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11. 发明授权

US07066872B2 Method and apparatus for treating a desired area in the vascular system of a patient 失效
公开(公告)号：US07066872B2
公开(公告)日：2006-06-27
申请号：US10411749
申请日：2003-04-11
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61N5/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

12. 发明授权

US06458070B1 Method and apparatus for treating a desired area in the vascular system of a patient 有权
标题翻译：用于治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US06458070B1
公开(公告)日：2002-10-01
申请号：US09469103
申请日：1999-12-21
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61N500
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于通过导管将治疗元件（例如辐射源）递送到患者（例如冠状动脉）的血管系统中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间延伸有内腔，并且具有足够小的直径以插入患者血管系统中的直径。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

13. 发明授权

US07160238B1 Method and apparatus for treating a desired area in the vascular system of a patient 失效
标题翻译：用于治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US07160238B1
公开(公告)日：2007-01-09
申请号：US09468496
申请日：1999-12-21
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61M3/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于将治疗元件（例如辐射源）通过导管递送到患者（例如冠状动脉）的血管系统中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间延伸有内腔，并且具有足够小的直径以插入患者血管系统中的直径。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

14. 发明授权

US5899882A Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient 失效
标题翻译：用于放射治疗患者血管系统中所需区域的导管装置
公开(公告)号：US5899882A
公开(公告)日：1999-05-04
申请号：US628231
申请日：1996-04-04
申请人： Ron Waksman , Thomas D. Weldon , Raphael F. Meloul , Richard A. Hillstead , Jonathan J. Rosen , George K. Bonnoitt, Jr. , David S. Halpern , Charles E. Larsen , Ian R. Crocker
发明人： Ron Waksman , Thomas D. Weldon , Raphael F. Meloul , Richard A. Hillstead , Jonathan J. Rosen , George K. Bonnoitt, Jr. , David S. Halpern , Charles E. Larsen , Ian R. Crocker
IPC分类号： A61N5/00 , A61F2/958 , A61M25/00 , A61M29/02 , A61M36/04 , A61N5/10 , A61M29/00
CPC分类号： A61M37/0069 , A61M25/1002 , A61N5/1002 , A61N5/1007 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M25/0029 , A61M25/1006 , A61N2005/1003 , A61N2005/1005 , A61N2005/1008 , A61N2005/1023
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the intraluminal passageways of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's intraluminal passageways. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于将治疗元件（例如辐射源）通过导管递送到患者（例如冠状动脉）的管腔内通道中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间具有内腔，并且其直径足够小以插入病人的管腔内通道。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

15. 发明申请

US20120330088A1 Methods and Apparatus for Intraocular Brachytherapy 审中-公开
标题翻译：眼内近距离放射疗法的方法与装置
公开(公告)号：US20120330088A1
公开(公告)日：2012-12-27
申请号：US13604212
申请日：2012-09-05
申请人： Richard A. Hillstead , Charles E. Larsen , Roelaf Trip , Cory S. Anderson , John N. Hendrick , Benjamin W. Woodward
发明人： Richard A. Hillstead , Charles E. Larsen , Roelaf Trip , Cory S. Anderson , John N. Hendrick , Benjamin W. Woodward
IPC分类号： A61M36/12
CPC分类号： A61N5/1017 , A61N5/1007 , A61N5/1049 , A61N2005/1058
摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.
摘要翻译：公开了用于眼内近距离放射治疗的方法和装置，其中将插管引入眼睛以将辐射递送至靶组织。公开了用于相对于目标组织适当地定位插管的技术，用于保护非目标组织，用于调节由x射线发射器产生的热量和用于组合疗法。

16. 发明授权

US06994665B2 Method and apparatus for treating a desired area in the vascular system of a patient 失效
公开(公告)号：US06994665B2
公开(公告)日：2006-02-07
申请号：US10817549
申请日：2004-04-02
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61M3/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

17. 发明授权

US06503185B1 Method and apparatus for treating a desired area in the vascular system of a patient 有权
公开(公告)号：US06503185B1
公开(公告)日：2003-01-07
申请号：US09469082
申请日：1999-12-21
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61N500
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

