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11. 发明申请

US20110183310A1 Apparatus and method for maintaining and/or restoring viability of organs 有权
公开(公告)号：US20110183310A1
公开(公告)日：2011-07-28
申请号：US13064497
申请日：2011-03-29
申请人： David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
发明人： David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
IPC分类号： A01N1/02
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

12. 发明申请

US20110053256A1 Apparatus and method for maintaining and/or restoring viability of organs 有权
公开(公告)号：US20110053256A1
公开(公告)日：2011-03-03
申请号：US12926277
申请日：2010-11-05
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J. Steibel , Richard Fraser , Stanley Harris , Douglas Schein
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J. Steibel , Richard Fraser , Stanley Harris , Douglas Schein
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

13. 发明申请

US20070088288A1 Fixed dose medication dispensing device 有权
标题翻译：固定剂量药物分配装置
公开(公告)号：US20070088288A1
公开(公告)日：2007-04-19
申请号：US10575502
申请日：2004-10-15
申请人： Traci Barron , Andrew Burroughs , David Hixson
发明人： Traci Barron , Andrew Burroughs , David Hixson
IPC分类号： A61M5/00
CPC分类号： A61M5/3158 , A61M5/24 , A61M5/31541 , A61M5/3155 , A61M5/31551 , A61M2005/3125 , A61M2205/581 , A61M2205/583 , A61M2205/585
摘要： A guide and follower cooperate to promote a user moving the driver relative to the housing along a travel path that operates the apparatus. The cooperating elements of the nut and the driver are disengaged when the driver is disposed in a reset segment of the travel path, and the cooperating elements of the nut and the driver become engaged when the driver is shifted through a nut engaging segment of the travel path from the reset segment to a nut rotating segment of the travel path. The engagement of the cooperating elements of the nut and the driver cause the nut to screw proximally along the threaded shaft of the drive member when the driver is shifted through the nut rotating segment from the nut engaging segment to an injecting section of the travel path. When the driver is shifted through the injecting section from the nut rotating segment to the reset segment, the nut and the drive member are shifted in the distal direction to axially advance a fluid container piston to dispense medicine, and the cooperating elements of the nut and the driver become disengaged.
摘要翻译：引导和跟随器协作以促进使用者沿着操作该装置的行进路径相对于壳体移动驾驶员。当驾驶员设置在行进路径的复位段中时，螺母和驾驶员的配合元件脱开，并且当驾驶员通过行进的螺母接合部分移动时，螺母和驾驶员的配合元件接合从复位段到行进路径的螺母旋转段的路径。当驾驶员通过螺母旋转部分从螺母接合部分移动到行进路径的注入部分时，螺母和驱动器的配合元件的接合使螺母沿着驱动部件的螺纹轴向近侧螺旋。当驾驶员通过注射部分从螺母旋转段移动到复位段时，螺母和驱动构件在远端方向上移动以轴向前进流体容器活塞以分配药物，并且螺母的协作元件司机变得脱离了。

14. 发明申请

US20050165435A1 Powered surgical apparatus, method of manufacturing powered surgical apparatus, and method of using powered surgical apparatus 有权
公开(公告)号：US20050165435A1
公开(公告)日：2005-07-28
申请号：US11045135
申请日：2005-01-31
申请人： Constance Johnston , Phillip Ryan , Carrie Mills , Perry Mykleby , Andrew Burroughs , Benjamin Rush , Tasos Karahalios , Jacob Brauer , Rodney Monson , Eric Sugalski , Dickon Isaacs , James Tappel , Thomas Enders , Benjamin Chow , Energy Cruse , Scott Brenneman
发明人： Constance Johnston , Phillip Ryan , Carrie Mills , Perry Mykleby , Andrew Burroughs , Benjamin Rush , Tasos Karahalios , Jacob Brauer , Rodney Monson , Eric Sugalski , Dickon Isaacs , James Tappel , Thomas Enders , Benjamin Chow , Energy Cruse , Scott Brenneman
IPC分类号： A61B17/14 , A61B17/00 , A61B17/16 , A61B17/24 , A61B17/28 , A61B17/32 , A61B17/3211 , A61B19/00 , A61M1/00
CPC分类号： A61B17/162 , A61B17/1622 , A61B17/1624 , A61B17/1626 , A61B17/1633 , A61B17/1679 , A61B17/1688 , A61B17/1695 , A61B17/24 , A61B17/2909 , A61B17/32002 , A61B34/74 , A61B2017/00199 , A61B2017/00367 , A61B2017/00398 , A61B2017/00424 , A61B2017/0046 , A61B2017/00477 , A61B2017/00526 , A61B2017/00973 , A61B2217/005 , A61B2217/007 , A61M1/008 , A61M1/0084 , A61M1/0086 , Y10T279/17752
摘要： A powered surgical apparatus can be used with a source of irrigation fluid and a source of suction. The powered surgical apparatus can include a cutting blade assembly and a handle. The handle can include an upper portion defining a distal section connectable to the cutting blade assembly and a lower portion extending downwardly from the upper portion. The handle can be connectable to the source of irrigation fluid and the source of suction. The system can also include a manually actuable input device that provides at least one signal relevant to at least one operation of the system, and a controller that receives the at least one input signal and provides an output signal to perform the at least one operation of the system.

