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11. 发明授权

US6153583A OP-3 induced morphogenesis 失效
标题翻译： OP-3诱导形态发生
公开(公告)号：US6153583A
公开(公告)日：2000-11-28
申请号：US219391
申请日：1998-12-23
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , A61K38/18
CPC分类号： C12Q1/6881 , A01N1/02 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , A61F2310/00365 , A61K38/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译：公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法体内的组织特异性生长和体内替换患病或受损组织的方法。

12. 发明授权

US6022853A Morphogen-enriched dietary composition 失效
标题翻译：丰富的富含膳食组成
公开(公告)号：US6022853A
公开(公告)日：2000-02-08
申请号：US278730
申请日：1994-07-20
申请人： Thangavel Kuberasampath , Charles M. Cohen , David C. Rueger , Hermann Oppermann , Roy H. L. Pang
发明人： Thangavel Kuberasampath , Charles M. Cohen , David C. Rueger , Hermann Oppermann , Roy H. L. Pang
IPC分类号： A01N1/02 , A23L1/305 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K16/22 , A61K38/18
CPC分类号： C07K16/22 , A23L33/18 , A61L27/227 , A61L27/24 , C07K14/51 , A61K38/00 , G01N2500/10
摘要： Disclosed are methods and compositions useful in dietary applications and capable of enhancing tissue morphogenesis, including tissue development and viability in a mammal, particularly a human. The methods and compositions include a morphogen which, when provided to an individual as a food formulation or supplement, is capable of enhancing tissue development and viability in the individual.
摘要翻译：公开了可用于饮食应用并且能够增强组织形态发生的方法和组合物，包括哺乳动物，特别是人的组织发育和活力。方法和组合物包括形态发生剂，当作为食物制剂或补充剂提供给个体时，能够增强个体的组织发育和活力。

13. 发明授权

US5741641A Morphogenic protein screening method 失效
公开(公告)号：US5741641A
公开(公告)日：1998-04-21
申请号：US451953
申请日：1995-05-26
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , G01N33/53
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.

14. 发明授权

US5733878A Morphogen-induced periodontal tissue regeneration 失效
标题翻译：形态诱导牙周组织再生
公开(公告)号：US5733878A
公开(公告)日：1998-03-31
申请号：US643763
申请日：1996-05-06
申请人： Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Charles M. Cohen , Roy H. L. Pang
发明人： Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Charles M. Cohen , Roy H. L. Pang
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/51 , C07K16/22 , G01N33/68
CPC分类号： G01N33/6872 , A01N1/0226 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/51 , C07K16/22 , A61F2310/00365 , G01N2500/10 , Y10S514/90 , Y10S514/902
摘要： Disclosed are methods and compositions for inducing periodontal tissue morphogenesis in a mammal which include a therapeutically effective concentration of a morphogen. The methods and compositions are useful for integrating an implanted tooth in a tooth socket and for inhibiting tissue loss associated with periodontal disease or injury.
摘要翻译：公开了在哺乳动物中诱导牙周组织形态发生的方法和组合物，其包括治疗有效浓度的形态发生。所述方法和组合物可用于将植入的牙齿整合到牙槽中并用于抑制与牙周病或损伤相关的组织损失。

15. 发明授权

US06800603B2 Morphogen-induced neural cell adhesion 失效
标题翻译：形态诱导神经细胞粘附
公开(公告)号：US06800603B2
公开(公告)日：2004-10-05
申请号：US08260675
申请日：1994-06-16
申请人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Roy H. L. Pang , Charles M. Cohen
发明人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A61K3800
CPC分类号： C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N2500/10 , A61K2300/00
摘要： Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
摘要翻译：公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。

16. 发明授权

US06565843B1 Protein-induced tissue morphogenesis 失效
标题翻译：蛋白质诱导的组织形态发生
公开(公告)号：US06565843B1
公开(公告)日：2003-05-20
申请号：US08404113
申请日：1995-03-14
申请人： Charles M. Cohen , Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger
发明人： Charles M. Cohen , Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger
IPC分类号： A61K3512
CPC分类号： A61K6/0032 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L2430/28 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , A61K2300/00
摘要： The invention provides methods, compositions and devices for inducing tissue-specific regeneration in a mammal, or for stimulating proliferation of mammalian progenitor cells. The present methods, compositions and devices make use of osteogenic protein 1 (OP-1), which is appreciated herein as a tissue morphogen, i.e., a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Alternatively, the present methods, compositions and devices make use of other naturally-occurring or biosynthetic proteins sharing a defined structural and functional relationship with OP-1 and thus appreciated herein also to function as tissue morphogens. Optionally, OP-1 or a related protein can be used alone or when adsorbed on a support matrix which provides an anchoring substratum for proliferation and/or differentiation of progenitor cells during tissue-specific morphogenesis. In another embodiment, OP-1 or a related protein is used to stimulate mammalian progenitor cells ex vivo, such that the stimulated cells, when disposed in vivo in a mammal, undergo tissue-specific morphogenesis to produce replacement tissue at a nonskeletal tissue locus in need thereof (i.e., at a nonbony or noncartilaginous tissue locus in need thereof).
摘要翻译：本发明提供用于在哺乳动物中诱导组织特异性再生或用于刺激哺乳动物祖细胞增殖的方法，组合物和装置。本发明的方法，组合物和装置利用成骨蛋白1（OP-1），其在本文中被认为是组织形态发生体，即，除骨骼和/或骨骼之外还能够诱导哺乳动物身体组织的组织特异性形态发生的物质软骨。或者，本发明的方法，组合物和装置利用与OP-1共享定义的结构和功能关系的其它天然存在或生物合成蛋白，因此在本文中也可以用作组织形态发生剂。任选地，OP-1或相关蛋白质可以单独使用或当被吸附在支持物基质上时，其在组织特异性形态发生过程中提供用于祖细胞增殖和/或分化的锚定底物。在另一个实施方案中，OP-1或相关蛋白用于离体刺激哺乳动物祖细胞，使得当被哺乳动物体内植入时，被刺激的细胞经历组织特异性形态发生以在非骨骼组织基因座处产生替代组织需要（即在有需要的非糖或非糖化组织位点）。

