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11. 发明申请

US20120084141A1 System and Method to Predict the Performance of Keywords for Advertising Campaigns Managed on the Internet 审中-公开
标题翻译：用于预测互联网上管理的广告活动关键词性能的系统和方法
公开(公告)号：US20120084141A1
公开(公告)日：2012-04-05
申请号：US13316854
申请日：2011-12-12
申请人： Patrick Quinn , Sandrine Paroz , Richard Couture , Marc Poirier
发明人： Patrick Quinn , Sandrine Paroz , Richard Couture , Marc Poirier
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0244
摘要： Historical data from keywords in a pay-per-click internet advertising campaign are used to predict performance of other keywords with the goal of optimizing a keyword portfolio to maximize returns from the advertising campaign. A computing system receives the keyword portfolio for the advertising campaign, and classifies the keywords based on whether or not sufficient historical data exist to generate acceptable predictions about the performance of the keywords in the advertising campaign. Historical data are then used to make performance predictions for keywords having sufficient data. For keywords without sufficient historical data, generic prediction functions are created based on a generic change rate obtained from keywords with sufficient historical data. These generic prediction functions are then used to predict keyword performance in the advertising campaign. Predictions for keywords with and without sufficient historical data are then used to optimize the advertising campaign.
摘要翻译：用于每次点击付费的互联网广告活动中的关键字的历史数据用于预测其他关键字的效果，目的是优化关键字组合，以最大限度地提高广告系列的收益。计算系统接收广告活动的关键词组合，并且基于是否存在足够的历史数据来生成关于广告活动中的关键字的表现的可接受的预测的关键词。然后，历史数据用于对具有足够数据的关键字进行性能预测。对于没有足够历史数据的关键字，基于从具有足够历史数据的关键字获得的通用变化率创建通用预测函数。然后，这些通用预测函数用于预测广告活动中的关键字表现。然后，使用具有和不具有足够历史数据的关键字的预测来优化广告活动。

12. 发明授权

US06820367B2 Drill/injector combination for plug fertilization at lift 有权
标题翻译：钻机/喷射器组合，用于电梯上的塞子受精
公开(公告)号：US06820367B2
公开(公告)日：2004-11-23
申请号：US10245262
申请日：2002-09-16
申请人： Marc Poirier , John Kitchen , Mark Ingram , Ted Bay , Andrew Jackson , Kyle Krushelniski , Philip Leduc , Troy Lucyshyn , Bradley Pauli , Andrew Rauert
发明人： Marc Poirier , John Kitchen , Mark Ingram , Ted Bay , Andrew Jackson , Kyle Krushelniski , Philip Leduc , Troy Lucyshyn , Bradley Pauli , Andrew Rauert
IPC分类号： A01G908
CPC分类号： A01G9/081 , A01C23/027 , A01G29/00
摘要： A drill/injector combination is provided to inject plants that are grown in containers such as blocks at lift with plant growth modulators. The drill/injector combination is comprised of a seedlings holder, a block restraint, a cavity tool apparatus, a metering apparatus, an injection apparatus and optionally, a bore closing apparatus. The combination may be manually operated or may be automated.
摘要翻译：提供钻/喷射器组合以将在植物生长调节剂的电梯上生长的容器如块中的植物注射。钻/喷射器组合由幼苗保持器，块限制器，腔工具装置，计量装置，注射装置和任选的孔闭合装置组成。该组合可以是手动操作的或可以是自动的。

13. 发明授权

US08898071B2 System and method for managing and optimizing advertising networks 有权
标题翻译：管理和优化广告网络的系统和方法
公开(公告)号：US08898071B2
公开(公告)日：2014-11-25
申请号：US12628492
申请日：2009-12-01
申请人： Marc Poirier , Richard Couture
发明人： Marc Poirier , Richard Couture
IPC分类号： G06Q30/00 , G06Q90/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0256 , G06Q30/0275
摘要： The system of the present invention is used to execute data consolidation to combine data from Google, MSN and Yahoo, at least. The user does not need anymore to combine by himself data in spreadsheets. The system allows creating consolidated campaigns that span across search providers, letting the user effortlessly build reports that previously took hours to create each month. The system of the present invention is particularly suited for agencies. A tool designed for agencies needs to allow for management at the client level as well as the agency level. The system client center gives each member of the team a summary view of the client accounts that they're responsible for, along with emerging trend indicators for every major metric.
摘要翻译：本发明的系统至少用于执行数据整合以组合Google，MSN和Yahoo的数据。用户不需要自己将数据合并在电子表格中。该系统允许创建跨越搜索提供商的合并广告系列，让用户轻松构建以前每个月创建几个小时的报告。本发明的系统特别适用于机构。为机构设计的工具需要在客户层面和机构层面进行管理。系统客户中心为团队的每个成员提供他们负责的客户帐户的摘要视图，以及每个主要指标的新兴趋势指标。

