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11. 发明授权

US07842293B2 Compositions and methods using anti-CS1 antibodies to treat multiple myeloma 有权
标题翻译：使用抗CS1抗体治疗多发性骨髓瘤的组合物和方法
公开(公告)号：US07842293B2
公开(公告)日：2010-11-30
申请号：US11835245
申请日：2007-08-07
申请人： Daniel Afar
发明人： Daniel Afar
IPC分类号： A61K39/395 , A61P35/00 , C12N5/06
CPC分类号： A61K39/39558 , A61K9/0019 , A61K9/127 , A61K31/454 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/22 , C07K16/2803 , C07K16/2896 , A61K2300/00
摘要： The present disclosure provides methods for treating multiple myeloma comprising administering to a subject with multiple myeloma the anti-CS1 antibody HuLuc63 in combination with dexamethasone and, optionally, thalidomide.
摘要翻译：本公开提供了治疗多发性骨髓瘤的方法，其包括向具有多发性骨髓瘤的受试者施用抗CS1抗体HuLuc63与地塞米松和任选的沙利度胺组合。

12. 发明申请

US20080019971A1 36P6D5: secreted tumor antigen 失效
标题翻译： 36P6D5：分泌肿瘤抗原
公开(公告)号：US20080019971A1
公开(公告)日：2008-01-24
申请号：US11805969
申请日：2007-05-24
申请人： Arthur Raitano , Aya Jakobovits , Mary Faris , Daniel Afar , Rene Hubert , Steve Mitchell
发明人： Arthur Raitano , Aya Jakobovits , Mary Faris , Daniel Afar , Rene Hubert , Steve Mitchell
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , A61P35/00 , C12Q1/68 , G01N33/53 , C12Q1/02 , A61K38/03 , A61K39/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译：描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和胰腺。

13. 发明申请

US20070048299A1 Methods of inducing an immune response 有权
公开(公告)号：US20070048299A1
公开(公告)日：2007-03-01
申请号：US11155906
申请日：2005-06-17
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K39/395 , A61K48/00 , C12N15/861
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

14. 发明申请

US20060154310A1 Diagnosis and therapy of cancer using SGP28-related molecules 失效
公开(公告)号：US20060154310A1
公开(公告)日：2006-07-13
申请号：US10992946
申请日：2004-11-18
申请人： Rene Hubert , Arthur Raitano , Daniel Afar , Steve Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene Hubert , Arthur Raitano , Daniel Afar , Steve Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.

15. 发明申请

US20050227253A1 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers 审中-公开
标题翻译：核酸和相应的名为158P1D7的蛋白质可用于膀胱癌和其他癌症的治疗和检测
公开(公告)号：US20050227253A1
公开(公告)日：2005-10-13
申请号：US10990137
申请日：2004-11-15
申请人： Mary Faris , Rene Hubert , Arthur Raitano , Daniel Afar , Elana Levin , Pia Challita-Eid , Aya Jakobovits
发明人： Mary Faris , Rene Hubert , Arthur Raitano , Daniel Afar , Elana Levin , Pia Challita-Eid , Aya Jakobovits
IPC分类号： A61K38/17 , A61K39/00 , A61K39/38 , A61K39/395 , A61K48/00 , C07K14/47 , C12M1/34 , C12N15/12 , C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C07K14/47
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers,. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译：描述了一种新型基因（称为158P1D7）及其编码的蛋白质。虽然158P1D7在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，158P1D7为癌症提供诊断和/或治疗靶标。 158P1D7基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

16. 发明申请

US20050064445A1 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US20050064445A1
公开(公告)日：2005-03-24
申请号：US10750262
申请日：2003-12-31
申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell
发明人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12P21/00 , C12P21/08 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two Intracellular loops. STRAP-1 protein expression Is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。这个家族中的两个蛋白质完全或主要地在前列腺中表达，也是在前列腺癌中，因此这个家族的成员被称为“前列腺的蛇纹石逆转膜抗原”。本文描述和表征了四种特定的人类STRAP。人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STRAP-1在某些其他人类癌症中高度过度表达。

17. 发明申请

US20050032065A1 Methods of prognosis of prostate cancer 审中-公开
标题翻译：前列腺癌预后的方法
公开(公告)号：US20050032065A1
公开(公告)日：2005-02-10
申请号：US10603505
申请日：2003-06-24
申请人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
发明人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , Y02A90/26
摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.
摘要翻译：本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。

18. 发明申请

US20050019870A1 Protein expressed in prostate cancer 有权
标题翻译：前列腺癌中表达的蛋白质
公开(公告)号：US20050019870A1
公开(公告)日：2005-01-27
申请号：US10936138
申请日：2004-09-07
申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran
发明人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran
IPC分类号： A61K38/17 , C07K14/705 , G01N33/574 , A61K39/395 , C07H21/04
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/1709 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers.
摘要翻译：描述了一种新型前列腺肿瘤相关基因（称为24P4C12）及其编码的蛋白质。 24P4C12在前列腺组织异种移植物中高度表达，提供证据表明它在至少一些前列腺癌中被开启。 24P4C12提供了前列腺癌和其他癌症的诊断和/或治疗靶点。

19. 发明授权

US08257708B2 Antibodies against cancer antigen TMEFF2 and uses thereof 有权
标题翻译：针对癌抗原TMEFF2的抗体及其用途
公开(公告)号：US08257708B2
公开(公告)日：2012-09-04
申请号：US12892725
申请日：2010-09-28
申请人： Vinay Bhaskar , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
发明人： Vinay Bhaskar , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22
CPC分类号： C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要： The invention relates to the identification and generation of antibodies that bind to TMEFF2 proteins which are involved in cancer. Further, the invention provides for the use of these antibodies in the treatment of cancer.
摘要翻译：本发明涉及与参与癌症的TMEFF2蛋白结合的抗体的鉴定和产生。此外，本发明提供了这些抗体在治疗癌症中的用途。

20. 发明申请

US20070270575A1 PROTEIN SHOWING ENHANCED EXPRESSION IN CANCER CELLS 有权
标题翻译：蛋白质显示癌细胞中增强的表达
公开(公告)号：US20070270575A1
公开(公告)日：2007-11-22
申请号：US11751621
申请日：2007-05-21
申请人： Aya Jakobovits , Mary Faris , Daniel Afar , Douglas Saffran , Rene Hubert , Mary Faris , Pia Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Daniel Afar , Douglas Saffran , Rene Hubert , Mary Faris , Pia Challita-Eid
IPC分类号： C07K14/00
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。

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