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11. 发明申请

US20120220744A1 Wettable Silicone Hydrogel Contact Lenses 有权
标题翻译：可湿性硅胶水凝胶隐形眼镜
公开(公告)号：US20120220744A1
公开(公告)日：2012-08-30
申请号：US13404037
申请日：2012-02-24
申请人： Yuwen Liu , Charlie Chen , Charles A. Francis , Junhao Ge , Yuan Xu , Li Yao , Arthur Back , Ying Zheng
发明人： Yuwen Liu , Charlie Chen , Charles A. Francis , Junhao Ge , Yuan Xu , Li Yao , Arthur Back , Ying Zheng
IPC分类号： C08F230/08
CPC分类号： G02C7/04 , B65B5/04 , G02B1/043 , C08L83/12 , C08L33/08 , C08L33/10
摘要： Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了眼科可接受的可湿性硅氧水凝胶隐形眼镜。透镜衍生自包含第一硅氧烷单体的可聚合组合物。当完全水合时，镜片具有眼科可接受的可润湿透镜表面。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

12. 发明申请

US20120220689A1 Silicone Hydrogel Contact Lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US20120220689A1
公开(公告)日：2012-08-30
申请号：US13404035
申请日：2012-02-24
申请人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
发明人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
IPC分类号： C08L43/04 , B65B55/02
CPC分类号： G02B1/043 , C08L83/12 , C08L101/14 , C08L33/10 , C08L33/08
摘要： Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.
摘要翻译：由可聚合组合物的反应产物形成具有良好的尺寸稳定性的眼科学可接受的硅酮水凝胶隐形眼镜，并且可以制造不含醇溶剂的可聚合组合物，该可聚合组合物包含至少一种含单分子丙烯酸酯的含有单官能丙烯酸酯的硅氧烷单体重量小于2000; 至少一种分子量至少为3,000的含二官能丙烯酸酯的硅氧烷单体; 和至少一种亲水性含乙烯基单体，其中所述可聚合组合物的含单体官能丙烯酸酯的硅氧烷单体的总量与含二官能丙烯酸酯的硅氧烷单体的总量的摩尔比分别为至少30:1 。

13. 发明申请

US20120216488A1 Silicone Hydrogel Contact Lenses And Related Compositions And Methods 有权
标题翻译：硅胶水凝胶隐形眼镜及相关成分及方法
公开(公告)号：US20120216488A1
公开(公告)日：2012-08-30
申请号：US13404027
申请日：2012-02-24
申请人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： B65B55/02 , G02C7/04
CPC分类号： G02B1/043 , B65B55/02 , C08L101/14 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.
摘要翻译：制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

14. 发明申请

US20070253953A1 Molecular Signature of the Pten Tumor Suppressor 审中-公开
标题翻译： Pten肿瘤抑制因子的分子标记
公开(公告)号：US20070253953A1
公开(公告)日：2007-11-01
申请号：US10582841
申请日：2004-12-15
申请人： Charlie Chen , Charles Sawyers
发明人： Charlie Chen , Charles Sawyers
IPC分类号： A61K39/395 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： The present invention relates to the identification a molecular signature for PTEN tumor suppressor. The molecular signature comprising a gene or genes that are of use for diagnosis, prognosis, drug research and development and therapeutics. Specifically, the present invention relates to identification of IGFBP2 gene, its mRNA and/or protein products that closely associate with PTEN mutations. The present invention further demonstrates that IGFBP2 expression is negatively regulated by PTEN, positively regulated by PI3K and Akt activation, that IGFBP2 plays a functional role in the PTEN signaling and is required for Akt transformation. The use of IGFBP2 gene, its gene product such as its RNA transcript, protein and molecular probes in diagnosis, prognosis, drug discovery and validation and therapeutic target and therapeutics is also contemplated.
摘要翻译：本发明涉及鉴定PTEN肿瘤抑制因子的分子特征。该分子标记包括用于诊断，预后，药物研究和开发以及治疗用途的基因或基因。具体地说，本发明涉及与PTEN突变密切相关的IGFBP2基因，其mRNA和/或蛋白质产物的鉴定。本发明进一步证明IGFBP2表达受PTEN负调节，由PI3K和Akt活化正调节，IGFBP2在PTEN信号中起着功能作用，是Akt转化所必需的。还考虑使用IGFBP2基因，其基因产物如其RNA转录物，蛋白质和分子探针在诊断，预后，药物发现和验证以及治疗靶标和治疗剂中。