18. 发明授权

US5683345A Method and apparatus for treating a desired area in the vascular system of a patient 失效
标题翻译：用于治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US5683345A
公开(公告)日：1997-11-04
申请号：US330327
申请日：1994-10-27
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61M36/04 , A61B20060101 , A61F2/82 , A61M20060101 , A61M3/00 , A61M25/00 , A61M25/10 , A61M29/00 , A61M29/02 , A61M31/00 , A61M36/00 , A61N20060101 , A61N5/00 , A61N5/10 , G21F5/02
CPC分类号： A61M25/1002 , A61N5/1002 , A61N5/1007 , A61M2025/0034 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于通过导管将治疗元件（例如辐射源）递送到患者（例如冠状动脉）的血管系统中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间延伸有内腔，并且具有足够小的直径以插入患者血管系统中的直径。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

19. 发明授权

US5501671A Vascular blood containment device 失效
标题翻译：血管收容装置
公开(公告)号：US5501671A
公开(公告)日：1996-03-26
申请号：US146555
申请日：1993-11-02
申请人： Jonathan J. Rosen , Richard A. Hillstead , Thomas D. Weldon , Charles E. Larsen , David O. Williams
发明人： Jonathan J. Rosen , Richard A. Hillstead , Thomas D. Weldon , Charles E. Larsen , David O. Williams
IPC分类号： A61M25/06 , A61M39/00 , A61M5/178
CPC分类号： A61M25/0693 , Y10S604/90
摘要： A blood containment, visualization and tactile confirmation device is provided for use with a vascular entry needle. The device includes a visualization channel and/or a complaint outer wall portion which indicates whether a needle connected to the device has entered a selected blood vessel. The visualization channel is vented to the outside to allow displaced air to escape, but has a gas permeable member to prevent blood from escaping. The visualization channel may have one, two, or more stages, with a first stage chamber which indicates initial penetration of a selected blood vessel, and a second stage chamber which fills more slowly and indicates that the needle remains positioned within the blood vessel. A third stage chamber with entrapped air which compresses slightly due to the heartbeat may also be used. Preferably, a compliant outer wall portion pulses with changes in blood pressure, thereby providing a tactile indication that the needle tip is properly positioned. The device has a guideway with a barrier of elastomeric material which prevents blood from passing therethrough, but which allows passage of an elongated medical instrument such as catheterization apparatus.
摘要翻译：提供血液容纳物，可视化和触觉确认装置用于血管入口针。该装置包括可视通道和/或投诉外壁部分，其指示连接到装置的针是否已经进入选定的血管。可视化通道被排放到外部以允许排出的空气逸出，但是具有气体可渗透构件以防止血液逸出。可视化通道可以具有一个，两个或更多个阶段，其中第一阶段室指示所选择的血管的初始穿透，以及填充更慢并且指示针保持定位在血管内的第二阶段室。也可以使用具有夹带空气的第三级室，其由于心跳而略微压缩。优选地，顺应性外壁部分以血压变化脉冲，从而提供针尖正确定位的触觉指示。该装置具有带有弹性体材料阻挡物的导轨，其阻止血液通过其中，但允许细长的医疗器械如导管插入装置通过。

20. 发明授权

US06306074B1 Method and apparatus for radiation treatment of a desired area in the vascular system of a patient 有权
标题翻译：辐射治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US06306074B1
公开(公告)日：2001-10-23
申请号：US09304783
申请日：1999-05-04
申请人： Ron Waksman , Thomas D. Weldon , Raphael F. Meloul , Richard A. Hillstead , Jonathan J. Rosen , George K. Bonnoitt, Jr. , David S. Halpern , Charles E. Larsen , Ian R. Crocker
发明人： Ron Waksman , Thomas D. Weldon , Raphael F. Meloul , Richard A. Hillstead , Jonathan J. Rosen , George K. Bonnoitt, Jr. , David S. Halpern , Charles E. Larsen , Ian R. Crocker
IPC分类号： A61M2902
CPC分类号： A61M37/0069 , A61M25/0029 , A61M25/1002 , A61M25/1006 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61N5/1002 , A61N5/1007 , A61N2005/1003 , A61N2005/1005 , A61N2005/1008 , A61N2005/1023
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the intraluminal passageways of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's intraluminal passageways. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于将治疗元件（例如辐射源）通过导管递送到患者（例如冠状动脉）的管腔内通道中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间具有内腔，并且其直径足够小以插入病人的管腔内通道。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

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