14. 发明授权

US07582763B2 Enantioselective process 失效
标题翻译：对映选择性工艺
公开(公告)号：US07582763B2
公开(公告)日：2009-09-01
申请号：US11287041
申请日：2005-11-23
申请人： Frank Xing Chen , Yee-Shing Wong , Feng Liang , Marc Poirier , George Wu
发明人： Frank Xing Chen , Yee-Shing Wong , Feng Liang , Marc Poirier , George Wu
IPC分类号： C07D221/22
CPC分类号： C07D401/14 , C07D221/16
摘要： An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed.
摘要翻译：公开了用于制备可用于制备式I的手性三环化合物的中间体的对映选择性方法。

15. 发明申请

US20060074241A1 Enantioselective process 失效
公开(公告)号：US20060074241A1
公开(公告)日：2006-04-06
申请号：US11287041
申请日：2005-11-23
申请人： Frank Chen , Yee-Shing Wong , Feng Liang , Marc Poirier , George Wu
发明人： Frank Chen , Yee-Shing Wong , Feng Liang , Marc Poirier , George Wu
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D221/16
摘要： An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed.

16. 发明授权

US06750347B2 Synthesis of intermediates useful in preparing tricyclic compounds 失效
标题翻译：可用于制备三环化合物的中间体的合成
公开(公告)号：US06750347B2
公开(公告)日：2004-06-15
申请号：US10174145
申请日：2002-06-18
申请人： Marc Poirier , Yee-Shing Wong , George G. Wu
发明人： Marc Poirier , Yee-Shing Wong , George G. Wu
IPC分类号： C07D22122
CPC分类号： C07D213/79 , C07D221/16
摘要： A process is provided for preparing a compound having the formula wherein R is H or Cl. Also provided is a process for preparing a compound having the formula
摘要翻译：提供了一种制备具有式R的化合物的方法，其中R为H或Cl。还提供了制备具有式

17. 发明授权

US06492519B2 Synthesis of intermediates useful in preparing tricyclic compounds 失效
标题翻译：可用于制备三环化合物的中间体的合成
公开(公告)号：US06492519B2
公开(公告)日：2002-12-10
申请号：US09836605
申请日：2001-04-17
申请人： Marc Poirier , Yee-Shing Wong , George G. Wu
发明人： Marc Poirier , Yee-Shing Wong , George G. Wu
IPC分类号： C07D22106
CPC分类号： C07D213/79 , C07D221/16
摘要： A process is provided for preparing a compound having the formula comprising: (a) reacting a compound having the formula with an isocyanate having the formula R1NCO to produce a compound having the formula (b) optionally hydrolyzing the compound of formula (III) to form an amide having the formula (c) reacting the compound of formula (III) or the amide of formula (IV) with a compound having the formula in the presence of a strong base to produce a compound having the formula and (d) cyclizing the compound of formula (VI) to obtain the compound of formula (I), wherein R is H or Cl; M is selected from the group consisting of Li, Na, K, MgX, ZnRA, and Al(RA)2; RA is alkyl; X is halo; R1 is selected from the group consisting of alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, and heterocycloalkylalkyl; and L is a leaving group.
摘要翻译：提供了一种制备具有以下方法的化合物的方法：（a）使具有式R1NCO的异氰酸酯的化合物与具有式（b）的化合物反应，任选地水解式（III）化合物以形成酰胺具有式（c）使式（III）的化合物或式（IV）的酰胺与具有式的化合物存在强碱反应以产生具有下式的化合物：（d）使式（III）的化合物（ VI），得到其中R为H或Cl的式（I）化合物; M选自Li，Na，K，MgX，ZnRA和Al（RA）2; RA是烷基; X是卤素; R 1选自烷基，芳基，芳烷基，杂芳基，杂芳烷基，环烷基，环烷基烷基，杂环烷基和杂环烷基烷基; 而L是离职团体。