15. 发明申请

US20060152893A1 Portable information device having a lift function 审中-公开
标题翻译：具有升降功能的便携式信息装置
公开(公告)号：US20060152893A1
公开(公告)日：2006-07-13
申请号：US11033635
申请日：2005-01-13
申请人： Charlie Chen
发明人： Charlie Chen
IPC分类号： G06F1/16
CPC分类号： G06F1/1681 , G06F1/1616
摘要： A portable information device, such as a personal digital assistant or a notebook, having a lift function, has a mainframe, a monitor, a pivotal structure, and a guiding rod. The guiding rod has an end connected to the pivotal structure. The monitor is liftably connected to the other end of the guiding rod. The monitor can be lifted and adjusted to an appropriate height, so that the user can watch the monitor comfortably.
摘要翻译：具有升降功能的便携式信息装置，例如个人数字助理或笔记本，具有主机，监视器，枢轴结构和引导杆。引导杆的端部连接到枢转结构。显示器可升降地连接到导杆的另一端。显示器可以提升并调整到适当的高度，以便用户可以舒适地观看显示器。

16. 发明申请

US20060117606A1 Shoe having a protective wrap 审中-公开
标题翻译：鞋子有保护膜
公开(公告)号：US20060117606A1
公开(公告)日：2006-06-08
申请号：US11003300
申请日：2004-12-03
申请人： Eddie Chen , Charlie Chen , Paul Yang
发明人： Eddie Chen , Charlie Chen , Paul Yang
IPC分类号： A43C11/00 , A43B7/22
CPC分类号： A43B7/223 , A43B7/1495 , A43B19/00 , A43B23/07 , A43C1/04 , A43C11/00
摘要： A shoe includes a protective wrap disposed inside an upper and includes a sole portion disposed removably on a sole unit, and two side portions extending upwardly and respectively from two sides of the sole portion and connected to a fastening unit. When the fastening unit is tightened, the fastening unit pulls the side portions, and the side portions lift the sole portion so that the protective wrap is wrapped tightly around the foot of the wearer.
摘要翻译：靴子包括设置在鞋面内部的保护性包裹物，其包括可拆卸地设置在鞋底单元上的底部部分和分别从鞋底部分的两侧向上延伸并连接到紧固单元的两个侧部。当紧固单元被紧固时，紧固单元拉动侧部，并且侧部提起鞋底部分，使得保护性包裹物紧紧地包裹在穿着者的脚下。

17. 发明授权

US09140908B2 Silicone hydrogel contact lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US09140908B2
公开(公告)日：2015-09-22
申请号：US13982032
申请日：2012-02-23
申请人： Junhao Ge , Yuwen Liu , Charlie Chen , Yuan Xu , Ye Hong , Hongjin Qiu
发明人： Junhao Ge , Yuwen Liu , Charlie Chen , Yuan Xu , Ye Hong , Hongjin Qiu
IPC分类号： G02C7/04 , G02B1/04
CPC分类号： G02C7/049 , G02B1/043 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one hydrophilic vinyl amide-containing monomer, at least one acrylate-containing siloxane monomer, and at least one hydrophilic vinyl ether-containing monomer. The contact lenses have ophthalmically-acceptable surface wettability and can be manufactured without the use of volatile organic solvents.
摘要翻译：硅氧水凝胶隐形眼镜由包含至少一种含亲水性乙烯基酰胺的单体，至少一种含丙烯酸酯的硅氧烷单体和至少一种含亲水性乙烯基醚的单体的可聚合组合物的反应产物形成。隐形眼镜具有眼科可接受的表面润湿性，并且可以在不使用挥发性有机溶剂的情况下制造。