17. 发明授权

US06194376B1 Method for modulating inflammatory response comprising administering morphogen 失效
标题翻译：调节炎症反应的方法，包括给予形态发生
公开(公告)号：US06194376B1
公开(公告)日：2001-02-27
申请号：US08414033
申请日：1995-03-30
申请人： Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger , Charles M. Cohen
发明人： Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger , Charles M. Cohen
IPC分类号： A61K3818
CPC分类号： C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , A61K2300/00
摘要： The invention provides methods for alleviating immune cell mediated inflammatory responses to injury to mammalian tissue. The present methods make use of osteogenic protein 1(OP-1), which is appreciated herein as tissue morphogen, i.e., a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Alternatively, the present methods make use of other naturally-occurring or biosynthetic proteins sharing a defined structural and functional relationship with OP-1 and thus appreciated herein also to be tissue morphogens. The invention is particularly adapted to alleviating tissue damage associated with ischemia-reperfusion injury or hyperoxia injury in mammals, including humans.
摘要翻译：本发明提供减轻免疫细胞介导的对哺乳动物组织损伤的炎症反应的方法。本方法利用成骨蛋白1（OP-1），其在本文中被认为是组织形态发生体，即除了骨和/或软骨之外能够诱导哺乳动物身体组织的组织特异性形态发生的物质。或者，本发明方法利用与OP-1共有限定的结构和功能关系的其它天然存在或生物合成蛋白，因此本文也认为是组织形态发生体。本发明特别适用于减轻包括人在内的哺乳动物的缺血再灌注损伤或高氧损伤相关的组织损伤。

18. 发明授权

US5994131A Morphogenic protein screening method 失效
标题翻译：形态蛋白筛选方法
公开(公告)号：US5994131A
公开(公告)日：1999-11-30
申请号：US912088
申请日：1997-08-15
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , C12N5/06 , C12N5/08
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.
摘要翻译：公开了一种筛选候选化合物以调节哺乳动物系统中形态发生蛋白水平的能力的方法。所述方法包括确定指示已知产生形态发生的细胞培养物中形态发生水平的参数的参数，将候选化合物与培养物孵育足以允许化合物影响形态发生蛋白质的产生的时间，以及然后再次测定培养物以检测形态发生蛋白质生产水平的变化。

19. 发明授权

US5652337A OP-3-induced morphogenesis 失效
标题翻译： OP-3诱导的形态发生
公开(公告)号：US5652337A
公开(公告)日：1997-07-29
申请号：US479666
申请日：1995-06-07
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , C07K19/51
CPC分类号： C12Q1/6881 , A01N1/02 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , A61F2310/00365 , A61K38/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译：公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法体内的组织特异性生长和体内替换患病或受损组织的方法。

20. 发明授权

US6077823A Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury 失效
标题翻译：减少与缺血再灌注或缺氧损伤有关的组织损伤的方法
公开(公告)号：US6077823A
公开(公告)日：2000-06-20
申请号：US445467
申请日：1995-05-22
申请人： Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger , Charles M. Cohen , John E. Smart
发明人： Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger , Charles M. Cohen , John E. Smart
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22
CPC分类号： A61K38/17 , A01N1/0226 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , A61F2310/00365 , G01N2500/10
摘要： The present invention is directed to methods and compositions for alleviating tissue destructive effects associated with the inflammatory response to tissue injury in a mammal. The methods and compositions include administering a therapeutically effective concentration of a morphogen or morphogen-stimulating agent sufficient to alleviate immune cell-mediated tissue destruction.
摘要翻译：本发明涉及减轻与哺乳动物对组织损伤的炎症反应相关的组织破坏作用的方法和组合物。所述方法和组合物包括施用足以减轻免疫细胞介导的组织破坏的治疗有效浓度的形态发生剂或形态发生剂。

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