18. 发明授权

US4295939A Method and device for detecting a gaseous anhydride in an oxygen bearing gas 失效
标题翻译：用于检测含氧气体中的气态酐的方法和装置
公开(公告)号：US4295939A
公开(公告)日：1981-10-20
申请号：US98978
申请日：1979-11-30
申请人： Marc Poirier , Michel Gauthier , Andre Belanger
发明人： Marc Poirier , Michel Gauthier , Andre Belanger
IPC分类号： G01N27/416 , G01N27/406 , G01N27/407 , G01N27/413 , G01N27/414 , G01N27/417 , G01N27/58
CPC分类号： G01N27/417 , G01N27/4074
摘要： A method and a device for detecting a gaseous anhydride and measuring its concentration in an oxygen-bearing gas. The method comprises the following steps: (a) forming an electrolytic junction by contact between a first solid-electrolyte element containing oxyanions of the anhydride to be detected and a second, 0.sup.-- ion-conducting solid-electrolyte element such as stabilized zirconia; (b) bringing this electrolytic junction into contact with the gas containing the gaseous anhydride to be detected so as to form a triple junction; (c) creating at this triple junction a difference of potential measurable by means of two reference electrodes in contact with the first and second electrolyte elements respectively, by fixation of a constant potential in the vicinity of each of these reference electrodes, which themselves are spatially removed from the triple junction; (d) heating the triple junction to such a temperature that a logarithmic variation in the concentration of the anhydride to be detected produces a proportional, substantially linear variation in the difference of potential at the triple junction, this temperature being lower than the melting temperatures of the first and second electrolyte elements; and (e) measuring this difference of potential by means of a potentiometer connected to the reference electrodes so as to obtain a measurement of the concentration of the anhydride to be detected. This method and device may advantageously be used for detecting sulfur carbon anhydrides.
摘要翻译：一种用于检测气态酸酐并测量其在含氧气体中的浓度的方法和装置。该方法包括以下步骤：（a）通过包含待检测的酸酐的含氧阴离子的第一固体电解质元件与稳定的氧化锆之类的第二种0-离子导电固体电解质元件之间的接触形成电解结; （b）使该电解结与待检测的含有气态酸酐的气体接触以形成三重结; （c）通过在这些参考电极中的每一个附近固定恒定电位，这两个参考电极本身在空间上，在该三重结点处产生可通过与第一和第二电解质元件接触的两个参考电极测量的电位差。从三联结点移除; （d）将三重连接点加热到待检测的酸酐浓度的对数变化在三连接点处的电位差产生比例的，基本线性的变化，该温度低于第一和第二电解质元件; 和（e）通过连接到参比电极的电位器来测量该电位差，从而获得待检测的酸酐浓度的测量值。该方法和装置可有利地用于检测硫酸酐。

19. 发明申请

US20160009696A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
公开(公告)号：US20160009696A1
公开(公告)日：2016-01-14
申请号：US14772290
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Joel HARRIS , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Joel Harris , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D403/14 , C07D401/14 , C07D491/107 , C07D417/14 , C07D471/10 , C07D413/14 , C07D498/08
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

20. 发明申请

US20110125590A1 System and method for managing and optimizing advertising campaigns managed on the internet 有权
标题翻译：用于管理和优化在互联网上管理的广告活动的系统和方法
公开(公告)号：US20110125590A1
公开(公告)日：2011-05-26
申请号：US12750352
申请日：2010-03-30
申请人： Sandrine Paroz , Richard Couture , Martin Mailloux , Martin LeSauteur , Marc Poirier , Benoit Allaire
发明人： Sandrine Paroz , Richard Couture , Martin Mailloux , Martin LeSauteur , Marc Poirier , Benoit Allaire
IPC分类号： G06Q30/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0256 , G06Q30/0275
摘要： The system of the present invention is used to optimize the returns of advertising campaigns on the internet. The system allows to create portfolios of keywords and to optimize these portfolios. Moreover, the system allows to classify the keywords in the portfolios according to their past data and to agitate the keywords which held a stagnant position over a pre-set period of time.The system support different implementations of the keyword classification in portfolios, different implementations of keyword bids agitation and different implementations of optimization. The various implementations can meet the specific aspects of different industries and/or the distinctive optimization approach of different agencies.The system can leverage the cloud computing whereby shared data, process and information are provided to computers and other devices on-demand. The delivery model involves the provision of dynamically scalable and virtualized resources as a service over the Internet. Some or all of the system components can be executed in the cloud through an on-demand instantiation of the resources required to perform the task.
摘要翻译：本发明的系统用于优化互联网广告活动的回报。该系统允许创建关键字组合并优化这些投资组合。此外，该系统允许根据其过去的数据对投资组合中的关键词进行分类，并且在预设的时间段内搅动保持停滞的关键词。系统支持关键字分类在投资组合中的不同实现，关键字出价激励的不同实现以及优化的不同实现。各种实现可以满足不同行业的特定方面和/或不同机构的独特优化方法。该系统可以利用云计算，从而根据需要将共享数据，过程和信息提供给计算机和其他设备。交付模型涉及通过互联网提供动态可扩展和虚拟化的资源作为服务。部分或全部系统组件可以通过对执行任务所需资源的按需实例化在云中执行。

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