散列值与所述第一散列值不匹配时，才使用所述通信电路来发送所请求的数据部分。

20. 发明申请

US20130045246A1 ENCLOSING MATERIALS IN NATURAL TRANSPORT SYSTEMS 有权
标题翻译：包装材料在自然运输系统
公开(公告)号：US20130045246A1
公开(公告)日：2013-02-21
申请号：US13580629
申请日：2011-02-22
申请人： David A. Edwards , Raphaël Haumont , Francois Azambourg
发明人： David A. Edwards , Raphaël Haumont , Francois Azambourg
IPC分类号： A23P1/08 , A23L2/00 , A61K9/00 , A23L1/00
CPC分类号： B05D3/002 , A23L29/256 , A23P10/30 , A23P20/105 , A23P20/15 , A23P20/17 , A23P20/20 , A23P20/25 , B05D2350/60 , B05D2401/20
摘要： Edible or potable substances can be transported in biodegradable vessel.
摘要翻译：食用或饮用物质可以在可生物降解的容器中运输。

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