15. 发明申请

US20050131437A1 Powered surgical apparatus, method of manufacturing powered surgical apparatus, and method of using powered surgical apparatus 有权
公开(公告)号：US20050131437A1
公开(公告)日：2005-06-16
申请号：US11045256
申请日：2005-01-31
申请人： Constance Johnston , Phillip Ryan , Carrie Mills , Perry Mykleby , Andrew Burroughs , Benjamin Rush , Tasos Karahalios , Jacob Brauer , Rodney Monson , Eric Sugalski , Dickon Isaacs , James Tappel , Thomas Enders , Benjamin Chow , Energy Cruse , Scott Brenneman
发明人： Constance Johnston , Phillip Ryan , Carrie Mills , Perry Mykleby , Andrew Burroughs , Benjamin Rush , Tasos Karahalios , Jacob Brauer , Rodney Monson , Eric Sugalski , Dickon Isaacs , James Tappel , Thomas Enders , Benjamin Chow , Energy Cruse , Scott Brenneman
IPC分类号： A61B17/14 , A61B17/00 , A61B17/16 , A61B17/24 , A61B17/28 , A61B17/32 , A61B17/3211 , A61B19/00 , A61M1/00
CPC分类号： A61B17/162 , A61B17/1622 , A61B17/1624 , A61B17/1626 , A61B17/1633 , A61B17/1679 , A61B17/1688 , A61B17/1695 , A61B17/24 , A61B17/2909 , A61B17/32002 , A61B34/74 , A61B2017/00199 , A61B2017/00367 , A61B2017/00398 , A61B2017/00424 , A61B2017/0046 , A61B2017/00477 , A61B2017/00526 , A61B2017/00973 , A61B2217/005 , A61B2217/007 , A61M1/008 , A61M1/0084 , A61M1/0086 , Y10T279/17752
摘要： A powered surgical apparatus can be used with a source of irrigation fluid and a source of suction. The powered surgical apparatus can include a cutting blade assembly and a handle. The handle can include an upper portion defining a distal section connectable to the cutting blade assembly and a lower portion extending downwardly from the upper portion. The handle can be connectable to the source of irrigation fluid and the source of suction. The system can also include a manually actuable input device that provides at least one signal relevant to at least one operation of the system, and a controller that receives the at least one input signal and provides an output signal to perform the at least one operation of the system.

16. 发明授权

US08431385B2 Apparatus and method for maintaining and/or restoring viability of organs 有权
公开(公告)号：US08431385B2
公开(公告)日：2013-04-30
申请号：US12929410
申请日：2011-01-21
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
IPC分类号： A01N1/02
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

17. 发明授权

US08349551B2 Method for controlling perfusion of an organ 有权
标题翻译：控制器官灌注的方法
公开(公告)号：US08349551B2
公开(公告)日：2013-01-08
申请号：US12926276
申请日：2010-11-05
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J. Steibel , Richard Fraser , Stanley Harris , Douglas Schein
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J. Steibel , Richard Fraser , Stanley Harris , Douglas Schein
IPC分类号： A01N1/00
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。可以使用控制程序自动控制灌注过程。

18. 发明授权

US08318415B2 Method of determining transport and/or storage parameters for maintaining viability of an organ 有权
标题翻译：确定用于保持器官活力的运输和/或储存参数的方法
公开(公告)号：US08318415B2
公开(公告)日：2012-11-27
申请号：US12910308
申请日：2010-10-22
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J Steibel , Richard Fraser , Stanley Harris , Douglas Schein , Christopher G. Curtis
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J Steibel , Richard Fraser , Stanley Harris , Douglas Schein , Christopher G. Curtis
IPC分类号： A01N1/00
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。可以使用控制程序自动控制灌注过程。

19. 发明申请

US20110129810A1 Apparatus and method for maintaining and/or restoring viability of organs 审中-公开
公开(公告)号：US20110129810A1
公开(公告)日：2011-06-02
申请号：US12929411
申请日：2011-01-21
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
IPC分类号： A01N1/02
CPC分类号： G06F16/955 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

20. 发明申请

US20110039253A1 APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS 有权
标题翻译：维护和/或恢复机关可行性的装置和方法
公开(公告)号：US20110039253A1
公开(公告)日：2011-02-17
申请号：US12910308
申请日：2010-10-22
申请人： Donald R. OWEN , David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J. Steibel , Richard Fraser , Stanley Harris , Douglas Schein , Christopher G. Curtis
发明人： Donald R. OWEN , David C. Kravitz , John Brassil , Kelvin G.M. Brockbank , Andrew Burroughs , Dickon Isaacs , Dennis J. Steibel , Richard Fraser , Stanley Harris , Douglas Schein , Christopher G. Curtis
IPC分类号： A01N1/02 , G06F17/30
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。可以使用控制程序自动控制灌注过程。

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