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11. 发明授权

US07081517B2 Genes differentially expressed in breast cancer 失效
公开(公告)号：US07081517B2
公开(公告)日：2006-07-25
申请号：US10200026
申请日：2002-07-18
申请人： Joerg Kaufmann , Greg Harrowe , Christoph Reinhard , Sanmao Kang
发明人： Joerg Kaufmann , Greg Harrowe , Christoph Reinhard , Sanmao Kang
IPC分类号： C07K16/00 , C07K14/00 , C07K17/00 , C07K2/00 , A61K38/00
CPC分类号： G01N33/57484 , C07K14/47 , C07K14/4748 , C07K16/18 , C07K16/3015 , C07K2317/34 , C07K2319/00 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415
摘要： A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

12. 发明授权

US06964868B1 Human genes and gene expression products II 失效
标题翻译：人类基因和基因表达产物二
公开(公告)号：US06964868B1
公开(公告)日：2005-11-15
申请号：US09297648
申请日：1999-01-28
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C07K14/47 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/4748
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

13. 发明授权

US07501242B2 Detection of colon or breast cancer by measuring TTK polynucleotide expression 失效
标题翻译：通过测量TTK多核苷酸表达检测结肠癌或乳腺癌
公开(公告)号：US07501242B2
公开(公告)日：2009-03-10
申请号：US10951389
申请日：2004-09-27
申请人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
发明人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： G01N33/68 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Y207/01037 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/6842 , G01N2500/00
摘要： The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
摘要翻译：本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。

14. 发明授权

US07122373B1 Human genes and gene expression products V 有权
标题翻译：人类基因和基因表达产物V
公开(公告)号：US07122373B1
公开(公告)日：2006-10-17
申请号：US09313292
申请日：1999-05-13
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C12N5/10 , C12N15/63 , C12N15/11
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

15. 发明授权

US07501243B2 Detection of colon or breast cancer by measuring TTK polypeptide expression 失效
标题翻译：通过测量TTK多肽表达来检测结肠癌或乳腺癌
公开(公告)号：US07501243B2
公开(公告)日：2009-03-10
申请号：US10951406
申请日：2004-09-27
申请人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
发明人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： G01N33/68 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Y207/01037 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/6842 , G01N2500/00
摘要： The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
摘要翻译：本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。

16. 发明授权

US07501244B2 Determining prognosis of colon or breast cancer by measuring TTK expression 失效
标题翻译：通过测量TTK表达来确定结肠癌或乳腺癌的预后
公开(公告)号：US07501244B2
公开(公告)日：2009-03-10
申请号：US10951477
申请日：2004-09-27
申请人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
发明人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： G01N33/6842 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N2500/00
摘要： The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
摘要翻译：本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。

17. 发明申请

US20070010469A1 Gene products differentially expressed in cancerous cells III 失效
标题翻译：在癌细胞中差异表达的基因产物III
公开(公告)号：US20070010469A1
公开(公告)日：2007-01-11
申请号：US10948737
申请日：2004-09-22
申请人： Vivien Chan , Jaime Escobedo , Pablo Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia Kennedy , George Lamson , Edward Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien Chan , Jaime Escobedo , Pablo Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia Kennedy , George Lamson , Edward Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K48/00 , A61K39/395 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

18. 发明申请

US20060089321A1 Cks1 inhibitors 审中-公开
标题翻译： Cks1抑制剂
公开(公告)号：US20060089321A1
公开(公告)日：2006-04-27
申请号：US10504487
申请日：2003-02-12
申请人： Annette Walter , Christoph Reinhard , Anne Jefferson , Blanche-Marie Shamoon
发明人： Annette Walter , Christoph Reinhard , Anne Jefferson , Blanche-Marie Shamoon
IPC分类号： A61K48/00
CPC分类号： C07K14/4702 , A61K38/00 , C12N15/1136 , C12N2310/11 , C12N2310/12
摘要： Inhibitors of human Cks1 and human Skp2, including antisense oligonucleotides, methods, and compositions specific for human Cks1 and human Skp2, are provided. Methods of using the compositions for modulating Cks1 expression and Skp2 expression, and for regulating cell growth, particularly tumor cell growth, are also provided.
摘要翻译：提供人Cks1和人Skp2的抑制剂，包括对人Cks1和人Skp2特异性的反义寡核苷酸，方法和组合物。还提供了使用组合物调节Cks1表达和Skp2表达以及调节细胞生长，特别是肿瘤细胞生长的方法。

19. 发明授权

US06809194B1 Akt3 inhibitors 失效
标题翻译： Akt3抑制剂
公开(公告)号：US06809194B1
公开(公告)日：2004-10-26
申请号：US09851670
申请日：2001-05-08
申请人： Christoph Reinhard , Anne B. Jefferson
发明人： Christoph Reinhard , Anne B. Jefferson
IPC分类号： C07H2104
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/04 , C12N2310/111 , C12Y207/01037
摘要： Inhibitors of human Akt3, including antisense oligonucleotides, methods, and compositions specific for human Akt3, are provided. Methods of using the compositions for modulating Akt3 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
摘要翻译：提供人Akt3的抑制剂，包括反义寡核苷酸，方法和对人Akt3特异的组合物。还提供了使用组合物调节Akt3表达和调节细胞生长，特别是肿瘤细胞生长的方法。

20. 发明申请

US20110273717A1 DEVICE AND METHOD FOR DETECTING REFLECTED AND/OR EMITTED LIGHT OF AN OBJECT 有权
标题翻译：用于检测物体的反射和/或发射光的装置和方法
公开(公告)号：US20110273717A1
公开(公告)日：2011-11-10
申请号：US13144072
申请日：2009-12-04
申请人： Christoph Reinhard , Reto Schletti
发明人： Christoph Reinhard , Reto Schletti
IPC分类号： G01N21/55
CPC分类号： G07D7/121
摘要： A device and a method for detecting reflected and/or emitted light of an object (1) are proposed having at least one illumination device (2) illuminating the object (1) with pulsed light, and having at least one sensor (4, 6) capturing the light reflected and/or emitted by the object (1), and having a transport device transporting the object relative to the illumination device (2) and past the sensor 4, 6) in the direction of transport, and having a power supply (16, 17, 18, 19, 20, 21, 22) for the illumination device (2) providing the illumination device (2) with a current that is a periodic function over time, wherein a period comprises at least two current pulses (23, 24) of different magnitudes.
摘要翻译：提出了一种用于检测物体（1）的反射和/或发射光的装置和方法，其具有至少一个用脉冲光照射物体（1）的照明装置（2），并且具有至少一个传感器（4,6））捕获由物体（1）反射和/或发射的光，并且具有相对于照明装置（2）传送物体并经过传感器4,6的传送装置沿传送方向传送，并具有电力为照明装置（2）提供具有随时间变化的周期性功能的电流（16,17,18,19,20,21,22），其中周期包括至少两个电流脉冲（23,24）不同程度。

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