18. 发明授权

US09121998B2 Silicone hydrogel contact lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US09121998B2
公开(公告)日：2015-09-01
申请号：US13983578
申请日：2012-02-23
申请人： Charlie Chen , Yuwen Liu , Yuan Xu , Ying Zheng , Junhao Ge , Li Yao , Arthur Back
发明人： Charlie Chen , Yuwen Liu , Yuan Xu , Ying Zheng , Junhao Ge , Li Yao , Arthur Back
IPC分类号： C08L101/14 , C08L83/04 , G02C7/04 , G02B1/04
CPC分类号： G02B1/043 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了硅酮水凝胶隐形眼镜。透镜衍生自可聚合组合物，其包含30-60单位重量份的具有一个N-乙烯基的亲水性单体，10-50单位重量份的甲基丙烯酸2-羟乙酯（HEMA）和第一个硅氧烷单体组分，其包含本文所述的式（1）的硅氧烷单体或本文所述的式（2）的硅氧烷单体或本文所述的式（3）的硅氧烷单体或其任何组合，其中硅氧烷单体的总量存在于聚合性组合物中的重量比为15〜40单位份。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

19. 发明授权

US08865929B2 Reactive dyes for contact lenses 有权
标题翻译：隐形眼镜用活性染料
公开(公告)号：US08865929B2
公开(公告)日：2014-10-21
申请号：US14131915
申请日：2012-07-17
申请人： Yuan Xu , Charlie Chen , Charles A. Francis , Shane Mao , Hong Xue , Xining Zhang
发明人： Yuan Xu , Charlie Chen , Charles A. Francis , Shane Mao , Hong Xue , Xining Zhang
IPC分类号： C09B62/465 , C09B1/34 , G02B1/04 , C09B62/80 , C09B69/10 , C09B1/16
CPC分类号： C09B1/343 , C09B1/16 , C09B1/34 , C09B62/80 , C09B69/101 , G02B1/043 , C08L101/14 , C08L101/12
摘要： A method for preparing a polymerizable monomer-dye compound is provided in which a monomer, a reactive dye, and base are combined under substantially anhydrous reaction conditions to form the polymerizable monomer-dye compound, wherein the monomer comprises a pendant reactive group that covalently links to the reactive dye to form the monomer-dye compound.
摘要翻译：提供了一种制备可聚合单体 - 染料化合物的方法，其中单体，活性染料和碱在基本上无水的反应条件下组合以形成可聚合单体 - 染料化合物，其中单体包括共价连接与活性染料反应形成单体 - 染料化合物。

20. 发明授权

US08865789B2 Silicone hydrogel contact lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US08865789B2
公开(公告)日：2014-10-21
申请号：US13404035
申请日：2012-02-24
申请人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
发明人： Li Yao , Ye Hong , Yuwen Liu , Charlie Chen , Charles A. Francis , Arthur Back
IPC分类号： C08L101/14 , B65B55/02 , G02C7/04 , C08G77/04 , G02B1/04
CPC分类号： G02B1/043 , C08L83/12 , C08L101/14 , C08L33/10 , C08L33/08
摘要： Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.
摘要翻译：由可聚合组合物的反应产物形成具有良好的尺寸稳定性的眼科学可接受的硅酮水凝胶隐形眼镜，并且可以制造不含醇溶剂的可聚合组合物，该可聚合组合物包含至少一种含单分子丙烯酸酯的含有单官能丙烯酸酯的硅氧烷单体重量小于2000; 至少一种分子量至少为3,000的含二官能丙烯酸酯的硅氧烷单体; 和至少一种亲水性含乙烯基单体，其中所述可聚合组合物的含单体官能丙烯酸酯的硅氧烷单体的总量与含二官能丙烯酸酯的硅氧烷单体的总量的摩尔比分别为至少30:1 。

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